Amino acid dipepetide frequency for Cyanidioschyzon merolae (strain 10D) (Red alga)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.739AlaAla: 14.739 ± 0.144	1.876AlaCys: 1.876 ± 0.03	5.107AlaAsp: 5.107 ± 0.046	6.508AlaGlu: 6.508 ± 0.054	3.64AlaPhe: 3.64 ± 0.039	6.949AlaGly: 6.949 ± 0.053	2.331AlaHis: 2.331 ± 0.031	3.449AlaIle: 3.449 ± 0.037	2.778AlaLys: 2.778 ± 0.041	12.614AlaLeu: 12.614 ± 0.106	1.931AlaMet: 1.931 ± 0.029	2.672AlaAsn: 2.672 ± 0.035	6.082AlaPro: 6.082 ± 0.064	4.203AlaGln: 4.203 ± 0.046	7.884AlaArg: 7.884 ± 0.061	10.058AlaSer: 10.058 ± 0.101	6.321AlaThr: 6.321 ± 0.072	7.165AlaVal: 7.165 ± 0.059	1.394AlaTrp: 1.394 ± 0.025	2.332AlaTyr: 2.332 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.822CysAla: 1.822 ± 0.028	0.484CysCys: 0.484 ± 0.015	0.752CysAsp: 0.752 ± 0.021	0.92CysGlu: 0.92 ± 0.02	0.799CysPhe: 0.799 ± 0.019	1.354CysGly: 1.354 ± 0.024	0.34CysHis: 0.34 ± 0.013	0.852CysIle: 0.852 ± 0.016	0.42CysLys: 0.42 ± 0.015	1.797CysLeu: 1.797 ± 0.028	0.337CysMet: 0.337 ± 0.01	0.434CysAsn: 0.434 ± 0.015	0.859CysPro: 0.859 ± 0.023	0.521CysGln: 0.521 ± 0.017	1.45CysArg: 1.45 ± 0.023	1.491CysSer: 1.491 ± 0.026	1.075CysThr: 1.075 ± 0.026	1.271CysVal: 1.271 ± 0.03	0.352CysTrp: 0.352 ± 0.012	0.4CysTyr: 0.4 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.931AspAla: 6.931 ± 0.061	0.671AspCys: 0.671 ± 0.016	3.094AspAsp: 3.094 ± 0.059	3.571AspGlu: 3.571 ± 0.043	1.449AspPhe: 1.449 ± 0.024	3.342AspGly: 3.342 ± 0.044	1.017AspHis: 1.017 ± 0.02	1.923AspIle: 1.923 ± 0.027	1.104AspLys: 1.104 ± 0.023	4.611AspLeu: 4.611 ± 0.043	0.922AspMet: 0.922 ± 0.02	1.022AspAsn: 1.022 ± 0.022	2.884AspPro: 2.884 ± 0.034	1.67AspGln: 1.67 ± 0.028	3.341AspArg: 3.341 ± 0.031	3.376AspSer: 3.376 ± 0.038	2.851AspThr: 2.851 ± 0.037	3.366AspVal: 3.366 ± 0.035	0.86AspTrp: 0.86 ± 0.022	0.98AspTyr: 0.98 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.024GluAla: 7.024 ± 0.066	0.935GluCys: 0.935 ± 0.019	2.726GluAsp: 2.726 ± 0.04	3.868GluGlu: 3.868 ± 0.05	1.564GluPhe: 1.564 ± 0.027	2.561GluGly: 2.561 ± 0.037	2.036GluHis: 2.036 ± 0.032	2.198GluIle: 2.198 ± 0.035	2.203GluLys: 2.203 ± 0.036	6.505GluLeu: 6.505 ± 0.059	1.135GluMet: 1.135 ± 0.022	1.921GluAsn: 1.921 ± 0.031	3.286GluPro: 3.286 ± 0.037	3.563GluGln: 3.563 ± 0.041	7.275GluArg: 7.275 ± 0.059	4.725GluSer: 4.725 ± 0.048	4.024GluThr: 4.024 ± 0.04	3.197GluVal: 3.197 ± 0.041	0.843GluTrp: 0.843 ± 0.02	1.395GluTyr: 1.395 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.298PheAla: 3.298 ± 0.043	0.703PheCys: 0.703 ± 0.018	1.757PheAsp: 1.757 ± 0.03	2.103PheGlu: 2.103 ± 0.034	1.282PhePhe: 1.282 ± 0.027	2.545PheGly: 2.545 ± 0.039	0.821PheHis: 0.821 ± 0.017	1.37PheIle: 1.37 ± 0.023	0.663PheLys: 0.663 ± 0.017	3.548PheLeu: 3.548 ± 0.046	0.626PheMet: 0.626 ± 0.016	0.655PheAsn: 0.655 ± 0.02	1.57PhePro: 1.57 ± 0.025	1.332PheGln: 1.332 ± 0.024	2.73PheArg: 2.73 ± 0.039	2.285PheSer: 2.285 ± 0.033	1.584PheThr: 1.584 ± 0.026	2.548PheVal: 2.548 ± 0.035	0.629PheTrp: 0.629 ± 0.017	0.956PheTyr: 0.956 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	7.178GlyAla: 7.178 ± 0.059	1.132GlyCys: 1.132 ± 0.022	3.198GlyAsp: 3.198 ± 0.041	3.365GlyGlu: 3.365 ± 0.039	2.314GlyPhe: 2.314 ± 0.039	4.501GlyGly: 4.501 ± 0.07	1.53GlyHis: 1.53 ± 0.028	2.916GlyIle: 2.916 ± 0.037	2.192GlyLys: 2.192 ± 0.037	5.54GlyLeu: 5.54 ± 0.054	1.286GlyMet: 1.286 ± 0.022	2.041GlyAsn: 2.041 ± 0.032	2.686GlyPro: 2.686 ± 0.034	2.132GlyGln: 2.132 ± 0.033	4.89GlyArg: 4.89 ± 0.048	5.648GlySer: 5.648 ± 0.06	4.552GlyThr: 4.552 ± 0.051	4.421GlyVal: 4.421 ± 0.042	0.876GlyTrp: 0.876 ± 0.021	1.589GlyTyr: 1.589 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.766HisAla: 2.766 ± 0.036	0.511HisCys: 0.511 ± 0.014	1.166HisAsp: 1.166 ± 0.021	1.619HisGlu: 1.619 ± 0.025	0.803HisPhe: 0.803 ± 0.018	1.834HisGly: 1.834 ± 0.029	0.725HisHis: 0.725 ± 0.02	0.935HisIle: 0.935 ± 0.02	0.507HisLys: 0.507 ± 0.015	2.465HisLeu: 2.465 ± 0.027	0.438HisMet: 0.438 ± 0.014	0.466HisAsn: 0.466 ± 0.013	1.544HisPro: 1.544 ± 0.025	1.159HisGln: 1.159 ± 0.022	2.271HisArg: 2.271 ± 0.03	1.669HisSer: 1.669 ± 0.025	1.19HisThr: 1.19 ± 0.026	1.765HisVal: 1.765 ± 0.032	0.524HisTrp: 0.524 ± 0.017	0.538HisTyr: 0.538 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	3.93IleAla: 3.93 ± 0.042	0.713IleCys: 0.713 ± 0.018	2.144IleAsp: 2.144 ± 0.03	2.694IleGlu: 2.694 ± 0.034	1.338IlePhe: 1.338 ± 0.028	2.598IleGly: 2.598 ± 0.038	1.004IleHis: 1.004 ± 0.023	1.413IleIle: 1.413 ± 0.028	0.854IleLys: 0.854 ± 0.021	3.71IleLeu: 3.71 ± 0.045	0.687IleMet: 0.687 ± 0.018	0.712IleAsn: 0.712 ± 0.02	2.166IlePro: 2.166 ± 0.028	1.623IleGln: 1.623 ± 0.027	3.228IleArg: 3.228 ± 0.034	2.33IleSer: 2.33 ± 0.033	1.675IleThr: 1.675 ± 0.029	2.65IleVal: 2.65 ± 0.04	0.579IleTrp: 0.579 ± 0.016	0.907IleTyr: 0.907 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.72LysAla: 2.72 ± 0.039	0.393LysCys: 0.393 ± 0.015	1.161LysAsp: 1.161 ± 0.028	1.616LysGlu: 1.616 ± 0.028	0.75LysPhe: 0.75 ± 0.02	1.397LysGly: 1.397 ± 0.029	0.851LysHis: 0.851 ± 0.021	1.062LysIle: 1.062 ± 0.024	1.154LysLys: 1.154 ± 0.034	2.936LysLeu: 2.936 ± 0.04	0.561LysMet: 0.561 ± 0.017	0.789LysAsn: 0.789 ± 0.024	1.66LysPro: 1.66 ± 0.036	1.524LysGln: 1.524 ± 0.03	3.231LysArg: 3.231 ± 0.044	1.944LysSer: 1.944 ± 0.03	1.611LysThr: 1.611 ± 0.029	1.642LysVal: 1.642 ± 0.03	0.351LysTrp: 0.351 ± 0.013	0.78LysTyr: 0.78 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	10.312LeuAla: 10.312 ± 0.082	1.976LeuCys: 1.976 ± 0.031	5.479LeuAsp: 5.479 ± 0.05	7.558LeuGlu: 7.558 ± 0.066	3.559LeuPhe: 3.559 ± 0.043	6.603LeuGly: 6.603 ± 0.057	2.82LeuHis: 2.82 ± 0.034	3.259LeuIle: 3.259 ± 0.038	2.645LeuLys: 2.645 ± 0.039	11.193LeuLeu: 11.193 ± 0.109	1.69LeuMet: 1.69 ± 0.027	2.444LeuAsn: 2.444 ± 0.035	5.484LeuPro: 5.484 ± 0.049	5.082LeuGln: 5.082 ± 0.055	9.55LeuArg: 9.55 ± 0.072	7.151LeuSer: 7.151 ± 0.051	4.367LeuThr: 4.367 ± 0.046	7.721LeuVal: 7.721 ± 0.068	1.767LeuTrp: 1.767 ± 0.033	2.542LeuTyr: 2.542 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	1.555MetAla: 1.555 ± 0.029	0.229MetCys: 0.229 ± 0.01	1.038MetAsp: 1.038 ± 0.021	1.255MetGlu: 1.255 ± 0.021	0.592MetPhe: 0.592 ± 0.018	0.93MetGly: 0.93 ± 0.021	0.583MetHis: 0.583 ± 0.014	0.744MetIle: 0.744 ± 0.018	0.62MetLys: 0.62 ± 0.016	2.129MetLeu: 2.129 ± 0.032	0.38MetMet: 0.38 ± 0.013	0.639MetAsn: 0.639 ± 0.018	1.175MetPro: 1.175 ± 0.02	1.005MetGln: 1.005 ± 0.022	1.71MetArg: 1.71 ± 0.027	1.237MetSer: 1.237 ± 0.022	0.985MetThr: 0.985 ± 0.019	1.094MetVal: 1.094 ± 0.023	0.193MetTrp: 0.193 ± 0.01	0.401MetTyr: 0.401 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.29AsnAla: 3.29 ± 0.035	0.415AsnCys: 0.415 ± 0.013	1.442AsnAsp: 1.442 ± 0.025	1.813AsnGlu: 1.813 ± 0.027	0.777AsnPhe: 0.777 ± 0.02	1.995AsnGly: 1.995 ± 0.034	0.55AsnHis: 0.55 ± 0.017	1.032AsnIle: 1.032 ± 0.024	0.708AsnLys: 0.708 ± 0.018	2.36AsnLeu: 2.36 ± 0.035	0.49AsnMet: 0.49 ± 0.015	0.682AsnAsn: 0.682 ± 0.025	1.429AsnPro: 1.429 ± 0.028	1.005AsnGln: 1.005 ± 0.023	1.981AsnArg: 1.981 ± 0.03	1.625AsnSer: 1.625 ± 0.03	1.431AsnThr: 1.431 ± 0.026	1.832AsnVal: 1.832 ± 0.031	0.431AsnTrp: 0.431 ± 0.013	0.534AsnTyr: 0.534 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	6.011ProAla: 6.011 ± 0.057	0.871ProCys: 0.871 ± 0.021	2.818ProAsp: 2.818 ± 0.035	3.899ProGlu: 3.899 ± 0.041	1.722ProPhe: 1.722 ± 0.031	3.904ProGly: 3.904 ± 0.05	1.224ProHis: 1.224 ± 0.022	1.599ProIle: 1.599 ± 0.025	1.47ProLys: 1.47 ± 0.028	5.301ProLeu: 5.301 ± 0.053	0.908ProMet: 0.908 ± 0.02	1.526ProAsn: 1.526 ± 0.025	3.491ProPro: 3.491 ± 0.056	2.114ProGln: 2.114 ± 0.03	4.035ProArg: 4.035 ± 0.041	4.869ProSer: 4.869 ± 0.058	3.272ProThr: 3.272 ± 0.166	3.999ProVal: 3.999 ± 0.042	0.848ProTrp: 0.848 ± 0.018	1.164ProTyr: 1.164 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.157GlnAla: 4.157 ± 0.043	0.712GlnCys: 0.712 ± 0.018	1.481GlnAsp: 1.481 ± 0.023	2.368GlnGlu: 2.368 ± 0.033	1.077GlnPhe: 1.077 ± 0.02	2.208GlnGly: 2.208 ± 0.029	1.345GlnHis: 1.345 ± 0.022	1.538GlnIle: 1.538 ± 0.027	1.374GlnLys: 1.374 ± 0.035	4.568GlnLeu: 4.568 ± 0.054	0.791GlnMet: 0.791 ± 0.017	1.119GlnAsn: 1.119 ± 0.022	2.237GlnPro: 2.237 ± 0.032	3.201GlnGln: 3.201 ± 0.066	5.184GlnArg: 5.184 ± 0.051	2.92GlnSer: 2.92 ± 0.035	2.305GlnThr: 2.305 ± 0.031	3.246GlnVal: 3.246 ± 0.046	0.639GlnTrp: 0.639 ± 0.015	0.924GlnTyr: 0.924 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.466ArgAla: 8.466 ± 0.059	1.749ArgCys: 1.749 ± 0.029	3.835ArgAsp: 3.835 ± 0.04	5.334ArgGlu: 5.334 ± 0.045	3.3ArgPhe: 3.3 ± 0.036	4.814ArgGly: 4.814 ± 0.049	2.236ArgHis: 2.236 ± 0.03	3.803ArgIle: 3.803 ± 0.038	2.994ArgLys: 2.994 ± 0.037	9.346ArgLeu: 9.346 ± 0.078	1.758ArgMet: 1.758 ± 0.028	2.415ArgAsn: 2.415 ± 0.032	4.019ArgPro: 4.019 ± 0.046	3.791ArgGln: 3.791 ± 0.044	8.235ArgArg: 8.235 ± 0.073	6.786ArgSer: 6.786 ± 0.053	4.708ArgThr: 4.708 ± 0.041	5.531ArgVal: 5.531 ± 0.048	1.438ArgTrp: 1.438 ± 0.027	2.286ArgTyr: 2.286 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	8.956SerAla: 8.956 ± 0.088	1.252SerCys: 1.252 ± 0.025	3.744SerAsp: 3.744 ± 0.044	4.787SerGlu: 4.787 ± 0.051	2.48SerPhe: 2.48 ± 0.032	6.008SerGly: 6.008 ± 0.056	1.394SerHis: 1.394 ± 0.025	2.875SerIle: 2.875 ± 0.029	2.232SerLys: 2.232 ± 0.033	7.208SerLeu: 7.208 ± 0.066	1.643SerMet: 1.643 ± 0.024	2.048SerAsn: 2.048 ± 0.036	4.413SerPro: 4.413 ± 0.062	2.657SerGln: 2.657 ± 0.032	6.0SerArg: 6.0 ± 0.053	8.038SerSer: 8.038 ± 0.109	5.21SerThr: 5.21 ± 0.064	5.278SerVal: 5.278 ± 0.049	1.166SerTrp: 1.166 ± 0.024	1.378SerTyr: 1.378 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.36ThrAla: 6.36 ± 0.074	1.017ThrCys: 1.017 ± 0.02	2.622ThrAsp: 2.622 ± 0.03	3.478ThrGlu: 3.478 ± 0.039	1.64ThrPhe: 1.64 ± 0.026	4.278ThrGly: 4.278 ± 0.045	1.152ThrHis: 1.152 ± 0.02	1.887ThrIle: 1.887 ± 0.031	1.533ThrLys: 1.533 ± 0.027	5.547ThrLeu: 5.547 ± 0.044	0.997ThrMet: 0.997 ± 0.021	1.49ThrAsn: 1.49 ± 0.025	3.954ThrPro: 3.954 ± 0.174	1.993ThrGln: 1.993 ± 0.026	4.243ThrArg: 4.243 ± 0.047	4.886ThrSer: 4.886 ± 0.065	3.429ThrThr: 3.429 ± 0.067	3.508ThrVal: 3.508 ± 0.04	0.79ThrTrp: 0.79 ± 0.019	1.09ThrTyr: 1.09 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	7.002ValAla: 7.002 ± 0.057	1.337ValCys: 1.337 ± 0.027	3.601ValAsp: 3.601 ± 0.029	4.083ValGlu: 4.083 ± 0.046	2.506ValPhe: 2.506 ± 0.035	3.681ValGly: 3.681 ± 0.044	1.969ValHis: 1.969 ± 0.03	2.423ValIle: 2.423 ± 0.034	1.576ValLys: 1.576 ± 0.03	7.515ValLeu: 7.515 ± 0.063	1.117ValMet: 1.117 ± 0.02	1.564ValAsn: 1.564 ± 0.025	4.284ValPro: 4.284 ± 0.042	3.155ValGln: 3.155 ± 0.036	5.673ValArg: 5.673 ± 0.058	5.166ValSer: 5.166 ± 0.054	3.288ValThr: 3.288 ± 0.037	4.743ValVal: 4.743 ± 0.052	0.984ValTrp: 0.984 ± 0.021	1.803ValTyr: 1.803 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.006TrpAla: 1.006 ± 0.021	0.368TrpCys: 0.368 ± 0.011	0.642TrpAsp: 0.642 ± 0.02	0.738TrpGlu: 0.738 ± 0.018	0.549TrpPhe: 0.549 ± 0.016	0.609TrpGly: 0.609 ± 0.018	0.423TrpHis: 0.423 ± 0.013	0.773TrpIle: 0.773 ± 0.021	0.577TrpLys: 0.577 ± 0.016	1.823TrpLeu: 1.823 ± 0.028	0.397TrpMet: 0.397 ± 0.014	0.59TrpAsn: 0.59 ± 0.015	0.652TrpPro: 0.652 ± 0.017	0.775TrpGln: 0.775 ± 0.018	1.655TrpArg: 1.655 ± 0.033	1.293TrpSer: 1.293 ± 0.024	0.945TrpThr: 0.945 ± 0.022	0.788TrpVal: 0.788 ± 0.02	0.27TrpTrp: 0.27 ± 0.01	0.445TrpTyr: 0.445 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.512TyrAla: 2.512 ± 0.034	0.385TyrCys: 0.385 ± 0.012	1.181TyrAsp: 1.181 ± 0.024	1.405TyrGlu: 1.405 ± 0.024	0.868TyrPhe: 0.868 ± 0.019	1.872TyrGly: 1.872 ± 0.031	0.544TyrHis: 0.544 ± 0.015	0.903TyrIle: 0.903 ± 0.019	0.527TyrLys: 0.527 ± 0.02	2.487TyrLeu: 2.487 ± 0.037	0.398TyrMet: 0.398 ± 0.012	0.593TyrAsn: 0.593 ± 0.018	1.17TyrPro: 1.17 ± 0.02	0.888TyrGln: 0.888 ± 0.019	2.279TyrArg: 2.279 ± 0.033	1.271TyrSer: 1.271 ± 0.025	1.067TyrThr: 1.067 ± 0.022	1.706TyrVal: 1.706 ± 0.028	0.385TyrTrp: 0.385 ± 0.014	0.605TyrTyr: 0.605 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4995 proteins (2516387 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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