Amino acid dipepetide frequency for Nocardioides szechwanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.24AlaAla: 18.24 ± 0.204
1.009AlaCys: 1.009 ± 0.027
8.272AlaAsp: 8.272 ± 0.084
7.996AlaGlu: 7.996 ± 0.096
3.544AlaPhe: 3.544 ± 0.062
11.761AlaGly: 11.761 ± 0.102
2.609AlaHis: 2.609 ± 0.045
4.465AlaIle: 4.465 ± 0.068
2.645AlaLys: 2.645 ± 0.062
13.187AlaLeu: 13.187 ± 0.124
2.818AlaMet: 2.818 ± 0.051
2.048AlaAsn: 2.048 ± 0.039
5.993AlaPro: 5.993 ± 0.079
3.491AlaGln: 3.491 ± 0.049
8.779AlaArg: 8.779 ± 0.101
6.361AlaSer: 6.361 ± 0.072
7.528AlaThr: 7.528 ± 0.084
11.278AlaVal: 11.278 ± 0.121
1.947AlaTrp: 1.947 ± 0.042
2.511AlaTyr: 2.511 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.919CysAla: 0.919 ± 0.032
0.08CysCys: 0.08 ± 0.008
0.534CysAsp: 0.534 ± 0.021
0.427CysGlu: 0.427 ± 0.018
0.226CysPhe: 0.226 ± 0.012
0.875CysGly: 0.875 ± 0.03
0.172CysHis: 0.172 ± 0.011
0.188CysIle: 0.188 ± 0.012
0.111CysLys: 0.111 ± 0.008
0.699CysLeu: 0.699 ± 0.027
0.102CysMet: 0.102 ± 0.009
0.153CysAsn: 0.153 ± 0.011
0.493CysPro: 0.493 ± 0.02
0.183CysGln: 0.183 ± 0.012
0.531CysArg: 0.531 ± 0.021
0.417CysSer: 0.417 ± 0.018
0.455CysThr: 0.455 ± 0.023
0.624CysVal: 0.624 ± 0.024
0.103CysTrp: 0.103 ± 0.011
0.175CysTyr: 0.175 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.884AspAla: 7.884 ± 0.08
0.378AspCys: 0.378 ± 0.017
4.956AspAsp: 4.956 ± 0.071
4.58AspGlu: 4.58 ± 0.067
1.741AspPhe: 1.741 ± 0.038
6.522AspGly: 6.522 ± 0.078
1.51AspHis: 1.51 ± 0.035
2.057AspIle: 2.057 ± 0.043
1.236AspLys: 1.236 ± 0.034
7.542AspLeu: 7.542 ± 0.081
0.852AspMet: 0.852 ± 0.023
1.22AspAsn: 1.22 ± 0.037
4.683AspPro: 4.683 ± 0.071
1.935AspGln: 1.935 ± 0.045
4.679AspArg: 4.679 ± 0.067
2.724AspSer: 2.724 ± 0.051
3.116AspThr: 3.116 ± 0.053
6.235AspVal: 6.235 ± 0.066
1.003AspTrp: 1.003 ± 0.029
1.399AspTyr: 1.399 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.092GluAla: 7.092 ± 0.098
0.373GluCys: 0.373 ± 0.019
2.95GluAsp: 2.95 ± 0.055
3.298GluGlu: 3.298 ± 0.065
1.529GluPhe: 1.529 ± 0.039
4.47GluGly: 4.47 ± 0.069
1.624GluHis: 1.624 ± 0.04
2.602GluIle: 2.602 ± 0.045
1.329GluLys: 1.329 ± 0.033
6.629GluLeu: 6.629 ± 0.085
1.143GluMet: 1.143 ± 0.027
0.859GluAsn: 0.859 ± 0.027
3.33GluPro: 3.33 ± 0.075
2.278GluGln: 2.278 ± 0.046
4.982GluArg: 4.982 ± 0.076
3.014GluSer: 3.014 ± 0.049
3.351GluThr: 3.351 ± 0.047
5.455GluVal: 5.455 ± 0.072
0.863GluTrp: 0.863 ± 0.027
0.999GluTyr: 0.999 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.684PheAla: 3.684 ± 0.052
0.273PheCys: 0.273 ± 0.014
2.146PheAsp: 2.146 ± 0.045
1.77PheGlu: 1.77 ± 0.034
0.922PhePhe: 0.922 ± 0.031
3.099PheGly: 3.099 ± 0.056
0.595PheHis: 0.595 ± 0.023
0.795PheIle: 0.795 ± 0.028
0.538PheLys: 0.538 ± 0.022
2.682PheLeu: 2.682 ± 0.044
0.466PheMet: 0.466 ± 0.018
0.64PheAsn: 0.64 ± 0.021
1.342PhePro: 1.342 ± 0.038
0.654PheGln: 0.654 ± 0.023
1.759PheArg: 1.759 ± 0.037
1.532PheSer: 1.532 ± 0.035
1.918PheThr: 1.918 ± 0.04
2.744PheVal: 2.744 ± 0.049
0.456PheTrp: 0.456 ± 0.02
0.633PheTyr: 0.633 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
10.068GlyAla: 10.068 ± 0.106
0.845GlyCys: 0.845 ± 0.026
5.819GlyAsp: 5.819 ± 0.077
5.031GlyGlu: 5.031 ± 0.061
3.074GlyPhe: 3.074 ± 0.05
8.129GlyGly: 8.129 ± 0.113
2.084GlyHis: 2.084 ± 0.041
3.71GlyIle: 3.71 ± 0.062
2.242GlyLys: 2.242 ± 0.05
9.525GlyLeu: 9.525 ± 0.1
1.973GlyMet: 1.973 ± 0.042
1.876GlyAsn: 1.876 ± 0.048
4.465GlyPro: 4.465 ± 0.054
2.604GlyGln: 2.604 ± 0.046
6.892GlyArg: 6.892 ± 0.084
5.446GlySer: 5.446 ± 0.073
5.773GlyThr: 5.773 ± 0.089
8.004GlyVal: 8.004 ± 0.082
1.659GlyTrp: 1.659 ± 0.037
2.208GlyTyr: 2.208 ± 0.045
0.001GlyXaa: 0.001 ± 0.001
His
2.508HisAla: 2.508 ± 0.055
0.184HisCys: 0.184 ± 0.014
1.543HisAsp: 1.543 ± 0.04
1.336HisGlu: 1.336 ± 0.034
0.601HisPhe: 0.601 ± 0.021
2.152HisGly: 2.152 ± 0.045
0.737HisHis: 0.737 ± 0.027
0.564HisIle: 0.564 ± 0.02
0.323HisLys: 0.323 ± 0.015
2.381HisLeu: 2.381 ± 0.041
0.308HisMet: 0.308 ± 0.014
0.375HisAsn: 0.375 ± 0.019
1.539HisPro: 1.539 ± 0.036
0.658HisGln: 0.658 ± 0.026
1.728HisArg: 1.728 ± 0.035
0.908HisSer: 0.908 ± 0.027
1.151HisThr: 1.151 ± 0.03
1.968HisVal: 1.968 ± 0.038
0.331HisTrp: 0.331 ± 0.015
0.474HisTyr: 0.474 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.945IleAla: 4.945 ± 0.073
0.311IleCys: 0.311 ± 0.016
2.708IleAsp: 2.708 ± 0.047
2.429IleGlu: 2.429 ± 0.046
0.934IlePhe: 0.934 ± 0.027
3.799IleGly: 3.799 ± 0.049
0.693IleHis: 0.693 ± 0.022
1.092IleIle: 1.092 ± 0.03
0.812IleLys: 0.812 ± 0.029
2.782IleLeu: 2.782 ± 0.054
0.495IleMet: 0.495 ± 0.019
0.825IleAsn: 0.825 ± 0.029
1.87IlePro: 1.87 ± 0.038
0.839IleGln: 0.839 ± 0.026
2.264IleArg: 2.264 ± 0.04
1.975IleSer: 1.975 ± 0.045
2.327IleThr: 2.327 ± 0.05
3.325IleVal: 3.325 ± 0.055
0.422IleTrp: 0.422 ± 0.017
0.678IleTyr: 0.678 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.676LysAla: 2.676 ± 0.056
0.12LysCys: 0.12 ± 0.01
1.161LysAsp: 1.161 ± 0.033
0.98LysGlu: 0.98 ± 0.031
0.51LysPhe: 0.51 ± 0.019
1.705LysGly: 1.705 ± 0.043
0.421LysHis: 0.421 ± 0.02
0.935LysIle: 0.935 ± 0.031
0.749LysLys: 0.749 ± 0.039
1.897LysLeu: 1.897 ± 0.042
0.428LysMet: 0.428 ± 0.021
0.477LysAsn: 0.477 ± 0.022
1.281LysPro: 1.281 ± 0.033
0.68LysGln: 0.68 ± 0.024
1.478LysArg: 1.478 ± 0.041
1.163LysSer: 1.163 ± 0.035
1.28LysThr: 1.28 ± 0.035
2.106LysVal: 2.106 ± 0.046
0.247LysTrp: 0.247 ± 0.014
0.447LysTyr: 0.447 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
14.946LeuAla: 14.946 ± 0.127
0.723LeuCys: 0.723 ± 0.022
7.304LeuAsp: 7.304 ± 0.081
5.537LeuGlu: 5.537 ± 0.072
2.602LeuPhe: 2.602 ± 0.052
9.62LeuGly: 9.62 ± 0.088
1.985LeuHis: 1.985 ± 0.044
3.022LeuIle: 3.022 ± 0.057
1.882LeuLys: 1.882 ± 0.04
10.829LeuLeu: 10.829 ± 0.128
1.738LeuMet: 1.738 ± 0.036
1.746LeuAsn: 1.746 ± 0.043
5.7LeuPro: 5.7 ± 0.057
2.31LeuGln: 2.31 ± 0.041
7.528LeuArg: 7.528 ± 0.087
5.496LeuSer: 5.496 ± 0.072
6.721LeuThr: 6.721 ± 0.069
10.618LeuVal: 10.618 ± 0.103
1.194LeuTrp: 1.194 ± 0.035
1.585LeuTyr: 1.585 ± 0.041
0.001LeuXaa: 0.001 ± 0.001
Met
2.233MetAla: 2.233 ± 0.041
0.144MetCys: 0.144 ± 0.011
0.93MetAsp: 0.93 ± 0.031
0.779MetGlu: 0.779 ± 0.024
0.547MetPhe: 0.547 ± 0.023
1.484MetGly: 1.484 ± 0.032
0.394MetHis: 0.394 ± 0.019
0.72MetIle: 0.72 ± 0.023
0.454MetLys: 0.454 ± 0.017
1.914MetLeu: 1.914 ± 0.041
0.376MetMet: 0.376 ± 0.022
0.434MetAsn: 0.434 ± 0.02
1.154MetPro: 1.154 ± 0.032
0.485MetGln: 0.485 ± 0.019
1.432MetArg: 1.432 ± 0.034
1.604MetSer: 1.604 ± 0.032
1.915MetThr: 1.915 ± 0.039
1.563MetVal: 1.563 ± 0.034
0.228MetTrp: 0.228 ± 0.014
0.279MetTyr: 0.279 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.274AsnAla: 2.274 ± 0.042
0.163AsnCys: 0.163 ± 0.012
1.188AsnAsp: 1.188 ± 0.033
0.902AsnGlu: 0.902 ± 0.028
0.498AsnPhe: 0.498 ± 0.021
1.837AsnGly: 1.837 ± 0.041
0.414AsnHis: 0.414 ± 0.019
0.726AsnIle: 0.726 ± 0.026
0.417AsnLys: 0.417 ± 0.02
1.919AsnLeu: 1.919 ± 0.046
0.304AsnMet: 0.304 ± 0.017
0.436AsnAsn: 0.436 ± 0.022
1.443AsnPro: 1.443 ± 0.036
0.553AsnGln: 0.553 ± 0.022
1.281AsnArg: 1.281 ± 0.031
0.827AsnSer: 0.827 ± 0.028
1.081AsnThr: 1.081 ± 0.034
1.59AsnVal: 1.59 ± 0.04
0.246AsnTrp: 0.246 ± 0.016
0.423AsnTyr: 0.423 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
6.973ProAla: 6.973 ± 0.088
0.297ProCys: 0.297 ± 0.017
4.603ProAsp: 4.603 ± 0.072
4.155ProGlu: 4.155 ± 0.082
1.535ProPhe: 1.535 ± 0.033
5.606ProGly: 5.606 ± 0.079
1.184ProHis: 1.184 ± 0.035
1.791ProIle: 1.791 ± 0.038
1.065ProLys: 1.065 ± 0.034
4.804ProLeu: 4.804 ± 0.061
1.141ProMet: 1.141 ± 0.026
0.868ProAsn: 0.868 ± 0.032
3.08ProPro: 3.08 ± 0.068
1.493ProGln: 1.493 ± 0.037
3.374ProArg: 3.374 ± 0.052
3.18ProSer: 3.18 ± 0.056
3.734ProThr: 3.734 ± 0.058
5.131ProVal: 5.131 ± 0.071
0.897ProTrp: 0.897 ± 0.029
1.149ProTyr: 1.149 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.621GlnAla: 3.621 ± 0.061
0.173GlnCys: 0.173 ± 0.013
1.357GlnAsp: 1.357 ± 0.032
1.365GlnGlu: 1.365 ± 0.033
0.732GlnPhe: 0.732 ± 0.026
2.146GlnGly: 2.146 ± 0.043
0.659GlnHis: 0.659 ± 0.022
1.151GlnIle: 1.151 ± 0.032
0.557GlnLys: 0.557 ± 0.022
3.027GlnLeu: 3.027 ± 0.052
0.565GlnMet: 0.565 ± 0.022
0.469GlnAsn: 0.469 ± 0.019
1.684GlnPro: 1.684 ± 0.044
1.148GlnGln: 1.148 ± 0.034
2.435GlnArg: 2.435 ± 0.045
1.263GlnSer: 1.263 ± 0.031
1.418GlnThr: 1.418 ± 0.032
2.941GlnVal: 2.941 ± 0.051
0.433GlnTrp: 0.433 ± 0.017
0.5GlnTyr: 0.5 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
8.346ArgAla: 8.346 ± 0.1
0.483ArgCys: 0.483 ± 0.021
4.524ArgAsp: 4.524 ± 0.061
4.305ArgGlu: 4.305 ± 0.067
2.25ArgPhe: 2.25 ± 0.039
5.367ArgGly: 5.367 ± 0.067
1.764ArgHis: 1.764 ± 0.037
3.045ArgIle: 3.045 ± 0.051
1.548ArgLys: 1.548 ± 0.042
8.013ArgLeu: 8.013 ± 0.099
1.705ArgMet: 1.705 ± 0.035
1.323ArgAsn: 1.323 ± 0.031
4.01ArgPro: 4.01 ± 0.067
2.132ArgGln: 2.132 ± 0.043
6.89ArgArg: 6.89 ± 0.077
3.982ArgSer: 3.982 ± 0.058
4.539ArgThr: 4.539 ± 0.067
6.145ArgVal: 6.145 ± 0.068
1.252ArgTrp: 1.252 ± 0.031
1.566ArgTyr: 1.566 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
6.283SerAla: 6.283 ± 0.077
0.372SerCys: 0.372 ± 0.018
3.32SerAsp: 3.32 ± 0.052
2.738SerGlu: 2.738 ± 0.04
1.776SerPhe: 1.776 ± 0.039
5.769SerGly: 5.769 ± 0.062
1.079SerHis: 1.079 ± 0.026
1.836SerIle: 1.836 ± 0.044
1.066SerLys: 1.066 ± 0.03
5.295SerLeu: 5.295 ± 0.076
1.326SerMet: 1.326 ± 0.034
1.011SerAsn: 1.011 ± 0.031
3.097SerPro: 3.097 ± 0.057
1.431SerGln: 1.431 ± 0.036
3.737SerArg: 3.737 ± 0.057
3.279SerSer: 3.279 ± 0.063
3.422SerThr: 3.422 ± 0.053
4.705SerVal: 4.705 ± 0.061
0.913SerTrp: 0.913 ± 0.028
1.464SerTyr: 1.464 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
7.258ThrAla: 7.258 ± 0.096
0.495ThrCys: 0.495 ± 0.024
3.891ThrAsp: 3.891 ± 0.061
3.168ThrGlu: 3.168 ± 0.048
1.924ThrPhe: 1.924 ± 0.04
6.193ThrGly: 6.193 ± 0.09
1.226ThrHis: 1.226 ± 0.035
2.34ThrIle: 2.34 ± 0.043
1.299ThrLys: 1.299 ± 0.037
6.01ThrLeu: 6.01 ± 0.069
1.208ThrMet: 1.208 ± 0.029
1.209ThrAsn: 1.209 ± 0.034
4.062ThrPro: 4.062 ± 0.063
1.601ThrGln: 1.601 ± 0.036
3.963ThrArg: 3.963 ± 0.058
3.781ThrSer: 3.781 ± 0.059
4.26ThrThr: 4.26 ± 0.075
5.97ThrVal: 5.97 ± 0.082
1.063ThrTrp: 1.063 ± 0.028
1.5ThrTyr: 1.5 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
12.347ValAla: 12.347 ± 0.121
0.722ValCys: 0.722 ± 0.024
6.334ValAsp: 6.334 ± 0.081
5.552ValGlu: 5.552 ± 0.067
2.505ValPhe: 2.505 ± 0.048
7.863ValGly: 7.863 ± 0.09
1.907ValHis: 1.907 ± 0.036
3.483ValIle: 3.483 ± 0.052
1.785ValLys: 1.785 ± 0.044
9.972ValLeu: 9.972 ± 0.101
1.593ValMet: 1.593 ± 0.037
1.823ValAsn: 1.823 ± 0.042
5.051ValPro: 5.051 ± 0.062
2.1ValGln: 2.1 ± 0.044
6.701ValArg: 6.701 ± 0.079
4.917ValSer: 4.917 ± 0.071
6.413ValThr: 6.413 ± 0.097
10.428ValVal: 10.428 ± 0.114
1.197ValTrp: 1.197 ± 0.027
1.522ValTyr: 1.522 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.556TrpAla: 1.556 ± 0.035
0.159TrpCys: 0.159 ± 0.012
0.846TrpAsp: 0.846 ± 0.028
0.721TrpGlu: 0.721 ± 0.024
0.54TrpPhe: 0.54 ± 0.022
1.075TrpGly: 1.075 ± 0.032
0.356TrpHis: 0.356 ± 0.018
0.51TrpIle: 0.51 ± 0.02
0.324TrpLys: 0.324 ± 0.016
1.782TrpLeu: 1.782 ± 0.046
0.307TrpMet: 0.307 ± 0.016
0.345TrpAsn: 0.345 ± 0.016
0.761TrpPro: 0.761 ± 0.025
0.545TrpGln: 0.545 ± 0.025
1.257TrpArg: 1.257 ± 0.036
1.02TrpSer: 1.02 ± 0.032
0.954TrpThr: 0.954 ± 0.028
1.366TrpVal: 1.366 ± 0.032
0.383TrpTrp: 0.383 ± 0.019
0.308TrpTyr: 0.308 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.627TyrAla: 2.627 ± 0.044
0.16TyrCys: 0.16 ± 0.012
1.869TyrAsp: 1.869 ± 0.04
1.101TyrGlu: 1.101 ± 0.031
0.659TyrPhe: 0.659 ± 0.023
1.954TyrGly: 1.954 ± 0.034
0.354TyrHis: 0.354 ± 0.016
0.493TyrIle: 0.493 ± 0.017
0.361TyrLys: 0.361 ± 0.016
2.197TyrLeu: 2.197 ± 0.045
0.22TyrMet: 0.22 ± 0.013
0.387TyrAsn: 0.387 ± 0.018
1.021TyrPro: 1.021 ± 0.027
0.524TyrGln: 0.524 ± 0.017
1.5TyrArg: 1.5 ± 0.035
1.03TyrSer: 1.03 ± 0.028
1.064TyrThr: 1.064 ± 0.033
2.017TyrVal: 2.017 ± 0.041
0.281TyrTrp: 0.281 ± 0.015
0.452TyrTyr: 0.452 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.001
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 4039 proteins (1303589 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski