Amino acid dipepetide frequency for Halostagnicola larsenii XH-48

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.844AlaAla: 10.844 ± 0.12
0.723AlaCys: 0.723 ± 0.03
8.825AlaAsp: 8.825 ± 0.109
8.019AlaGlu: 8.019 ± 0.105
3.701AlaPhe: 3.701 ± 0.062
8.515AlaGly: 8.515 ± 0.097
1.731AlaHis: 1.731 ± 0.042
5.62AlaIle: 5.62 ± 0.094
1.855AlaLys: 1.855 ± 0.046
9.296AlaLeu: 9.296 ± 0.115
2.062AlaMet: 2.062 ± 0.042
2.496AlaAsn: 2.496 ± 0.053
3.313AlaPro: 3.313 ± 0.056
2.274AlaGln: 2.274 ± 0.052
5.413AlaArg: 5.413 ± 0.077
5.4AlaSer: 5.4 ± 0.075
6.639AlaThr: 6.639 ± 0.086
9.079AlaVal: 9.079 ± 0.099
0.962AlaTrp: 0.962 ± 0.029
2.541AlaTyr: 2.541 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
0.562CysAla: 0.562 ± 0.021
0.106CysCys: 0.106 ± 0.01
0.587CysAsp: 0.587 ± 0.024
0.637CysGlu: 0.637 ± 0.029
0.221CysPhe: 0.221 ± 0.015
0.817CysGly: 0.817 ± 0.032
0.197CysHis: 0.197 ± 0.013
0.299CysIle: 0.299 ± 0.016
0.144CysLys: 0.144 ± 0.012
0.614CysLeu: 0.614 ± 0.023
0.118CysMet: 0.118 ± 0.011
0.172CysAsn: 0.172 ± 0.011
0.51CysPro: 0.51 ± 0.021
0.198CysGln: 0.198 ± 0.014
0.496CysArg: 0.496 ± 0.021
0.501CysSer: 0.501 ± 0.025
0.427CysThr: 0.427 ± 0.022
0.48CysVal: 0.48 ± 0.024
0.107CysTrp: 0.107 ± 0.01
0.235CysTyr: 0.235 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
8.662AspAla: 8.662 ± 0.094
0.634AspCys: 0.634 ± 0.026
7.881AspAsp: 7.881 ± 0.12
8.644AspGlu: 8.644 ± 0.118
1.996AspPhe: 1.996 ± 0.042
8.177AspGly: 8.177 ± 0.125
1.758AspHis: 1.758 ± 0.042
3.7AspIle: 3.7 ± 0.064
0.96AspLys: 0.96 ± 0.033
6.886AspLeu: 6.886 ± 0.089
1.194AspMet: 1.194 ± 0.037
1.432AspAsn: 1.432 ± 0.039
4.496AspPro: 4.496 ± 0.075
1.916AspGln: 1.916 ± 0.041
6.162AspArg: 6.162 ± 0.087
4.445AspSer: 4.445 ± 0.08
3.946AspThr: 3.946 ± 0.075
7.038AspVal: 7.038 ± 0.08
0.947AspTrp: 0.947 ± 0.033
1.759AspTyr: 1.759 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
8.396GluAla: 8.396 ± 0.088
0.561GluCys: 0.561 ± 0.026
6.419GluAsp: 6.419 ± 0.1
7.226GluGlu: 7.226 ± 0.114
3.256GluPhe: 3.256 ± 0.058
5.521GluGly: 5.521 ± 0.076
2.091GluHis: 2.091 ± 0.044
4.749GluIle: 4.749 ± 0.072
2.079GluLys: 2.079 ± 0.052
7.866GluLeu: 7.866 ± 0.089
2.074GluMet: 2.074 ± 0.044
2.928GluAsn: 2.928 ± 0.054
4.398GluPro: 4.398 ± 0.063
3.135GluGln: 3.135 ± 0.063
7.563GluArg: 7.563 ± 0.106
6.459GluSer: 6.459 ± 0.083
7.726GluThr: 7.726 ± 0.095
5.486GluVal: 5.486 ± 0.08
1.22GluTrp: 1.22 ± 0.037
3.137GluTyr: 3.137 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.44PheAla: 3.44 ± 0.06
0.308PheCys: 0.308 ± 0.015
3.369PheAsp: 3.369 ± 0.058
3.441PheGlu: 3.441 ± 0.06
1.14PhePhe: 1.14 ± 0.038
3.258PheGly: 3.258 ± 0.066
0.671PheHis: 0.671 ± 0.025
1.269PheIle: 1.269 ± 0.04
0.476PheLys: 0.476 ± 0.021
2.812PheLeu: 2.812 ± 0.058
0.535PheMet: 0.535 ± 0.027
0.758PheAsn: 0.758 ± 0.03
1.336PhePro: 1.336 ± 0.035
0.856PheGln: 0.856 ± 0.028
1.723PheArg: 1.723 ± 0.036
1.894PheSer: 1.894 ± 0.044
1.925PheThr: 1.925 ± 0.047
3.305PheVal: 3.305 ± 0.064
0.421PheTrp: 0.421 ± 0.02
0.878PheTyr: 0.878 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
7.367GlyAla: 7.367 ± 0.099
0.732GlyCys: 0.732 ± 0.029
6.49GlyAsp: 6.49 ± 0.097
7.14GlyGlu: 7.14 ± 0.087
3.149GlyPhe: 3.149 ± 0.061
7.0GlyGly: 7.0 ± 0.119
1.629GlyHis: 1.629 ± 0.046
4.817GlyIle: 4.817 ± 0.075
1.892GlyLys: 1.892 ± 0.045
7.133GlyLeu: 7.133 ± 0.092
1.653GlyMet: 1.653 ± 0.047
2.129GlyAsn: 2.129 ± 0.043
3.297GlyPro: 3.297 ± 0.063
2.078GlyGln: 2.078 ± 0.044
4.442GlyArg: 4.442 ± 0.067
5.433GlySer: 5.433 ± 0.077
5.908GlyThr: 5.908 ± 0.082
7.093GlyVal: 7.093 ± 0.09
1.064GlyTrp: 1.064 ± 0.033
2.684GlyTyr: 2.684 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.9HisAla: 1.9 ± 0.041
0.225HisCys: 0.225 ± 0.012
1.82HisAsp: 1.82 ± 0.043
1.79HisGlu: 1.79 ± 0.042
0.599HisPhe: 0.599 ± 0.027
1.95HisGly: 1.95 ± 0.05
0.522HisHis: 0.522 ± 0.025
0.773HisIle: 0.773 ± 0.029
0.29HisLys: 0.29 ± 0.018
1.704HisLeu: 1.704 ± 0.043
0.321HisMet: 0.321 ± 0.016
0.478HisAsn: 0.478 ± 0.022
1.183HisPro: 1.183 ± 0.032
0.511HisGln: 0.511 ± 0.021
1.284HisArg: 1.284 ± 0.033
0.947HisSer: 0.947 ± 0.031
1.091HisThr: 1.091 ± 0.034
1.821HisVal: 1.821 ± 0.042
0.243HisTrp: 0.243 ± 0.014
0.542HisTyr: 0.542 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.537IleAla: 5.537 ± 0.085
0.353IleCys: 0.353 ± 0.017
4.858IleAsp: 4.858 ± 0.063
4.972IleGlu: 4.972 ± 0.07
1.244IlePhe: 1.244 ± 0.04
4.71IleGly: 4.71 ± 0.068
0.917IleHis: 0.917 ± 0.03
1.861IleIle: 1.861 ± 0.051
0.77IleLys: 0.77 ± 0.024
3.489IleLeu: 3.489 ± 0.07
0.589IleMet: 0.589 ± 0.023
1.213IleAsn: 1.213 ± 0.033
2.392IlePro: 2.392 ± 0.043
1.292IleGln: 1.292 ± 0.035
2.702IleArg: 2.702 ± 0.047
2.72IleSer: 2.72 ± 0.06
2.845IleThr: 2.845 ± 0.047
4.478IleVal: 4.478 ± 0.076
0.412IleTrp: 0.412 ± 0.02
1.081IleTyr: 1.081 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
1.764LysAla: 1.764 ± 0.044
0.11LysCys: 0.11 ± 0.012
1.088LysAsp: 1.088 ± 0.035
1.297LysGlu: 1.297 ± 0.044
0.52LysPhe: 0.52 ± 0.022
1.279LysGly: 1.279 ± 0.033
0.5LysHis: 0.5 ± 0.023
0.92LysIle: 0.92 ± 0.032
0.519LysLys: 0.519 ± 0.028
1.733LysLeu: 1.733 ± 0.041
0.452LysMet: 0.452 ± 0.021
0.604LysAsn: 0.604 ± 0.024
0.989LysPro: 0.989 ± 0.033
0.758LysGln: 0.758 ± 0.03
1.673LysArg: 1.673 ± 0.046
1.249LysSer: 1.249 ± 0.038
1.402LysThr: 1.402 ± 0.04
1.091LysVal: 1.091 ± 0.034
0.218LysTrp: 0.218 ± 0.015
0.57LysTyr: 0.57 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
9.578LeuAla: 9.578 ± 0.116
0.625LeuCys: 0.625 ± 0.024
5.513LeuAsp: 5.513 ± 0.066
12.19LeuGlu: 12.19 ± 0.123
3.185LeuPhe: 3.185 ± 0.067
7.035LeuGly: 7.035 ± 0.097
1.411LeuHis: 1.411 ± 0.034
3.448LeuIle: 3.448 ± 0.065
1.453LeuLys: 1.453 ± 0.034
8.071LeuLeu: 8.071 ± 0.128
1.318LeuMet: 1.318 ± 0.038
1.774LeuAsn: 1.774 ± 0.047
3.874LeuPro: 3.874 ± 0.052
2.051LeuGln: 2.051 ± 0.04
4.582LeuArg: 4.582 ± 0.069
5.65LeuSer: 5.65 ± 0.079
5.018LeuThr: 5.018 ± 0.079
7.682LeuVal: 7.682 ± 0.112
0.804LeuTrp: 0.804 ± 0.026
2.166LeuTyr: 2.166 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
1.91MetAla: 1.91 ± 0.047
0.108MetCys: 0.108 ± 0.01
1.27MetAsp: 1.27 ± 0.033
1.182MetGlu: 1.182 ± 0.032
0.567MetPhe: 0.567 ± 0.024
1.539MetGly: 1.539 ± 0.041
0.376MetHis: 0.376 ± 0.018
0.858MetIle: 0.858 ± 0.029
0.485MetLys: 0.485 ± 0.02
1.582MetLeu: 1.582 ± 0.038
0.365MetMet: 0.365 ± 0.018
0.692MetAsn: 0.692 ± 0.026
0.782MetPro: 0.782 ± 0.03
0.498MetGln: 0.498 ± 0.026
1.03MetArg: 1.03 ± 0.03
1.536MetSer: 1.536 ± 0.037
1.601MetThr: 1.601 ± 0.035
1.395MetVal: 1.395 ± 0.041
0.186MetTrp: 0.186 ± 0.014
0.445MetTyr: 0.445 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.767AsnAla: 2.767 ± 0.053
0.249AsnCys: 0.249 ± 0.015
1.964AsnAsp: 1.964 ± 0.049
2.233AsnGlu: 2.233 ± 0.056
0.713AsnPhe: 0.713 ± 0.025
2.326AsnGly: 2.326 ± 0.052
0.593AsnHis: 0.593 ± 0.024
1.068AsnIle: 1.068 ± 0.037
0.43AsnLys: 0.43 ± 0.021
2.089AsnLeu: 2.089 ± 0.046
0.481AsnMet: 0.481 ± 0.02
0.588AsnAsn: 0.588 ± 0.025
1.549AsnPro: 1.549 ± 0.037
0.72AsnGln: 0.72 ± 0.025
1.755AsnArg: 1.755 ± 0.04
1.253AsnSer: 1.253 ± 0.037
1.415AsnThr: 1.415 ± 0.041
2.379AsnVal: 2.379 ± 0.043
0.355AsnTrp: 0.355 ± 0.016
0.734AsnTyr: 0.734 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
4.248ProAla: 4.248 ± 0.067
0.234ProCys: 0.234 ± 0.015
4.619ProAsp: 4.619 ± 0.071
4.543ProGlu: 4.543 ± 0.066
1.615ProPhe: 1.615 ± 0.036
3.463ProGly: 3.463 ± 0.059
0.919ProHis: 0.919 ± 0.032
2.352ProIle: 2.352 ± 0.051
0.904ProLys: 0.904 ± 0.031
3.607ProLeu: 3.607 ± 0.064
0.885ProMet: 0.885 ± 0.029
1.282ProAsn: 1.282 ± 0.034
2.032ProPro: 2.032 ± 0.047
0.998ProGln: 0.998 ± 0.029
2.138ProArg: 2.138 ± 0.048
2.765ProSer: 2.765 ± 0.053
3.134ProThr: 3.134 ± 0.053
3.869ProVal: 3.869 ± 0.056
0.505ProTrp: 0.505 ± 0.022
1.171ProTyr: 1.171 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
2.425GlnAla: 2.425 ± 0.051
0.173GlnCys: 0.173 ± 0.013
1.46GlnAsp: 1.46 ± 0.038
1.874GlnGlu: 1.874 ± 0.048
1.096GlnPhe: 1.096 ± 0.031
1.677GlnGly: 1.677 ± 0.04
0.614GlnHis: 0.614 ± 0.023
1.379GlnIle: 1.379 ± 0.042
0.641GlnLys: 0.641 ± 0.03
2.54GlnLeu: 2.54 ± 0.05
0.583GlnMet: 0.583 ± 0.023
0.839GlnAsn: 0.839 ± 0.032
1.194GlnPro: 1.194 ± 0.028
1.119GlnGln: 1.119 ± 0.043
1.944GlnArg: 1.944 ± 0.046
1.791GlnSer: 1.791 ± 0.039
1.857GlnThr: 1.857 ± 0.047
1.763GlnVal: 1.763 ± 0.042
0.382GlnTrp: 0.382 ± 0.02
0.954GlnTyr: 0.954 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
5.627ArgAla: 5.627 ± 0.081
0.489ArgCys: 0.489 ± 0.025
4.67ArgAsp: 4.67 ± 0.059
6.13ArgGlu: 6.13 ± 0.09
2.172ArgPhe: 2.172 ± 0.049
4.122ArgGly: 4.122 ± 0.071
1.091ArgHis: 1.091 ± 0.031
3.17ArgIle: 3.17 ± 0.053
1.373ArgLys: 1.373 ± 0.039
5.544ArgLeu: 5.544 ± 0.077
1.309ArgMet: 1.309 ± 0.033
1.703ArgAsn: 1.703 ± 0.038
2.409ArgPro: 2.409 ± 0.048
1.718ArgGln: 1.718 ± 0.044
4.287ArgArg: 4.287 ± 0.082
3.992ArgSer: 3.992 ± 0.059
4.199ArgThr: 4.199 ± 0.071
4.769ArgVal: 4.769 ± 0.078
0.774ArgTrp: 0.774 ± 0.031
1.921ArgTyr: 1.921 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
5.472SerAla: 5.472 ± 0.086
0.339SerCys: 0.339 ± 0.018
4.835SerAsp: 4.835 ± 0.076
4.932SerGlu: 4.932 ± 0.078
2.083SerPhe: 2.083 ± 0.041
5.612SerGly: 5.612 ± 0.079
1.162SerHis: 1.162 ± 0.034
3.299SerIle: 3.299 ± 0.061
1.305SerLys: 1.305 ± 0.034
5.19SerLeu: 5.19 ± 0.077
1.328SerMet: 1.328 ± 0.038
1.705SerAsn: 1.705 ± 0.037
2.619SerPro: 2.619 ± 0.052
1.564SerGln: 1.564 ± 0.038
3.499SerArg: 3.499 ± 0.05
4.04SerSer: 4.04 ± 0.08
4.04SerThr: 4.04 ± 0.066
5.295SerVal: 5.295 ± 0.07
0.678SerTrp: 0.678 ± 0.024
1.545SerTyr: 1.545 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
6.889ThrAla: 6.889 ± 0.084
0.415ThrCys: 0.415 ± 0.022
6.029ThrAsp: 6.029 ± 0.084
5.11ThrGlu: 5.11 ± 0.062
2.17ThrPhe: 2.17 ± 0.048
5.803ThrGly: 5.803 ± 0.064
1.255ThrHis: 1.255 ± 0.042
3.717ThrIle: 3.717 ± 0.065
1.144ThrLys: 1.144 ± 0.033
5.711ThrLeu: 5.711 ± 0.06
1.151ThrMet: 1.151 ± 0.032
1.827ThrAsn: 1.827 ± 0.044
3.079ThrPro: 3.079 ± 0.052
1.55ThrGln: 1.55 ± 0.04
3.214ThrArg: 3.214 ± 0.049
3.177ThrSer: 3.177 ± 0.064
4.4ThrThr: 4.4 ± 0.071
6.668ThrVal: 6.668 ± 0.097
0.64ThrTrp: 0.64 ± 0.023
1.807ThrTyr: 1.807 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
8.401ValAla: 8.401 ± 0.087
0.691ValCys: 0.691 ± 0.027
7.363ValAsp: 7.363 ± 0.095
7.329ValGlu: 7.329 ± 0.099
3.054ValPhe: 3.054 ± 0.064
7.036ValGly: 7.036 ± 0.104
1.642ValHis: 1.642 ± 0.035
3.689ValIle: 3.689 ± 0.069
1.3ValLys: 1.3 ± 0.033
7.899ValLeu: 7.899 ± 0.107
1.295ValMet: 1.295 ± 0.039
1.943ValAsn: 1.943 ± 0.047
4.064ValPro: 4.064 ± 0.065
1.9ValGln: 1.9 ± 0.043
4.952ValArg: 4.952 ± 0.082
5.326ValSer: 5.326 ± 0.08
5.868ValThr: 5.868 ± 0.083
7.902ValVal: 7.902 ± 0.107
0.812ValTrp: 0.812 ± 0.028
2.106ValTyr: 2.106 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.882TrpAla: 0.882 ± 0.032
0.104TrpCys: 0.104 ± 0.009
0.816TrpAsp: 0.816 ± 0.032
0.871TrpGlu: 0.871 ± 0.028
0.428TrpPhe: 0.428 ± 0.019
0.884TrpGly: 0.884 ± 0.027
0.266TrpHis: 0.266 ± 0.017
0.583TrpIle: 0.583 ± 0.026
0.317TrpLys: 0.317 ± 0.018
1.162TrpLeu: 1.162 ± 0.038
0.258TrpMet: 0.258 ± 0.015
0.429TrpAsn: 0.429 ± 0.021
0.479TrpPro: 0.479 ± 0.021
0.348TrpGln: 0.348 ± 0.021
0.751TrpArg: 0.751 ± 0.023
0.64TrpSer: 0.64 ± 0.023
0.749TrpThr: 0.749 ± 0.027
0.775TrpVal: 0.775 ± 0.028
0.196TrpTrp: 0.196 ± 0.016
0.361TrpTyr: 0.361 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.639TyrAla: 2.639 ± 0.055
0.249TyrCys: 0.249 ± 0.014
2.758TyrAsp: 2.758 ± 0.048
2.728TyrGlu: 2.728 ± 0.057
0.903TyrPhe: 0.903 ± 0.027
2.408TyrGly: 2.408 ± 0.047
0.648TyrHis: 0.648 ± 0.024
0.866TyrIle: 0.866 ± 0.025
0.398TyrLys: 0.398 ± 0.019
2.5TyrLeu: 2.5 ± 0.049
0.435TyrMet: 0.435 ± 0.017
0.668TyrAsn: 0.668 ± 0.022
1.291TyrPro: 1.291 ± 0.034
0.821TyrGln: 0.821 ± 0.03
1.86TyrArg: 1.86 ± 0.042
1.325TyrSer: 1.325 ± 0.036
1.565TyrThr: 1.565 ± 0.038
2.204TyrVal: 2.204 ± 0.044
0.372TyrTrp: 0.372 ± 0.02
0.878TyrTyr: 0.878 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4086 proteins (1126012 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski