Human papillomavirus 179

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 15

Average proteome isoelectric point is 6.26

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|S6FWD1|S6FWD1_9PAPI Protein E6 OS=Human papillomavirus 179 OX=1472342 GN=E6 PE=3 SV=1
MM1 pKa = 7.45LRR3 pKa = 11.84ARR5 pKa = 11.84RR6 pKa = 11.84QKK8 pKa = 10.19RR9 pKa = 11.84ASINDD14 pKa = 3.96LYY16 pKa = 11.18RR17 pKa = 11.84NCRR20 pKa = 11.84LGGDD24 pKa = 3.81CPEE27 pKa = 4.16DD28 pKa = 3.14VKK30 pKa = 11.65NKK32 pKa = 10.14VEE34 pKa = 4.15GTTLADD40 pKa = 3.54RR41 pKa = 11.84LLQIFGSILYY51 pKa = 9.61FGNLGIGTGKK61 pKa = 8.83GTGGFGGYY69 pKa = 9.82KK70 pKa = 10.04PIGGTASKK78 pKa = 10.6GPEE81 pKa = 3.7ITVSRR86 pKa = 11.84PNVPIDD92 pKa = 3.62PLGGADD98 pKa = 5.25VIPLDD103 pKa = 4.57IINPEE108 pKa = 4.09APSVIPLQEE117 pKa = 4.55GGLPNIPVTDD127 pKa = 3.65TGITTTDD134 pKa = 2.94IAEE137 pKa = 4.05IDD139 pKa = 4.09IITTTNPIDD148 pKa = 3.83NPITTDD154 pKa = 3.39TQPTVITQNNDD165 pKa = 2.19IFIVDD170 pKa = 4.27MQPGPPPPKK179 pKa = 10.09RR180 pKa = 11.84IALDD184 pKa = 3.23VGTRR188 pKa = 11.84PFADD192 pKa = 2.81IEE194 pKa = 4.64LNVFRR199 pKa = 11.84EE200 pKa = 3.94PHH202 pKa = 6.22FDD204 pKa = 3.54SNVNVFVDD212 pKa = 3.84PNITGDD218 pKa = 3.72VVGLEE223 pKa = 4.19EE224 pKa = 5.69IEE226 pKa = 4.51LGPLNEE232 pKa = 4.1VAEE235 pKa = 4.29FAIEE239 pKa = 3.98EE240 pKa = 4.36GAGPSTSTPTQSIEE254 pKa = 4.07RR255 pKa = 11.84IINQGQRR262 pKa = 11.84LYY264 pKa = 11.36NRR266 pKa = 11.84FVQQVQTRR274 pKa = 11.84NPDD277 pKa = 3.43FVTKK281 pKa = 9.96PSRR284 pKa = 11.84LVTFEE289 pKa = 4.25FEE291 pKa = 4.6NPAFDD296 pKa = 5.93DD297 pKa = 4.59DD298 pKa = 3.99VTLTFEE304 pKa = 4.47QDD306 pKa = 3.23INDD309 pKa = 3.4VAAAPDD315 pKa = 3.7YY316 pKa = 10.31EE317 pKa = 4.12FRR319 pKa = 11.84DD320 pKa = 3.59IVRR323 pKa = 11.84LEE325 pKa = 3.92RR326 pKa = 11.84PIFTTTDD333 pKa = 2.64AGLRR337 pKa = 11.84LSRR340 pKa = 11.84LGQRR344 pKa = 11.84GSITTRR350 pKa = 11.84SGLTIGPRR358 pKa = 11.84VHH360 pKa = 7.14FYY362 pKa = 11.42YY363 pKa = 10.64DD364 pKa = 3.42FSEE367 pKa = 4.18ILPEE371 pKa = 3.89EE372 pKa = 4.5SIEE375 pKa = 4.08LSTFAIHH382 pKa = 6.89SNEE385 pKa = 4.26DD386 pKa = 3.37VFIDD390 pKa = 3.85PMAEE394 pKa = 3.9SSIVNSDD401 pKa = 2.76IGRR404 pKa = 11.84NPTFSDD410 pKa = 4.78DD411 pKa = 3.64YY412 pKa = 11.55LEE414 pKa = 6.45DD415 pKa = 3.41IFTEE419 pKa = 4.22NFNNAHH425 pKa = 6.3LVLTFGEE432 pKa = 4.01RR433 pKa = 11.84DD434 pKa = 3.47IIEE437 pKa = 4.28VPISVPKK444 pKa = 10.64AGINVFITGNSNTTVVDD461 pKa = 3.45YY462 pKa = 10.55TSIKK466 pKa = 8.27EE467 pKa = 4.25TTIITPSTNLINLKK481 pKa = 9.7PALGLYY487 pKa = 9.23TLGEE491 pKa = 4.38DD492 pKa = 5.57FIFDD496 pKa = 3.7PDD498 pKa = 3.78LFRR501 pKa = 11.84KK502 pKa = 9.07RR503 pKa = 11.84RR504 pKa = 11.84KK505 pKa = 9.5RR506 pKa = 11.84KK507 pKa = 9.64YY508 pKa = 10.39SDD510 pKa = 3.05VV511 pKa = 3.5

Molecular weight: 56.31 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|S6G386|S6G386_9PAPI Regulatory protein E2 OS=Human papillomavirus 179 OX=1472342 GN=E2 PE=3 SV=1
MM1 pKa = 6.99NQADD5 pKa = 3.75LTEE8 pKa = 5.0RR9 pKa = 11.84FDD11 pKa = 4.39ALQDD15 pKa = 3.62QLLTLYY21 pKa = 7.6EE22 pKa = 4.17TAPTDD27 pKa = 3.25IQSQITHH34 pKa = 6.52WALTRR39 pKa = 11.84RR40 pKa = 11.84LNVLMYY46 pKa = 8.72YY47 pKa = 10.37ARR49 pKa = 11.84QEE51 pKa = 4.31GYY53 pKa = 10.83RR54 pKa = 11.84NLGLQALPTLVVSEE68 pKa = 4.63YY69 pKa = 9.55NAKK72 pKa = 10.17VAIKK76 pKa = 10.34MMMLLKK82 pKa = 10.46SLSEE86 pKa = 4.03SQYY89 pKa = 11.39GKK91 pKa = 10.6EE92 pKa = 3.82PWTLADD98 pKa = 4.24ASAEE102 pKa = 4.03LVLTSPKK109 pKa = 9.21HH110 pKa = 4.43TFKK113 pKa = 10.89KK114 pKa = 10.26GAFQVEE120 pKa = 4.66VYY122 pKa = 10.82YY123 pKa = 11.15DD124 pKa = 4.0NDD126 pKa = 3.67PQNANVYY133 pKa = 7.16TQWEE137 pKa = 4.37HH138 pKa = 7.41IYY140 pKa = 11.22YY141 pKa = 10.43EE142 pKa = 4.3DD143 pKa = 6.11LNDD146 pKa = 3.23IWHH149 pKa = 6.65KK150 pKa = 10.9VPGDD154 pKa = 3.42VDD156 pKa = 4.19HH157 pKa = 7.16NGLSFTDD164 pKa = 3.43VTGDD168 pKa = 3.08KK169 pKa = 11.02NYY171 pKa = 10.58FLLFHH176 pKa = 7.39EE177 pKa = 4.89DD178 pKa = 3.0AQRR181 pKa = 11.84YY182 pKa = 9.24SNTGQWTVKK191 pKa = 10.2FKK193 pKa = 10.42STTISSVVTSSRR205 pKa = 11.84QQSSNQKK212 pKa = 9.45RR213 pKa = 11.84DD214 pKa = 3.37QQSRR218 pKa = 11.84RR219 pKa = 11.84RR220 pKa = 11.84DD221 pKa = 3.38SSPEE225 pKa = 3.82EE226 pKa = 3.89GTSRR230 pKa = 11.84AFRR233 pKa = 11.84RR234 pKa = 11.84SEE236 pKa = 3.84RR237 pKa = 11.84DD238 pKa = 3.24PEE240 pKa = 4.08EE241 pKa = 4.89SISTTTTSPTTTRR254 pKa = 11.84QRR256 pKa = 11.84RR257 pKa = 11.84RR258 pKa = 11.84RR259 pKa = 11.84RR260 pKa = 11.84RR261 pKa = 11.84GEE263 pKa = 3.99RR264 pKa = 11.84GDD266 pKa = 3.51QQGEE270 pKa = 4.42STPEE274 pKa = 3.39RR275 pKa = 11.84PRR277 pKa = 11.84AKK279 pKa = 9.93RR280 pKa = 11.84SRR282 pKa = 11.84GSSPVSPEE290 pKa = 3.87EE291 pKa = 3.52VGSRR295 pKa = 11.84HH296 pKa = 5.92RR297 pKa = 11.84SVPKK301 pKa = 9.76HH302 pKa = 4.78HH303 pKa = 7.18LGRR306 pKa = 11.84LRR308 pKa = 11.84RR309 pKa = 11.84LQEE312 pKa = 3.79EE313 pKa = 4.14ARR315 pKa = 11.84DD316 pKa = 3.93PPVLCIKK323 pKa = 10.78GPANNLKK330 pKa = 10.12CWRR333 pKa = 11.84NRR335 pKa = 11.84FNVRR339 pKa = 11.84FASLFFKK346 pKa = 10.79ASSVFKK352 pKa = 10.47WLGDD356 pKa = 3.59TDD358 pKa = 4.86CPTNTSRR365 pKa = 11.84MLIAFHH371 pKa = 6.52SLNEE375 pKa = 3.96RR376 pKa = 11.84SRR378 pKa = 11.84FLQLVTLPKK387 pKa = 9.4GTSYY391 pKa = 11.27SYY393 pKa = 11.76GSLDD397 pKa = 3.5SLL399 pKa = 4.67

Molecular weight: 46.0 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2257

95

602

376.2

42.59

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.937 ± 0.733

2.171 ± 0.907

6.823 ± 0.525

5.76 ± 0.354

4.962 ± 0.417

5.405 ± 0.817

1.994 ± 0.332

6.07 ± 1.316

4.829 ± 0.631

8.994 ± 0.626

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.639 ± 0.351

5.76 ± 0.338

5.804 ± 1.086

3.81 ± 0.548

6.336 ± 0.895

6.868 ± 0.849

6.602 ± 0.943

5.716 ± 0.306

1.063 ± 0.302

3.456 ± 0.52
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski