Amino acid dipepetide frequency for Trichophyton rubrum (Athlete s foot fungus) (Epidermophyton rubrum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.764AlaAla: 8.764 ± 0.078	0.962AlaCys: 0.962 ± 0.015	4.072AlaAsp: 4.072 ± 0.033	5.064AlaGlu: 5.064 ± 0.044	2.877AlaPhe: 2.877 ± 0.031	5.615AlaGly: 5.615 ± 0.05	1.695AlaHis: 1.695 ± 0.022	4.223AlaIle: 4.223 ± 0.037	4.048AlaLys: 4.048 ± 0.037	7.223AlaLeu: 7.223 ± 0.056	1.834AlaMet: 1.834 ± 0.021	2.891AlaAsn: 2.891 ± 0.033	4.538AlaPro: 4.538 ± 0.046	3.225AlaGln: 3.225 ± 0.032	4.751AlaArg: 4.751 ± 0.041	7.38AlaSer: 7.38 ± 0.053	5.002AlaThr: 5.002 ± 0.04	5.067AlaVal: 5.067 ± 0.042	0.988AlaTrp: 0.988 ± 0.019	1.995AlaTyr: 1.995 ± 0.026	0.001AlaXaa: 0.001 ± 0.001
Cys	0.839CysAla: 0.839 ± 0.014	0.242CysCys: 0.242 ± 0.009	0.606CysAsp: 0.606 ± 0.015	0.599CysGlu: 0.599 ± 0.014	0.511CysPhe: 0.511 ± 0.012	0.895CysGly: 0.895 ± 0.018	0.311CysHis: 0.311 ± 0.009	0.699CysIle: 0.699 ± 0.014	0.511CysLys: 0.511 ± 0.012	1.254CysLeu: 1.254 ± 0.019	0.259CysMet: 0.259 ± 0.008	0.415CysAsn: 0.415 ± 0.011	0.675CysPro: 0.675 ± 0.014	0.444CysGln: 0.444 ± 0.012	0.758CysArg: 0.758 ± 0.013	0.953CysSer: 0.953 ± 0.019	0.624CysThr: 0.624 ± 0.013	0.74CysVal: 0.74 ± 0.016	0.174CysTrp: 0.174 ± 0.007	0.355CysTyr: 0.355 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.334AspAla: 4.334 ± 0.032	0.624AspCys: 0.624 ± 0.014	4.191AspAsp: 4.191 ± 0.05	4.592AspGlu: 4.592 ± 0.046	2.07AspPhe: 2.07 ± 0.026	4.003AspGly: 4.003 ± 0.033	1.172AspHis: 1.172 ± 0.018	3.424AspIle: 3.424 ± 0.038	2.588AspLys: 2.588 ± 0.029	4.793AspLeu: 4.793 ± 0.039	1.273AspMet: 1.273 ± 0.021	2.044AspAsn: 2.044 ± 0.024	3.172AspPro: 3.172 ± 0.032	1.857AspGln: 1.857 ± 0.023	3.063AspArg: 3.063 ± 0.039	4.376AspSer: 4.376 ± 0.041	3.111AspThr: 3.111 ± 0.031	3.368AspVal: 3.368 ± 0.032	0.769AspTrp: 0.769 ± 0.015	1.526AspTyr: 1.526 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	5.287GluAla: 5.287 ± 0.046	0.637GluCys: 0.637 ± 0.013	4.29GluAsp: 4.29 ± 0.045	5.827GluGlu: 5.827 ± 0.072	1.983GluPhe: 1.983 ± 0.025	3.612GluGly: 3.612 ± 0.031	1.359GluHis: 1.359 ± 0.019	3.248GluIle: 3.248 ± 0.03	4.079GluLys: 4.079 ± 0.044	5.306GluLeu: 5.306 ± 0.044	1.442GluMet: 1.442 ± 0.018	2.518GluAsn: 2.518 ± 0.027	2.956GluPro: 2.956 ± 0.043	2.548GluGln: 2.548 ± 0.03	3.95GluArg: 3.95 ± 0.04	4.564GluSer: 4.564 ± 0.039	3.499GluThr: 3.499 ± 0.031	3.478GluVal: 3.478 ± 0.033	0.808GluTrp: 0.808 ± 0.014	1.762GluTyr: 1.762 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	2.779PheAla: 2.779 ± 0.027	0.527PheCys: 0.527 ± 0.012	2.23PheAsp: 2.23 ± 0.024	2.07PheGlu: 2.07 ± 0.028	1.491PhePhe: 1.491 ± 0.028	2.614PheGly: 2.614 ± 0.029	0.887PheHis: 0.887 ± 0.015	1.847PheIle: 1.847 ± 0.025	1.582PheLys: 1.582 ± 0.023	3.29PheLeu: 3.29 ± 0.034	0.718PheMet: 0.718 ± 0.013	1.467PheAsn: 1.467 ± 0.02	1.939PhePro: 1.939 ± 0.023	1.328PheGln: 1.328 ± 0.018	1.948PheArg: 1.948 ± 0.024	3.154PheSer: 3.154 ± 0.03	2.12PheThr: 2.12 ± 0.024	2.184PheVal: 2.184 ± 0.028	0.55PheTrp: 0.55 ± 0.012	1.06PheTyr: 1.06 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.787GlyAla: 4.787 ± 0.042	0.849GlyCys: 0.849 ± 0.016	3.555GlyAsp: 3.555 ± 0.032	3.725GlyGlu: 3.725 ± 0.032	2.56GlyPhe: 2.56 ± 0.028	5.456GlyGly: 5.456 ± 0.061	1.625GlyHis: 1.625 ± 0.022	3.541GlyIle: 3.541 ± 0.037	3.61GlyLys: 3.61 ± 0.035	5.658GlyLeu: 5.658 ± 0.04	1.524GlyMet: 1.524 ± 0.023	2.539GlyAsn: 2.539 ± 0.032	3.3GlyPro: 3.3 ± 0.036	2.564GlyGln: 2.564 ± 0.028	4.11GlyArg: 4.11 ± 0.038	5.836GlySer: 5.836 ± 0.044	3.823GlyThr: 3.823 ± 0.035	4.065GlyVal: 4.065 ± 0.037	1.023GlyTrp: 1.023 ± 0.019	2.062GlyTyr: 2.062 ± 0.022	0.001GlyXaa: 0.001 ± 0.0
His	1.718HisAla: 1.718 ± 0.023	0.301HisCys: 0.301 ± 0.009	1.302HisAsp: 1.302 ± 0.019	1.288HisGlu: 1.288 ± 0.021	0.873HisPhe: 0.873 ± 0.018	1.72HisGly: 1.72 ± 0.026	0.991HisHis: 0.991 ± 0.023	1.317HisIle: 1.317 ± 0.02	0.929HisLys: 0.929 ± 0.014	2.216HisLeu: 2.216 ± 0.021	0.471HisMet: 0.471 ± 0.012	0.888HisAsn: 0.888 ± 0.017	1.747HisPro: 1.747 ± 0.021	1.149HisGln: 1.149 ± 0.025	1.6HisArg: 1.6 ± 0.023	2.054HisSer: 2.054 ± 0.033	1.3HisThr: 1.3 ± 0.02	1.316HisVal: 1.316 ± 0.019	0.298HisTrp: 0.298 ± 0.009	0.665HisTyr: 0.665 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.964IleAla: 3.964 ± 0.035	0.772IleCys: 0.772 ± 0.017	3.033IleAsp: 3.033 ± 0.028	3.044IleGlu: 3.044 ± 0.032	2.049IlePhe: 2.049 ± 0.027	3.11IleGly: 3.11 ± 0.035	1.268IleHis: 1.268 ± 0.018	2.692IleIle: 2.692 ± 0.027	2.424IleLys: 2.424 ± 0.028	4.721IleLeu: 4.721 ± 0.048	1.014IleMet: 1.014 ± 0.018	1.949IleAsn: 1.949 ± 0.021	3.4IlePro: 3.4 ± 0.034	2.026IleGln: 2.026 ± 0.027	3.003IleArg: 3.003 ± 0.027	4.442IleSer: 4.442 ± 0.038	2.908IleThr: 2.908 ± 0.029	3.021IleVal: 3.021 ± 0.031	0.681IleTrp: 0.681 ± 0.015	1.473IleTyr: 1.473 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.33LysAla: 4.33 ± 0.042	0.533LysCys: 0.533 ± 0.011	2.931LysAsp: 2.931 ± 0.033	3.737LysGlu: 3.737 ± 0.043	1.568LysPhe: 1.568 ± 0.022	3.128LysGly: 3.128 ± 0.03	1.143LysHis: 1.143 ± 0.018	2.48LysIle: 2.48 ± 0.026	3.706LysLys: 3.706 ± 0.06	4.381LysLeu: 4.381 ± 0.042	1.065LysMet: 1.065 ± 0.016	1.9LysAsn: 1.9 ± 0.023	3.08LysPro: 3.08 ± 0.034	2.069LysGln: 2.069 ± 0.027	3.658LysArg: 3.658 ± 0.039	3.925LysSer: 3.925 ± 0.039	2.846LysThr: 2.846 ± 0.029	2.828LysVal: 2.828 ± 0.033	0.64LysTrp: 0.64 ± 0.013	1.485LysTyr: 1.485 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.439LeuAla: 7.439 ± 0.048	1.152LeuCys: 1.152 ± 0.018	5.118LeuAsp: 5.118 ± 0.045	5.563LeuGlu: 5.563 ± 0.045	3.265LeuPhe: 3.265 ± 0.032	5.503LeuGly: 5.503 ± 0.043	2.198LeuHis: 2.198 ± 0.026	3.988LeuIle: 3.988 ± 0.039	4.493LeuLys: 4.493 ± 0.039	8.308LeuLeu: 8.308 ± 0.069	1.661LeuMet: 1.661 ± 0.022	3.261LeuAsn: 3.261 ± 0.03	5.589LeuPro: 5.589 ± 0.044	3.79LeuGln: 3.79 ± 0.036	5.789LeuArg: 5.789 ± 0.046	7.616LeuSer: 7.616 ± 0.06	4.718LeuThr: 4.718 ± 0.041	5.117LeuVal: 5.117 ± 0.042	1.063LeuTrp: 1.063 ± 0.019	2.274LeuTyr: 2.274 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.158MetAla: 2.158 ± 0.023	0.214MetCys: 0.214 ± 0.007	1.259MetAsp: 1.259 ± 0.018	1.364MetGlu: 1.364 ± 0.019	0.728MetPhe: 0.728 ± 0.016	1.448MetGly: 1.448 ± 0.02	0.463MetHis: 0.463 ± 0.011	1.01MetIle: 1.01 ± 0.017	1.126MetLys: 1.126 ± 0.019	1.804MetLeu: 1.804 ± 0.024	0.527MetMet: 0.527 ± 0.012	0.826MetAsn: 0.826 ± 0.014	1.177MetPro: 1.177 ± 0.019	0.824MetGln: 0.824 ± 0.015	1.154MetArg: 1.154 ± 0.019	1.756MetSer: 1.756 ± 0.023	1.205MetThr: 1.205 ± 0.018	1.283MetVal: 1.283 ± 0.021	0.217MetTrp: 0.217 ± 0.009	0.47MetTyr: 0.47 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.041AsnAla: 3.041 ± 0.029	0.441AsnCys: 0.441 ± 0.011	2.054AsnAsp: 2.054 ± 0.026	2.199AsnGlu: 2.199 ± 0.021	1.37AsnPhe: 1.37 ± 0.018	3.018AsnGly: 3.018 ± 0.034	0.888AsnHis: 0.888 ± 0.015	2.312AsnIle: 2.312 ± 0.029	1.731AsnLys: 1.731 ± 0.018	3.272AsnLeu: 3.272 ± 0.033	0.867AsnMet: 0.867 ± 0.014	1.801AsnAsn: 1.801 ± 0.03	2.563AsnPro: 2.563 ± 0.026	1.433AsnGln: 1.433 ± 0.022	2.056AsnArg: 2.056 ± 0.022	3.105AsnSer: 3.105 ± 0.032	2.389AsnThr: 2.389 ± 0.029	2.233AsnVal: 2.233 ± 0.023	0.497AsnTrp: 0.497 ± 0.012	1.043AsnTyr: 1.043 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	5.356ProAla: 5.356 ± 0.054	0.551ProCys: 0.551 ± 0.015	3.238ProAsp: 3.238 ± 0.032	3.971ProGlu: 3.971 ± 0.039	2.037ProPhe: 2.037 ± 0.025	4.004ProGly: 4.004 ± 0.041	1.395ProHis: 1.395 ± 0.018	2.669ProIle: 2.669 ± 0.026	2.864ProLys: 2.864 ± 0.033	4.796ProLeu: 4.796 ± 0.044	1.076ProMet: 1.076 ± 0.019	2.29ProAsn: 2.29 ± 0.03	5.602ProPro: 5.602 ± 0.084	2.658ProGln: 2.658 ± 0.034	3.471ProArg: 3.471 ± 0.036	6.549ProSer: 6.549 ± 0.064	4.141ProThr: 4.141 ± 0.049	3.618ProVal: 3.618 ± 0.032	0.651ProTrp: 0.651 ± 0.013	1.517ProTyr: 1.517 ± 0.021	0.001ProXaa: 0.001 ± 0.0
Gln	3.391GlnAla: 3.391 ± 0.034	0.416GlnCys: 0.416 ± 0.011	2.008GlnAsp: 2.008 ± 0.023	2.427GlnGlu: 2.427 ± 0.03	1.297GlnPhe: 1.297 ± 0.019	2.375GlnGly: 2.375 ± 0.025	1.26GlnHis: 1.26 ± 0.023	1.883GlnIle: 1.883 ± 0.023	2.156GlnLys: 2.156 ± 0.021	3.587GlnLeu: 3.587 ± 0.037	0.842GlnMet: 0.842 ± 0.015	1.612GlnAsn: 1.612 ± 0.021	2.934GlnPro: 2.934 ± 0.045	3.299GlnGln: 3.299 ± 0.093	2.753GlnArg: 2.753 ± 0.031	3.285GlnSer: 3.285 ± 0.033	2.279GlnThr: 2.279 ± 0.027	2.108GlnVal: 2.108 ± 0.024	0.49GlnTrp: 0.49 ± 0.012	1.16GlnTyr: 1.16 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.607ArgAla: 4.607 ± 0.041	0.732ArgCys: 0.732 ± 0.015	3.421ArgAsp: 3.421 ± 0.037	4.023ArgGlu: 4.023 ± 0.041	2.073ArgPhe: 2.073 ± 0.023	3.702ArgGly: 3.702 ± 0.042	1.601ArgHis: 1.601 ± 0.023	2.996ArgIle: 2.996 ± 0.027	3.601ArgLys: 3.601 ± 0.032	5.503ArgLeu: 5.503 ± 0.047	1.28ArgMet: 1.28 ± 0.02	2.363ArgAsn: 2.363 ± 0.025	3.629ArgPro: 3.629 ± 0.039	2.75ArgGln: 2.75 ± 0.031	5.311ArgArg: 5.311 ± 0.059	5.062ArgSer: 5.062 ± 0.053	3.218ArgThr: 3.218 ± 0.027	3.29ArgVal: 3.29 ± 0.032	0.843ArgTrp: 0.843 ± 0.013	1.689ArgTyr: 1.689 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	6.639SerAla: 6.639 ± 0.049	0.894SerCys: 0.894 ± 0.017	4.224SerAsp: 4.224 ± 0.039	4.336SerGlu: 4.336 ± 0.037	3.048SerPhe: 3.048 ± 0.028	5.683SerGly: 5.683 ± 0.045	2.168SerHis: 2.168 ± 0.027	4.371SerIle: 4.371 ± 0.037	4.328SerLys: 4.328 ± 0.039	7.584SerLeu: 7.584 ± 0.057	1.834SerMet: 1.834 ± 0.021	3.465SerAsn: 3.465 ± 0.034	6.029SerPro: 6.029 ± 0.069	3.638SerGln: 3.638 ± 0.039	5.553SerArg: 5.553 ± 0.053	10.081SerSer: 10.081 ± 0.1	6.111SerThr: 6.111 ± 0.053	4.58SerVal: 4.58 ± 0.032	1.025SerTrp: 1.025 ± 0.017	2.11SerTyr: 2.11 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	5.169ThrAla: 5.169 ± 0.039	0.7ThrCys: 0.7 ± 0.014	2.817ThrAsp: 2.817 ± 0.027	3.198ThrGlu: 3.198 ± 0.029	2.072ThrPhe: 2.072 ± 0.024	4.054ThrGly: 4.054 ± 0.041	1.3ThrHis: 1.3 ± 0.02	3.105ThrIle: 3.105 ± 0.028	2.715ThrLys: 2.715 ± 0.028	5.148ThrLeu: 5.148 ± 0.035	1.166ThrMet: 1.166 ± 0.017	2.198ThrAsn: 2.198 ± 0.028	4.579ThrPro: 4.579 ± 0.044	2.116ThrGln: 2.116 ± 0.027	3.099ThrArg: 3.099 ± 0.025	5.737ThrSer: 5.737 ± 0.05	4.309ThrThr: 4.309 ± 0.049	3.571ThrVal: 3.571 ± 0.034	0.721ThrTrp: 0.721 ± 0.014	1.523ThrTyr: 1.523 ± 0.021	0.0ThrXaa: 0.0 ± 0.0
Val	4.707ValAla: 4.707 ± 0.037	0.764ValCys: 0.764 ± 0.014	3.611ValAsp: 3.611 ± 0.03	3.828ValGlu: 3.828 ± 0.038	2.29ValPhe: 2.29 ± 0.027	3.604ValGly: 3.604 ± 0.039	1.326ValHis: 1.326 ± 0.019	2.985ValIle: 2.985 ± 0.032	3.008ValLys: 3.008 ± 0.031	5.209ValLeu: 5.209 ± 0.048	1.253ValMet: 1.253 ± 0.017	2.198ValAsn: 2.198 ± 0.024	3.453ValPro: 3.453 ± 0.029	2.219ValGln: 2.219 ± 0.027	3.233ValArg: 3.233 ± 0.031	4.712ValSer: 4.712 ± 0.035	3.356ValThr: 3.356 ± 0.03	3.924ValVal: 3.924 ± 0.037	0.72ValTrp: 0.72 ± 0.014	1.638ValTyr: 1.638 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	0.98TrpAla: 0.98 ± 0.016	0.166TrpCys: 0.166 ± 0.007	0.793TrpAsp: 0.793 ± 0.015	0.788TrpGlu: 0.788 ± 0.014	0.462TrpPhe: 0.462 ± 0.012	0.767TrpGly: 0.767 ± 0.014	0.311TrpHis: 0.311 ± 0.01	0.694TrpIle: 0.694 ± 0.014	0.789TrpLys: 0.789 ± 0.015	1.193TrpLeu: 1.193 ± 0.02	0.323TrpMet: 0.323 ± 0.009	0.592TrpAsn: 0.592 ± 0.013	0.543TrpPro: 0.543 ± 0.01	0.484TrpGln: 0.484 ± 0.009	0.84TrpArg: 0.84 ± 0.015	0.956TrpSer: 0.956 ± 0.015	0.761TrpThr: 0.761 ± 0.016	0.739TrpVal: 0.739 ± 0.014	0.233TrpTrp: 0.233 ± 0.008	0.364TrpTyr: 0.364 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.927TyrAla: 1.927 ± 0.021	0.386TyrCys: 0.386 ± 0.011	1.598TyrAsp: 1.598 ± 0.022	1.513TyrGlu: 1.513 ± 0.02	1.162TyrPhe: 1.162 ± 0.018	1.9TyrGly: 1.9 ± 0.027	0.78TyrHis: 0.78 ± 0.014	1.511TyrIle: 1.511 ± 0.022	1.146TyrLys: 1.146 ± 0.019	2.656TyrLeu: 2.656 ± 0.027	0.584TyrMet: 0.584 ± 0.012	1.097TyrAsn: 1.097 ± 0.018	1.549TyrPro: 1.549 ± 0.021	1.14TyrGln: 1.14 ± 0.018	1.595TyrArg: 1.595 ± 0.021	2.156TyrSer: 2.156 ± 0.027	1.576TyrThr: 1.576 ± 0.022	1.508TyrVal: 1.508 ± 0.023	0.389TyrTrp: 0.389 ± 0.009	0.911TyrTyr: 0.911 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 7033 proteins (3906683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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