Amino acid dipepetide frequency for Trichoplax adhaerens (Trichoplax reptans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.411AlaAla: 4.411 ± 0.047	1.203AlaCys: 1.203 ± 0.02	3.086AlaAsp: 3.086 ± 0.032	3.333AlaGlu: 3.333 ± 0.057	2.508AlaPhe: 2.508 ± 0.025	2.953AlaGly: 2.953 ± 0.039	1.076AlaHis: 1.076 ± 0.015	5.07AlaIle: 5.07 ± 0.045	4.073AlaLys: 4.073 ± 0.039	5.774AlaLeu: 5.774 ± 0.044	1.48AlaMet: 1.48 ± 0.019	3.299AlaAsn: 3.299 ± 0.031	1.761AlaPro: 1.761 ± 0.024	1.944AlaGln: 1.944 ± 0.026	2.647AlaArg: 2.647 ± 0.029	4.911AlaSer: 4.911 ± 0.035	3.824AlaThr: 3.824 ± 0.033	3.97AlaVal: 3.97 ± 0.03	0.617AlaTrp: 0.617 ± 0.012	1.999AlaTyr: 1.999 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.936CysAla: 0.936 ± 0.018	0.554CysCys: 0.554 ± 0.013	1.098CysAsp: 1.098 ± 0.021	0.919CysGlu: 0.919 ± 0.02	0.837CysPhe: 0.837 ± 0.013	1.199CysGly: 1.199 ± 0.023	0.598CysHis: 0.598 ± 0.014	1.544CysIle: 1.544 ± 0.025	1.31CysLys: 1.31 ± 0.022	2.001CysLeu: 2.001 ± 0.025	0.422CysMet: 0.422 ± 0.009	1.336CysAsn: 1.336 ± 0.025	0.928CysPro: 0.928 ± 0.06	1.124CysGln: 1.124 ± 0.032	1.119CysArg: 1.119 ± 0.019	1.721CysSer: 1.721 ± 0.032	1.111CysThr: 1.111 ± 0.026	1.056CysVal: 1.056 ± 0.019	0.263CysTrp: 0.263 ± 0.007	0.884CysTyr: 0.884 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.077AspAla: 3.077 ± 0.038	1.156AspCys: 1.156 ± 0.02	4.205AspAsp: 4.205 ± 0.042	4.048AspGlu: 4.048 ± 0.033	2.248AspPhe: 2.248 ± 0.025	3.099AspGly: 3.099 ± 0.029	1.352AspHis: 1.352 ± 0.018	4.494AspIle: 4.494 ± 0.033	3.635AspLys: 3.635 ± 0.03	4.761AspLeu: 4.761 ± 0.035	1.147AspMet: 1.147 ± 0.015	3.398AspAsn: 3.398 ± 0.039	1.991AspPro: 1.991 ± 0.021	2.237AspGln: 2.237 ± 0.026	2.7AspArg: 2.7 ± 0.025	4.383AspSer: 4.383 ± 0.037	2.736AspThr: 2.736 ± 0.025	3.356AspVal: 3.356 ± 0.031	0.662AspTrp: 0.662 ± 0.013	2.191AspTyr: 2.191 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	3.527GluAla: 3.527 ± 0.058	1.077GluCys: 1.077 ± 0.026	3.653GluAsp: 3.653 ± 0.037	4.813GluGlu: 4.813 ± 0.064	2.221GluPhe: 2.221 ± 0.021	2.41GluGly: 2.41 ± 0.03	1.065GluHis: 1.065 ± 0.015	4.571GluIle: 4.571 ± 0.035	4.665GluLys: 4.665 ± 0.043	5.356GluLeu: 5.356 ± 0.04	1.425GluMet: 1.425 ± 0.019	3.774GluAsn: 3.774 ± 0.034	1.498GluPro: 1.498 ± 0.022	2.106GluGln: 2.106 ± 0.025	2.866GluArg: 2.866 ± 0.031	4.352GluSer: 4.352 ± 0.038	2.874GluThr: 2.874 ± 0.028	3.219GluVal: 3.219 ± 0.03	0.606GluTrp: 0.606 ± 0.012	1.988GluTyr: 1.988 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.462PheAla: 2.462 ± 0.025	0.916PheCys: 0.916 ± 0.014	2.428PheAsp: 2.428 ± 0.024	2.089PheGlu: 2.089 ± 0.027	1.706PhePhe: 1.706 ± 0.024	2.491PheGly: 2.491 ± 0.031	1.062PheHis: 1.062 ± 0.016	3.07PheIle: 3.07 ± 0.031	2.357PheLys: 2.357 ± 0.023	3.813PheLeu: 3.813 ± 0.035	0.93PheMet: 0.93 ± 0.014	2.357PheAsn: 2.357 ± 0.024	1.524PhePro: 1.524 ± 0.02	1.637PheGln: 1.637 ± 0.021	1.934PheArg: 1.934 ± 0.023	3.227PheSer: 3.227 ± 0.026	2.48PheThr: 2.48 ± 0.024	2.364PheVal: 2.364 ± 0.023	0.473PheTrp: 0.473 ± 0.012	1.711PheTyr: 1.711 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	2.588GlyAla: 2.588 ± 0.025	1.005GlyCys: 1.005 ± 0.017	2.783GlyAsp: 2.783 ± 0.036	2.493GlyGlu: 2.493 ± 0.031	2.306GlyPhe: 2.306 ± 0.029	2.911GlyGly: 2.911 ± 0.037	1.324GlyHis: 1.324 ± 0.02	3.975GlyIle: 3.975 ± 0.035	3.777GlyLys: 3.777 ± 0.044	4.412GlyLeu: 4.412 ± 0.034	1.093GlyMet: 1.093 ± 0.014	3.219GlyAsn: 3.219 ± 0.034	1.55GlyPro: 1.55 ± 0.026	1.97GlyGln: 1.97 ± 0.023	2.531GlyArg: 2.531 ± 0.027	4.202GlySer: 4.202 ± 0.047	2.741GlyThr: 2.741 ± 0.038	2.876GlyVal: 2.876 ± 0.03	0.642GlyTrp: 0.642 ± 0.016	2.318GlyTyr: 2.318 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.177HisAla: 1.177 ± 0.014	0.568HisCys: 0.568 ± 0.014	1.301HisAsp: 1.301 ± 0.019	1.233HisGlu: 1.233 ± 0.019	1.034HisPhe: 1.034 ± 0.015	1.321HisGly: 1.321 ± 0.018	0.839HisHis: 0.839 ± 0.015	1.438HisIle: 1.438 ± 0.014	1.272HisLys: 1.272 ± 0.016	2.302HisLeu: 2.302 ± 0.025	0.419HisMet: 0.419 ± 0.01	1.285HisAsn: 1.285 ± 0.018	1.218HisPro: 1.218 ± 0.024	1.204HisGln: 1.204 ± 0.018	1.275HisArg: 1.275 ± 0.015	1.819HisSer: 1.819 ± 0.02	1.129HisThr: 1.129 ± 0.016	1.265HisVal: 1.265 ± 0.016	0.278HisTrp: 0.278 ± 0.007	1.045HisTyr: 1.045 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.06IleAla: 5.06 ± 0.042	1.56IleCys: 1.56 ± 0.021	4.334IleAsp: 4.334 ± 0.036	4.04IleGlu: 4.04 ± 0.033	3.025IlePhe: 3.025 ± 0.031	4.031IleGly: 4.031 ± 0.034	1.639IleHis: 1.639 ± 0.022	5.32IleIle: 5.32 ± 0.05	4.598IleLys: 4.598 ± 0.036	6.63IleLeu: 6.63 ± 0.049	1.498IleMet: 1.498 ± 0.017	4.159IleAsn: 4.159 ± 0.039	3.02IlePro: 3.02 ± 0.029	2.884IleGln: 2.884 ± 0.027	3.468IleArg: 3.468 ± 0.028	6.01IleSer: 6.01 ± 0.039	4.282IleThr: 4.282 ± 0.034	4.231IleVal: 4.231 ± 0.035	0.782IleTrp: 0.782 ± 0.013	2.699IleTyr: 2.699 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.007LysAla: 4.007 ± 0.048	1.226LysCys: 1.226 ± 0.02	3.731LysAsp: 3.731 ± 0.034	4.594LysGlu: 4.594 ± 0.039	2.534LysPhe: 2.534 ± 0.024	2.789LysGly: 2.789 ± 0.039	1.471LysHis: 1.471 ± 0.019	4.901LysIle: 4.901 ± 0.042	5.184LysLys: 5.184 ± 0.043	6.656LysLeu: 6.656 ± 0.048	1.523LysMet: 1.523 ± 0.016	3.589LysAsn: 3.589 ± 0.028	2.389LysPro: 2.389 ± 0.025	2.742LysGln: 2.742 ± 0.027	3.607LysArg: 3.607 ± 0.032	5.555LysSer: 5.555 ± 0.043	3.405LysThr: 3.405 ± 0.03	3.734LysVal: 3.734 ± 0.028	0.742LysTrp: 0.742 ± 0.012	2.617LysTyr: 2.617 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	6.158LeuAla: 6.158 ± 0.045	1.891LeuCys: 1.891 ± 0.023	4.921LeuAsp: 4.921 ± 0.034	5.198LeuGlu: 5.198 ± 0.042	3.729LeuPhe: 3.729 ± 0.035	4.515LeuGly: 4.515 ± 0.035	2.309LeuHis: 2.309 ± 0.024	6.243LeuIle: 6.243 ± 0.046	6.482LeuLys: 6.482 ± 0.045	9.233LeuLeu: 9.233 ± 0.061	2.032LeuMet: 2.032 ± 0.019	4.858LeuAsn: 4.858 ± 0.032	4.319LeuPro: 4.319 ± 0.036	4.632LeuGln: 4.632 ± 0.038	4.827LeuArg: 4.827 ± 0.039	7.943LeuSer: 7.943 ± 0.05	5.276LeuThr: 5.276 ± 0.037	4.926LeuVal: 4.926 ± 0.039	1.022LeuTrp: 1.022 ± 0.014	3.24LeuTyr: 3.24 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	1.823MetAla: 1.823 ± 0.022	0.341MetCys: 0.341 ± 0.009	1.225MetAsp: 1.225 ± 0.017	1.427MetGlu: 1.427 ± 0.017	0.764MetPhe: 0.764 ± 0.012	0.941MetGly: 0.941 ± 0.013	0.473MetHis: 0.473 ± 0.009	1.539MetIle: 1.539 ± 0.019	1.631MetLys: 1.631 ± 0.018	1.999MetLeu: 1.999 ± 0.018	0.553MetMet: 0.553 ± 0.01	1.1MetAsn: 1.1 ± 0.016	0.952MetPro: 0.952 ± 0.015	0.99MetGln: 0.99 ± 0.015	0.908MetArg: 0.908 ± 0.013	1.589MetSer: 1.589 ± 0.017	1.248MetThr: 1.248 ± 0.015	1.185MetVal: 1.185 ± 0.017	0.205MetTrp: 0.205 ± 0.006	0.818MetTyr: 0.818 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.08AsnAla: 3.08 ± 0.027	1.324AsnCys: 1.324 ± 0.029	3.417AsnAsp: 3.417 ± 0.028	3.401AsnGlu: 3.401 ± 0.031	2.34AsnPhe: 2.34 ± 0.024	3.155AsnGly: 3.155 ± 0.035	1.582AsnHis: 1.582 ± 0.031	4.356AsnIle: 4.356 ± 0.036	3.689AsnLys: 3.689 ± 0.033	5.271AsnLeu: 5.271 ± 0.034	1.147AsnMet: 1.147 ± 0.017	3.753AsnAsn: 3.753 ± 0.041	2.411AsnPro: 2.411 ± 0.027	2.632AsnGln: 2.632 ± 0.023	2.823AsnArg: 2.823 ± 0.022	4.724AsnSer: 4.724 ± 0.037	2.999AsnThr: 2.999 ± 0.029	3.36AsnVal: 3.36 ± 0.027	0.634AsnTrp: 0.634 ± 0.011	2.338AsnTyr: 2.338 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	2.157ProAla: 2.157 ± 0.028	0.789ProCys: 0.789 ± 0.032	2.157ProAsp: 2.157 ± 0.023	2.25ProGlu: 2.25 ± 0.023	1.677ProPhe: 1.677 ± 0.022	1.897ProGly: 1.897 ± 0.033	0.808ProHis: 0.808 ± 0.014	2.669ProIle: 2.669 ± 0.026	2.342ProLys: 2.342 ± 0.024	3.337ProLeu: 3.337 ± 0.03	0.74ProMet: 0.74 ± 0.014	2.215ProAsn: 2.215 ± 0.024	2.141ProPro: 2.141 ± 0.045	1.492ProGln: 1.492 ± 0.02	1.641ProArg: 1.641 ± 0.02	3.589ProSer: 3.589 ± 0.036	2.465ProThr: 2.465 ± 0.033	2.404ProVal: 2.404 ± 0.03	0.433ProTrp: 0.433 ± 0.011	1.499ProTyr: 1.499 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	2.498GlnAla: 2.498 ± 0.032	0.894GlnCys: 0.894 ± 0.022	2.203GlnAsp: 2.203 ± 0.021	2.568GlnGlu: 2.568 ± 0.031	1.827GlnPhe: 1.827 ± 0.021	1.951GlnGly: 1.951 ± 0.033	1.02GlnHis: 1.02 ± 0.018	2.806GlnIle: 2.806 ± 0.025	2.511GlnLys: 2.511 ± 0.028	4.503GlnLeu: 4.503 ± 0.042	0.891GlnMet: 0.891 ± 0.015	2.319GlnAsn: 2.319 ± 0.026	1.634GlnPro: 1.634 ± 0.024	2.473GlnGln: 2.473 ± 0.04	2.141GlnArg: 2.141 ± 0.023	3.438GlnSer: 3.438 ± 0.028	2.033GlnThr: 2.033 ± 0.023	2.295GlnVal: 2.295 ± 0.024	0.474GlnTrp: 0.474 ± 0.01	1.557GlnTyr: 1.557 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	2.442ArgAla: 2.442 ± 0.03	1.046ArgCys: 1.046 ± 0.017	2.514ArgAsp: 2.514 ± 0.027	2.693ArgGlu: 2.693 ± 0.026	2.008ArgPhe: 2.008 ± 0.02	2.159ArgGly: 2.159 ± 0.027	1.287ArgHis: 1.287 ± 0.015	3.436ArgIle: 3.436 ± 0.027	3.889ArgLys: 3.889 ± 0.036	4.846ArgLeu: 4.846 ± 0.043	1.091ArgMet: 1.091 ± 0.017	2.998ArgAsn: 2.998 ± 0.026	1.715ArgPro: 1.715 ± 0.024	2.345ArgGln: 2.345 ± 0.027	3.151ArgArg: 3.151 ± 0.039	3.87ArgSer: 3.87 ± 0.035	2.287ArgThr: 2.287 ± 0.024	2.398ArgVal: 2.398 ± 0.022	0.593ArgTrp: 0.593 ± 0.011	2.073ArgTyr: 2.073 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	4.427SerAla: 4.427 ± 0.032	1.724SerCys: 1.724 ± 0.032	4.585SerAsp: 4.585 ± 0.038	4.24SerGlu: 4.24 ± 0.037	3.202SerPhe: 3.202 ± 0.029	4.148SerGly: 4.148 ± 0.048	1.864SerHis: 1.864 ± 0.02	5.848SerIle: 5.848 ± 0.045	5.475SerLys: 5.475 ± 0.038	7.588SerLeu: 7.588 ± 0.049	1.848SerMet: 1.848 ± 0.025	5.325SerAsn: 5.325 ± 0.043	3.271SerPro: 3.271 ± 0.036	3.323SerGln: 3.323 ± 0.029	3.784SerArg: 3.784 ± 0.03	8.193SerSer: 8.193 ± 0.076	4.944SerThr: 4.944 ± 0.036	4.671SerVal: 4.671 ± 0.034	0.875SerTrp: 0.875 ± 0.013	3.154SerTyr: 3.154 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	3.669ThrAla: 3.669 ± 0.031	1.31ThrCys: 1.31 ± 0.034	2.972ThrAsp: 2.972 ± 0.028	3.049ThrGlu: 3.049 ± 0.031	2.4ThrPhe: 2.4 ± 0.024	3.145ThrGly: 3.145 ± 0.039	1.015ThrHis: 1.015 ± 0.015	4.116ThrIle: 4.116 ± 0.03	3.271ThrLys: 3.271 ± 0.026	5.145ThrLeu: 5.145 ± 0.037	1.1ThrMet: 1.1 ± 0.015	3.135ThrAsn: 3.135 ± 0.029	2.315ThrPro: 2.315 ± 0.03	1.879ThrGln: 1.879 ± 0.022	2.237ThrArg: 2.237 ± 0.026	4.929ThrSer: 4.929 ± 0.042	3.757ThrThr: 3.757 ± 0.046	3.662ThrVal: 3.662 ± 0.035	0.634ThrTrp: 0.634 ± 0.013	1.985ThrTyr: 1.985 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	3.941ValAla: 3.941 ± 0.035	1.132ValCys: 1.132 ± 0.018	3.359ValAsp: 3.359 ± 0.03	3.166ValGlu: 3.166 ± 0.028	2.316ValPhe: 2.316 ± 0.026	2.958ValGly: 2.958 ± 0.033	1.227ValHis: 1.227 ± 0.015	4.457ValIle: 4.457 ± 0.032	3.748ValLys: 3.748 ± 0.028	5.175ValLeu: 5.175 ± 0.039	1.335ValMet: 1.335 ± 0.018	3.203ValAsn: 3.203 ± 0.025	2.201ValPro: 2.201 ± 0.024	2.134ValGln: 2.134 ± 0.023	2.523ValArg: 2.523 ± 0.026	4.269ValSer: 4.269 ± 0.039	3.586ValThr: 3.586 ± 0.031	3.703ValVal: 3.703 ± 0.035	0.643ValTrp: 0.643 ± 0.013	2.176ValTyr: 2.176 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	0.51TrpAla: 0.51 ± 0.011	0.223TrpCys: 0.223 ± 0.007	0.595TrpAsp: 0.595 ± 0.013	0.505TrpGlu: 0.505 ± 0.01	0.473TrpPhe: 0.473 ± 0.011	0.527TrpGly: 0.527 ± 0.016	0.278TrpHis: 0.278 ± 0.007	0.928TrpIle: 0.928 ± 0.016	0.873TrpLys: 0.873 ± 0.013	1.249TrpLeu: 1.249 ± 0.019	0.288TrpMet: 0.288 ± 0.007	0.719TrpAsn: 0.719 ± 0.011	0.382TrpPro: 0.382 ± 0.009	0.506TrpGln: 0.506 ± 0.011	0.575TrpArg: 0.575 ± 0.012	0.871TrpSer: 0.871 ± 0.015	0.622TrpThr: 0.622 ± 0.014	0.489TrpVal: 0.489 ± 0.01	0.183TrpTrp: 0.183 ± 0.006	0.419TrpTyr: 0.419 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.991TyrAla: 1.991 ± 0.022	1.025TyrCys: 1.025 ± 0.036	2.311TyrAsp: 2.311 ± 0.031	2.005TyrGlu: 2.005 ± 0.025	1.877TyrPhe: 1.877 ± 0.021	2.114TyrGly: 2.114 ± 0.023	1.132TyrHis: 1.132 ± 0.018	2.489TyrIle: 2.489 ± 0.027	2.213TyrLys: 2.213 ± 0.02	3.705TyrLeu: 3.705 ± 0.034	0.749TyrMet: 0.749 ± 0.012	2.396TyrAsn: 2.396 ± 0.041	1.48TyrPro: 1.48 ± 0.02	1.78TyrGln: 1.78 ± 0.022	2.085TyrArg: 2.085 ± 0.021	2.891TyrSer: 2.891 ± 0.028	1.926TyrThr: 1.926 ± 0.024	2.09TyrVal: 2.09 ± 0.027	0.451TyrTrp: 0.451 ± 0.011	1.84TyrTyr: 1.84 ± 0.028	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 11520 proteins (5222991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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