Amino acid dipepetide frequency for Amphiamblys sp. WSBS2006

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.171AlaAla: 6.171 ± 0.098	1.217AlaCys: 1.217 ± 0.035	3.116AlaAsp: 3.116 ± 0.051	6.46AlaGlu: 6.46 ± 0.09	2.265AlaPhe: 2.265 ± 0.057	4.638AlaGly: 4.638 ± 0.067	1.278AlaHis: 1.278 ± 0.036	3.366AlaIle: 3.366 ± 0.054	4.181AlaLys: 4.181 ± 0.07	6.578AlaLeu: 6.578 ± 0.095	1.28AlaMet: 1.28 ± 0.038	1.548AlaAsn: 1.548 ± 0.039	2.294AlaPro: 2.294 ± 0.052	2.205AlaGln: 2.205 ± 0.048	4.199AlaArg: 4.199 ± 0.069	3.944AlaSer: 3.944 ± 0.066	2.869AlaThr: 2.869 ± 0.057	6.863AlaVal: 6.863 ± 0.084	0.592AlaTrp: 0.592 ± 0.023	1.297AlaTyr: 1.297 ± 0.037	0.002AlaXaa: 0.002 ± 0.001
Cys	1.251CysAla: 1.251 ± 0.037	0.635CysCys: 0.635 ± 0.026	0.857CysAsp: 0.857 ± 0.029	1.445CysGlu: 1.445 ± 0.04	1.527CysPhe: 1.527 ± 0.042	1.611CysGly: 1.611 ± 0.041	0.346CysHis: 0.346 ± 0.019	1.146CysIle: 1.146 ± 0.035	0.858CysLys: 0.858 ± 0.028	2.42CysLeu: 2.42 ± 0.053	0.414CysMet: 0.414 ± 0.02	0.359CysAsn: 0.359 ± 0.019	0.82CysPro: 0.82 ± 0.027	0.434CysGln: 0.434 ± 0.019	1.355CysArg: 1.355 ± 0.036	1.67CysSer: 1.67 ± 0.043	0.875CysThr: 0.875 ± 0.027	2.261CysVal: 2.261 ± 0.062	0.231CysTrp: 0.231 ± 0.012	0.502CysTyr: 0.502 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.158AspAla: 3.158 ± 0.051	1.286AspCys: 1.286 ± 0.042	1.87AspAsp: 1.87 ± 0.048	4.089AspGlu: 4.089 ± 0.062	1.982AspPhe: 1.982 ± 0.04	3.753AspGly: 3.753 ± 0.068	0.74AspHis: 0.74 ± 0.024	3.138AspIle: 3.138 ± 0.054	2.705AspLys: 2.705 ± 0.061	3.874AspLeu: 3.874 ± 0.069	1.133AspMet: 1.133 ± 0.033	1.527AspAsn: 1.527 ± 0.047	1.441AspPro: 1.441 ± 0.038	0.871AspGln: 0.871 ± 0.029	2.971AspArg: 2.971 ± 0.048	3.249AspSer: 3.249 ± 0.057	3.295AspThr: 3.295 ± 0.07	3.305AspVal: 3.305 ± 0.06	0.439AspTrp: 0.439 ± 0.019	1.321AspTyr: 1.321 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.769GluAla: 5.769 ± 0.096	1.555GluCys: 1.555 ± 0.038	5.204GluAsp: 5.204 ± 0.09	11.938GluGlu: 11.938 ± 0.166	2.58GluPhe: 2.58 ± 0.055	4.648GluGly: 4.648 ± 0.07	2.445GluHis: 2.445 ± 0.059	6.731GluIle: 6.731 ± 0.091	10.096GluLys: 10.096 ± 0.127	7.115GluLeu: 7.115 ± 0.107	2.816GluMet: 2.816 ± 0.052	5.446GluAsn: 5.446 ± 0.091	1.805GluPro: 1.805 ± 0.045	2.789GluGln: 2.789 ± 0.06	6.183GluArg: 6.183 ± 0.082	4.42GluSer: 4.42 ± 0.073	7.095GluThr: 7.095 ± 0.122	4.445GluVal: 4.445 ± 0.069	0.737GluTrp: 0.737 ± 0.023	2.62GluTyr: 2.62 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.525PheAla: 2.525 ± 0.053	1.528PheCys: 1.528 ± 0.046	2.059PheAsp: 2.059 ± 0.044	2.747PheGlu: 2.747 ± 0.058	3.48PhePhe: 3.48 ± 0.07	3.004PheGly: 3.004 ± 0.061	0.983PheHis: 0.983 ± 0.033	1.944PheIle: 1.944 ± 0.042	1.8PheLys: 1.8 ± 0.049	5.81PheLeu: 5.81 ± 0.096	0.726PheMet: 0.726 ± 0.024	0.808PheAsn: 0.808 ± 0.026	1.701PhePro: 1.701 ± 0.04	1.238PheGln: 1.238 ± 0.04	2.106PheArg: 2.106 ± 0.047	4.154PheSer: 4.154 ± 0.08	1.647PheThr: 1.647 ± 0.039	3.884PheVal: 3.884 ± 0.064	0.503PheTrp: 0.503 ± 0.021	1.508PheTyr: 1.508 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	3.73GlyAla: 3.73 ± 0.077	1.529GlyCys: 1.529 ± 0.045	3.401GlyAsp: 3.401 ± 0.055	6.447GlyGlu: 6.447 ± 0.081	2.396GlyPhe: 2.396 ± 0.05	4.347GlyGly: 4.347 ± 0.091	1.322GlyHis: 1.322 ± 0.043	3.79GlyIle: 3.79 ± 0.064	5.513GlyLys: 5.513 ± 0.09	5.224GlyLeu: 5.224 ± 0.081	1.62GlyMet: 1.62 ± 0.04	2.386GlyAsn: 2.386 ± 0.049	1.566GlyPro: 1.566 ± 0.039	1.472GlyGln: 1.472 ± 0.045	4.596GlyArg: 4.596 ± 0.089	3.715GlySer: 3.715 ± 0.073	3.223GlyThr: 3.223 ± 0.063	4.796GlyVal: 4.796 ± 0.071	0.709GlyTrp: 0.709 ± 0.027	2.102GlyTyr: 2.102 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.527HisAla: 1.527 ± 0.035	0.435HisCys: 0.435 ± 0.022	0.665HisAsp: 0.665 ± 0.026	1.924HisGlu: 1.924 ± 0.055	0.849HisPhe: 0.849 ± 0.028	1.979HisGly: 1.979 ± 0.044	0.388HisHis: 0.388 ± 0.021	1.337HisIle: 1.337 ± 0.038	1.084HisLys: 1.084 ± 0.035	1.832HisLeu: 1.832 ± 0.038	0.433HisMet: 0.433 ± 0.02	0.474HisAsn: 0.474 ± 0.021	1.009HisPro: 1.009 ± 0.027	0.555HisGln: 0.555 ± 0.024	1.557HisArg: 1.557 ± 0.036	1.403HisSer: 1.403 ± 0.038	1.31HisThr: 1.31 ± 0.034	1.706HisVal: 1.706 ± 0.05	0.217HisTrp: 0.217 ± 0.016	0.462HisTyr: 0.462 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.689IleAla: 3.689 ± 0.06	1.253IleCys: 1.253 ± 0.035	2.944IleAsp: 2.944 ± 0.055	5.344IleGlu: 5.344 ± 0.07	2.103IlePhe: 2.103 ± 0.051	3.524IleGly: 3.524 ± 0.063	1.688IleHis: 1.688 ± 0.047	1.82IleIle: 1.82 ± 0.049	3.919IleLys: 3.919 ± 0.068	6.353IleLeu: 6.353 ± 0.105	0.68IleMet: 0.68 ± 0.023	1.894IleAsn: 1.894 ± 0.047	2.373IlePro: 2.373 ± 0.05	1.846IleGln: 1.846 ± 0.046	3.444IleArg: 3.444 ± 0.057	3.534IleSer: 3.534 ± 0.056	3.077IleThr: 3.077 ± 0.061	3.425IleVal: 3.425 ± 0.062	0.903IleTrp: 0.903 ± 0.049	1.255IleTyr: 1.255 ± 0.034	0.001IleXaa: 0.001 ± 0.001
Lys	4.026LysAla: 4.026 ± 0.067	0.826LysCys: 0.826 ± 0.027	3.54LysAsp: 3.54 ± 0.056	9.239LysGlu: 9.239 ± 0.115	1.302LysPhe: 1.302 ± 0.035	3.567LysGly: 3.567 ± 0.062	1.942LysHis: 1.942 ± 0.046	5.545LysIle: 5.545 ± 0.092	9.493LysLys: 9.493 ± 0.112	6.474LysLeu: 6.474 ± 0.138	2.271LysMet: 2.271 ± 0.051	4.076LysAsn: 4.076 ± 0.061	1.866LysPro: 1.866 ± 0.05	2.677LysGln: 2.677 ± 0.057	5.58LysArg: 5.58 ± 0.068	3.19LysSer: 3.19 ± 0.059	7.091LysThr: 7.091 ± 0.093	3.338LysVal: 3.338 ± 0.058	0.556LysTrp: 0.556 ± 0.025	1.782LysTyr: 1.782 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	6.277LeuAla: 6.277 ± 0.094	2.718LeuCys: 2.718 ± 0.06	4.348LeuAsp: 4.348 ± 0.049	8.593LeuGlu: 8.593 ± 0.095	6.191LeuPhe: 6.191 ± 0.092	6.913LeuGly: 6.913 ± 0.09	2.237LeuHis: 2.237 ± 0.063	2.942LeuIle: 2.942 ± 0.053	6.914LeuLys: 6.914 ± 0.108	10.517LeuLeu: 10.517 ± 0.13	1.321LeuMet: 1.321 ± 0.032	2.362LeuAsn: 2.362 ± 0.044	4.234LeuPro: 4.234 ± 0.07	2.894LeuGln: 2.894 ± 0.056	6.534LeuArg: 6.534 ± 0.092	8.336LeuSer: 8.336 ± 0.1	3.485LeuThr: 3.485 ± 0.062	6.451LeuVal: 6.451 ± 0.077	1.161LeuTrp: 1.161 ± 0.039	2.655LeuTyr: 2.655 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.653MetAla: 1.653 ± 0.045	0.452MetCys: 0.452 ± 0.019	1.233MetAsp: 1.233 ± 0.036	2.911MetGlu: 2.911 ± 0.065	1.16MetPhe: 1.16 ± 0.032	1.084MetGly: 1.084 ± 0.032	0.504MetHis: 0.504 ± 0.021	0.699MetIle: 0.699 ± 0.025	1.908MetLys: 1.908 ± 0.044	2.044MetLeu: 2.044 ± 0.042	0.363MetMet: 0.363 ± 0.016	0.578MetAsn: 0.578 ± 0.024	0.728MetPro: 0.728 ± 0.027	0.736MetGln: 0.736 ± 0.028	1.178MetArg: 1.178 ± 0.04	1.311MetSer: 1.311 ± 0.037	0.846MetThr: 0.846 ± 0.029	1.165MetVal: 1.165 ± 0.032	0.265MetTrp: 0.265 ± 0.017	0.398MetTyr: 0.398 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	1.968AsnAla: 1.968 ± 0.045	0.442AsnCys: 0.442 ± 0.021	0.947AsnAsp: 0.947 ± 0.032	2.529AsnGlu: 2.529 ± 0.06	0.995AsnPhe: 0.995 ± 0.031	1.901AsnGly: 1.901 ± 0.049	0.471AsnHis: 0.471 ± 0.021	3.627AsnIle: 3.627 ± 0.072	2.72AsnLys: 2.72 ± 0.052	2.375AsnLeu: 2.375 ± 0.048	0.865AsnMet: 0.865 ± 0.03	1.494AsnAsn: 1.494 ± 0.055	1.403AsnPro: 1.403 ± 0.041	0.641AsnGln: 0.641 ± 0.022	1.982AsnArg: 1.982 ± 0.043	2.548AsnSer: 2.548 ± 0.054	3.491AsnThr: 3.491 ± 0.066	2.265AsnVal: 2.265 ± 0.056	0.27AsnTrp: 0.27 ± 0.016	0.732AsnTyr: 0.732 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	2.46ProAla: 2.46 ± 0.058	0.57ProCys: 0.57 ± 0.024	1.766ProAsp: 1.766 ± 0.04	3.926ProGlu: 3.926 ± 0.063	1.747ProPhe: 1.747 ± 0.052	2.314ProGly: 2.314 ± 0.055	0.734ProHis: 0.734 ± 0.027	1.223ProIle: 1.223 ± 0.041	3.24ProLys: 3.24 ± 0.07	2.643ProLeu: 2.643 ± 0.049	0.573ProMet: 0.573 ± 0.021	1.083ProAsn: 1.083 ± 0.036	1.514ProPro: 1.514 ± 0.054	1.241ProGln: 1.241 ± 0.044	2.427ProArg: 2.427 ± 0.055	2.489ProSer: 2.489 ± 0.063	1.504ProThr: 1.504 ± 0.038	2.503ProVal: 2.503 ± 0.054	0.293ProTrp: 0.293 ± 0.017	0.807ProTyr: 0.807 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	1.904GlnAla: 1.904 ± 0.045	0.496GlnCys: 0.496 ± 0.024	1.228GlnAsp: 1.228 ± 0.034	3.003GlnGlu: 3.003 ± 0.066	0.808GlnPhe: 0.808 ± 0.03	1.334GlnGly: 1.334 ± 0.034	0.581GlnHis: 0.581 ± 0.024	1.77GlnIle: 1.77 ± 0.041	3.419GlnLys: 3.419 ± 0.063	2.092GlnLeu: 2.092 ± 0.046	0.65GlnMet: 0.65 ± 0.027	1.395GlnAsn: 1.395 ± 0.033	1.204GlnPro: 1.204 ± 0.042	1.094GlnGln: 1.094 ± 0.043	2.268GlnArg: 2.268 ± 0.049	1.646GlnSer: 1.646 ± 0.043	2.422GlnThr: 2.422 ± 0.054	1.148GlnVal: 1.148 ± 0.033	0.24GlnTrp: 0.24 ± 0.015	0.58GlnTyr: 0.58 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.793ArgAla: 3.793 ± 0.069	1.139ArgCys: 1.139 ± 0.032	2.844ArgAsp: 2.844 ± 0.052	6.603ArgGlu: 6.603 ± 0.086	2.231ArgPhe: 2.231 ± 0.052	3.724ArgGly: 3.724 ± 0.064	1.349ArgHis: 1.349 ± 0.035	4.13ArgIle: 4.13 ± 0.067	6.202ArgLys: 6.202 ± 0.08	5.978ArgLeu: 5.978 ± 0.085	1.691ArgMet: 1.691 ± 0.038	2.547ArgAsn: 2.547 ± 0.053	1.837ArgPro: 1.837 ± 0.045	2.018ArgGln: 2.018 ± 0.044	5.255ArgArg: 5.255 ± 0.107	3.15ArgSer: 3.15 ± 0.051	3.439ArgThr: 3.439 ± 0.062	4.549ArgVal: 4.549 ± 0.075	0.666ArgTrp: 0.666 ± 0.022	1.648ArgTyr: 1.648 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.416SerAla: 4.416 ± 0.063	1.176SerCys: 1.176 ± 0.035	2.726SerAsp: 2.726 ± 0.052	5.473SerGlu: 5.473 ± 0.08	3.823SerPhe: 3.823 ± 0.073	4.434SerGly: 4.434 ± 0.085	1.094SerHis: 1.094 ± 0.032	4.516SerIle: 4.516 ± 0.081	3.552SerLys: 3.552 ± 0.057	7.341SerLeu: 7.341 ± 0.095	1.213SerMet: 1.213 ± 0.032	1.452SerAsn: 1.452 ± 0.04	3.074SerPro: 3.074 ± 0.062	1.809SerGln: 1.809 ± 0.045	3.639SerArg: 3.639 ± 0.071	4.866SerSer: 4.866 ± 0.098	3.013SerThr: 3.013 ± 0.054	5.659SerVal: 5.659 ± 0.084	0.552SerTrp: 0.552 ± 0.023	1.315SerTyr: 1.315 ± 0.036	0.001SerXaa: 0.001 ± 0.001
Thr	4.495ThrAla: 4.495 ± 0.067	0.809ThrCys: 0.809 ± 0.027	2.734ThrAsp: 2.734 ± 0.057	6.206ThrGlu: 6.206 ± 0.098	1.785ThrPhe: 1.785 ± 0.039	3.991ThrGly: 3.991 ± 0.058	1.276ThrHis: 1.276 ± 0.037	2.698ThrIle: 2.698 ± 0.054	4.644ThrLys: 4.644 ± 0.079	5.435ThrLeu: 5.435 ± 0.087	1.011ThrMet: 1.011 ± 0.032	1.663ThrAsn: 1.663 ± 0.045	2.672ThrPro: 2.672 ± 0.051	2.224ThrGln: 2.224 ± 0.05	3.578ThrArg: 3.578 ± 0.058	2.573ThrSer: 2.573 ± 0.056	3.042ThrThr: 3.042 ± 0.09	4.4ThrVal: 4.4 ± 0.081	0.411ThrTrp: 0.411 ± 0.021	0.919ThrTyr: 0.919 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	4.429ValAla: 4.429 ± 0.063	2.169ValCys: 2.169 ± 0.044	3.118ValAsp: 3.118 ± 0.052	5.291ValGlu: 5.291 ± 0.067	5.327ValPhe: 5.327 ± 0.098	4.848ValGly: 4.848 ± 0.084	1.21ValHis: 1.21 ± 0.034	2.628ValIle: 2.628 ± 0.057	3.819ValLys: 3.819 ± 0.076	9.298ValLeu: 9.298 ± 0.115	1.392ValMet: 1.392 ± 0.04	1.357ValAsn: 1.357 ± 0.035	2.386ValPro: 2.386 ± 0.051	1.732ValGln: 1.732 ± 0.045	3.534ValArg: 3.534 ± 0.067	6.507ValSer: 6.507 ± 0.103	2.624ValThr: 2.624 ± 0.067	5.028ValVal: 5.028 ± 0.08	0.875ValTrp: 0.875 ± 0.032	2.134ValTyr: 2.134 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.616TrpAla: 0.616 ± 0.023	0.25TrpCys: 0.25 ± 0.017	0.512TrpAsp: 0.512 ± 0.023	0.691TrpGlu: 0.691 ± 0.027	0.363TrpPhe: 0.363 ± 0.021	0.632TrpGly: 0.632 ± 0.023	0.134TrpHis: 0.134 ± 0.01	0.644TrpIle: 0.644 ± 0.029	0.854TrpLys: 0.854 ± 0.028	1.148TrpLeu: 1.148 ± 0.05	0.262TrpMet: 0.262 ± 0.016	0.443TrpAsn: 0.443 ± 0.02	0.236TrpPro: 0.236 ± 0.016	0.178TrpGln: 0.178 ± 0.011	0.732TrpArg: 0.732 ± 0.028	0.625TrpSer: 0.625 ± 0.027	0.498TrpThr: 0.498 ± 0.018	0.808TrpVal: 0.808 ± 0.032	0.096TrpTrp: 0.096 ± 0.009	0.234TrpTyr: 0.234 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.504TyrAla: 2.504 ± 0.067	0.532TyrCys: 0.532 ± 0.022	1.038TyrAsp: 1.038 ± 0.032	1.574TyrGlu: 1.574 ± 0.041	1.239TyrPhe: 1.239 ± 0.032	1.637TyrGly: 1.637 ± 0.037	0.423TyrHis: 0.423 ± 0.017	1.377TyrIle: 1.377 ± 0.033	1.459TyrLys: 1.459 ± 0.037	2.534TyrLeu: 2.534 ± 0.052	0.502TyrMet: 0.502 ± 0.022	0.777TyrAsn: 0.777 ± 0.026	0.895TyrPro: 0.895 ± 0.028	0.625TyrGln: 0.625 ± 0.027	1.674TyrArg: 1.674 ± 0.037	1.813TyrSer: 1.813 ± 0.041	1.721TyrThr: 1.721 ± 0.041	1.708TyrVal: 1.708 ± 0.042	0.239TyrTrp: 0.239 ± 0.016	0.617TyrTyr: 0.617 ± 0.029	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.041XaaXaa: 0.041 ± 0.022

Statistics based on 3608 proteins (1182352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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