Amino acid dipepetide frequency for Leptosomus discolor (Madagascar cuckoo roller) (Cuculus discolor)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.656AlaAla: 5.656 ± 0.055	1.296AlaCys: 1.296 ± 0.021	3.041AlaAsp: 3.041 ± 0.028	4.551AlaGlu: 4.551 ± 0.044	2.642AlaPhe: 2.642 ± 0.033	3.91AlaGly: 3.91 ± 0.041	1.331AlaHis: 1.331 ± 0.02	3.057AlaIle: 3.057 ± 0.033	3.751AlaLys: 3.751 ± 0.037	6.368AlaLeu: 6.368 ± 0.05	1.489AlaMet: 1.489 ± 0.022	2.254AlaAsn: 2.254 ± 0.023	2.945AlaPro: 2.945 ± 0.039	2.737AlaGln: 2.737 ± 0.03	2.941AlaArg: 2.941 ± 0.032	5.226AlaSer: 5.226 ± 0.044	3.362AlaThr: 3.362 ± 0.035	4.916AlaVal: 4.916 ± 0.036	0.701AlaTrp: 0.701 ± 0.015	1.662AlaTyr: 1.662 ± 0.021	0.001AlaXaa: 0.001 ± 0.001
Cys	1.182CysAla: 1.182 ± 0.02	0.679CysCys: 0.679 ± 0.018	1.097CysAsp: 1.097 ± 0.021	1.347CysGlu: 1.347 ± 0.025	0.934CysPhe: 0.934 ± 0.017	1.454CysGly: 1.454 ± 0.028	0.642CysHis: 0.642 ± 0.016	1.177CysIle: 1.177 ± 0.021	1.34CysLys: 1.34 ± 0.02	2.178CysLeu: 2.178 ± 0.03	0.464CysMet: 0.464 ± 0.013	0.965CysAsn: 0.965 ± 0.021	1.257CysPro: 1.257 ± 0.028	1.085CysGln: 1.085 ± 0.022	1.23CysArg: 1.23 ± 0.018	2.045CysSer: 2.045 ± 0.027	1.212CysThr: 1.212 ± 0.021	1.366CysVal: 1.366 ± 0.023	0.297CysTrp: 0.297 ± 0.009	0.673CysTyr: 0.673 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.902AspAla: 2.902 ± 0.029	1.132AspCys: 1.132 ± 0.024	2.869AspAsp: 2.869 ± 0.037	3.699AspGlu: 3.699 ± 0.041	2.279AspPhe: 2.279 ± 0.026	3.328AspGly: 3.328 ± 0.036	1.189AspHis: 1.189 ± 0.017	3.036AspIle: 3.036 ± 0.029	2.835AspLys: 2.835 ± 0.03	5.019AspLeu: 5.019 ± 0.039	1.178AspMet: 1.178 ± 0.017	1.977AspAsn: 1.977 ± 0.03	2.652AspPro: 2.652 ± 0.03	1.852AspGln: 1.852 ± 0.021	2.401AspArg: 2.401 ± 0.025	4.131AspSer: 4.131 ± 0.04	2.528AspThr: 2.528 ± 0.025	3.28AspVal: 3.28 ± 0.032	0.656AspTrp: 0.656 ± 0.015	1.698AspTyr: 1.698 ± 0.022	0.001AspXaa: 0.001 ± 0.0
Glu	4.667GluAla: 4.667 ± 0.044	1.355GluCys: 1.355 ± 0.034	4.543GluAsp: 4.543 ± 0.044	7.794GluGlu: 7.794 ± 0.094	2.214GluPhe: 2.214 ± 0.026	3.898GluGly: 3.898 ± 0.034	1.536GluHis: 1.536 ± 0.019	3.546GluIle: 3.546 ± 0.035	5.71GluLys: 5.71 ± 0.057	6.29GluLeu: 6.29 ± 0.059	1.792GluMet: 1.792 ± 0.024	3.498GluAsn: 3.498 ± 0.037	2.564GluPro: 2.564 ± 0.035	3.193GluGln: 3.193 ± 0.037	3.867GluArg: 3.867 ± 0.046	4.53GluSer: 4.53 ± 0.042	3.572GluThr: 3.572 ± 0.033	4.395GluVal: 4.395 ± 0.039	0.731GluTrp: 0.731 ± 0.016	1.854GluTyr: 1.854 ± 0.023	0.001GluXaa: 0.001 ± 0.0
Phe	2.185PheAla: 2.185 ± 0.027	1.007PheCys: 1.007 ± 0.019	1.865PheAsp: 1.865 ± 0.025	2.179PheGlu: 2.179 ± 0.025	1.881PhePhe: 1.881 ± 0.03	2.292PheGly: 2.292 ± 0.034	1.109PheHis: 1.109 ± 0.019	2.127PheIle: 2.127 ± 0.029	2.175PheLys: 2.175 ± 0.021	4.199PheLeu: 4.199 ± 0.043	0.805PheMet: 0.805 ± 0.015	1.529PheAsn: 1.529 ± 0.019	1.963PhePro: 1.963 ± 0.025	1.835PheGln: 1.835 ± 0.022	2.008PheArg: 2.008 ± 0.025	3.492PheSer: 3.492 ± 0.036	2.288PheThr: 2.288 ± 0.024	2.401PheVal: 2.401 ± 0.033	0.519PheTrp: 0.519 ± 0.012	1.351PheTyr: 1.351 ± 0.023	0.001PheXaa: 0.001 ± 0.0
Gly	3.491GlyAla: 3.491 ± 0.041	1.235GlyCys: 1.235 ± 0.022	2.986GlyAsp: 2.986 ± 0.035	3.765GlyGlu: 3.765 ± 0.045	2.541GlyPhe: 2.541 ± 0.031	3.829GlyGly: 3.829 ± 0.055	1.524GlyHis: 1.524 ± 0.022	3.12GlyIle: 3.12 ± 0.033	3.983GlyLys: 3.983 ± 0.038	5.179GlyLeu: 5.179 ± 0.049	1.376GlyMet: 1.376 ± 0.021	2.657GlyAsn: 2.657 ± 0.031	2.809GlyPro: 2.809 ± 0.069	2.537GlyGln: 2.537 ± 0.031	3.196GlyArg: 3.196 ± 0.04	5.019GlySer: 5.019 ± 0.048	3.418GlyThr: 3.418 ± 0.04	3.501GlyVal: 3.501 ± 0.032	0.758GlyTrp: 0.758 ± 0.015	1.921GlyTyr: 1.921 ± 0.028	0.001GlyXaa: 0.001 ± 0.001
His	1.309HisAla: 1.309 ± 0.017	0.719HisCys: 0.719 ± 0.016	0.931HisAsp: 0.931 ± 0.016	1.376HisGlu: 1.376 ± 0.019	1.094HisPhe: 1.094 ± 0.016	1.477HisGly: 1.477 ± 0.02	0.863HisHis: 0.863 ± 0.02	1.323HisIle: 1.323 ± 0.022	1.399HisLys: 1.399 ± 0.017	2.812HisLeu: 2.812 ± 0.03	0.581HisMet: 0.581 ± 0.013	1.005HisAsn: 1.005 ± 0.016	1.486HisPro: 1.486 ± 0.021	1.176HisGln: 1.176 ± 0.018	1.435HisArg: 1.435 ± 0.022	2.202HisSer: 2.202 ± 0.028	1.263HisThr: 1.263 ± 0.018	1.54HisVal: 1.54 ± 0.021	0.425HisTrp: 0.425 ± 0.01	0.867HisTyr: 0.867 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.033IleAla: 3.033 ± 0.03	1.222IleCys: 1.222 ± 0.02	2.376IleAsp: 2.376 ± 0.026	2.914IleGlu: 2.914 ± 0.032	2.203IlePhe: 2.203 ± 0.028	2.529IleGly: 2.529 ± 0.027	1.39IleHis: 1.39 ± 0.02	2.755IleIle: 2.755 ± 0.031	3.049IleLys: 3.049 ± 0.027	4.975IleLeu: 4.975 ± 0.044	1.069IleMet: 1.069 ± 0.018	2.196IleAsn: 2.196 ± 0.025	2.842IlePro: 2.842 ± 0.026	2.439IleGln: 2.439 ± 0.026	2.557IleArg: 2.557 ± 0.03	4.124IleSer: 4.124 ± 0.038	2.887IleThr: 2.887 ± 0.028	2.947IleVal: 2.947 ± 0.03	0.592IleTrp: 0.592 ± 0.013	1.631IleTyr: 1.631 ± 0.025	0.001IleXaa: 0.001 ± 0.0
Lys	4.158LysAla: 4.158 ± 0.037	1.262LysCys: 1.262 ± 0.02	3.504LysAsp: 3.504 ± 0.036	5.705LysGlu: 5.705 ± 0.062	1.993LysPhe: 1.993 ± 0.021	3.479LysGly: 3.479 ± 0.044	1.614LysHis: 1.614 ± 0.021	3.2LysIle: 3.2 ± 0.029	5.458LysLys: 5.458 ± 0.065	5.72LysLeu: 5.72 ± 0.045	1.564LysMet: 1.564 ± 0.02	2.802LysAsn: 2.802 ± 0.033	3.11LysPro: 3.11 ± 0.038	3.008LysGln: 3.008 ± 0.033	3.579LysArg: 3.579 ± 0.039	4.349LysSer: 4.349 ± 0.04	3.475LysThr: 3.475 ± 0.034	3.794LysVal: 3.794 ± 0.035	0.687LysTrp: 0.687 ± 0.014	1.884LysTyr: 1.884 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	6.187LeuAla: 6.187 ± 0.057	2.182LeuCys: 2.182 ± 0.032	4.944LeuAsp: 4.944 ± 0.039	6.918LeuGlu: 6.918 ± 0.063	3.561LeuPhe: 3.561 ± 0.038	5.188LeuGly: 5.188 ± 0.044	2.66LeuHis: 2.66 ± 0.031	4.245LeuIle: 4.245 ± 0.04	6.474LeuLys: 6.474 ± 0.055	9.914LeuLeu: 9.914 ± 0.083	2.043LeuMet: 2.043 ± 0.021	3.913LeuAsn: 3.913 ± 0.036	5.46LeuPro: 5.46 ± 0.048	5.569LeuGln: 5.569 ± 0.053	5.103LeuArg: 5.103 ± 0.044	7.801LeuSer: 7.801 ± 0.051	5.027LeuThr: 5.027 ± 0.045	5.472LeuVal: 5.472 ± 0.045	1.093LeuTrp: 1.093 ± 0.018	2.78LeuTyr: 2.78 ± 0.032	0.001LeuXaa: 0.001 ± 0.001
Met	1.6MetAla: 1.6 ± 0.021	0.44MetCys: 0.44 ± 0.012	1.292MetAsp: 1.292 ± 0.019	1.853MetGlu: 1.853 ± 0.023	0.831MetPhe: 0.831 ± 0.015	1.277MetGly: 1.277 ± 0.02	0.523MetHis: 0.523 ± 0.012	0.99MetIle: 0.99 ± 0.016	1.597MetLys: 1.597 ± 0.022	2.073MetLeu: 2.073 ± 0.026	0.608MetMet: 0.608 ± 0.013	1.007MetAsn: 1.007 ± 0.016	1.042MetPro: 1.042 ± 0.018	1.022MetGln: 1.022 ± 0.017	1.081MetArg: 1.081 ± 0.016	1.543MetSer: 1.543 ± 0.022	1.168MetThr: 1.168 ± 0.019	1.437MetVal: 1.437 ± 0.017	0.257MetTrp: 0.257 ± 0.008	0.673MetTyr: 0.673 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.364AsnAla: 2.364 ± 0.025	0.997AsnCys: 0.997 ± 0.02	1.758AsnAsp: 1.758 ± 0.029	2.619AsnGlu: 2.619 ± 0.032	1.657AsnPhe: 1.657 ± 0.024	2.869AsnGly: 2.869 ± 0.039	0.998AsnHis: 0.998 ± 0.017	2.504AsnIle: 2.504 ± 0.03	2.623AsnLys: 2.623 ± 0.027	4.17AsnLeu: 4.17 ± 0.036	1.005AsnMet: 1.005 ± 0.017	1.875AsnAsn: 1.875 ± 0.026	2.313AsnPro: 2.313 ± 0.031	1.741AsnGln: 1.741 ± 0.025	2.078AsnArg: 2.078 ± 0.023	3.497AsnSer: 3.497 ± 0.036	2.263AsnThr: 2.263 ± 0.028	2.54AsnVal: 2.54 ± 0.028	0.502AsnTrp: 0.502 ± 0.011	1.34AsnTyr: 1.34 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	3.719ProAla: 3.719 ± 0.038	1.075ProCys: 1.075 ± 0.022	2.601ProAsp: 2.601 ± 0.027	3.858ProGlu: 3.858 ± 0.038	1.937ProPhe: 1.937 ± 0.024	3.746ProGly: 3.746 ± 0.095	1.252ProHis: 1.252 ± 0.021	1.97ProIle: 1.97 ± 0.026	2.788ProLys: 2.788 ± 0.033	4.582ProLeu: 4.582 ± 0.041	0.935ProMet: 0.935 ± 0.017	1.944ProAsn: 1.944 ± 0.025	4.267ProPro: 4.267 ± 0.068	2.338ProGln: 2.338 ± 0.031	2.541ProArg: 2.541 ± 0.03	4.966ProSer: 4.966 ± 0.051	2.651ProThr: 2.651 ± 0.03	3.794ProVal: 3.794 ± 0.037	0.559ProTrp: 0.559 ± 0.013	1.46ProTyr: 1.46 ± 0.018	0.001ProXaa: 0.001 ± 0.001
Gln	3.015GlnAla: 3.015 ± 0.033	0.988GlnCys: 0.988 ± 0.02	2.217GlnAsp: 2.217 ± 0.023	3.662GlnGlu: 3.662 ± 0.042	1.485GlnPhe: 1.485 ± 0.018	2.474GlnGly: 2.474 ± 0.035	1.276GlnHis: 1.276 ± 0.02	2.265GlnIle: 2.265 ± 0.024	3.213GlnLys: 3.213 ± 0.034	4.561GlnLeu: 4.561 ± 0.047	1.095GlnMet: 1.095 ± 0.017	2.06GlnAsn: 2.06 ± 0.025	2.373GlnPro: 2.373 ± 0.031	3.039GlnGln: 3.039 ± 0.057	2.6GlnArg: 2.6 ± 0.031	3.232GlnSer: 3.232 ± 0.032	2.397GlnThr: 2.397 ± 0.028	2.816GlnVal: 2.816 ± 0.029	0.51GlnTrp: 0.51 ± 0.012	1.325GlnTyr: 1.325 ± 0.019	0.001GlnXaa: 0.001 ± 0.001
Arg	3.019ArgAla: 3.019 ± 0.031	1.173ArgCys: 1.173 ± 0.021	2.583ArgAsp: 2.583 ± 0.03	3.776ArgGlu: 3.776 ± 0.04	1.962ArgPhe: 1.962 ± 0.023	2.842ArgGly: 2.842 ± 0.043	1.438ArgHis: 1.438 ± 0.018	2.574ArgIle: 2.574 ± 0.027	3.931ArgLys: 3.931 ± 0.044	4.925ArgLeu: 4.925 ± 0.043	1.178ArgMet: 1.178 ± 0.018	2.265ArgAsn: 2.265 ± 0.026	2.381ArgPro: 2.381 ± 0.025	2.488ArgGln: 2.488 ± 0.031	3.612ArgArg: 3.612 ± 0.038	3.954ArgSer: 3.954 ± 0.049	2.702ArgThr: 2.702 ± 0.025	2.967ArgVal: 2.967 ± 0.024	0.624ArgTrp: 0.624 ± 0.013	1.601ArgTyr: 1.601 ± 0.018	0.001ArgXaa: 0.001 ± 0.0
Ser	5.154SerAla: 5.154 ± 0.044	1.886SerCys: 1.886 ± 0.026	4.039SerAsp: 4.039 ± 0.042	5.125SerGlu: 5.125 ± 0.048	3.185SerPhe: 3.185 ± 0.032	4.972SerGly: 4.972 ± 0.045	2.029SerHis: 2.029 ± 0.026	3.596SerIle: 3.596 ± 0.036	4.564SerLys: 4.564 ± 0.039	7.959SerLeu: 7.959 ± 0.053	1.631SerMet: 1.631 ± 0.023	3.126SerAsn: 3.126 ± 0.035	5.118SerPro: 5.118 ± 0.063	3.658SerGln: 3.658 ± 0.039	4.052SerArg: 4.052 ± 0.045	9.177SerSer: 9.177 ± 0.096	4.614SerThr: 4.614 ± 0.043	5.162SerVal: 5.162 ± 0.043	0.974SerTrp: 0.974 ± 0.018	2.286SerTyr: 2.286 ± 0.025	0.001SerXaa: 0.001 ± 0.001
Thr	3.831ThrAla: 3.831 ± 0.037	1.354ThrCys: 1.354 ± 0.027	2.773ThrAsp: 2.773 ± 0.033	3.778ThrGlu: 3.778 ± 0.036	2.2ThrPhe: 2.2 ± 0.024	3.464ThrGly: 3.464 ± 0.034	1.187ThrHis: 1.187 ± 0.019	2.627ThrIle: 2.627 ± 0.031	2.915ThrLys: 2.915 ± 0.027	5.16ThrLeu: 5.16 ± 0.04	1.117ThrMet: 1.117 ± 0.016	1.981ThrAsn: 1.981 ± 0.021	3.124ThrPro: 3.124 ± 0.04	2.137ThrGln: 2.137 ± 0.023	2.297ThrArg: 2.297 ± 0.026	4.686ThrSer: 4.686 ± 0.046	3.059ThrThr: 3.059 ± 0.037	4.169ThrVal: 4.169 ± 0.047	0.666ThrTrp: 0.666 ± 0.016	1.581ThrTyr: 1.581 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.09ValAla: 4.09 ± 0.029	1.575ValCys: 1.575 ± 0.026	3.092ValAsp: 3.092 ± 0.028	4.007ValGlu: 4.007 ± 0.036	2.708ValPhe: 2.708 ± 0.035	3.35ValGly: 3.35 ± 0.034	1.596ValHis: 1.596 ± 0.019	3.333ValIle: 3.333 ± 0.029	3.922ValLys: 3.922 ± 0.037	6.328ValLeu: 6.328 ± 0.048	1.395ValMet: 1.395 ± 0.018	2.654ValAsn: 2.654 ± 0.028	3.473ValPro: 3.473 ± 0.033	2.85ValGln: 2.85 ± 0.029	3.039ValArg: 3.039 ± 0.028	5.022ValSer: 5.022 ± 0.041	3.905ValThr: 3.905 ± 0.035	4.411ValVal: 4.411 ± 0.038	0.72ValTrp: 0.72 ± 0.016	1.907ValTyr: 1.907 ± 0.023	0.001ValXaa: 0.001 ± 0.0
Trp	0.672TrpAla: 0.672 ± 0.013	0.25TrpCys: 0.25 ± 0.008	0.658TrpAsp: 0.658 ± 0.014	0.781TrpGlu: 0.781 ± 0.018	0.478TrpPhe: 0.478 ± 0.012	0.645TrpGly: 0.645 ± 0.015	0.311TrpHis: 0.311 ± 0.009	0.629TrpIle: 0.629 ± 0.014	0.903TrpLys: 0.903 ± 0.016	1.154TrpLeu: 1.154 ± 0.022	0.309TrpMet: 0.309 ± 0.009	0.671TrpAsn: 0.671 ± 0.012	0.43TrpPro: 0.43 ± 0.01	0.55TrpGln: 0.55 ± 0.013	0.645TrpArg: 0.645 ± 0.013	0.881TrpSer: 0.881 ± 0.017	0.661TrpThr: 0.661 ± 0.017	0.668TrpVal: 0.668 ± 0.015	0.195TrpTrp: 0.195 ± 0.007	0.385TrpTyr: 0.385 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.601TyrAla: 1.601 ± 0.021	0.797TyrCys: 0.797 ± 0.015	1.475TyrAsp: 1.475 ± 0.022	1.84TyrGlu: 1.84 ± 0.021	1.426TyrPhe: 1.426 ± 0.024	1.823TyrGly: 1.823 ± 0.021	0.814TyrHis: 0.814 ± 0.016	1.654TyrIle: 1.654 ± 0.023	1.716TyrLys: 1.716 ± 0.022	2.967TyrLeu: 2.967 ± 0.032	0.678TyrMet: 0.678 ± 0.013	1.335TyrAsn: 1.335 ± 0.021	1.374TyrPro: 1.374 ± 0.02	1.351TyrGln: 1.351 ± 0.02	1.733TyrArg: 1.733 ± 0.02	2.43TyrSer: 2.43 ± 0.029	1.652TyrThr: 1.652 ± 0.024	1.802TyrVal: 1.802 ± 0.023	0.412TyrTrp: 0.412 ± 0.015	1.133TyrTyr: 1.133 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.086XaaXaa: 0.086 ± 0.012

Statistics based on 9574 proteins (4034616 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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