Amino acid dipepetide frequency for Salarchaeum sp. JOR-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.547AlaAla: 14.547 ± 0.253
0.716AlaCys: 0.716 ± 0.036
10.498AlaAsp: 10.498 ± 0.158
7.985AlaGlu: 7.985 ± 0.129
4.556AlaPhe: 4.556 ± 0.094
9.936AlaGly: 9.936 ± 0.152
1.997AlaHis: 1.997 ± 0.055
4.156AlaIle: 4.156 ± 0.089
2.116AlaLys: 2.116 ± 0.055
11.871AlaLeu: 11.871 ± 0.186
2.075AlaMet: 2.075 ± 0.054
2.745AlaAsn: 2.745 ± 0.07
4.063AlaPro: 4.063 ± 0.083
2.326AlaGln: 2.326 ± 0.06
6.723AlaArg: 6.723 ± 0.107
5.831AlaSer: 5.831 ± 0.102
6.808AlaThr: 6.808 ± 0.128
11.237AlaVal: 11.237 ± 0.16
1.35AlaTrp: 1.35 ± 0.047
3.225AlaTyr: 3.225 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
0.595CysAla: 0.595 ± 0.03
0.059CysCys: 0.059 ± 0.009
0.529CysAsp: 0.529 ± 0.036
0.563CysGlu: 0.563 ± 0.03
0.175CysPhe: 0.175 ± 0.017
0.821CysGly: 0.821 ± 0.042
0.164CysHis: 0.164 ± 0.018
0.249CysIle: 0.249 ± 0.018
0.099CysLys: 0.099 ± 0.012
0.521CysLeu: 0.521 ± 0.028
0.097CysMet: 0.097 ± 0.012
0.173CysAsn: 0.173 ± 0.015
0.527CysPro: 0.527 ± 0.029
0.155CysGln: 0.155 ± 0.014
0.372CysArg: 0.372 ± 0.024
0.365CysSer: 0.365 ± 0.022
0.387CysThr: 0.387 ± 0.022
0.504CysVal: 0.504 ± 0.03
0.091CysTrp: 0.091 ± 0.01
0.16CysTyr: 0.16 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
12.681AspAla: 12.681 ± 0.195
0.63AspCys: 0.63 ± 0.031
7.908AspAsp: 7.908 ± 0.119
7.333AspGlu: 7.333 ± 0.137
2.283AspPhe: 2.283 ± 0.062
7.371AspGly: 7.371 ± 0.111
1.798AspHis: 1.798 ± 0.051
3.523AspIle: 3.523 ± 0.076
0.951AspLys: 0.951 ± 0.044
7.5AspLeu: 7.5 ± 0.118
1.192AspMet: 1.192 ± 0.042
1.217AspAsn: 1.217 ± 0.043
4.109AspPro: 4.109 ± 0.087
1.655AspGln: 1.655 ± 0.054
5.683AspArg: 5.683 ± 0.112
3.51AspSer: 3.51 ± 0.068
5.01AspThr: 5.01 ± 0.086
8.234AspVal: 8.234 ± 0.13
1.135AspTrp: 1.135 ± 0.047
2.271AspTyr: 2.271 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
7.362GluAla: 7.362 ± 0.116
0.508GluCys: 0.508 ± 0.035
5.993GluAsp: 5.993 ± 0.11
6.353GluGlu: 6.353 ± 0.116
3.11GluPhe: 3.11 ± 0.076
4.979GluGly: 4.979 ± 0.102
2.224GluHis: 2.224 ± 0.055
3.062GluIle: 3.062 ± 0.083
2.144GluLys: 2.144 ± 0.064
7.182GluLeu: 7.182 ± 0.121
1.665GluMet: 1.665 ± 0.048
2.823GluAsn: 2.823 ± 0.061
3.387GluPro: 3.387 ± 0.077
2.402GluGln: 2.402 ± 0.073
7.634GluArg: 7.634 ± 0.13
4.932GluSer: 4.932 ± 0.081
5.966GluThr: 5.966 ± 0.104
5.416GluVal: 5.416 ± 0.093
1.072GluTrp: 1.072 ± 0.039
2.791GluTyr: 2.791 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
4.171PheAla: 4.171 ± 0.079
0.289PheCys: 0.289 ± 0.019
3.371PheAsp: 3.371 ± 0.071
2.917PheGlu: 2.917 ± 0.061
1.083PhePhe: 1.083 ± 0.041
3.163PheGly: 3.163 ± 0.068
0.638PheHis: 0.638 ± 0.03
0.957PheIle: 0.957 ± 0.033
0.508PheLys: 0.508 ± 0.025
3.067PheLeu: 3.067 ± 0.08
0.489PheMet: 0.489 ± 0.032
0.692PheAsn: 0.692 ± 0.033
1.372PhePro: 1.372 ± 0.046
0.794PheGln: 0.794 ± 0.035
1.792PheArg: 1.792 ± 0.045
1.872PheSer: 1.872 ± 0.053
1.954PheThr: 1.954 ± 0.048
3.489PheVal: 3.489 ± 0.08
0.403PheTrp: 0.403 ± 0.022
0.908PheTyr: 0.908 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
8.036GlyAla: 8.036 ± 0.132
0.614GlyCys: 0.614 ± 0.033
6.773GlyAsp: 6.773 ± 0.098
6.795GlyGlu: 6.795 ± 0.114
3.342GlyPhe: 3.342 ± 0.09
7.036GlyGly: 7.036 ± 0.125
1.697GlyHis: 1.697 ± 0.048
3.647GlyIle: 3.647 ± 0.076
1.862GlyLys: 1.862 ± 0.051
7.374GlyLeu: 7.374 ± 0.135
1.616GlyMet: 1.616 ± 0.052
1.943GlyAsn: 1.943 ± 0.058
2.905GlyPro: 2.905 ± 0.065
1.837GlyGln: 1.837 ± 0.053
4.814GlyArg: 4.814 ± 0.086
4.596GlySer: 4.596 ± 0.083
5.397GlyThr: 5.397 ± 0.087
8.641GlyVal: 8.641 ± 0.132
1.06GlyTrp: 1.06 ± 0.045
2.679GlyTyr: 2.679 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
2.412HisAla: 2.412 ± 0.06
0.155HisCys: 0.155 ± 0.016
2.033HisAsp: 2.033 ± 0.058
1.728HisGlu: 1.728 ± 0.046
0.567HisPhe: 0.567 ± 0.028
1.927HisGly: 1.927 ± 0.052
0.562HisHis: 0.562 ± 0.029
0.72HisIle: 0.72 ± 0.029
0.289HisLys: 0.289 ± 0.02
1.662HisLeu: 1.662 ± 0.046
0.274HisMet: 0.274 ± 0.021
0.433HisAsn: 0.433 ± 0.024
1.262HisPro: 1.262 ± 0.045
0.484HisGln: 0.484 ± 0.025
1.302HisArg: 1.302 ± 0.044
0.926HisSer: 0.926 ± 0.037
1.174HisThr: 1.174 ± 0.047
2.091HisVal: 2.091 ± 0.046
0.215HisTrp: 0.215 ± 0.018
0.614HisTyr: 0.614 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
4.267IleAla: 4.267 ± 0.078
0.199IleCys: 0.199 ± 0.018
3.438IleAsp: 3.438 ± 0.074
3.7IleGlu: 3.7 ± 0.073
0.783IlePhe: 0.783 ± 0.038
3.25IleGly: 3.25 ± 0.073
0.786IleHis: 0.786 ± 0.033
1.119IleIle: 1.119 ± 0.041
0.625IleLys: 0.625 ± 0.032
2.694IleLeu: 2.694 ± 0.076
0.403IleMet: 0.403 ± 0.025
0.813IleAsn: 0.813 ± 0.032
2.007IlePro: 2.007 ± 0.052
1.065IleGln: 1.065 ± 0.043
2.292IleArg: 2.292 ± 0.057
1.928IleSer: 1.928 ± 0.054
2.269IleThr: 2.269 ± 0.067
3.172IleVal: 3.172 ± 0.081
0.239IleTrp: 0.239 ± 0.021
0.801IleTyr: 0.801 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
1.671LysAla: 1.671 ± 0.058
0.124LysCys: 0.124 ± 0.014
1.137LysAsp: 1.137 ± 0.045
1.329LysGlu: 1.329 ± 0.046
0.55LysPhe: 0.55 ± 0.027
1.307LysGly: 1.307 ± 0.044
0.521LysHis: 0.521 ± 0.026
0.773LysIle: 0.773 ± 0.033
0.575LysLys: 0.575 ± 0.028
1.693LysLeu: 1.693 ± 0.05
0.372LysMet: 0.372 ± 0.021
0.679LysAsn: 0.679 ± 0.031
1.022LysPro: 1.022 ± 0.045
0.904LysGln: 0.904 ± 0.046
1.663LysArg: 1.663 ± 0.051
1.262LysSer: 1.262 ± 0.043
1.487LysThr: 1.487 ± 0.046
1.241LysVal: 1.241 ± 0.044
0.232LysTrp: 0.232 ± 0.016
0.668LysTyr: 0.668 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
12.376LeuAla: 12.376 ± 0.2
0.529LeuCys: 0.529 ± 0.026
8.915LeuAsp: 8.915 ± 0.139
5.971LeuGlu: 5.971 ± 0.11
2.976LeuPhe: 2.976 ± 0.083
7.659LeuGly: 7.659 ± 0.117
1.622LeuHis: 1.622 ± 0.051
2.252LeuIle: 2.252 ± 0.066
1.646LeuLys: 1.646 ± 0.052
8.302LeuLeu: 8.302 ± 0.142
1.246LeuMet: 1.246 ± 0.049
1.956LeuAsn: 1.956 ± 0.055
4.336LeuPro: 4.336 ± 0.086
1.928LeuGln: 1.928 ± 0.053
5.732LeuArg: 5.732 ± 0.099
5.423LeuSer: 5.423 ± 0.092
5.585LeuThr: 5.585 ± 0.098
9.033LeuVal: 9.033 ± 0.135
0.826LeuTrp: 0.826 ± 0.035
2.252LeuTyr: 2.252 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
1.62MetAla: 1.62 ± 0.043
0.107MetCys: 0.107 ± 0.012
1.243MetAsp: 1.243 ± 0.046
1.139MetGlu: 1.139 ± 0.041
0.473MetPhe: 0.473 ± 0.028
1.381MetGly: 1.381 ± 0.047
0.336MetHis: 0.336 ± 0.019
0.5MetIle: 0.5 ± 0.026
0.465MetLys: 0.465 ± 0.025
1.407MetLeu: 1.407 ± 0.044
0.306MetMet: 0.306 ± 0.024
0.626MetAsn: 0.626 ± 0.026
0.779MetPro: 0.779 ± 0.033
0.498MetGln: 0.498 ± 0.028
1.133MetArg: 1.133 ± 0.037
1.487MetSer: 1.487 ± 0.038
1.391MetThr: 1.391 ± 0.054
1.204MetVal: 1.204 ± 0.046
0.146MetTrp: 0.146 ± 0.014
0.395MetTyr: 0.395 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.166AsnAla: 3.166 ± 0.057
0.192AsnCys: 0.192 ± 0.017
1.838AsnAsp: 1.838 ± 0.05
1.8AsnGlu: 1.8 ± 0.062
0.665AsnPhe: 0.665 ± 0.032
2.005AsnGly: 2.005 ± 0.058
0.486AsnHis: 0.486 ± 0.026
0.918AsnIle: 0.918 ± 0.039
0.485AsnLys: 0.485 ± 0.026
1.979AsnLeu: 1.979 ± 0.054
0.425AsnMet: 0.425 ± 0.024
0.595AsnAsn: 0.595 ± 0.031
1.708AsnPro: 1.708 ± 0.039
0.658AsnGln: 0.658 ± 0.033
1.651AsnArg: 1.651 ± 0.047
0.998AsnSer: 0.998 ± 0.039
1.575AsnThr: 1.575 ± 0.051
2.337AsnVal: 2.337 ± 0.062
0.321AsnTrp: 0.321 ± 0.02
0.763AsnTyr: 0.763 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
4.674ProAla: 4.674 ± 0.092
0.226ProCys: 0.226 ± 0.019
5.012ProAsp: 5.012 ± 0.088
4.309ProGlu: 4.309 ± 0.074
1.538ProPhe: 1.538 ± 0.048
3.866ProGly: 3.866 ± 0.072
0.974ProHis: 0.974 ± 0.034
1.614ProIle: 1.614 ± 0.048
0.809ProLys: 0.809 ± 0.032
3.715ProLeu: 3.715 ± 0.079
0.798ProMet: 0.798 ± 0.035
1.174ProAsn: 1.174 ± 0.043
2.099ProPro: 2.099 ± 0.06
1.014ProGln: 1.014 ± 0.038
2.427ProArg: 2.427 ± 0.062
2.499ProSer: 2.499 ± 0.062
2.991ProThr: 2.991 ± 0.066
4.107ProVal: 4.107 ± 0.08
0.468ProTrp: 0.468 ± 0.027
1.209ProTyr: 1.209 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.471GlnAla: 2.471 ± 0.064
0.145GlnCys: 0.145 ± 0.014
1.465GlnAsp: 1.465 ± 0.043
1.853GlnGlu: 1.853 ± 0.059
1.001GlnPhe: 1.001 ± 0.036
1.588GlnGly: 1.588 ± 0.048
0.606GlnHis: 0.606 ± 0.029
1.017GlnIle: 1.017 ± 0.039
0.625GlnLys: 0.625 ± 0.029
2.147GlnLeu: 2.147 ± 0.059
0.489GlnMet: 0.489 ± 0.028
0.821GlnAsn: 0.821 ± 0.032
1.157GlnPro: 1.157 ± 0.04
1.048GlnGln: 1.048 ± 0.049
1.851GlnArg: 1.851 ± 0.055
1.639GlnSer: 1.639 ± 0.062
1.651GlnThr: 1.651 ± 0.049
1.788GlnVal: 1.788 ± 0.049
0.321GlnTrp: 0.321 ± 0.021
0.922GlnTyr: 0.922 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
6.938ArgAla: 6.938 ± 0.115
0.422ArgCys: 0.422 ± 0.026
5.763ArgAsp: 5.763 ± 0.089
7.019ArgGlu: 7.019 ± 0.113
2.162ArgPhe: 2.162 ± 0.056
4.532ArgGly: 4.532 ± 0.07
1.262ArgHis: 1.262 ± 0.042
2.664ArgIle: 2.664 ± 0.062
1.375ArgLys: 1.375 ± 0.045
5.804ArgLeu: 5.804 ± 0.094
1.196ArgMet: 1.196 ± 0.041
1.671ArgAsn: 1.671 ± 0.05
2.495ArgPro: 2.495 ± 0.064
1.661ArgGln: 1.661 ± 0.047
4.457ArgArg: 4.457 ± 0.097
3.137ArgSer: 3.137 ± 0.066
3.917ArgThr: 3.917 ± 0.062
6.158ArgVal: 6.158 ± 0.104
0.665ArgTrp: 0.665 ± 0.033
1.888ArgTyr: 1.888 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.432SerAla: 5.432 ± 0.095
0.294SerCys: 0.294 ± 0.024
4.204SerAsp: 4.204 ± 0.091
4.275SerGlu: 4.275 ± 0.09
1.986SerPhe: 1.986 ± 0.058
5.165SerGly: 5.165 ± 0.085
1.067SerHis: 1.067 ± 0.041
2.114SerIle: 2.114 ± 0.057
1.186SerLys: 1.186 ± 0.04
5.078SerLeu: 5.078 ± 0.082
1.024SerMet: 1.024 ± 0.034
1.29SerAsn: 1.29 ± 0.042
2.503SerPro: 2.503 ± 0.055
1.415SerGln: 1.415 ± 0.053
3.307SerArg: 3.307 ± 0.061
2.851SerSer: 2.851 ± 0.083
3.222SerThr: 3.222 ± 0.077
5.213SerVal: 5.213 ± 0.1
0.617SerTrp: 0.617 ± 0.029
1.428SerTyr: 1.428 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
7.034ThrAla: 7.034 ± 0.129
0.34ThrCys: 0.34 ± 0.026
5.338ThrAsp: 5.338 ± 0.094
4.454ThrGlu: 4.454 ± 0.089
2.049ThrPhe: 2.049 ± 0.051
5.803ThrGly: 5.803 ± 0.085
1.317ThrHis: 1.317 ± 0.048
2.582ThrIle: 2.582 ± 0.072
1.099ThrLys: 1.099 ± 0.042
5.886ThrLeu: 5.886 ± 0.105
1.027ThrMet: 1.027 ± 0.037
1.545ThrAsn: 1.545 ± 0.054
3.691ThrPro: 3.691 ± 0.085
1.487ThrGln: 1.487 ± 0.055
3.504ThrArg: 3.504 ± 0.074
2.948ThrSer: 2.948 ± 0.075
4.641ThrThr: 4.641 ± 0.135
7.106ThrVal: 7.106 ± 0.125
0.649ThrTrp: 0.649 ± 0.033
1.909ThrTyr: 1.909 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
11.083ValAla: 11.083 ± 0.155
0.734ValCys: 0.734 ± 0.034
7.03ValAsp: 7.03 ± 0.112
8.141ValGlu: 8.141 ± 0.128
3.3ValPhe: 3.3 ± 0.082
7.538ValGly: 7.538 ± 0.123
1.892ValHis: 1.892 ± 0.05
2.852ValIle: 2.852 ± 0.073
1.557ValLys: 1.557 ± 0.05
8.955ValLeu: 8.955 ± 0.153
1.329ValMet: 1.329 ± 0.039
2.345ValAsn: 2.345 ± 0.054
4.336ValPro: 4.336 ± 0.08
2.084ValGln: 2.084 ± 0.051
5.924ValArg: 5.924 ± 0.099
5.607ValSer: 5.607 ± 0.087
6.508ValThr: 6.508 ± 0.099
9.772ValVal: 9.772 ± 0.153
0.837ValTrp: 0.837 ± 0.032
2.378ValTyr: 2.378 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.935TrpAla: 0.935 ± 0.037
0.09TrpCys: 0.09 ± 0.01
0.684TrpAsp: 0.684 ± 0.03
0.816TrpGlu: 0.816 ± 0.033
0.457TrpPhe: 0.457 ± 0.027
0.838TrpGly: 0.838 ± 0.031
0.227TrpHis: 0.227 ± 0.016
0.399TrpIle: 0.399 ± 0.023
0.3TrpLys: 0.3 ± 0.022
1.186TrpLeu: 1.186 ± 0.044
0.223TrpMet: 0.223 ± 0.016
0.394TrpAsn: 0.394 ± 0.023
0.43TrpPro: 0.43 ± 0.025
0.4TrpGln: 0.4 ± 0.024
0.888TrpArg: 0.888 ± 0.033
0.564TrpSer: 0.564 ± 0.03
0.818TrpThr: 0.818 ± 0.033
0.914TrpVal: 0.914 ± 0.04
0.189TrpTrp: 0.189 ± 0.017
0.408TrpTyr: 0.408 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.288TyrAla: 3.288 ± 0.071
0.234TyrCys: 0.234 ± 0.017
2.824TyrAsp: 2.824 ± 0.069
2.526TyrGlu: 2.526 ± 0.06
0.873TyrPhe: 0.873 ± 0.032
2.499TyrGly: 2.499 ± 0.067
0.653TyrHis: 0.653 ± 0.031
0.736TyrIle: 0.736 ± 0.032
0.494TyrLys: 0.494 ± 0.027
2.541TyrLeu: 2.541 ± 0.063
0.392TyrMet: 0.392 ± 0.024
0.63TyrAsn: 0.63 ± 0.031
1.336TyrPro: 1.336 ± 0.046
0.789TyrGln: 0.789 ± 0.034
2.034TyrArg: 2.034 ± 0.058
1.294TyrSer: 1.294 ± 0.046
1.658TyrThr: 1.658 ± 0.054
2.545TyrVal: 2.545 ± 0.062
0.322TyrTrp: 0.322 ± 0.025
0.954TyrTyr: 0.954 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2527 proteins (744264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski