Amino acid dipepetide frequency for Nostoc flagelliforme CCNUN1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.164AlaAla: 7.164 ± 0.08	0.785AlaCys: 0.785 ± 0.019	3.953AlaAsp: 3.953 ± 0.045	5.001AlaGlu: 5.001 ± 0.056	2.948AlaPhe: 2.948 ± 0.038	5.459AlaGly: 5.459 ± 0.077	1.243AlaHis: 1.243 ± 0.024	6.775AlaIle: 6.775 ± 0.064	4.24AlaLys: 4.24 ± 0.051	8.46AlaLeu: 8.46 ± 0.071	1.678AlaMet: 1.678 ± 0.028	3.524AlaAsn: 3.524 ± 0.051	2.862AlaPro: 2.862 ± 0.047	4.193AlaGln: 4.193 ± 0.053	3.477AlaArg: 3.477 ± 0.04	5.12AlaSer: 5.12 ± 0.061	4.799AlaThr: 4.799 ± 0.054	5.372AlaVal: 5.372 ± 0.054	1.028AlaTrp: 1.028 ± 0.021	2.306AlaTyr: 2.306 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.622CysAla: 0.622 ± 0.017	0.173CysCys: 0.173 ± 0.009	0.561CysAsp: 0.561 ± 0.016	0.541CysGlu: 0.541 ± 0.017	0.442CysPhe: 0.442 ± 0.015	0.742CysGly: 0.742 ± 0.018	0.268CysHis: 0.268 ± 0.011	0.564CysIle: 0.564 ± 0.016	0.429CysLys: 0.429 ± 0.012	1.155CysLeu: 1.155 ± 0.024	0.17CysMet: 0.17 ± 0.009	0.417CysAsn: 0.417 ± 0.014	0.581CysPro: 0.581 ± 0.017	0.579CysGln: 0.579 ± 0.016	0.533CysArg: 0.533 ± 0.015	0.663CysSer: 0.663 ± 0.016	0.512CysThr: 0.512 ± 0.015	0.589CysVal: 0.589 ± 0.018	0.179CysTrp: 0.179 ± 0.01	0.365CysTyr: 0.365 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.759AspAla: 3.759 ± 0.047	0.504AspCys: 0.504 ± 0.013	2.292AspAsp: 2.292 ± 0.045	3.168AspGlu: 3.168 ± 0.05	2.374AspPhe: 2.374 ± 0.032	3.331AspGly: 3.331 ± 0.043	0.669AspHis: 0.669 ± 0.017	3.509AspIle: 3.509 ± 0.037	2.393AspLys: 2.393 ± 0.033	5.426AspLeu: 5.426 ± 0.052	0.709AspMet: 0.709 ± 0.018	2.1AspAsn: 2.1 ± 0.032	2.208AspPro: 2.208 ± 0.032	1.677AspGln: 1.677 ± 0.025	2.988AspArg: 2.988 ± 0.039	3.089AspSer: 3.089 ± 0.043	2.492AspThr: 2.492 ± 0.042	2.903AspVal: 2.903 ± 0.037	0.898AspTrp: 0.898 ± 0.021	1.907AspTyr: 1.907 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	5.284GluAla: 5.284 ± 0.055	0.569GluCys: 0.569 ± 0.015	2.615GluAsp: 2.615 ± 0.032	4.078GluGlu: 4.078 ± 0.057	2.461GluPhe: 2.461 ± 0.039	3.145GluGly: 3.145 ± 0.043	1.002GluHis: 1.002 ± 0.021	4.886GluIle: 4.886 ± 0.044	3.674GluLys: 3.674 ± 0.051	7.064GluLeu: 7.064 ± 0.067	1.319GluMet: 1.319 ± 0.026	2.785GluAsn: 2.785 ± 0.037	2.325GluPro: 2.325 ± 0.036	3.806GluGln: 3.806 ± 0.046	3.523GluArg: 3.523 ± 0.044	3.787GluSer: 3.787 ± 0.047	3.379GluThr: 3.379 ± 0.046	4.279GluVal: 4.279 ± 0.049	0.819GluTrp: 0.819 ± 0.02	1.945GluTyr: 1.945 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.084PheAla: 3.084 ± 0.039	0.594PheCys: 0.594 ± 0.017	2.231PheAsp: 2.231 ± 0.031	2.255PheGlu: 2.255 ± 0.031	1.683PhePhe: 1.683 ± 0.028	2.957PheGly: 2.957 ± 0.048	0.729PheHis: 0.729 ± 0.018	2.379PheIle: 2.379 ± 0.034	1.703PheLys: 1.703 ± 0.028	4.115PheLeu: 4.115 ± 0.051	0.738PheMet: 0.738 ± 0.018	1.933PheAsn: 1.933 ± 0.032	1.769PhePro: 1.769 ± 0.027	1.794PheGln: 1.794 ± 0.027	1.855PheArg: 1.855 ± 0.028	3.075PheSer: 3.075 ± 0.036	2.27PheThr: 2.27 ± 0.03	2.457PheVal: 2.457 ± 0.034	0.673PheTrp: 0.673 ± 0.017	1.352PheTyr: 1.352 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	4.761GlyAla: 4.761 ± 0.066	0.782GlyCys: 0.782 ± 0.02	3.433GlyAsp: 3.433 ± 0.048	4.074GlyGlu: 4.074 ± 0.048	2.935GlyPhe: 2.935 ± 0.041	5.01GlyGly: 5.01 ± 0.09	1.185GlyHis: 1.185 ± 0.025	5.005GlyIle: 5.005 ± 0.052	4.145GlyLys: 4.145 ± 0.044	6.52GlyLeu: 6.52 ± 0.056	1.411GlyMet: 1.411 ± 0.028	3.484GlyAsn: 3.484 ± 0.082	1.149GlyPro: 1.149 ± 0.024	2.871GlyGln: 2.871 ± 0.044	3.258GlyArg: 3.258 ± 0.036	4.341GlySer: 4.341 ± 0.059	3.872GlyThr: 3.872 ± 0.062	4.683GlyVal: 4.683 ± 0.049	1.078GlyTrp: 1.078 ± 0.02	2.289GlyTyr: 2.289 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	1.063HisAla: 1.063 ± 0.022	0.258HisCys: 0.258 ± 0.011	0.728HisAsp: 0.728 ± 0.019	0.923HisGlu: 0.923 ± 0.023	0.773HisPhe: 0.773 ± 0.022	1.06HisGly: 1.06 ± 0.024	0.54HisHis: 0.54 ± 0.018	1.109HisIle: 1.109 ± 0.02	0.816HisLys: 0.816 ± 0.019	2.239HisLeu: 2.239 ± 0.033	0.219HisMet: 0.219 ± 0.008	0.723HisAsn: 0.723 ± 0.017	1.269HisPro: 1.269 ± 0.028	1.089HisGln: 1.089 ± 0.028	1.103HisArg: 1.103 ± 0.024	1.209HisSer: 1.209 ± 0.028	0.882HisThr: 0.882 ± 0.018	0.8HisVal: 0.8 ± 0.019	0.389HisTrp: 0.389 ± 0.012	0.647HisTyr: 0.647 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.095IleAla: 7.095 ± 0.064	0.746IleCys: 0.746 ± 0.019	3.717IleAsp: 3.717 ± 0.041	4.387IleGlu: 4.387 ± 0.047	2.605IlePhe: 2.605 ± 0.041	4.347IleGly: 4.347 ± 0.042	1.212IleHis: 1.212 ± 0.023	3.89IleIle: 3.89 ± 0.047	3.256IleLys: 3.256 ± 0.042	6.613IleLeu: 6.613 ± 0.064	0.868IleMet: 0.868 ± 0.022	3.304IleAsn: 3.304 ± 0.046	3.396IlePro: 3.396 ± 0.035	3.051IleGln: 3.051 ± 0.035	3.154IleArg: 3.154 ± 0.041	4.649IleSer: 4.649 ± 0.042	3.888IleThr: 3.888 ± 0.053	4.202IleVal: 4.202 ± 0.046	0.867IleTrp: 0.867 ± 0.021	1.991IleTyr: 1.991 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.146LysAla: 4.146 ± 0.046	0.375LysCys: 0.375 ± 0.012	2.285LysAsp: 2.285 ± 0.037	2.945LysGlu: 2.945 ± 0.04	1.933LysPhe: 1.933 ± 0.029	2.848LysGly: 2.848 ± 0.032	0.886LysHis: 0.886 ± 0.02	3.683LysIle: 3.683 ± 0.048	2.656LysLys: 2.656 ± 0.043	5.726LysLeu: 5.726 ± 0.061	0.97LysMet: 0.97 ± 0.022	2.425LysAsn: 2.425 ± 0.035	2.547LysPro: 2.547 ± 0.042	2.867LysGln: 2.867 ± 0.033	2.56LysArg: 2.56 ± 0.04	3.341LysSer: 3.341 ± 0.04	3.094LysThr: 3.094 ± 0.034	3.33LysVal: 3.33 ± 0.041	0.577LysTrp: 0.577 ± 0.014	1.563LysTyr: 1.563 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	9.295LeuAla: 9.295 ± 0.067	1.037LeuCys: 1.037 ± 0.02	5.15LeuAsp: 5.15 ± 0.046	7.264LeuGlu: 7.264 ± 0.065	3.77LeuPhe: 3.77 ± 0.043	7.458LeuGly: 7.458 ± 0.056	1.912LeuHis: 1.912 ± 0.033	6.66LeuIle: 6.66 ± 0.066	5.717LeuLys: 5.717 ± 0.056	11.309LeuLeu: 11.309 ± 0.11	2.054LeuMet: 2.054 ± 0.034	4.899LeuAsn: 4.899 ± 0.047	5.626LeuPro: 5.626 ± 0.056	5.639LeuGln: 5.639 ± 0.061	5.715LeuArg: 5.715 ± 0.056	7.665LeuSer: 7.665 ± 0.066	6.458LeuThr: 6.458 ± 0.057	7.083LeuVal: 7.083 ± 0.064	1.401LeuTrp: 1.401 ± 0.032	2.672LeuTyr: 2.672 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.583MetAla: 1.583 ± 0.033	0.147MetCys: 0.147 ± 0.008	0.699MetAsp: 0.699 ± 0.019	0.995MetGlu: 0.995 ± 0.023	0.555MetPhe: 0.555 ± 0.016	1.277MetGly: 1.277 ± 0.023	0.327MetHis: 0.327 ± 0.011	1.09MetIle: 1.09 ± 0.022	0.954MetLys: 0.954 ± 0.022	1.99MetLeu: 1.99 ± 0.032	0.373MetMet: 0.373 ± 0.013	0.834MetAsn: 0.834 ± 0.023	1.064MetPro: 1.064 ± 0.019	0.942MetGln: 0.942 ± 0.019	0.984MetArg: 0.984 ± 0.02	1.332MetSer: 1.332 ± 0.028	1.247MetThr: 1.247 ± 0.021	1.218MetVal: 1.218 ± 0.026	0.167MetTrp: 0.167 ± 0.008	0.37MetTyr: 0.37 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.262AsnAla: 3.262 ± 0.05	0.48AsnCys: 0.48 ± 0.015	1.973AsnAsp: 1.973 ± 0.047	2.054AsnGlu: 2.054 ± 0.04	2.063AsnPhe: 2.063 ± 0.033	3.078AsnGly: 3.078 ± 0.068	0.854AsnHis: 0.854 ± 0.021	3.003AsnIle: 3.003 ± 0.044	1.954AsnLys: 1.954 ± 0.032	5.649AsnLeu: 5.649 ± 0.057	0.681AsnMet: 0.681 ± 0.018	2.337AsnAsn: 2.337 ± 0.05	2.957AsnPro: 2.957 ± 0.041	2.662AsnGln: 2.662 ± 0.04	2.374AsnArg: 2.374 ± 0.031	3.451AsnSer: 3.451 ± 0.049	2.473AsnThr: 2.473 ± 0.043	2.391AsnVal: 2.391 ± 0.047	0.739AsnTrp: 0.739 ± 0.017	1.583AsnTyr: 1.583 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	3.099ProAla: 3.099 ± 0.041	0.386ProCys: 0.386 ± 0.014	2.75ProAsp: 2.75 ± 0.035	3.714ProGlu: 3.714 ± 0.047	1.701ProPhe: 1.701 ± 0.026	2.806ProGly: 2.806 ± 0.044	0.868ProHis: 0.868 ± 0.02	2.943ProIle: 2.943 ± 0.036	2.386ProLys: 2.386 ± 0.028	4.655ProLeu: 4.655 ± 0.061	0.778ProMet: 0.778 ± 0.017	2.358ProAsn: 2.358 ± 0.039	2.286ProPro: 2.286 ± 0.036	2.519ProGln: 2.519 ± 0.038	1.743ProArg: 1.743 ± 0.027	3.124ProSer: 3.124 ± 0.042	2.865ProThr: 2.865 ± 0.045	3.141ProVal: 3.141 ± 0.037	0.54ProTrp: 0.54 ± 0.016	1.273ProTyr: 1.273 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.583GlnAla: 4.583 ± 0.047	0.384GlnCys: 0.384 ± 0.014	2.059GlnAsp: 2.059 ± 0.029	3.643GlnGlu: 3.643 ± 0.045	1.745GlnPhe: 1.745 ± 0.025	3.179GlnGly: 3.179 ± 0.038	0.886GlnHis: 0.886 ± 0.023	3.725GlnIle: 3.725 ± 0.04	2.899GlnLys: 2.899 ± 0.038	6.025GlnLeu: 6.025 ± 0.075	1.061GlnMet: 1.061 ± 0.024	2.163GlnAsn: 2.163 ± 0.026	2.469GlnPro: 2.469 ± 0.038	3.887GlnGln: 3.887 ± 0.071	2.866GlnArg: 2.866 ± 0.037	3.102GlnSer: 3.102 ± 0.041	2.921GlnThr: 2.921 ± 0.036	3.713GlnVal: 3.713 ± 0.046	0.687GlnTrp: 0.687 ± 0.017	1.232GlnTyr: 1.232 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.226ArgAla: 3.226 ± 0.044	0.508ArgCys: 0.508 ± 0.013	2.479ArgAsp: 2.479 ± 0.035	3.269ArgGlu: 3.269 ± 0.048	2.215ArgPhe: 2.215 ± 0.033	2.907ArgGly: 2.907 ± 0.033	1.032ArgHis: 1.032 ± 0.021	3.397ArgIle: 3.397 ± 0.039	2.384ArgLys: 2.384 ± 0.036	6.003ArgLeu: 6.003 ± 0.058	0.975ArgMet: 0.975 ± 0.021	2.162ArgAsn: 2.162 ± 0.031	2.0ArgPro: 2.0 ± 0.03	3.122ArgGln: 3.122 ± 0.042	3.119ArgArg: 3.119 ± 0.049	3.345ArgSer: 3.345 ± 0.04	2.687ArgThr: 2.687 ± 0.032	3.421ArgVal: 3.421 ± 0.043	0.822ArgTrp: 0.822 ± 0.019	1.883ArgTyr: 1.883 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	4.875SerAla: 4.875 ± 0.052	0.664SerCys: 0.664 ± 0.018	3.42SerAsp: 3.42 ± 0.045	3.976SerGlu: 3.976 ± 0.046	2.704SerPhe: 2.704 ± 0.042	4.949SerGly: 4.949 ± 0.068	1.25SerHis: 1.25 ± 0.023	4.045SerIle: 4.045 ± 0.048	3.138SerLys: 3.138 ± 0.036	7.668SerLeu: 7.668 ± 0.065	1.195SerMet: 1.195 ± 0.021	3.09SerAsn: 3.09 ± 0.044	3.511SerPro: 3.511 ± 0.046	3.702SerGln: 3.702 ± 0.043	3.27SerArg: 3.27 ± 0.034	4.837SerSer: 4.837 ± 0.06	3.801SerThr: 3.801 ± 0.051	4.225SerVal: 4.225 ± 0.049	0.907SerTrp: 0.907 ± 0.02	1.896SerTyr: 1.896 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	4.847ThrAla: 4.847 ± 0.059	0.461ThrCys: 0.461 ± 0.015	2.685ThrAsp: 2.685 ± 0.042	3.352ThrGlu: 3.352 ± 0.036	2.227ThrPhe: 2.227 ± 0.029	4.309ThrGly: 4.309 ± 0.066	1.028ThrHis: 1.028 ± 0.024	3.785ThrIle: 3.785 ± 0.045	2.558ThrLys: 2.558 ± 0.035	6.289ThrLeu: 6.289 ± 0.066	0.815ThrMet: 0.815 ± 0.02	2.459ThrAsn: 2.459 ± 0.052	3.39ThrPro: 3.39 ± 0.046	2.977ThrGln: 2.977 ± 0.041	2.431ThrArg: 2.431 ± 0.041	3.754ThrSer: 3.754 ± 0.051	3.523ThrThr: 3.523 ± 0.052	3.999ThrVal: 3.999 ± 0.055	0.699ThrTrp: 0.699 ± 0.018	1.581ThrTyr: 1.581 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	5.623ValAla: 5.623 ± 0.059	0.67ValCys: 0.67 ± 0.017	3.29ValAsp: 3.29 ± 0.041	4.473ValGlu: 4.473 ± 0.054	2.556ValPhe: 2.556 ± 0.038	4.491ValGly: 4.491 ± 0.049	0.965ValHis: 0.965 ± 0.021	4.275ValIle: 4.275 ± 0.044	3.392ValLys: 3.392 ± 0.037	6.397ValLeu: 6.397 ± 0.053	1.358ValMet: 1.358 ± 0.027	3.11ValAsn: 3.11 ± 0.04	2.756ValPro: 2.756 ± 0.041	2.9ValGln: 2.9 ± 0.038	3.29ValArg: 3.29 ± 0.038	4.325ValSer: 4.325 ± 0.06	3.848ValThr: 3.848 ± 0.051	4.701ValVal: 4.701 ± 0.051	0.824ValTrp: 0.824 ± 0.019	1.799ValTyr: 1.799 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	0.901TrpAla: 0.901 ± 0.02	0.154TrpCys: 0.154 ± 0.008	0.658TrpAsp: 0.658 ± 0.019	0.893TrpGlu: 0.893 ± 0.021	0.601TrpPhe: 0.601 ± 0.015	0.988TrpGly: 0.988 ± 0.025	0.349TrpHis: 0.349 ± 0.013	0.828TrpIle: 0.828 ± 0.021	0.628TrpLys: 0.628 ± 0.018	1.859TrpLeu: 1.859 ± 0.027	0.336TrpMet: 0.336 ± 0.014	0.656TrpAsn: 0.656 ± 0.02	0.25TrpPro: 0.25 ± 0.01	1.095TrpGln: 1.095 ± 0.027	0.82TrpArg: 0.82 ± 0.019	0.831TrpSer: 0.831 ± 0.018	0.612TrpThr: 0.612 ± 0.019	0.942TrpVal: 0.942 ± 0.019	0.236TrpTrp: 0.236 ± 0.009	0.442TrpTyr: 0.442 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.119TyrAla: 2.119 ± 0.029	0.408TyrCys: 0.408 ± 0.012	1.414TyrAsp: 1.414 ± 0.028	1.738TyrGlu: 1.738 ± 0.031	1.352TyrPhe: 1.352 ± 0.024	1.946TyrGly: 1.946 ± 0.029	0.633TyrHis: 0.633 ± 0.018	1.687TyrIle: 1.687 ± 0.03	1.433TyrLys: 1.433 ± 0.026	3.621TyrLeu: 3.621 ± 0.041	0.442TyrMet: 0.442 ± 0.014	1.255TyrAsn: 1.255 ± 0.03	1.52TyrPro: 1.52 ± 0.029	1.857TyrGln: 1.857 ± 0.035	1.894TyrArg: 1.894 ± 0.03	2.083TyrSer: 2.083 ± 0.034	1.548TyrThr: 1.548 ± 0.031	1.596TyrVal: 1.596 ± 0.032	0.553TyrTrp: 0.553 ± 0.015	1.046TyrTyr: 1.046 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10244 proteins (2470546 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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