Amino acid dipepetide frequency for Nesterenkonia jeotgali

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.887AlaAla: 18.887 ± 0.234	0.697AlaCys: 0.697 ± 0.031	6.735AlaAsp: 6.735 ± 0.085	10.431AlaGlu: 10.431 ± 0.146	3.232AlaPhe: 3.232 ± 0.066	11.981AlaGly: 11.981 ± 0.139	2.563AlaHis: 2.563 ± 0.06	4.487AlaIle: 4.487 ± 0.092	2.843AlaLys: 2.843 ± 0.078	13.016AlaLeu: 13.016 ± 0.143	2.745AlaMet: 2.745 ± 0.059	1.995AlaAsn: 1.995 ± 0.05	6.038AlaPro: 6.038 ± 0.114	5.448AlaGln: 5.448 ± 0.09	7.959AlaArg: 7.959 ± 0.125	6.864AlaSer: 6.864 ± 0.102	6.184AlaThr: 6.184 ± 0.083	10.291AlaVal: 10.291 ± 0.137	1.669AlaTrp: 1.669 ± 0.05	2.101AlaTyr: 2.101 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.721CysAla: 0.721 ± 0.027	0.049CysCys: 0.049 ± 0.007	0.288CysAsp: 0.288 ± 0.017	0.312CysGlu: 0.312 ± 0.023	0.194CysPhe: 0.194 ± 0.015	0.647CysGly: 0.647 ± 0.029	0.139CysHis: 0.139 ± 0.013	0.206CysIle: 0.206 ± 0.016	0.074CysLys: 0.074 ± 0.01	0.533CysLeu: 0.533 ± 0.027	0.107CysMet: 0.107 ± 0.012	0.096CysAsn: 0.096 ± 0.012	0.317CysPro: 0.317 ± 0.021	0.152CysGln: 0.152 ± 0.014	0.394CysArg: 0.394 ± 0.024	0.351CysSer: 0.351 ± 0.022	0.357CysThr: 0.357 ± 0.024	0.396CysVal: 0.396 ± 0.023	0.089CysTrp: 0.089 ± 0.01	0.112CysTyr: 0.112 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.371AspAla: 7.371 ± 0.099	0.289AspCys: 0.289 ± 0.02	3.124AspAsp: 3.124 ± 0.074	3.962AspGlu: 3.962 ± 0.07	1.889AspPhe: 1.889 ± 0.052	4.771AspGly: 4.771 ± 0.096	1.411AspHis: 1.411 ± 0.043	2.1AspIle: 2.1 ± 0.053	0.955AspLys: 0.955 ± 0.035	5.998AspLeu: 5.998 ± 0.088	1.042AspMet: 1.042 ± 0.034	0.714AspAsn: 0.714 ± 0.031	4.299AspPro: 4.299 ± 0.073	2.179AspGln: 2.179 ± 0.063	3.678AspArg: 3.678 ± 0.074	3.259AspSer: 3.259 ± 0.068	2.694AspThr: 2.694 ± 0.068	4.28AspVal: 4.28 ± 0.084	0.885AspTrp: 0.885 ± 0.034	1.328AspTyr: 1.328 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.322GluAla: 8.322 ± 0.109	0.278GluCys: 0.278 ± 0.019	4.303GluAsp: 4.303 ± 0.084	4.796GluGlu: 4.796 ± 0.092	1.899GluPhe: 1.899 ± 0.05	4.644GluGly: 4.644 ± 0.09	1.974GluHis: 1.974 ± 0.053	3.418GluIle: 3.418 ± 0.066	1.804GluLys: 1.804 ± 0.052	7.628GluLeu: 7.628 ± 0.098	1.145GluMet: 1.145 ± 0.041	1.683GluAsn: 1.683 ± 0.047	3.369GluPro: 3.369 ± 0.077	3.145GluGln: 3.145 ± 0.066	4.489GluArg: 4.489 ± 0.083	3.942GluSer: 3.942 ± 0.08	3.859GluThr: 3.859 ± 0.072	5.374GluVal: 5.374 ± 0.092	0.729GluTrp: 0.729 ± 0.029	1.161GluTyr: 1.161 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.673PheAla: 3.673 ± 0.07	0.213PheCys: 0.213 ± 0.016	2.058PheAsp: 2.058 ± 0.055	1.775PheGlu: 1.775 ± 0.052	1.121PhePhe: 1.121 ± 0.045	3.174PheGly: 3.174 ± 0.072	0.628PheHis: 0.628 ± 0.027	1.37PheIle: 1.37 ± 0.045	0.587PheLys: 0.587 ± 0.032	2.867PheLeu: 2.867 ± 0.067	0.541PheMet: 0.541 ± 0.026	0.842PheAsn: 0.842 ± 0.032	1.354PhePro: 1.354 ± 0.042	0.849PheGln: 0.849 ± 0.031	1.633PheArg: 1.633 ± 0.048	2.174PheSer: 2.174 ± 0.05	2.212PheThr: 2.212 ± 0.061	2.123PheVal: 2.123 ± 0.054	0.448PheTrp: 0.448 ± 0.024	0.714PheTyr: 0.714 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.445GlyAla: 10.445 ± 0.146	0.539GlyCys: 0.539 ± 0.028	4.341GlyAsp: 4.341 ± 0.084	5.67GlyGlu: 5.67 ± 0.08	3.305GlyPhe: 3.305 ± 0.066	7.131GlyGly: 7.131 ± 0.135	2.012GlyHis: 2.012 ± 0.053	4.268GlyIle: 4.268 ± 0.073	2.191GlyLys: 2.191 ± 0.07	9.154GlyLeu: 9.154 ± 0.138	2.151GlyMet: 2.151 ± 0.057	1.69GlyAsn: 1.69 ± 0.048	4.064GlyPro: 4.064 ± 0.075	2.895GlyGln: 2.895 ± 0.061	5.807GlyArg: 5.807 ± 0.089	5.8GlySer: 5.8 ± 0.084	5.219GlyThr: 5.219 ± 0.084	7.397GlyVal: 7.397 ± 0.103	1.504GlyTrp: 1.504 ± 0.043	2.112GlyTyr: 2.112 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.515HisAla: 2.515 ± 0.057	0.156HisCys: 0.156 ± 0.013	1.225HisAsp: 1.225 ± 0.043	1.294HisGlu: 1.294 ± 0.041	0.643HisPhe: 0.643 ± 0.028	2.19HisGly: 2.19 ± 0.062	0.689HisHis: 0.689 ± 0.031	0.793HisIle: 0.793 ± 0.03	0.383HisLys: 0.383 ± 0.02	2.376HisLeu: 2.376 ± 0.058	0.45HisMet: 0.45 ± 0.023	0.396HisAsn: 0.396 ± 0.024	1.715HisPro: 1.715 ± 0.046	0.971HisGln: 0.971 ± 0.036	1.99HisArg: 1.99 ± 0.049	1.29HisSer: 1.29 ± 0.042	1.181HisThr: 1.181 ± 0.041	1.546HisVal: 1.546 ± 0.043	0.357HisTrp: 0.357 ± 0.021	0.512HisTyr: 0.512 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.68IleAla: 5.68 ± 0.093	0.318IleCys: 0.318 ± 0.021	2.802IleAsp: 2.802 ± 0.064	2.756IleGlu: 2.756 ± 0.062	1.454IlePhe: 1.454 ± 0.05	4.38IleGly: 4.38 ± 0.081	0.883IleHis: 0.883 ± 0.037	1.928IleIle: 1.928 ± 0.06	0.897IleLys: 0.897 ± 0.04	3.895IleLeu: 3.895 ± 0.086	0.743IleMet: 0.743 ± 0.031	1.131IleAsn: 1.131 ± 0.04	2.356IlePro: 2.356 ± 0.051	1.203IleGln: 1.203 ± 0.039	2.607IleArg: 2.607 ± 0.061	3.034IleSer: 3.034 ± 0.064	3.036IleThr: 3.036 ± 0.063	3.191IleVal: 3.191 ± 0.066	0.612IleTrp: 0.612 ± 0.03	0.868IleTyr: 0.868 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	2.525LysAla: 2.525 ± 0.069	0.061LysCys: 0.061 ± 0.009	1.304LysAsp: 1.304 ± 0.042	1.174LysGlu: 1.174 ± 0.044	0.513LysPhe: 0.513 ± 0.024	1.526LysGly: 1.526 ± 0.054	0.595LysHis: 0.595 ± 0.028	1.099LysIle: 1.099 ± 0.043	0.98LysLys: 0.98 ± 0.049	2.234LysLeu: 2.234 ± 0.061	0.475LysMet: 0.475 ± 0.026	0.639LysAsn: 0.639 ± 0.029	1.219LysPro: 1.219 ± 0.051	0.849LysGln: 0.849 ± 0.035	1.496LysArg: 1.496 ± 0.046	1.365LysSer: 1.365 ± 0.047	1.404LysThr: 1.404 ± 0.047	1.869LysVal: 1.869 ± 0.053	0.246LysTrp: 0.246 ± 0.018	0.464LysTyr: 0.464 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.288LeuAla: 13.288 ± 0.147	0.593LeuCys: 0.593 ± 0.031	6.069LeuAsp: 6.069 ± 0.104	6.173LeuGlu: 6.173 ± 0.114	2.837LeuPhe: 2.837 ± 0.073	9.66LeuGly: 9.66 ± 0.14	2.242LeuHis: 2.242 ± 0.056	5.002LeuIle: 5.002 ± 0.091	2.184LeuLys: 2.184 ± 0.056	11.07LeuLeu: 11.07 ± 0.172	2.041LeuMet: 2.041 ± 0.054	2.274LeuAsn: 2.274 ± 0.054	5.537LeuPro: 5.537 ± 0.103	3.372LeuGln: 3.372 ± 0.071	7.427LeuArg: 7.427 ± 0.109	6.586LeuSer: 6.586 ± 0.088	6.604LeuThr: 6.604 ± 0.105	7.981LeuVal: 7.981 ± 0.128	1.248LeuTrp: 1.248 ± 0.046	1.704LeuTyr: 1.704 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.477MetAla: 2.477 ± 0.054	0.104MetCys: 0.104 ± 0.011	1.053MetAsp: 1.053 ± 0.036	1.128MetGlu: 1.128 ± 0.041	0.607MetPhe: 0.607 ± 0.03	1.588MetGly: 1.588 ± 0.046	0.429MetHis: 0.429 ± 0.024	1.159MetIle: 1.159 ± 0.036	0.475MetLys: 0.475 ± 0.026	2.206MetLeu: 2.206 ± 0.053	0.428MetMet: 0.428 ± 0.02	0.574MetAsn: 0.574 ± 0.026	1.172MetPro: 1.172 ± 0.032	0.628MetGln: 0.628 ± 0.029	1.403MetArg: 1.403 ± 0.042	1.57MetSer: 1.57 ± 0.042	1.797MetThr: 1.797 ± 0.045	1.622MetVal: 1.622 ± 0.041	0.245MetTrp: 0.245 ± 0.017	0.285MetTyr: 0.285 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.385AsnAla: 2.385 ± 0.056	0.126AsnCys: 0.126 ± 0.012	1.078AsnAsp: 1.078 ± 0.04	1.093AsnGlu: 1.093 ± 0.037	0.676AsnPhe: 0.676 ± 0.027	1.672AsnGly: 1.672 ± 0.043	0.453AsnHis: 0.453 ± 0.025	1.003AsnIle: 1.003 ± 0.036	0.417AsnLys: 0.417 ± 0.026	2.111AsnLeu: 2.111 ± 0.053	0.403AsnMet: 0.403 ± 0.022	0.511AsnAsn: 0.511 ± 0.025	1.661AsnPro: 1.661 ± 0.046	0.795AsnGln: 0.795 ± 0.031	1.379AsnArg: 1.379 ± 0.048	1.161AsnSer: 1.161 ± 0.038	1.326AsnThr: 1.326 ± 0.041	1.57AsnVal: 1.57 ± 0.048	0.341AsnTrp: 0.341 ± 0.02	0.507AsnTyr: 0.507 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.223ProAla: 7.223 ± 0.118	0.213ProCys: 0.213 ± 0.017	3.341ProAsp: 3.341 ± 0.072	5.152ProGlu: 5.152 ± 0.082	1.49ProPhe: 1.49 ± 0.047	5.486ProGly: 5.486 ± 0.109	1.17ProHis: 1.17 ± 0.039	1.728ProIle: 1.728 ± 0.04	1.165ProLys: 1.165 ± 0.044	4.723ProLeu: 4.723 ± 0.091	1.124ProMet: 1.124 ± 0.037	1.014ProAsn: 1.014 ± 0.038	2.061ProPro: 2.061 ± 0.064	2.04ProGln: 2.04 ± 0.051	3.299ProArg: 3.299 ± 0.07	3.088ProSer: 3.088 ± 0.064	2.967ProThr: 2.967 ± 0.066	4.498ProVal: 4.498 ± 0.079	0.781ProTrp: 0.781 ± 0.036	0.97ProTyr: 0.97 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.743GlnAla: 4.743 ± 0.088	0.156GlnCys: 0.156 ± 0.012	2.144GlnAsp: 2.144 ± 0.059	2.326GlnGlu: 2.326 ± 0.058	0.863GlnPhe: 0.863 ± 0.04	2.705GlnGly: 2.705 ± 0.058	0.885GlnHis: 0.885 ± 0.034	1.699GlnIle: 1.699 ± 0.046	0.765GlnLys: 0.765 ± 0.035	4.079GlnLeu: 4.079 ± 0.074	0.757GlnMet: 0.757 ± 0.031	0.796GlnAsn: 0.796 ± 0.03	1.874GlnPro: 1.874 ± 0.051	1.635GlnGln: 1.635 ± 0.051	3.139GlnArg: 3.139 ± 0.065	1.793GlnSer: 1.793 ± 0.049	1.936GlnThr: 1.936 ± 0.048	3.066GlnVal: 3.066 ± 0.064	0.537GlnTrp: 0.537 ± 0.025	0.592GlnTyr: 0.592 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.776ArgAla: 7.776 ± 0.112	0.363ArgCys: 0.363 ± 0.021	3.527ArgAsp: 3.527 ± 0.067	4.839ArgGlu: 4.839 ± 0.089	2.209ArgPhe: 2.209 ± 0.052	5.307ArgGly: 5.307 ± 0.084	1.651ArgHis: 1.651 ± 0.042	3.232ArgIle: 3.232 ± 0.059	1.442ArgLys: 1.442 ± 0.051	6.972ArgLeu: 6.972 ± 0.106	1.76ArgMet: 1.76 ± 0.05	1.4ArgAsn: 1.4 ± 0.052	3.397ArgPro: 3.397 ± 0.075	2.331ArgGln: 2.331 ± 0.049	6.472ArgArg: 6.472 ± 0.121	4.37ArgSer: 4.37 ± 0.084	3.946ArgThr: 3.946 ± 0.069	4.887ArgVal: 4.887 ± 0.074	1.113ArgTrp: 1.113 ± 0.034	1.476ArgTyr: 1.476 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	8.01SerAla: 8.01 ± 0.099	0.35SerCys: 0.35 ± 0.021	2.906SerAsp: 2.906 ± 0.063	3.842SerGlu: 3.842 ± 0.085	2.134SerPhe: 2.134 ± 0.046	6.232SerGly: 6.232 ± 0.092	1.247SerHis: 1.247 ± 0.042	2.387SerIle: 2.387 ± 0.056	1.293SerLys: 1.293 ± 0.046	5.747SerLeu: 5.747 ± 0.088	1.57SerMet: 1.57 ± 0.044	1.228SerAsn: 1.228 ± 0.041	3.428SerPro: 3.428 ± 0.08	2.091SerGln: 2.091 ± 0.044	4.045SerArg: 4.045 ± 0.077	4.27SerSer: 4.27 ± 0.097	3.848SerThr: 3.848 ± 0.067	4.564SerVal: 4.564 ± 0.076	0.982SerTrp: 0.982 ± 0.04	1.329SerTyr: 1.329 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.55ThrAla: 7.55 ± 0.104	0.32ThrCys: 0.32 ± 0.02	3.232ThrAsp: 3.232 ± 0.065	4.087ThrGlu: 4.087 ± 0.078	1.583ThrPhe: 1.583 ± 0.049	5.831ThrGly: 5.831 ± 0.089	1.233ThrHis: 1.233 ± 0.035	2.31ThrIle: 2.31 ± 0.049	1.148ThrLys: 1.148 ± 0.04	6.014ThrLeu: 6.014 ± 0.085	1.172ThrMet: 1.172 ± 0.042	1.036ThrAsn: 1.036 ± 0.039	3.773ThrPro: 3.773 ± 0.069	2.013ThrGln: 2.013 ± 0.052	3.758ThrArg: 3.758 ± 0.063	3.545ThrSer: 3.545 ± 0.07	3.414ThrThr: 3.414 ± 0.064	5.118ThrVal: 5.118 ± 0.089	0.813ThrTrp: 0.813 ± 0.032	1.13ThrTyr: 1.13 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.859ValAla: 8.859 ± 0.116	0.468ValCys: 0.468 ± 0.025	4.735ValAsp: 4.735 ± 0.073	5.13ValGlu: 5.13 ± 0.08	2.464ValPhe: 2.464 ± 0.059	6.0ValGly: 6.0 ± 0.093	1.801ValHis: 1.801 ± 0.05	4.165ValIle: 4.165 ± 0.071	1.717ValLys: 1.717 ± 0.046	9.522ValLeu: 9.522 ± 0.11	1.637ValMet: 1.637 ± 0.043	1.772ValAsn: 1.772 ± 0.048	4.16ValPro: 4.16 ± 0.062	2.603ValGln: 2.603 ± 0.068	4.955ValArg: 4.955 ± 0.082	4.929ValSer: 4.929 ± 0.081	5.034ValThr: 5.034 ± 0.074	7.092ValVal: 7.092 ± 0.118	0.927ValTrp: 0.927 ± 0.041	1.383ValTyr: 1.383 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.467TrpAla: 1.467 ± 0.045	0.082TrpCys: 0.082 ± 0.01	0.784TrpAsp: 0.784 ± 0.032	0.848TrpGlu: 0.848 ± 0.028	0.533TrpPhe: 0.533 ± 0.029	0.974TrpGly: 0.974 ± 0.036	0.325TrpHis: 0.325 ± 0.022	0.725TrpIle: 0.725 ± 0.032	0.356TrpLys: 0.356 ± 0.022	1.677TrpLeu: 1.677 ± 0.058	0.344TrpMet: 0.344 ± 0.021	0.442TrpAsn: 0.442 ± 0.026	0.602TrpPro: 0.602 ± 0.027	0.552TrpGln: 0.552 ± 0.025	1.022TrpArg: 1.022 ± 0.036	0.834TrpSer: 0.834 ± 0.037	0.899TrpThr: 0.899 ± 0.037	1.082TrpVal: 1.082 ± 0.038	0.319TrpTrp: 0.319 ± 0.018	0.278TrpTyr: 0.278 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.251TyrAla: 2.251 ± 0.05	0.16TyrCys: 0.16 ± 0.014	1.181TyrAsp: 1.181 ± 0.036	1.172TyrGlu: 1.172 ± 0.046	0.713TyrPhe: 0.713 ± 0.029	1.795TyrGly: 1.795 ± 0.042	0.342TyrHis: 0.342 ± 0.021	0.693TyrIle: 0.693 ± 0.032	0.361TyrLys: 0.361 ± 0.023	2.072TyrLeu: 2.072 ± 0.057	0.313TyrMet: 0.313 ± 0.019	0.435TyrAsn: 0.435 ± 0.025	1.137TyrPro: 1.137 ± 0.045	0.737TyrGln: 0.737 ± 0.027	1.517TyrArg: 1.517 ± 0.045	1.277TyrSer: 1.277 ± 0.048	1.163TyrThr: 1.163 ± 0.037	1.409TyrVal: 1.409 ± 0.04	0.299TyrTrp: 0.299 ± 0.021	0.474TyrTyr: 0.474 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2504 proteins (820621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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