Amino acid dipepetide frequency for Desulfurococcaceae archaeon AG1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.614AlaAla: 5.614 ± 0.124	0.51AlaCys: 0.51 ± 0.032	2.66AlaAsp: 2.66 ± 0.071	4.557AlaGlu: 4.557 ± 0.085	2.466AlaPhe: 2.466 ± 0.072	5.43AlaGly: 5.43 ± 0.112	0.958AlaHis: 0.958 ± 0.04	7.404AlaIle: 7.404 ± 0.147	3.726AlaLys: 3.726 ± 0.095	8.526AlaLeu: 8.526 ± 0.138	2.215AlaMet: 2.215 ± 0.066	1.605AlaAsn: 1.605 ± 0.052	2.752AlaPro: 2.752 ± 0.075	1.408AlaGln: 1.408 ± 0.056	6.109AlaArg: 6.109 ± 0.107	6.381AlaSer: 6.381 ± 0.122	3.123AlaThr: 3.123 ± 0.085	6.012AlaVal: 6.012 ± 0.113	0.854AlaTrp: 0.854 ± 0.041	2.822AlaTyr: 2.822 ± 0.073	0.0AlaXaa: 0.0 ± 0.0
Cys	0.321CysAla: 0.321 ± 0.022	0.072CysCys: 0.072 ± 0.014	0.315CysAsp: 0.315 ± 0.023	0.373CysGlu: 0.373 ± 0.026	0.236CysPhe: 0.236 ± 0.021	0.868CysGly: 0.868 ± 0.041	0.117CysHis: 0.117 ± 0.014	0.53CysIle: 0.53 ± 0.031	0.267CysLys: 0.267 ± 0.025	0.549CysLeu: 0.549 ± 0.033	0.133CysMet: 0.133 ± 0.016	0.178CysAsn: 0.178 ± 0.017	0.528CysPro: 0.528 ± 0.034	0.119CysGln: 0.119 ± 0.014	0.549CysArg: 0.549 ± 0.033	0.6CysSer: 0.6 ± 0.037	0.247CysThr: 0.247 ± 0.026	0.524CysVal: 0.524 ± 0.031	0.088CysTrp: 0.088 ± 0.014	0.249CysTyr: 0.249 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.173AspAla: 3.173 ± 0.083	0.198AspCys: 0.198 ± 0.019	1.765AspAsp: 1.765 ± 0.06	3.208AspGlu: 3.208 ± 0.075	1.286AspPhe: 1.286 ± 0.049	2.799AspGly: 2.799 ± 0.074	0.913AspHis: 0.913 ± 0.042	4.667AspIle: 4.667 ± 0.095	2.489AspLys: 2.489 ± 0.073	7.275AspLeu: 7.275 ± 0.122	1.18AspMet: 1.18 ± 0.045	1.259AspAsn: 1.259 ± 0.045	3.984AspPro: 3.984 ± 0.089	0.962AspGln: 0.962 ± 0.048	3.244AspArg: 3.244 ± 0.071	2.475AspSer: 2.475 ± 0.067	1.952AspThr: 1.952 ± 0.054	3.528AspVal: 3.528 ± 0.087	0.447AspTrp: 0.447 ± 0.029	1.778AspTyr: 1.778 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	6.369GluAla: 6.369 ± 0.106	0.421GluCys: 0.421 ± 0.027	3.98GluAsp: 3.98 ± 0.092	6.25GluGlu: 6.25 ± 0.14	1.718GluPhe: 1.718 ± 0.058	4.674GluGly: 4.674 ± 0.091	1.095GluHis: 1.095 ± 0.049	7.465GluIle: 7.465 ± 0.143	5.169GluLys: 5.169 ± 0.109	6.376GluLeu: 6.376 ± 0.123	1.459GluMet: 1.459 ± 0.059	2.19GluAsn: 2.19 ± 0.06	2.698GluPro: 2.698 ± 0.068	1.104GluGln: 1.104 ± 0.044	5.129GluArg: 5.129 ± 0.112	3.202GluSer: 3.202 ± 0.073	2.802GluThr: 2.802 ± 0.072	5.176GluVal: 5.176 ± 0.085	0.783GluTrp: 0.783 ± 0.039	2.419GluTyr: 2.419 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	1.929PheAla: 1.929 ± 0.063	0.196PheCys: 0.196 ± 0.018	1.558PheAsp: 1.558 ± 0.054	2.037PheGlu: 2.037 ± 0.069	1.174PhePhe: 1.174 ± 0.054	2.304PheGly: 2.304 ± 0.062	0.551PheHis: 0.551 ± 0.033	2.909PheIle: 2.909 ± 0.082	1.797PheLys: 1.797 ± 0.053	3.146PheLeu: 3.146 ± 0.088	0.74PheMet: 0.74 ± 0.04	0.967PheAsn: 0.967 ± 0.043	1.297PhePro: 1.297 ± 0.05	0.634PheGln: 0.634 ± 0.036	2.064PheArg: 2.064 ± 0.062	2.5PheSer: 2.5 ± 0.075	1.673PheThr: 1.673 ± 0.057	2.239PheVal: 2.239 ± 0.059	0.358PheTrp: 0.358 ± 0.026	1.3PheTyr: 1.3 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	5.187GlyAla: 5.187 ± 0.114	0.607GlyCys: 0.607 ± 0.038	3.977GlyAsp: 3.977 ± 0.086	5.236GlyGlu: 5.236 ± 0.103	3.534GlyPhe: 3.534 ± 0.087	5.969GlyGly: 5.969 ± 0.115	1.174GlyHis: 1.174 ± 0.045	6.927GlyIle: 6.927 ± 0.115	4.024GlyLys: 4.024 ± 0.088	7.723GlyLeu: 7.723 ± 0.128	1.92GlyMet: 1.92 ± 0.067	1.922GlyAsn: 1.922 ± 0.069	2.327GlyPro: 2.327 ± 0.072	1.012GlyGln: 1.012 ± 0.044	4.951GlyArg: 4.951 ± 0.1	6.507GlySer: 6.507 ± 0.119	2.696GlyThr: 2.696 ± 0.074	7.3GlyVal: 7.3 ± 0.126	0.965GlyTrp: 0.965 ± 0.047	4.06GlyTyr: 4.06 ± 0.094	0.0GlyXaa: 0.0 ± 0.0
His	1.136HisAla: 1.136 ± 0.048	0.101HisCys: 0.101 ± 0.014	0.677HisAsp: 0.677 ± 0.032	0.904HisGlu: 0.904 ± 0.039	0.402HisPhe: 0.402 ± 0.026	1.403HisGly: 1.403 ± 0.048	0.384HisHis: 0.384 ± 0.024	1.401HisIle: 1.401 ± 0.055	0.504HisLys: 0.504 ± 0.03	1.322HisLeu: 1.322 ± 0.047	0.456HisMet: 0.456 ± 0.03	0.429HisAsn: 0.429 ± 0.026	0.892HisPro: 0.892 ± 0.041	0.279HisGln: 0.279 ± 0.024	1.144HisArg: 1.144 ± 0.048	0.881HisSer: 0.881 ± 0.042	0.654HisThr: 0.654 ± 0.034	1.234HisVal: 1.234 ± 0.047	0.158HisTrp: 0.158 ± 0.017	0.594HisTyr: 0.594 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	9.425IleAla: 9.425 ± 0.141	0.607IleCys: 0.607 ± 0.031	5.891IleAsp: 5.891 ± 0.115	7.001IleGlu: 7.001 ± 0.128	2.907IlePhe: 2.907 ± 0.077	6.306IleGly: 6.306 ± 0.104	1.562IleHis: 1.562 ± 0.053	6.522IleIle: 6.522 ± 0.141	4.348IleLys: 4.348 ± 0.092	9.276IleLeu: 9.276 ± 0.158	2.046IleMet: 2.046 ± 0.058	2.858IleAsn: 2.858 ± 0.074	4.665IlePro: 4.665 ± 0.087	1.38IleGln: 1.38 ± 0.047	4.623IleArg: 4.623 ± 0.096	6.909IleSer: 6.909 ± 0.131	4.186IleThr: 4.186 ± 0.09	7.341IleVal: 7.341 ± 0.119	0.832IleTrp: 0.832 ± 0.046	4.541IleTyr: 4.541 ± 0.086	0.0IleXaa: 0.0 ± 0.0
Lys	4.564LysAla: 4.564 ± 0.097	0.466LysCys: 0.466 ± 0.029	2.509LysAsp: 2.509 ± 0.064	3.743LysGlu: 3.743 ± 0.097	0.863LysPhe: 0.863 ± 0.044	4.35LysGly: 4.35 ± 0.089	0.904LysHis: 0.904 ± 0.036	5.778LysIle: 5.778 ± 0.113	3.296LysLys: 3.296 ± 0.104	4.715LysLeu: 4.715 ± 0.107	1.091LysMet: 1.091 ± 0.047	1.659LysAsn: 1.659 ± 0.053	3.028LysPro: 3.028 ± 0.073	0.935LysGln: 0.935 ± 0.042	3.995LysArg: 3.995 ± 0.089	2.864LysSer: 2.864 ± 0.079	2.552LysThr: 2.552 ± 0.068	3.22LysVal: 3.22 ± 0.08	0.533LysTrp: 0.533 ± 0.029	1.913LysTyr: 1.913 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	8.427LeuAla: 8.427 ± 0.149	0.65LeuCys: 0.65 ± 0.039	4.942LeuAsp: 4.942 ± 0.08	7.691LeuGlu: 7.691 ± 0.142	2.943LeuPhe: 2.943 ± 0.082	9.236LeuGly: 9.236 ± 0.151	1.214LeuHis: 1.214 ± 0.047	7.514LeuIle: 7.514 ± 0.132	5.52LeuLys: 5.52 ± 0.117	9.472LeuLeu: 9.472 ± 0.169	2.125LeuMet: 2.125 ± 0.073	2.467LeuAsn: 2.467 ± 0.066	3.811LeuPro: 3.811 ± 0.079	1.522LeuGln: 1.522 ± 0.059	7.642LeuArg: 7.642 ± 0.129	8.162LeuSer: 8.162 ± 0.121	3.968LeuThr: 3.968 ± 0.099	8.006LeuVal: 8.006 ± 0.151	1.07LeuTrp: 1.07 ± 0.048	4.247LeuTyr: 4.247 ± 0.096	0.0LeuXaa: 0.0 ± 0.0
Met	1.859MetAla: 1.859 ± 0.049	0.155MetCys: 0.155 ± 0.016	1.243MetAsp: 1.243 ± 0.044	1.374MetGlu: 1.374 ± 0.057	0.706MetPhe: 0.706 ± 0.038	2.313MetGly: 2.313 ± 0.068	0.331MetHis: 0.331 ± 0.025	2.482MetIle: 2.482 ± 0.065	1.201MetLys: 1.201 ± 0.05	2.73MetLeu: 2.73 ± 0.068	0.526MetMet: 0.526 ± 0.04	0.663MetAsn: 0.663 ± 0.033	1.16MetPro: 1.16 ± 0.045	0.286MetGln: 0.286 ± 0.023	1.787MetArg: 1.787 ± 0.055	1.554MetSer: 1.554 ± 0.049	0.785MetThr: 0.785 ± 0.034	2.1MetVal: 2.1 ± 0.056	0.306MetTrp: 0.306 ± 0.026	0.639MetTyr: 0.639 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.059AsnAla: 2.059 ± 0.063	0.158AsnCys: 0.158 ± 0.018	1.025AsnAsp: 1.025 ± 0.044	1.5AsnGlu: 1.5 ± 0.051	0.614AsnPhe: 0.614 ± 0.038	1.679AsnGly: 1.679 ± 0.057	0.402AsnHis: 0.402 ± 0.029	3.366AsnIle: 3.366 ± 0.078	1.399AsnLys: 1.399 ± 0.051	2.754AsnLeu: 2.754 ± 0.059	0.946AsnMet: 0.946 ± 0.039	1.178AsnAsn: 1.178 ± 0.053	2.087AsnPro: 2.087 ± 0.06	0.515AsnGln: 0.515 ± 0.033	1.58AsnArg: 1.58 ± 0.058	1.461AsnSer: 1.461 ± 0.053	1.635AsnThr: 1.635 ± 0.052	2.048AsnVal: 2.048 ± 0.062	0.295AsnTrp: 0.295 ± 0.024	1.106AsnTyr: 1.106 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.588ProAla: 2.588 ± 0.075	0.272ProCys: 0.272 ± 0.024	2.078ProAsp: 2.078 ± 0.065	3.705ProGlu: 3.705 ± 0.083	1.443ProPhe: 1.443 ± 0.05	4.058ProGly: 4.058 ± 0.094	0.857ProHis: 0.857 ± 0.043	3.136ProIle: 3.136 ± 0.078	2.102ProLys: 2.102 ± 0.058	4.537ProLeu: 4.537 ± 0.111	0.985ProMet: 0.985 ± 0.045	1.234ProAsn: 1.234 ± 0.048	2.493ProPro: 2.493 ± 0.086	1.165ProGln: 1.165 ± 0.046	3.206ProArg: 3.206 ± 0.088	3.345ProSer: 3.345 ± 0.071	1.94ProThr: 1.94 ± 0.06	3.563ProVal: 3.563 ± 0.084	0.735ProTrp: 0.735 ± 0.036	1.927ProTyr: 1.927 ± 0.065	0.0ProXaa: 0.0 ± 0.0
Gln	1.504GlnAla: 1.504 ± 0.052	0.126GlnCys: 0.126 ± 0.017	0.881GlnAsp: 0.881 ± 0.045	1.133GlnGlu: 1.133 ± 0.052	0.416GlnPhe: 0.416 ± 0.026	1.461GlnGly: 1.461 ± 0.058	0.268GlnHis: 0.268 ± 0.022	1.434GlnIle: 1.434 ± 0.049	0.828GlnLys: 0.828 ± 0.04	1.635GlnLeu: 1.635 ± 0.058	0.403GlnMet: 0.403 ± 0.026	0.497GlnAsn: 0.497 ± 0.027	0.767GlnPro: 0.767 ± 0.038	0.548GlnGln: 0.548 ± 0.047	1.275GlnArg: 1.275 ± 0.043	0.924GlnSer: 0.924 ± 0.045	0.816GlnThr: 0.816 ± 0.042	1.275GlnVal: 1.275 ± 0.056	0.184GlnTrp: 0.184 ± 0.018	0.587GlnTyr: 0.587 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.971ArgAla: 4.971 ± 0.088	0.627ArgCys: 0.627 ± 0.031	4.042ArgAsp: 4.042 ± 0.087	5.987ArgGlu: 5.987 ± 0.112	2.413ArgPhe: 2.413 ± 0.069	5.89ArgGly: 5.89 ± 0.119	0.845ArgHis: 0.845 ± 0.042	7.309ArgIle: 7.309 ± 0.129	3.615ArgLys: 3.615 ± 0.098	6.478ArgLeu: 6.478 ± 0.122	1.439ArgMet: 1.439 ± 0.05	1.942ArgAsn: 1.942 ± 0.061	2.084ArgPro: 2.084 ± 0.071	0.837ArgGln: 0.837 ± 0.041	4.937ArgArg: 4.937 ± 0.112	5.151ArgSer: 5.151 ± 0.092	2.37ArgThr: 2.37 ± 0.062	5.969ArgVal: 5.969 ± 0.112	0.848ArgTrp: 0.848 ± 0.033	2.833ArgTyr: 2.833 ± 0.083	0.0ArgXaa: 0.0 ± 0.0
Ser	3.667SerAla: 3.667 ± 0.087	0.499SerCys: 0.499 ± 0.03	2.992SerAsp: 2.992 ± 0.073	4.215SerGlu: 4.215 ± 0.091	2.406SerPhe: 2.406 ± 0.06	5.621SerGly: 5.621 ± 0.101	1.054SerHis: 1.054 ± 0.045	7.546SerIle: 7.546 ± 0.129	3.952SerLys: 3.952 ± 0.09	7.635SerLeu: 7.635 ± 0.152	2.257SerMet: 2.257 ± 0.073	1.805SerAsn: 1.805 ± 0.059	3.337SerPro: 3.337 ± 0.071	1.432SerGln: 1.432 ± 0.054	5.319SerArg: 5.319 ± 0.117	5.4SerSer: 5.4 ± 0.132	3.008SerThr: 3.008 ± 0.078	4.712SerVal: 4.712 ± 0.095	0.922SerTrp: 0.922 ± 0.039	2.966SerTyr: 2.966 ± 0.076	0.0SerXaa: 0.0 ± 0.0
Thr	3.28ThrAla: 3.28 ± 0.08	0.319ThrCys: 0.319 ± 0.022	1.616ThrAsp: 1.616 ± 0.05	1.985ThrGlu: 1.985 ± 0.069	1.318ThrPhe: 1.318 ± 0.054	3.842ThrGly: 3.842 ± 0.087	0.812ThrHis: 0.812 ± 0.041	4.092ThrIle: 4.092 ± 0.098	1.774ThrLys: 1.774 ± 0.058	4.595ThrLeu: 4.595 ± 0.091	1.099ThrMet: 1.099 ± 0.048	1.192ThrAsn: 1.192 ± 0.045	2.649ThrPro: 2.649 ± 0.072	0.895ThrGln: 0.895 ± 0.045	2.664ThrArg: 2.664 ± 0.059	2.858ThrSer: 2.858 ± 0.078	2.244ThrThr: 2.244 ± 0.15	2.992ThrVal: 2.992 ± 0.085	0.501ThrTrp: 0.501 ± 0.036	1.668ThrTyr: 1.668 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	5.711ValAla: 5.711 ± 0.118	0.504ValCys: 0.504 ± 0.03	4.099ValAsp: 4.099 ± 0.087	6.379ValGlu: 6.379 ± 0.121	3.013ValPhe: 3.013 ± 0.085	5.576ValGly: 5.576 ± 0.118	0.78ValHis: 0.78 ± 0.038	7.392ValIle: 7.392 ± 0.122	4.6ValLys: 4.6 ± 0.081	6.855ValLeu: 6.855 ± 0.114	1.716ValMet: 1.716 ± 0.06	2.179ValAsn: 2.179 ± 0.058	2.669ValPro: 2.669 ± 0.068	0.98ValGln: 0.98 ± 0.041	5.727ValArg: 5.727 ± 0.108	5.994ValSer: 5.994 ± 0.107	3.4ValThr: 3.4 ± 0.092	6.624ValVal: 6.624 ± 0.12	0.787ValTrp: 0.787 ± 0.044	2.826ValTyr: 2.826 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.758TrpAla: 0.758 ± 0.042	0.076TrpCys: 0.076 ± 0.012	0.645TrpAsp: 0.645 ± 0.036	0.683TrpGlu: 0.683 ± 0.039	0.468TrpPhe: 0.468 ± 0.031	1.059TrpGly: 1.059 ± 0.038	0.167TrpHis: 0.167 ± 0.018	1.118TrpIle: 1.118 ± 0.055	0.512TrpLys: 0.512 ± 0.029	1.102TrpLeu: 1.102 ± 0.049	0.252TrpMet: 0.252 ± 0.019	0.366TrpAsn: 0.366 ± 0.025	0.339TrpPro: 0.339 ± 0.026	0.186TrpGln: 0.186 ± 0.016	1.039TrpArg: 1.039 ± 0.042	0.74TrpSer: 0.74 ± 0.042	0.283TrpThr: 0.283 ± 0.024	0.911TrpVal: 0.911 ± 0.045	0.196TrpTrp: 0.196 ± 0.02	0.429TrpTyr: 0.429 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.592TyrAla: 2.592 ± 0.075	0.297TyrCys: 0.297 ± 0.022	1.686TyrAsp: 1.686 ± 0.059	2.523TyrGlu: 2.523 ± 0.065	1.048TyrPhe: 1.048 ± 0.047	3.182TyrGly: 3.182 ± 0.086	0.566TyrHis: 0.566 ± 0.036	4.233TyrIle: 4.233 ± 0.097	1.853TyrLys: 1.853 ± 0.054	3.928TyrLeu: 3.928 ± 0.089	1.21TyrMet: 1.21 ± 0.05	1.218TyrAsn: 1.218 ± 0.052	1.801TyrPro: 1.801 ± 0.053	0.764TyrGln: 0.764 ± 0.043	3.602TyrArg: 3.602 ± 0.076	2.837TyrSer: 2.837 ± 0.072	2.059TyrThr: 2.059 ± 0.067	3.04TyrVal: 3.04 ± 0.081	0.465TyrTrp: 0.465 ± 0.034	1.662TyrTyr: 1.662 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1903 proteins (555226 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---