Amino acid dipepetide frequency for Tabrizicola piscis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.286AlaAla: 19.286 ± 0.18	1.079AlaCys: 1.079 ± 0.029	7.373AlaAsp: 7.373 ± 0.085	8.609AlaGlu: 8.609 ± 0.092	4.698AlaPhe: 4.698 ± 0.07	11.419AlaGly: 11.419 ± 0.108	2.396AlaHis: 2.396 ± 0.046	5.881AlaIle: 5.881 ± 0.072	3.939AlaLys: 3.939 ± 0.072	15.111AlaLeu: 15.111 ± 0.127	4.081AlaMet: 4.081 ± 0.056	2.71AlaAsn: 2.71 ± 0.05	6.246AlaPro: 6.246 ± 0.08	4.212AlaGln: 4.212 ± 0.058	9.414AlaArg: 9.414 ± 0.105	5.681AlaSer: 5.681 ± 0.071	6.881AlaThr: 6.881 ± 0.073	9.451AlaVal: 9.451 ± 0.088	1.529AlaTrp: 1.529 ± 0.033	2.56AlaTyr: 2.56 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.984CysAla: 0.984 ± 0.032	0.105CysCys: 0.105 ± 0.009	0.599CysAsp: 0.599 ± 0.021	0.383CysGlu: 0.383 ± 0.019	0.321CysPhe: 0.321 ± 0.014	0.936CysGly: 0.936 ± 0.03	0.239CysHis: 0.239 ± 0.013	0.381CysIle: 0.381 ± 0.018	0.165CysLys: 0.165 ± 0.011	0.881CysLeu: 0.881 ± 0.026	0.171CysMet: 0.171 ± 0.011	0.205CysAsn: 0.205 ± 0.013	0.515CysPro: 0.515 ± 0.023	0.232CysGln: 0.232 ± 0.012	0.569CysArg: 0.569 ± 0.022	0.37CysSer: 0.37 ± 0.014	0.463CysThr: 0.463 ± 0.021	0.568CysVal: 0.568 ± 0.022	0.12CysTrp: 0.12 ± 0.009	0.179CysTyr: 0.179 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.984AspAla: 6.984 ± 0.069	0.548AspCys: 0.548 ± 0.02	3.017AspAsp: 3.017 ± 0.063	2.934AspGlu: 2.934 ± 0.051	2.218AspPhe: 2.218 ± 0.042	5.485AspGly: 5.485 ± 0.082	1.424AspHis: 1.424 ± 0.034	2.69AspIle: 2.69 ± 0.045	1.366AspLys: 1.366 ± 0.035	6.855AspLeu: 6.855 ± 0.097	1.516AspMet: 1.516 ± 0.034	1.017AspAsn: 1.017 ± 0.029	3.957AspPro: 3.957 ± 0.056	1.987AspGln: 1.987 ± 0.042	4.775AspArg: 4.775 ± 0.061	2.063AspSer: 2.063 ± 0.039	2.769AspThr: 2.769 ± 0.056	4.034AspVal: 4.034 ± 0.052	1.293AspTrp: 1.293 ± 0.035	1.44AspTyr: 1.44 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.43GluAla: 8.43 ± 0.092	0.32GluCys: 0.32 ± 0.017	2.913GluAsp: 2.913 ± 0.047	2.847GluGlu: 2.847 ± 0.058	1.634GluPhe: 1.634 ± 0.041	5.025GluGly: 5.025 ± 0.068	0.895GluHis: 0.895 ± 0.029	3.011GluIle: 3.011 ± 0.057	1.719GluLys: 1.719 ± 0.036	4.451GluLeu: 4.451 ± 0.066	1.605GluMet: 1.605 ± 0.032	1.288GluAsn: 1.288 ± 0.034	2.549GluPro: 2.549 ± 0.046	1.481GluGln: 1.481 ± 0.035	3.761GluArg: 3.761 ± 0.054	1.902GluSer: 1.902 ± 0.038	3.43GluThr: 3.43 ± 0.05	4.58GluVal: 4.58 ± 0.058	0.665GluTrp: 0.665 ± 0.027	0.898GluTyr: 0.898 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.734PheAla: 4.734 ± 0.067	0.39PheCys: 0.39 ± 0.018	2.64PheAsp: 2.64 ± 0.043	1.813PheGlu: 1.813 ± 0.038	1.329PhePhe: 1.329 ± 0.036	3.679PheGly: 3.679 ± 0.055	0.769PheHis: 0.769 ± 0.023	1.509PheIle: 1.509 ± 0.041	0.794PheLys: 0.794 ± 0.024	3.683PheLeu: 3.683 ± 0.063	0.785PheMet: 0.785 ± 0.022	0.95PheAsn: 0.95 ± 0.027	1.721PhePro: 1.721 ± 0.042	1.072PheGln: 1.072 ± 0.03	2.345PheArg: 2.345 ± 0.039	1.902PheSer: 1.902 ± 0.044	2.078PheThr: 2.078 ± 0.043	2.62PheVal: 2.62 ± 0.049	0.614PheTrp: 0.614 ± 0.025	0.857PheTyr: 0.857 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.178GlyAla: 10.178 ± 0.106	0.867GlyCys: 0.867 ± 0.03	4.663GlyAsp: 4.663 ± 0.08	4.43GlyGlu: 4.43 ± 0.065	3.775GlyPhe: 3.775 ± 0.06	7.597GlyGly: 7.597 ± 0.116	1.995GlyHis: 1.995 ± 0.042	4.457GlyIle: 4.457 ± 0.058	3.065GlyLys: 3.065 ± 0.058	10.028GlyLeu: 10.028 ± 0.106	2.744GlyMet: 2.744 ± 0.044	2.009GlyAsn: 2.009 ± 0.049	4.19GlyPro: 4.19 ± 0.064	3.304GlyGln: 3.304 ± 0.057	6.176GlyArg: 6.176 ± 0.079	4.286GlySer: 4.286 ± 0.065	4.961GlyThr: 4.961 ± 0.065	6.74GlyVal: 6.74 ± 0.068	1.656GlyTrp: 1.656 ± 0.036	2.244GlyTyr: 2.244 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.462HisAla: 2.462 ± 0.047	0.228HisCys: 0.228 ± 0.013	1.263HisAsp: 1.263 ± 0.031	0.945HisGlu: 0.945 ± 0.027	0.799HisPhe: 0.799 ± 0.028	1.997HisGly: 1.997 ± 0.046	0.598HisHis: 0.598 ± 0.024	0.866HisIle: 0.866 ± 0.027	0.415HisLys: 0.415 ± 0.017	2.288HisLeu: 2.288 ± 0.048	0.516HisMet: 0.516 ± 0.019	0.417HisAsn: 0.417 ± 0.018	1.447HisPro: 1.447 ± 0.037	0.564HisGln: 0.564 ± 0.022	1.44HisArg: 1.44 ± 0.037	0.935HisSer: 0.935 ± 0.031	0.769HisThr: 0.769 ± 0.024	1.485HisVal: 1.485 ± 0.032	0.374HisTrp: 0.374 ± 0.016	0.522HisTyr: 0.522 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.96IleAla: 6.96 ± 0.079	0.52IleCys: 0.52 ± 0.02	3.41IleAsp: 3.41 ± 0.048	2.934IleGlu: 2.934 ± 0.049	1.648IlePhe: 1.648 ± 0.041	4.76IleGly: 4.76 ± 0.064	0.915IleHis: 0.915 ± 0.029	2.013IleIle: 2.013 ± 0.041	1.155IleLys: 1.155 ± 0.03	4.925IleLeu: 4.925 ± 0.065	0.937IleMet: 0.937 ± 0.03	1.168IleAsn: 1.168 ± 0.025	2.406IlePro: 2.406 ± 0.043	1.046IleGln: 1.046 ± 0.03	3.189IleArg: 3.189 ± 0.045	2.564IleSer: 2.564 ± 0.048	2.827IleThr: 2.827 ± 0.053	3.587IleVal: 3.587 ± 0.053	0.726IleTrp: 0.726 ± 0.026	0.966IleTyr: 0.966 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.035LysAla: 4.035 ± 0.07	0.149LysCys: 0.149 ± 0.011	1.625LysAsp: 1.625 ± 0.036	1.206LysGlu: 1.206 ± 0.031	0.735LysPhe: 0.735 ± 0.023	2.827LysGly: 2.827 ± 0.07	0.537LysHis: 0.537 ± 0.024	1.434LysIle: 1.434 ± 0.037	0.903LysLys: 0.903 ± 0.036	2.689LysLeu: 2.689 ± 0.047	0.748LysMet: 0.748 ± 0.022	0.627LysAsn: 0.627 ± 0.024	1.739LysPro: 1.739 ± 0.037	0.713LysGln: 0.713 ± 0.021	1.971LysArg: 1.971 ± 0.047	1.54LysSer: 1.54 ± 0.038	1.751LysThr: 1.751 ± 0.039	2.287LysVal: 2.287 ± 0.051	0.322LysTrp: 0.322 ± 0.017	0.506LysTyr: 0.506 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.349LeuAla: 15.349 ± 0.145	0.96LeuCys: 0.96 ± 0.029	5.936LeuAsp: 5.936 ± 0.074	4.936LeuGlu: 4.936 ± 0.069	3.41LeuPhe: 3.41 ± 0.062	8.979LeuGly: 8.979 ± 0.104	2.004LeuHis: 2.004 ± 0.042	5.258LeuIle: 5.258 ± 0.063	3.026LeuLys: 3.026 ± 0.049	9.488LeuLeu: 9.488 ± 0.12	2.737LeuMet: 2.737 ± 0.048	2.448LeuAsn: 2.448 ± 0.045	6.307LeuPro: 6.307 ± 0.082	2.94LeuGln: 2.94 ± 0.049	7.556LeuArg: 7.556 ± 0.08	6.278LeuSer: 6.278 ± 0.075	6.638LeuThr: 6.638 ± 0.078	7.625LeuVal: 7.625 ± 0.094	1.539LeuTrp: 1.539 ± 0.04	1.918LeuTyr: 1.918 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.838MetAla: 3.838 ± 0.068	0.156MetCys: 0.156 ± 0.012	1.387MetAsp: 1.387 ± 0.033	1.205MetGlu: 1.205 ± 0.033	0.746MetPhe: 0.746 ± 0.026	2.318MetGly: 2.318 ± 0.043	0.443MetHis: 0.443 ± 0.019	1.388MetIle: 1.388 ± 0.036	0.95MetLys: 0.95 ± 0.028	2.616MetLeu: 2.616 ± 0.051	0.702MetMet: 0.702 ± 0.027	0.727MetAsn: 0.727 ± 0.024	1.572MetPro: 1.572 ± 0.033	0.99MetGln: 0.99 ± 0.029	1.821MetArg: 1.821 ± 0.038	1.451MetSer: 1.451 ± 0.038	2.165MetThr: 2.165 ± 0.037	2.055MetVal: 2.055 ± 0.037	0.235MetTrp: 0.235 ± 0.014	0.308MetTyr: 0.308 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.825AsnAla: 2.825 ± 0.051	0.215AsnCys: 0.215 ± 0.014	1.274AsnAsp: 1.274 ± 0.04	0.944AsnGlu: 0.944 ± 0.029	0.808AsnPhe: 0.808 ± 0.027	2.086AsnGly: 2.086 ± 0.048	0.482AsnHis: 0.482 ± 0.019	1.148AsnIle: 1.148 ± 0.03	0.513AsnLys: 0.513 ± 0.02	2.498AsnLeu: 2.498 ± 0.045	0.558AsnMet: 0.558 ± 0.019	0.531AsnAsn: 0.531 ± 0.023	1.869AsnPro: 1.869 ± 0.037	0.584AsnGln: 0.584 ± 0.023	1.676AsnArg: 1.676 ± 0.036	1.046AsnSer: 1.046 ± 0.034	1.123AsnThr: 1.123 ± 0.029	1.628AsnVal: 1.628 ± 0.044	0.429AsnTrp: 0.429 ± 0.017	0.556AsnTyr: 0.556 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	6.842ProAla: 6.842 ± 0.076	0.35ProCys: 0.35 ± 0.015	4.158ProAsp: 4.158 ± 0.062	4.066ProGlu: 4.066 ± 0.062	2.02ProPhe: 2.02 ± 0.043	5.294ProGly: 5.294 ± 0.065	1.065ProHis: 1.065 ± 0.033	2.231ProIle: 2.231 ± 0.045	1.656ProLys: 1.656 ± 0.044	5.041ProLeu: 5.041 ± 0.068	1.488ProMet: 1.488 ± 0.035	1.232ProAsn: 1.232 ± 0.033	2.646ProPro: 2.646 ± 0.054	1.698ProGln: 1.698 ± 0.041	2.923ProArg: 2.923 ± 0.05	2.537ProSer: 2.537 ± 0.048	2.681ProThr: 2.681 ± 0.047	4.709ProVal: 4.709 ± 0.06	0.758ProTrp: 0.758 ± 0.024	1.161ProTyr: 1.161 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.082GlnAla: 4.082 ± 0.051	0.193GlnCys: 0.193 ± 0.012	1.633GlnAsp: 1.633 ± 0.035	1.273GlnGlu: 1.273 ± 0.036	0.981GlnPhe: 0.981 ± 0.028	2.723GlnGly: 2.723 ± 0.049	0.563GlnHis: 0.563 ± 0.021	1.844GlnIle: 1.844 ± 0.039	0.943GlnLys: 0.943 ± 0.032	2.766GlnLeu: 2.766 ± 0.047	1.003GlnMet: 1.003 ± 0.029	0.766GlnAsn: 0.766 ± 0.029	1.743GlnPro: 1.743 ± 0.037	0.874GlnGln: 0.874 ± 0.035	2.188GlnArg: 2.188 ± 0.05	1.701GlnSer: 1.701 ± 0.033	1.828GlnThr: 1.828 ± 0.039	2.369GlnVal: 2.369 ± 0.047	0.392GlnTrp: 0.392 ± 0.017	0.498GlnTyr: 0.498 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	8.724ArgAla: 8.724 ± 0.099	0.449ArgCys: 0.449 ± 0.019	4.053ArgAsp: 4.053 ± 0.057	3.512ArgGlu: 3.512 ± 0.053	2.779ArgPhe: 2.779 ± 0.046	4.698ArgGly: 4.698 ± 0.064	1.635ArgHis: 1.635 ± 0.04	3.763ArgIle: 3.763 ± 0.053	2.071ArgLys: 2.071 ± 0.036	8.278ArgLeu: 8.278 ± 0.108	2.066ArgMet: 2.066 ± 0.04	1.61ArgAsn: 1.61 ± 0.037	3.639ArgPro: 3.639 ± 0.064	2.367ArgGln: 2.367 ± 0.045	5.049ArgArg: 5.049 ± 0.068	3.43ArgSer: 3.43 ± 0.063	3.117ArgThr: 3.117 ± 0.052	4.978ArgVal: 4.978 ± 0.063	1.005ArgTrp: 1.005 ± 0.028	1.484ArgTyr: 1.484 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.841SerAla: 5.841 ± 0.063	0.397SerCys: 0.397 ± 0.018	2.837SerAsp: 2.837 ± 0.048	2.303SerGlu: 2.303 ± 0.044	2.107SerPhe: 2.107 ± 0.043	5.234SerGly: 5.234 ± 0.072	1.019SerHis: 1.019 ± 0.025	2.268SerIle: 2.268 ± 0.047	1.195SerLys: 1.195 ± 0.031	5.181SerLeu: 5.181 ± 0.07	1.197SerMet: 1.197 ± 0.03	1.124SerAsn: 1.124 ± 0.034	2.672SerPro: 2.672 ± 0.045	1.388SerGln: 1.388 ± 0.034	3.227SerArg: 3.227 ± 0.061	2.352SerSer: 2.352 ± 0.064	2.449SerThr: 2.449 ± 0.043	3.736SerVal: 3.736 ± 0.05	0.685SerTrp: 0.685 ± 0.026	1.15SerTyr: 1.15 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.93ThrAla: 6.93 ± 0.076	0.473ThrCys: 0.473 ± 0.017	3.26ThrAsp: 3.26 ± 0.07	2.918ThrGlu: 2.918 ± 0.045	2.057ThrPhe: 2.057 ± 0.042	5.554ThrGly: 5.554 ± 0.071	1.177ThrHis: 1.177 ± 0.036	2.732ThrIle: 2.732 ± 0.047	1.408ThrLys: 1.408 ± 0.036	6.506ThrLeu: 6.506 ± 0.089	1.253ThrMet: 1.253 ± 0.033	1.236ThrAsn: 1.236 ± 0.031	3.548ThrPro: 3.548 ± 0.052	1.421ThrGln: 1.421 ± 0.034	3.499ThrArg: 3.499 ± 0.06	2.608ThrSer: 2.608 ± 0.043	2.97ThrThr: 2.97 ± 0.056	4.569ThrVal: 4.569 ± 0.067	0.752ThrTrp: 0.752 ± 0.023	1.158ThrTyr: 1.158 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	10.069ValAla: 10.069 ± 0.097	0.61ValCys: 0.61 ± 0.021	4.09ValAsp: 4.09 ± 0.066	4.434ValGlu: 4.434 ± 0.058	2.839ValPhe: 2.839 ± 0.048	5.642ValGly: 5.642 ± 0.076	1.35ValHis: 1.35 ± 0.037	4.287ValIle: 4.287 ± 0.061	2.132ValLys: 2.132 ± 0.047	8.052ValLeu: 8.052 ± 0.096	2.12ValMet: 2.12 ± 0.044	1.8ValAsn: 1.8 ± 0.039	3.871ValPro: 3.871 ± 0.053	2.192ValGln: 2.192 ± 0.04	4.414ValArg: 4.414 ± 0.065	3.846ValSer: 3.846 ± 0.061	5.225ValThr: 5.225 ± 0.07	6.075ValVal: 6.075 ± 0.09	1.108ValTrp: 1.108 ± 0.032	1.456ValTyr: 1.456 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.538TrpAla: 1.538 ± 0.042	0.153TrpCys: 0.153 ± 0.011	0.805TrpAsp: 0.805 ± 0.026	0.669TrpGlu: 0.669 ± 0.025	0.559TrpPhe: 0.559 ± 0.024	1.101TrpGly: 1.101 ± 0.03	0.357TrpHis: 0.357 ± 0.02	0.633TrpIle: 0.633 ± 0.023	0.44TrpLys: 0.44 ± 0.018	1.836TrpLeu: 1.836 ± 0.044	0.39TrpMet: 0.39 ± 0.018	0.425TrpAsn: 0.425 ± 0.017	0.808TrpPro: 0.808 ± 0.029	0.667TrpGln: 0.667 ± 0.02	1.148TrpArg: 1.148 ± 0.03	0.822TrpSer: 0.822 ± 0.024	0.858TrpThr: 0.858 ± 0.025	1.056TrpVal: 1.056 ± 0.032	0.277TrpTrp: 0.277 ± 0.014	0.284TrpTyr: 0.284 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.466TyrAla: 2.466 ± 0.044	0.227TyrCys: 0.227 ± 0.013	1.437TyrAsp: 1.437 ± 0.032	1.042TyrGlu: 1.042 ± 0.03	0.82TyrPhe: 0.82 ± 0.024	2.012TyrGly: 2.012 ± 0.041	0.466TyrHis: 0.466 ± 0.02	0.861TyrIle: 0.861 ± 0.024	0.487TyrLys: 0.487 ± 0.02	2.162TyrLeu: 2.162 ± 0.04	0.456TyrMet: 0.456 ± 0.018	0.507TyrAsn: 0.507 ± 0.019	1.111TyrPro: 1.111 ± 0.027	0.631TyrGln: 0.631 ± 0.023	1.566TyrArg: 1.566 ± 0.032	1.048TyrSer: 1.048 ± 0.033	1.042TyrThr: 1.042 ± 0.03	1.46TyrVal: 1.46 ± 0.034	0.346TyrTrp: 0.346 ± 0.016	0.509TyrTyr: 0.509 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4119 proteins (1303656 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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