Amino acid dipepetide frequency for Aotus nancymaae (Ma s night monkey)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.667AlaAla: 6.667 ± 0.027
1.365AlaCys: 1.365 ± 0.01
2.942AlaAsp: 2.942 ± 0.014
4.805AlaGlu: 4.805 ± 0.023
2.612AlaPhe: 2.612 ± 0.014
4.643AlaGly: 4.643 ± 0.023
1.542AlaHis: 1.542 ± 0.01
2.789AlaIle: 2.789 ± 0.013
3.498AlaLys: 3.498 ± 0.019
7.028AlaLeu: 7.028 ± 0.028
1.5AlaMet: 1.5 ± 0.009
2.031AlaAsn: 2.031 ± 0.01
4.105AlaPro: 4.105 ± 0.021
3.235AlaGln: 3.235 ± 0.015
3.634AlaArg: 3.634 ± 0.017
5.699AlaSer: 5.699 ± 0.02
3.621AlaThr: 3.621 ± 0.018
4.661AlaVal: 4.661 ± 0.02
0.8AlaTrp: 0.8 ± 0.006
1.526AlaTyr: 1.526 ± 0.009
0.001AlaXaa: 0.001 ± 0.0
Cys
1.205CysAla: 1.205 ± 0.009
0.632CysCys: 0.632 ± 0.009
1.014CysAsp: 1.014 ± 0.01
1.292CysGlu: 1.292 ± 0.011
0.834CysPhe: 0.834 ± 0.007
1.718CysGly: 1.718 ± 0.016
0.665CysHis: 0.665 ± 0.007
0.959CysIle: 0.959 ± 0.008
1.168CysLys: 1.168 ± 0.01
2.176CysLeu: 2.176 ± 0.011
0.421CysMet: 0.421 ± 0.004
0.819CysAsn: 0.819 ± 0.008
1.349CysPro: 1.349 ± 0.013
1.055CysGln: 1.055 ± 0.009
1.276CysArg: 1.276 ± 0.01
1.984CysSer: 1.984 ± 0.012
1.086CysThr: 1.086 ± 0.009
1.275CysVal: 1.275 ± 0.009
0.29CysTrp: 0.29 ± 0.004
0.567CysTyr: 0.567 ± 0.005
0.0CysXaa: 0.0 ± 0.0
Asp
2.885AspAla: 2.885 ± 0.013
1.065AspCys: 1.065 ± 0.008
2.715AspAsp: 2.715 ± 0.015
3.526AspGlu: 3.526 ± 0.018
2.138AspPhe: 2.138 ± 0.012
3.354AspGly: 3.354 ± 0.02
1.147AspHis: 1.147 ± 0.008
2.644AspIle: 2.644 ± 0.015
2.578AspLys: 2.578 ± 0.013
5.049AspLeu: 5.049 ± 0.019
1.13AspMet: 1.13 ± 0.007
1.718AspAsn: 1.718 ± 0.011
2.896AspPro: 2.896 ± 0.011
1.855AspGln: 1.855 ± 0.01
2.445AspArg: 2.445 ± 0.013
4.239AspSer: 4.239 ± 0.021
2.478AspThr: 2.478 ± 0.011
3.112AspVal: 3.112 ± 0.016
0.624AspTrp: 0.624 ± 0.006
1.519AspTyr: 1.519 ± 0.011
0.0AspXaa: 0.0 ± 0.0
Glu
5.259GluAla: 5.259 ± 0.026
1.477GluCys: 1.477 ± 0.018
4.515GluAsp: 4.515 ± 0.019
8.067GluGlu: 8.067 ± 0.044
2.078GluPhe: 2.078 ± 0.011
4.204GluGly: 4.204 ± 0.016
1.526GluHis: 1.526 ± 0.008
3.207GluIle: 3.207 ± 0.017
5.546GluLys: 5.546 ± 0.028
6.53GluLeu: 6.53 ± 0.031
1.704GluMet: 1.704 ± 0.01
3.201GluAsn: 3.201 ± 0.016
3.205GluPro: 3.205 ± 0.019
3.181GluGln: 3.181 ± 0.018
4.053GluArg: 4.053 ± 0.021
4.418GluSer: 4.418 ± 0.018
3.437GluThr: 3.437 ± 0.014
4.2GluVal: 4.2 ± 0.015
0.716GluTrp: 0.716 ± 0.006
1.648GluTyr: 1.648 ± 0.013
0.001GluXaa: 0.001 ± 0.0
Phe
1.958PheAla: 1.958 ± 0.011
0.898PheCys: 0.898 ± 0.007
1.702PheAsp: 1.702 ± 0.01
2.04PheGlu: 2.04 ± 0.011
1.557PhePhe: 1.557 ± 0.01
2.188PheGly: 2.188 ± 0.013
1.046PheHis: 1.046 ± 0.008
1.813PheIle: 1.813 ± 0.012
1.832PheLys: 1.832 ± 0.01
4.0PheLeu: 4.0 ± 0.018
0.776PheMet: 0.776 ± 0.007
1.358PheAsn: 1.358 ± 0.008
1.98PhePro: 1.98 ± 0.011
1.815PheGln: 1.815 ± 0.01
1.982PheArg: 1.982 ± 0.012
3.419PheSer: 3.419 ± 0.017
2.035PheThr: 2.035 ± 0.013
2.118PheVal: 2.118 ± 0.011
0.488PheTrp: 0.488 ± 0.005
1.158PheTyr: 1.158 ± 0.008
0.0PheXaa: 0.0 ± 0.0
Gly
4.397GlyAla: 4.397 ± 0.024
1.253GlyCys: 1.253 ± 0.011
3.17GlyAsp: 3.17 ± 0.015
4.175GlyGlu: 4.175 ± 0.019
2.401GlyPhe: 2.401 ± 0.014
5.017GlyGly: 5.017 ± 0.032
1.69GlyHis: 1.69 ± 0.012
2.781GlyIle: 2.781 ± 0.014
3.909GlyLys: 3.909 ± 0.019
5.819GlyLeu: 5.819 ± 0.024
1.326GlyMet: 1.326 ± 0.01
2.375GlyAsn: 2.375 ± 0.012
4.166GlyPro: 4.166 ± 0.032
2.754GlyGln: 2.754 ± 0.016
3.765GlyArg: 3.765 ± 0.02
5.777GlySer: 5.777 ± 0.024
3.584GlyThr: 3.584 ± 0.016
3.537GlyVal: 3.537 ± 0.015
0.795GlyTrp: 0.795 ± 0.007
1.754GlyTyr: 1.754 ± 0.012
0.001GlyXaa: 0.001 ± 0.0
His
1.319HisAla: 1.319 ± 0.008
0.729HisCys: 0.729 ± 0.007
0.913HisAsp: 0.913 ± 0.007
1.347HisGlu: 1.347 ± 0.008
1.079HisPhe: 1.079 ± 0.007
1.543HisGly: 1.543 ± 0.01
0.916HisHis: 0.916 ± 0.009
1.264HisIle: 1.264 ± 0.008
1.311HisLys: 1.311 ± 0.009
2.943HisLeu: 2.943 ± 0.015
0.587HisMet: 0.587 ± 0.005
0.866HisAsn: 0.866 ± 0.007
1.653HisPro: 1.653 ± 0.01
1.364HisGln: 1.364 ± 0.013
1.591HisArg: 1.591 ± 0.009
2.323HisSer: 2.323 ± 0.013
1.545HisThr: 1.545 ± 0.015
1.498HisVal: 1.498 ± 0.009
0.352HisTrp: 0.352 ± 0.004
0.808HisTyr: 0.808 ± 0.006
0.001HisXaa: 0.001 ± 0.0
Ile
2.598IleAla: 2.598 ± 0.013
1.062IleCys: 1.062 ± 0.008
2.064IleAsp: 2.064 ± 0.012
2.664IleGlu: 2.664 ± 0.013
1.882IlePhe: 1.882 ± 0.012
2.238IleGly: 2.238 ± 0.013
1.389IleHis: 1.389 ± 0.011
2.378IleIle: 2.378 ± 0.012
2.689IleLys: 2.689 ± 0.013
4.54IleLeu: 4.54 ± 0.019
1.004IleMet: 1.004 ± 0.007
1.863IleAsn: 1.863 ± 0.01
2.622IlePro: 2.622 ± 0.011
2.325IleGln: 2.325 ± 0.011
2.395IleArg: 2.395 ± 0.011
3.713IleSer: 3.713 ± 0.017
2.6IleThr: 2.6 ± 0.016
2.503IleVal: 2.503 ± 0.015
0.515IleTrp: 0.515 ± 0.005
1.375IleTyr: 1.375 ± 0.009
0.0IleXaa: 0.0 ± 0.0
Lys
4.08LysAla: 4.08 ± 0.022
1.195LysCys: 1.195 ± 0.011
3.215LysAsp: 3.215 ± 0.017
5.219LysGlu: 5.219 ± 0.027
1.765LysPhe: 1.765 ± 0.01
3.305LysGly: 3.305 ± 0.019
1.441LysHis: 1.441 ± 0.01
2.867LysIle: 2.867 ± 0.014
4.829LysLys: 4.829 ± 0.029
5.296LysLeu: 5.296 ± 0.022
1.46LysMet: 1.46 ± 0.01
2.453LysAsn: 2.453 ± 0.014
3.176LysPro: 3.176 ± 0.021
2.665LysGln: 2.665 ± 0.015
3.356LysArg: 3.356 ± 0.014
3.923LysSer: 3.923 ± 0.019
3.135LysThr: 3.135 ± 0.014
3.505LysVal: 3.505 ± 0.019
0.612LysTrp: 0.612 ± 0.005
1.595LysTyr: 1.595 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
6.733LeuAla: 6.733 ± 0.025
2.171LeuCys: 2.171 ± 0.013
4.743LeuAsp: 4.743 ± 0.016
7.266LeuGlu: 7.266 ± 0.031
3.325LeuPhe: 3.325 ± 0.015
5.785LeuGly: 5.785 ± 0.024
2.737LeuHis: 2.737 ± 0.015
3.867LeuIle: 3.867 ± 0.015
5.912LeuLys: 5.912 ± 0.022
10.619LeuLeu: 10.619 ± 0.036
2.021LeuMet: 2.021 ± 0.011
3.528LeuAsn: 3.528 ± 0.017
5.942LeuPro: 5.942 ± 0.024
5.799LeuGln: 5.799 ± 0.028
5.846LeuArg: 5.846 ± 0.023
7.91LeuSer: 7.91 ± 0.023
5.065LeuThr: 5.065 ± 0.016
5.454LeuVal: 5.454 ± 0.021
1.127LeuTrp: 1.127 ± 0.008
2.542LeuTyr: 2.542 ± 0.014
0.001LeuXaa: 0.001 ± 0.0
Met
1.912MetAla: 1.912 ± 0.009
0.4MetCys: 0.4 ± 0.005
1.269MetAsp: 1.269 ± 0.008
1.903MetGlu: 1.903 ± 0.011
0.728MetPhe: 0.728 ± 0.007
1.303MetGly: 1.303 ± 0.008
0.472MetHis: 0.472 ± 0.005
0.857MetIle: 0.857 ± 0.007
1.476MetLys: 1.476 ± 0.009
1.986MetLeu: 1.986 ± 0.01
0.571MetMet: 0.571 ± 0.006
0.925MetAsn: 0.925 ± 0.007
1.116MetPro: 1.116 ± 0.011
0.93MetGln: 0.93 ± 0.007
1.045MetArg: 1.045 ± 0.006
1.563MetSer: 1.563 ± 0.009
1.141MetThr: 1.141 ± 0.008
1.388MetVal: 1.388 ± 0.009
0.242MetTrp: 0.242 ± 0.004
0.553MetTyr: 0.553 ± 0.005
0.0MetXaa: 0.0 ± 0.0
Asn
2.093AsnAla: 2.093 ± 0.011
0.83AsnCys: 0.83 ± 0.007
1.556AsnAsp: 1.556 ± 0.009
2.278AsnGlu: 2.278 ± 0.013
1.497AsnPhe: 1.497 ± 0.009
2.46AsnGly: 2.46 ± 0.014
0.965AsnHis: 0.965 ± 0.008
2.134AsnIle: 2.134 ± 0.012
2.26AsnLys: 2.26 ± 0.012
3.763AsnLeu: 3.763 ± 0.019
0.927AsnMet: 0.927 ± 0.007
1.533AsnAsn: 1.533 ± 0.01
2.169AsnPro: 2.169 ± 0.011
1.692AsnGln: 1.692 ± 0.01
1.854AsnArg: 1.854 ± 0.009
3.169AsnSer: 3.169 ± 0.016
1.969AsnThr: 1.969 ± 0.012
2.216AsnVal: 2.216 ± 0.011
0.457AsnTrp: 0.457 ± 0.005
1.133AsnTyr: 1.133 ± 0.008
0.0AsnXaa: 0.0 ± 0.0
Pro
4.791ProAla: 4.791 ± 0.023
1.13ProCys: 1.13 ± 0.012
2.797ProAsp: 2.797 ± 0.015
4.428ProGlu: 4.428 ± 0.02
1.893ProPhe: 1.893 ± 0.011
5.221ProGly: 5.221 ± 0.045
1.45ProHis: 1.45 ± 0.009
1.914ProIle: 1.914 ± 0.014
2.786ProLys: 2.786 ± 0.02
5.18ProLeu: 5.18 ± 0.022
1.047ProMet: 1.047 ± 0.008
1.828ProAsn: 1.828 ± 0.011
6.036ProPro: 6.036 ± 0.045
2.81ProGln: 2.81 ± 0.015
3.291ProArg: 3.291 ± 0.016
5.677ProSer: 5.677 ± 0.026
3.1ProThr: 3.1 ± 0.017
3.792ProVal: 3.792 ± 0.019
0.686ProTrp: 0.686 ± 0.006
1.552ProTyr: 1.552 ± 0.013
0.0ProXaa: 0.0 ± 0.0
Gln
3.539GlnAla: 3.539 ± 0.018
0.946GlnCys: 0.946 ± 0.009
2.346GlnAsp: 2.346 ± 0.011
3.929GlnGlu: 3.929 ± 0.022
1.393GlnPhe: 1.393 ± 0.009
2.832GlnGly: 2.832 ± 0.014
1.316GlnHis: 1.316 ± 0.011
2.014GlnIle: 2.014 ± 0.01
2.999GlnLys: 2.999 ± 0.016
4.751GlnLeu: 4.751 ± 0.024
1.129GlnMet: 1.129 ± 0.009
1.876GlnAsn: 1.876 ± 0.01
2.814GlnPro: 2.814 ± 0.017
3.133GlnGln: 3.133 ± 0.029
2.982GlnArg: 2.982 ± 0.014
3.147GlnSer: 3.147 ± 0.018
2.302GlnThr: 2.302 ± 0.01
2.818GlnVal: 2.818 ± 0.012
0.548GlnTrp: 0.548 ± 0.005
1.162GlnTyr: 1.162 ± 0.008
0.0GlnXaa: 0.0 ± 0.0
Arg
3.802ArgAla: 3.802 ± 0.015
1.215ArgCys: 1.215 ± 0.012
2.784ArgAsp: 2.784 ± 0.012
3.996ArgGlu: 3.996 ± 0.018
1.846ArgPhe: 1.846 ± 0.01
3.627ArgGly: 3.627 ± 0.019
1.538ArgHis: 1.538 ± 0.01
2.47ArgIle: 2.47 ± 0.013
3.715ArgLys: 3.715 ± 0.016
5.381ArgLeu: 5.381 ± 0.023
1.202ArgMet: 1.202 ± 0.008
2.124ArgAsn: 2.124 ± 0.01
3.191ArgPro: 3.191 ± 0.016
2.644ArgGln: 2.644 ± 0.014
4.297ArgArg: 4.297 ± 0.019
4.258ArgSer: 4.258 ± 0.023
2.823ArgThr: 2.823 ± 0.015
3.153ArgVal: 3.153 ± 0.018
0.703ArgTrp: 0.703 ± 0.007
1.438ArgTyr: 1.438 ± 0.009
0.001ArgXaa: 0.001 ± 0.0
Ser
5.284SerAla: 5.284 ± 0.021
1.809SerCys: 1.809 ± 0.012
3.931SerAsp: 3.931 ± 0.021
5.238SerGlu: 5.238 ± 0.022
3.03SerPhe: 3.03 ± 0.013
5.63SerGly: 5.63 ± 0.024
2.114SerHis: 2.114 ± 0.013
3.229SerIle: 3.229 ± 0.015
4.122SerLys: 4.122 ± 0.019
8.143SerLeu: 8.143 ± 0.026
1.608SerMet: 1.608 ± 0.009
2.747SerAsn: 2.747 ± 0.012
5.98SerPro: 5.98 ± 0.028
3.883SerGln: 3.883 ± 0.017
4.561SerArg: 4.561 ± 0.023
9.358SerSer: 9.358 ± 0.049
4.476SerThr: 4.476 ± 0.02
4.842SerVal: 4.842 ± 0.016
1.071SerTrp: 1.071 ± 0.007
2.069SerTyr: 2.069 ± 0.012
0.001SerXaa: 0.001 ± 0.0
Thr
3.753ThrAla: 3.753 ± 0.014
1.269ThrCys: 1.269 ± 0.01
2.5ThrAsp: 2.5 ± 0.012
3.56ThrGlu: 3.56 ± 0.015
2.084ThrPhe: 2.084 ± 0.011
3.596ThrGly: 3.596 ± 0.016
1.343ThrHis: 1.343 ± 0.01
2.385ThrIle: 2.385 ± 0.014
2.682ThrLys: 2.682 ± 0.015
5.279ThrLeu: 5.279 ± 0.018
1.12ThrMet: 1.12 ± 0.008
1.767ThrAsn: 1.767 ± 0.01
3.573ThrPro: 3.573 ± 0.02
2.293ThrGln: 2.293 ± 0.011
2.474ThrArg: 2.474 ± 0.011
4.648ThrSer: 4.648 ± 0.021
3.02ThrThr: 3.02 ± 0.022
3.822ThrVal: 3.822 ± 0.019
0.698ThrTrp: 0.698 ± 0.007
1.43ThrTyr: 1.43 ± 0.01
0.001ThrXaa: 0.001 ± 0.0
Val
4.242ValAla: 4.242 ± 0.019
1.414ValCys: 1.414 ± 0.009
2.966ValAsp: 2.966 ± 0.016
3.888ValGlu: 3.888 ± 0.017
2.386ValPhe: 2.386 ± 0.011
3.372ValGly: 3.372 ± 0.015
1.573ValHis: 1.573 ± 0.01
2.903ValIle: 2.903 ± 0.015
3.435ValLys: 3.435 ± 0.018
6.093ValLeu: 6.093 ± 0.02
1.32ValMet: 1.32 ± 0.008
2.28ValAsn: 2.28 ± 0.013
3.593ValPro: 3.593 ± 0.017
2.725ValGln: 2.725 ± 0.012
3.029ValArg: 3.029 ± 0.014
4.847ValSer: 4.847 ± 0.018
3.753ValThr: 3.753 ± 0.022
3.966ValVal: 3.966 ± 0.02
0.711ValTrp: 0.711 ± 0.006
1.619ValTyr: 1.619 ± 0.01
0.001ValXaa: 0.001 ± 0.0
Trp
0.785TrpAla: 0.785 ± 0.006
0.25TrpCys: 0.25 ± 0.004
0.661TrpAsp: 0.661 ± 0.006
0.816TrpGlu: 0.816 ± 0.007
0.435TrpPhe: 0.435 ± 0.004
0.74TrpGly: 0.74 ± 0.007
0.314TrpHis: 0.314 ± 0.004
0.55TrpIle: 0.55 ± 0.005
0.805TrpLys: 0.805 ± 0.006
1.206TrpLeu: 1.206 ± 0.008
0.322TrpMet: 0.322 ± 0.004
0.547TrpAsn: 0.547 ± 0.006
0.534TrpPro: 0.534 ± 0.005
0.544TrpGln: 0.544 ± 0.006
0.728TrpArg: 0.728 ± 0.006
0.873TrpSer: 0.873 ± 0.007
0.671TrpThr: 0.671 ± 0.008
0.689TrpVal: 0.689 ± 0.006
0.199TrpTrp: 0.199 ± 0.003
0.331TrpTyr: 0.331 ± 0.005
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.399TyrAla: 1.399 ± 0.008
0.674TyrCys: 0.674 ± 0.007
1.313TyrAsp: 1.313 ± 0.01
1.736TyrGlu: 1.736 ± 0.011
1.201TyrPhe: 1.201 ± 0.009
1.67TyrGly: 1.67 ± 0.011
0.766TyrHis: 0.766 ± 0.006
1.395TyrIle: 1.395 ± 0.011
1.538TyrLys: 1.538 ± 0.017
2.612TyrLeu: 2.612 ± 0.013
0.601TyrMet: 0.601 ± 0.005
1.116TyrAsn: 1.116 ± 0.008
1.309TyrPro: 1.309 ± 0.01
1.277TyrGln: 1.277 ± 0.008
1.605TyrArg: 1.605 ± 0.011
2.18TyrSer: 2.18 ± 0.012
1.452TyrThr: 1.452 ± 0.01
1.567TyrVal: 1.567 ± 0.01
0.366TyrTrp: 0.366 ± 0.006
0.935TyrTyr: 0.935 ± 0.008
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.001XaaPhe: 0.001 ± 0.0
0.001XaaGly: 0.001 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.001XaaIle: 0.001 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.001XaaMet: 0.001 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.001XaaVal: 0.001 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.168XaaXaa: 0.168 ± 0.017
Statistics based on 41725 proteins (22903399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski