Amino acid dipepetide frequency for Ursus americanus (American black bear) (Euarctos americanus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.669AlaAla: 6.669 ± 0.034	1.511AlaCys: 1.511 ± 0.013	2.969AlaAsp: 2.969 ± 0.013	4.733AlaGlu: 4.733 ± 0.023	2.678AlaPhe: 2.678 ± 0.016	4.841AlaGly: 4.841 ± 0.024	1.604AlaHis: 1.604 ± 0.01	2.795AlaIle: 2.795 ± 0.014	3.359AlaLys: 3.359 ± 0.025	7.364AlaLeu: 7.364 ± 0.032	1.47AlaMet: 1.47 ± 0.011	2.006AlaAsn: 2.006 ± 0.012	4.292AlaPro: 4.292 ± 0.027	3.217AlaGln: 3.217 ± 0.019	3.782AlaArg: 3.782 ± 0.017	5.744AlaSer: 5.744 ± 0.022	3.485AlaThr: 3.485 ± 0.018	4.795AlaVal: 4.795 ± 0.02	0.835AlaTrp: 0.835 ± 0.008	1.567AlaTyr: 1.567 ± 0.01	0.003AlaXaa: 0.003 ± 0.0
Cys	1.357CysAla: 1.357 ± 0.013	0.653CysCys: 0.653 ± 0.011	1.058CysAsp: 1.058 ± 0.014	1.334CysGlu: 1.334 ± 0.015	0.912CysPhe: 0.912 ± 0.008	1.792CysGly: 1.792 ± 0.02	0.701CysHis: 0.701 ± 0.007	0.998CysIle: 0.998 ± 0.01	1.125CysLys: 1.125 ± 0.011	2.309CysLeu: 2.309 ± 0.018	0.426CysMet: 0.426 ± 0.005	0.812CysAsn: 0.812 ± 0.009	1.507CysPro: 1.507 ± 0.018	1.116CysGln: 1.116 ± 0.014	1.388CysArg: 1.388 ± 0.012	2.076CysSer: 2.076 ± 0.018	1.125CysThr: 1.125 ± 0.012	1.446CysVal: 1.446 ± 0.015	0.298CysTrp: 0.298 ± 0.004	0.583CysTyr: 0.583 ± 0.006	0.001CysXaa: 0.001 ± 0.0
Asp	2.876AspAla: 2.876 ± 0.014	1.088AspCys: 1.088 ± 0.013	2.561AspAsp: 2.561 ± 0.026	3.419AspGlu: 3.419 ± 0.021	2.103AspPhe: 2.103 ± 0.013	3.324AspGly: 3.324 ± 0.02	1.131AspHis: 1.131 ± 0.008	2.576AspIle: 2.576 ± 0.014	2.491AspLys: 2.491 ± 0.016	5.031AspLeu: 5.031 ± 0.02	1.087AspMet: 1.087 ± 0.008	1.664AspAsn: 1.664 ± 0.011	2.931AspPro: 2.931 ± 0.016	1.805AspGln: 1.805 ± 0.011	2.499AspArg: 2.499 ± 0.014	4.031AspSer: 4.031 ± 0.021	2.431AspThr: 2.431 ± 0.013	3.121AspVal: 3.121 ± 0.019	0.641AspTrp: 0.641 ± 0.008	1.48AspTyr: 1.48 ± 0.011	0.002AspXaa: 0.002 ± 0.0
Glu	5.274GluAla: 5.274 ± 0.025	1.493GluCys: 1.493 ± 0.023	4.301GluAsp: 4.301 ± 0.021	7.589GluGlu: 7.589 ± 0.045	2.021GluPhe: 2.021 ± 0.012	4.288GluGly: 4.288 ± 0.02	1.515GluHis: 1.515 ± 0.009	3.088GluIle: 3.088 ± 0.017	5.153GluLys: 5.153 ± 0.031	6.406GluLeu: 6.406 ± 0.028	1.592GluMet: 1.592 ± 0.01	3.013GluAsn: 3.013 ± 0.019	3.177GluPro: 3.177 ± 0.018	3.073GluGln: 3.073 ± 0.017	4.044GluArg: 4.044 ± 0.026	4.247GluSer: 4.247 ± 0.022	3.245GluThr: 3.245 ± 0.015	4.193GluVal: 4.193 ± 0.017	0.71GluTrp: 0.71 ± 0.007	1.584GluTyr: 1.584 ± 0.009	0.002GluXaa: 0.002 ± 0.0
Phe	2.039PheAla: 2.039 ± 0.012	1.018PheCys: 1.018 ± 0.008	1.692PheAsp: 1.692 ± 0.011	1.982PheGlu: 1.982 ± 0.01	1.821PhePhe: 1.821 ± 0.013	2.266PheGly: 2.266 ± 0.016	1.051PheHis: 1.051 ± 0.008	1.895PheIle: 1.895 ± 0.012	1.755PheLys: 1.755 ± 0.011	4.374PheLeu: 4.374 ± 0.022	0.779PheMet: 0.779 ± 0.007	1.341PheAsn: 1.341 ± 0.01	2.073PhePro: 2.073 ± 0.014	1.823PheGln: 1.823 ± 0.01	2.023PheArg: 2.023 ± 0.013	3.494PheSer: 3.494 ± 0.017	2.088PheThr: 2.088 ± 0.012	2.248PheVal: 2.248 ± 0.014	0.501PheTrp: 0.501 ± 0.005	1.27PheTyr: 1.27 ± 0.009	0.002PheXaa: 0.002 ± 0.0
Gly	4.627GlyAla: 4.627 ± 0.023	1.337GlyCys: 1.337 ± 0.011	3.173GlyAsp: 3.173 ± 0.016	4.173GlyGlu: 4.173 ± 0.022	2.462GlyPhe: 2.462 ± 0.015	5.095GlyGly: 5.095 ± 0.031	1.722GlyHis: 1.722 ± 0.012	2.729GlyIle: 2.729 ± 0.015	3.773GlyLys: 3.773 ± 0.021	5.998GlyLeu: 5.998 ± 0.026	1.301GlyMet: 1.301 ± 0.009	2.352GlyAsn: 2.352 ± 0.013	4.276GlyPro: 4.276 ± 0.036	2.829GlyGln: 2.829 ± 0.016	3.961GlyArg: 3.961 ± 0.023	5.785GlySer: 5.785 ± 0.022	3.615GlyThr: 3.615 ± 0.019	3.691GlyVal: 3.691 ± 0.017	0.857GlyTrp: 0.857 ± 0.008	1.733GlyTyr: 1.733 ± 0.012	0.004GlyXaa: 0.004 ± 0.0
His	1.383HisAla: 1.383 ± 0.009	0.749HisCys: 0.749 ± 0.008	0.884HisAsp: 0.884 ± 0.007	1.302HisGlu: 1.302 ± 0.009	1.123HisPhe: 1.123 ± 0.008	1.585HisGly: 1.585 ± 0.012	0.837HisHis: 0.837 ± 0.009	1.244HisIle: 1.244 ± 0.009	1.225HisLys: 1.225 ± 0.009	2.946HisLeu: 2.946 ± 0.013	0.564HisMet: 0.564 ± 0.005	0.845HisAsn: 0.845 ± 0.007	1.652HisPro: 1.652 ± 0.012	1.322HisGln: 1.322 ± 0.013	1.623HisArg: 1.623 ± 0.01	2.23HisSer: 2.23 ± 0.013	1.554HisThr: 1.554 ± 0.014	1.547HisVal: 1.547 ± 0.011	0.356HisTrp: 0.356 ± 0.005	0.81HisTyr: 0.81 ± 0.008	0.001HisXaa: 0.001 ± 0.0
Ile	2.563IleAla: 2.563 ± 0.013	1.111IleCys: 1.111 ± 0.01	2.025IleAsp: 2.025 ± 0.015	2.523IleGlu: 2.523 ± 0.015	1.978IlePhe: 1.978 ± 0.013	2.223IleGly: 2.223 ± 0.013	1.343IleHis: 1.343 ± 0.011	2.36IleIle: 2.36 ± 0.016	2.531IleLys: 2.531 ± 0.015	4.645IleLeu: 4.645 ± 0.017	0.979IleMet: 0.979 ± 0.007	1.811IleAsn: 1.811 ± 0.012	2.533IlePro: 2.533 ± 0.014	2.236IleGln: 2.236 ± 0.013	2.392IleArg: 2.392 ± 0.012	3.659IleSer: 3.659 ± 0.017	2.513IleThr: 2.513 ± 0.015	2.543IleVal: 2.543 ± 0.014	0.502IleTrp: 0.502 ± 0.005	1.424IleTyr: 1.424 ± 0.009	0.001IleXaa: 0.001 ± 0.0
Lys	3.932LysAla: 3.932 ± 0.024	1.127LysCys: 1.127 ± 0.013	3.054LysAsp: 3.054 ± 0.019	4.903LysGlu: 4.903 ± 0.031	1.729LysPhe: 1.729 ± 0.01	3.175LysGly: 3.175 ± 0.021	1.343LysHis: 1.343 ± 0.01	2.687LysIle: 2.687 ± 0.016	4.43LysLys: 4.43 ± 0.035	5.123LysLeu: 5.123 ± 0.024	1.382LysMet: 1.382 ± 0.01	2.348LysAsn: 2.348 ± 0.016	2.946LysPro: 2.946 ± 0.02	2.531LysGln: 2.531 ± 0.016	3.163LysArg: 3.163 ± 0.015	3.77LysSer: 3.77 ± 0.022	2.987LysThr: 2.987 ± 0.016	3.46LysVal: 3.46 ± 0.016	0.596LysTrp: 0.596 ± 0.006	1.538LysTyr: 1.538 ± 0.013	0.002LysXaa: 0.002 ± 0.0
Leu	7.004LeuAla: 7.004 ± 0.027	2.317LeuCys: 2.317 ± 0.017	4.766LeuAsp: 4.766 ± 0.018	7.136LeuGlu: 7.136 ± 0.035	3.627LeuPhe: 3.627 ± 0.018	6.103LeuGly: 6.103 ± 0.022	2.786LeuHis: 2.786 ± 0.014	3.988LeuIle: 3.988 ± 0.021	5.685LeuLys: 5.685 ± 0.025	11.108LeuLeu: 11.108 ± 0.042	2.033LeuMet: 2.033 ± 0.012	3.539LeuAsn: 3.539 ± 0.017	6.098LeuPro: 6.098 ± 0.025	5.77LeuGln: 5.77 ± 0.029	6.133LeuArg: 6.133 ± 0.025	8.175LeuSer: 8.175 ± 0.028	5.195LeuThr: 5.195 ± 0.02	5.708LeuVal: 5.708 ± 0.024	1.171LeuTrp: 1.171 ± 0.01	2.614LeuTyr: 2.614 ± 0.015	0.005LeuXaa: 0.005 ± 0.001
Met	1.848MetAla: 1.848 ± 0.011	0.416MetCys: 0.416 ± 0.006	1.222MetAsp: 1.222 ± 0.008	1.783MetGlu: 1.783 ± 0.011	0.756MetPhe: 0.756 ± 0.006	1.264MetGly: 1.264 ± 0.009	0.459MetHis: 0.459 ± 0.005	0.816MetIle: 0.816 ± 0.007	1.385MetLys: 1.385 ± 0.01	1.995MetLeu: 1.995 ± 0.012	0.544MetMet: 0.544 ± 0.006	0.888MetAsn: 0.888 ± 0.008	1.022MetPro: 1.022 ± 0.012	0.902MetGln: 0.902 ± 0.009	1.049MetArg: 1.049 ± 0.008	1.5MetSer: 1.5 ± 0.011	1.081MetThr: 1.081 ± 0.008	1.388MetVal: 1.388 ± 0.009	0.243MetTrp: 0.243 ± 0.004	0.624MetTyr: 0.624 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.049AsnAla: 2.049 ± 0.013	0.845AsnCys: 0.845 ± 0.009	1.515AsnAsp: 1.515 ± 0.013	2.169AsnGlu: 2.169 ± 0.014	1.487AsnPhe: 1.487 ± 0.01	2.404AsnGly: 2.404 ± 0.017	0.943AsnHis: 0.943 ± 0.007	2.099AsnIle: 2.099 ± 0.013	2.159AsnLys: 2.159 ± 0.013	3.676AsnLeu: 3.676 ± 0.017	0.883AsnMet: 0.883 ± 0.008	1.479AsnAsn: 1.479 ± 0.011	2.21AsnPro: 2.21 ± 0.014	1.622AsnGln: 1.622 ± 0.013	1.829AsnArg: 1.829 ± 0.011	2.996AsnSer: 2.996 ± 0.015	1.909AsnThr: 1.909 ± 0.012	2.218AsnVal: 2.218 ± 0.011	0.456AsnTrp: 0.456 ± 0.006	1.089AsnTyr: 1.089 ± 0.008	0.002AsnXaa: 0.002 ± 0.0
Pro	4.899ProAla: 4.899 ± 0.029	1.237ProCys: 1.237 ± 0.018	2.797ProAsp: 2.797 ± 0.016	4.399ProGlu: 4.399 ± 0.021	2.011ProPhe: 2.011 ± 0.011	5.283ProGly: 5.283 ± 0.048	1.457ProHis: 1.457 ± 0.011	1.815ProIle: 1.815 ± 0.012	2.651ProLys: 2.651 ± 0.021	5.398ProLeu: 5.398 ± 0.023	1.05ProMet: 1.05 ± 0.01	1.827ProAsn: 1.827 ± 0.014	5.931ProPro: 5.931 ± 0.047	2.781ProGln: 2.781 ± 0.017	3.431ProArg: 3.431 ± 0.018	5.658ProSer: 5.658 ± 0.03	3.017ProThr: 3.017 ± 0.016	3.828ProVal: 3.828 ± 0.018	0.701ProTrp: 0.701 ± 0.006	1.512ProTyr: 1.512 ± 0.014	0.004ProXaa: 0.004 ± 0.0
Gln	3.541GlnAla: 3.541 ± 0.02	0.982GlnCys: 0.982 ± 0.011	2.318GlnAsp: 2.318 ± 0.012	3.788GlnGlu: 3.788 ± 0.023	1.383GlnPhe: 1.383 ± 0.009	2.873GlnGly: 2.873 ± 0.017	1.285GlnHis: 1.285 ± 0.009	1.997GlnIle: 1.997 ± 0.011	2.812GlnLys: 2.812 ± 0.017	4.79GlnLeu: 4.79 ± 0.025	1.087GlnMet: 1.087 ± 0.008	1.805GlnAsn: 1.805 ± 0.012	2.693GlnPro: 2.693 ± 0.018	2.872GlnGln: 2.872 ± 0.028	2.959GlnArg: 2.959 ± 0.018	3.028GlnSer: 3.028 ± 0.017	2.285GlnThr: 2.285 ± 0.014	2.875GlnVal: 2.875 ± 0.014	0.551GlnTrp: 0.551 ± 0.005	1.144GlnTyr: 1.144 ± 0.009	0.001GlnXaa: 0.001 ± 0.0
Arg	4.007ArgAla: 4.007 ± 0.018	1.32ArgCys: 1.32 ± 0.015	2.828ArgAsp: 2.828 ± 0.014	4.039ArgGlu: 4.039 ± 0.021	1.907ArgPhe: 1.907 ± 0.009	3.743ArgGly: 3.743 ± 0.021	1.522ArgHis: 1.522 ± 0.01	2.444ArgIle: 2.444 ± 0.012	3.618ArgLys: 3.618 ± 0.02	5.595ArgLeu: 5.595 ± 0.023	1.179ArgMet: 1.179 ± 0.009	2.13ArgAsn: 2.13 ± 0.011	3.352ArgPro: 3.352 ± 0.019	2.662ArgGln: 2.662 ± 0.016	4.299ArgArg: 4.299 ± 0.026	4.177ArgSer: 4.177 ± 0.021	2.811ArgThr: 2.811 ± 0.016	3.298ArgVal: 3.298 ± 0.015	0.718ArgTrp: 0.718 ± 0.006	1.472ArgTyr: 1.472 ± 0.009	0.003ArgXaa: 0.003 ± 0.0
Ser	5.29SerAla: 5.29 ± 0.021	1.883SerCys: 1.883 ± 0.014	3.789SerAsp: 3.789 ± 0.025	4.997SerGlu: 4.997 ± 0.024	3.141SerPhe: 3.141 ± 0.016	5.663SerGly: 5.663 ± 0.022	2.119SerHis: 2.119 ± 0.014	3.148SerIle: 3.148 ± 0.011	3.907SerLys: 3.907 ± 0.019	8.379SerLeu: 8.379 ± 0.027	1.53SerMet: 1.53 ± 0.01	2.623SerAsn: 2.623 ± 0.013	5.92SerPro: 5.92 ± 0.033	3.747SerGln: 3.747 ± 0.016	4.472SerArg: 4.472 ± 0.02	8.91SerSer: 8.91 ± 0.047	4.257SerThr: 4.257 ± 0.023	5.005SerVal: 5.005 ± 0.018	1.101SerTrp: 1.101 ± 0.009	2.07SerTyr: 2.07 ± 0.012	0.004SerXaa: 0.004 ± 0.0
Thr	3.712ThrAla: 3.712 ± 0.017	1.386ThrCys: 1.386 ± 0.018	2.438ThrAsp: 2.438 ± 0.012	3.426ThrGlu: 3.426 ± 0.018	2.141ThrPhe: 2.141 ± 0.013	3.56ThrGly: 3.56 ± 0.019	1.299ThrHis: 1.299 ± 0.011	2.337ThrIle: 2.337 ± 0.014	2.552ThrLys: 2.552 ± 0.013	5.313ThrLeu: 5.313 ± 0.02	1.061ThrMet: 1.061 ± 0.008	1.68ThrAsn: 1.68 ± 0.011	3.546ThrPro: 3.546 ± 0.02	2.265ThrGln: 2.265 ± 0.014	2.452ThrArg: 2.452 ± 0.013	4.403ThrSer: 4.403 ± 0.022	2.775ThrThr: 2.775 ± 0.017	3.922ThrVal: 3.922 ± 0.018	0.681ThrTrp: 0.681 ± 0.006	1.432ThrTyr: 1.432 ± 0.012	0.002ThrXaa: 0.002 ± 0.0
Val	4.364ValAla: 4.364 ± 0.018	1.597ValCys: 1.597 ± 0.013	2.966ValAsp: 2.966 ± 0.015	3.809ValGlu: 3.809 ± 0.017	2.512ValPhe: 2.512 ± 0.015	3.518ValGly: 3.518 ± 0.017	1.614ValHis: 1.614 ± 0.009	2.961ValIle: 2.961 ± 0.016	3.342ValLys: 3.342 ± 0.017	6.507ValLeu: 6.507 ± 0.026	1.336ValMet: 1.336 ± 0.009	2.27ValAsn: 2.27 ± 0.013	3.679ValPro: 3.679 ± 0.016	2.73ValGln: 2.73 ± 0.014	3.259ValArg: 3.259 ± 0.014	5.026ValSer: 5.026 ± 0.021	3.811ValThr: 3.811 ± 0.019	4.107ValVal: 4.107 ± 0.018	0.73ValTrp: 0.73 ± 0.007	1.663ValTyr: 1.663 ± 0.011	0.001ValXaa: 0.001 ± 0.0
Trp	0.839TrpAla: 0.839 ± 0.008	0.261TrpCys: 0.261 ± 0.004	0.655TrpAsp: 0.655 ± 0.006	0.819TrpGlu: 0.819 ± 0.007	0.46TrpPhe: 0.46 ± 0.006	0.807TrpGly: 0.807 ± 0.009	0.296TrpHis: 0.296 ± 0.005	0.544TrpIle: 0.544 ± 0.007	0.786TrpLys: 0.786 ± 0.006	1.229TrpLeu: 1.229 ± 0.01	0.317TrpMet: 0.317 ± 0.005	0.544TrpAsn: 0.544 ± 0.007	0.553TrpPro: 0.553 ± 0.006	0.534TrpGln: 0.534 ± 0.006	0.758TrpArg: 0.758 ± 0.007	0.868TrpSer: 0.868 ± 0.009	0.688TrpThr: 0.688 ± 0.008	0.747TrpVal: 0.747 ± 0.007	0.201TrpTrp: 0.201 ± 0.004	0.334TrpTyr: 0.334 ± 0.004	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.444TyrAla: 1.444 ± 0.011	0.685TyrCys: 0.685 ± 0.006	1.283TyrAsp: 1.283 ± 0.01	1.684TyrGlu: 1.684 ± 0.012	1.28TyrPhe: 1.28 ± 0.009	1.676TyrGly: 1.676 ± 0.012	0.757TyrHis: 0.757 ± 0.007	1.371TyrIle: 1.371 ± 0.01	1.485TyrLys: 1.485 ± 0.016	2.772TyrLeu: 2.772 ± 0.013	0.586TyrMet: 0.586 ± 0.005	1.059TyrAsn: 1.059 ± 0.008	1.291TyrPro: 1.291 ± 0.01	1.233TyrGln: 1.233 ± 0.01	1.604TyrArg: 1.604 ± 0.011	2.177TyrSer: 2.177 ± 0.012	1.51TyrThr: 1.51 ± 0.01	1.658TyrVal: 1.658 ± 0.011	0.39TyrTrp: 0.39 ± 0.008	0.947TyrTyr: 0.947 ± 0.009	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.0	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.007XaaGly: 0.007 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.004XaaLeu: 0.004 ± 0.0	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.004XaaPro: 0.004 ± 0.0	0.002XaaGln: 0.002 ± 0.0	0.002XaaArg: 0.002 ± 0.0	0.003XaaSer: 0.003 ± 0.0	0.002XaaThr: 0.002 ± 0.0	0.003XaaVal: 0.003 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.638XaaXaa: 0.638 ± 0.118

Statistics based on 32512 proteins (18648622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---