Amino acid dipepetide frequency for Novosphingobium pentaromativorans US6-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.735AlaAla: 16.735 ± 0.136
1.201AlaCys: 1.201 ± 0.028
7.007AlaAsp: 7.007 ± 0.077
7.394AlaGlu: 7.394 ± 0.08
4.208AlaPhe: 4.208 ± 0.058
10.703AlaGly: 10.703 ± 0.104
2.339AlaHis: 2.339 ± 0.042
6.668AlaIle: 6.668 ± 0.065
3.931AlaLys: 3.931 ± 0.065
13.172AlaLeu: 13.172 ± 0.112
4.045AlaMet: 4.045 ± 0.059
3.094AlaAsn: 3.094 ± 0.045
5.729AlaPro: 5.729 ± 0.077
4.641AlaGln: 4.641 ± 0.067
9.529AlaArg: 9.529 ± 0.09
7.159AlaSer: 7.159 ± 0.088
5.727AlaThr: 5.727 ± 0.068
8.143AlaVal: 8.143 ± 0.076
1.671AlaTrp: 1.671 ± 0.037
2.508AlaTyr: 2.508 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
1.142CysAla: 1.142 ± 0.028
0.132CysCys: 0.132 ± 0.011
0.628CysAsp: 0.628 ± 0.023
0.572CysGlu: 0.572 ± 0.02
0.338CysPhe: 0.338 ± 0.017
1.014CysGly: 1.014 ± 0.029
0.255CysHis: 0.255 ± 0.015
0.399CysIle: 0.399 ± 0.014
0.217CysLys: 0.217 ± 0.012
0.812CysLeu: 0.812 ± 0.026
0.183CysMet: 0.183 ± 0.012
0.27CysAsn: 0.27 ± 0.015
0.52CysPro: 0.52 ± 0.023
0.24CysGln: 0.24 ± 0.013
0.683CysArg: 0.683 ± 0.023
0.576CysSer: 0.576 ± 0.019
0.415CysThr: 0.415 ± 0.018
0.584CysVal: 0.584 ± 0.021
0.148CysTrp: 0.148 ± 0.011
0.196CysTyr: 0.196 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.177AspAla: 7.177 ± 0.069
0.596AspCys: 0.596 ± 0.021
3.385AspAsp: 3.385 ± 0.049
3.872AspGlu: 3.872 ± 0.056
2.221AspPhe: 2.221 ± 0.036
5.193AspGly: 5.193 ± 0.069
1.37AspHis: 1.37 ± 0.03
2.892AspIle: 2.892 ± 0.049
1.913AspLys: 1.913 ± 0.041
5.956AspLeu: 5.956 ± 0.069
1.471AspMet: 1.471 ± 0.032
1.411AspAsn: 1.411 ± 0.035
3.717AspPro: 3.717 ± 0.052
1.69AspGln: 1.69 ± 0.03
4.579AspArg: 4.579 ± 0.06
2.428AspSer: 2.428 ± 0.044
2.672AspThr: 2.672 ± 0.041
3.996AspVal: 3.996 ± 0.058
1.132AspTrp: 1.132 ± 0.03
1.611AspTyr: 1.611 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
8.099GluAla: 8.099 ± 0.088
0.446GluCys: 0.446 ± 0.018
3.12GluAsp: 3.12 ± 0.05
3.393GluGlu: 3.393 ± 0.05
1.801GluPhe: 1.801 ± 0.035
4.843GluGly: 4.843 ± 0.061
1.256GluHis: 1.256 ± 0.032
3.261GluIle: 3.261 ± 0.047
2.256GluLys: 2.256 ± 0.044
5.521GluLeu: 5.521 ± 0.069
1.583GluMet: 1.583 ± 0.03
1.552GluAsn: 1.552 ± 0.037
2.721GluPro: 2.721 ± 0.051
2.344GluGln: 2.344 ± 0.035
5.196GluArg: 5.196 ± 0.06
2.592GluSer: 2.592 ± 0.044
3.397GluThr: 3.397 ± 0.055
3.963GluVal: 3.963 ± 0.051
0.859GluTrp: 0.859 ± 0.026
1.035GluTyr: 1.035 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.691PheAla: 4.691 ± 0.062
0.378PheCys: 0.378 ± 0.015
2.705PheAsp: 2.705 ± 0.042
2.27PheGlu: 2.27 ± 0.034
1.255PhePhe: 1.255 ± 0.033
3.602PheGly: 3.602 ± 0.055
0.792PheHis: 0.792 ± 0.026
1.492PheIle: 1.492 ± 0.033
0.905PheLys: 0.905 ± 0.027
3.185PheLeu: 3.185 ± 0.051
0.809PheMet: 0.809 ± 0.024
1.018PheAsn: 1.018 ± 0.027
1.562PhePro: 1.562 ± 0.03
0.912PheGln: 0.912 ± 0.022
2.155PheArg: 2.155 ± 0.039
2.246PheSer: 2.246 ± 0.038
1.952PheThr: 1.952 ± 0.038
2.637PheVal: 2.637 ± 0.045
0.579PheTrp: 0.579 ± 0.022
0.903PheTyr: 0.903 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
9.267GlyAla: 9.267 ± 0.092
0.875GlyCys: 0.875 ± 0.023
4.76GlyAsp: 4.76 ± 0.065
5.207GlyGlu: 5.207 ± 0.052
3.532GlyPhe: 3.532 ± 0.048
7.543GlyGly: 7.543 ± 0.124
1.905GlyHis: 1.905 ± 0.04
4.536GlyIle: 4.536 ± 0.062
3.634GlyLys: 3.634 ± 0.049
8.506GlyLeu: 8.506 ± 0.07
2.447GlyMet: 2.447 ± 0.045
2.41GlyAsn: 2.41 ± 0.056
3.639GlyPro: 3.639 ± 0.053
3.01GlyGln: 3.01 ± 0.045
6.097GlyArg: 6.097 ± 0.072
5.109GlySer: 5.109 ± 0.073
4.693GlyThr: 4.693 ± 0.068
5.904GlyVal: 5.904 ± 0.061
1.447GlyTrp: 1.447 ± 0.029
2.347GlyTyr: 2.347 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.429HisAla: 2.429 ± 0.048
0.256HisCys: 0.256 ± 0.013
1.278HisAsp: 1.278 ± 0.031
1.17HisGlu: 1.17 ± 0.032
0.886HisPhe: 0.886 ± 0.023
2.008HisGly: 2.008 ± 0.04
0.578HisHis: 0.578 ± 0.022
0.965HisIle: 0.965 ± 0.026
0.509HisLys: 0.509 ± 0.019
1.984HisLeu: 1.984 ± 0.037
0.514HisMet: 0.514 ± 0.02
0.443HisAsn: 0.443 ± 0.017
1.308HisPro: 1.308 ± 0.03
0.55HisGln: 0.55 ± 0.019
1.552HisArg: 1.552 ± 0.036
1.05HisSer: 1.05 ± 0.025
0.759HisThr: 0.759 ± 0.023
1.548HisVal: 1.548 ± 0.034
0.355HisTrp: 0.355 ± 0.016
0.631HisTyr: 0.631 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.609IleAla: 7.609 ± 0.085
0.508IleCys: 0.508 ± 0.019
3.844IleAsp: 3.844 ± 0.055
3.764IleGlu: 3.764 ± 0.052
1.573IlePhe: 1.573 ± 0.03
4.975IleGly: 4.975 ± 0.054
0.942IleHis: 0.942 ± 0.027
1.884IleIle: 1.884 ± 0.046
1.247IleLys: 1.247 ± 0.03
4.001IleLeu: 4.001 ± 0.054
0.998IleMet: 0.998 ± 0.025
1.306IleAsn: 1.306 ± 0.032
2.292IlePro: 2.292 ± 0.039
1.177IleGln: 1.177 ± 0.03
3.157IleArg: 3.157 ± 0.041
2.859IleSer: 2.859 ± 0.047
2.46IleThr: 2.46 ± 0.038
4.144IleVal: 4.144 ± 0.053
0.601IleTrp: 0.601 ± 0.022
1.138IleTyr: 1.138 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.259LysAla: 4.259 ± 0.064
0.205LysCys: 0.205 ± 0.013
1.667LysAsp: 1.667 ± 0.037
1.457LysGlu: 1.457 ± 0.038
0.91LysPhe: 0.91 ± 0.024
2.758LysGly: 2.758 ± 0.046
0.622LysHis: 0.622 ± 0.025
1.466LysIle: 1.466 ± 0.033
1.052LysLys: 1.052 ± 0.033
3.296LysLeu: 3.296 ± 0.043
0.809LysMet: 0.809 ± 0.027
0.746LysAsn: 0.746 ± 0.023
1.983LysPro: 1.983 ± 0.04
1.035LysGln: 1.035 ± 0.029
2.311LysArg: 2.311 ± 0.046
1.759LysSer: 1.759 ± 0.033
1.629LysThr: 1.629 ± 0.034
2.438LysVal: 2.438 ± 0.038
0.408LysTrp: 0.408 ± 0.02
0.595LysTyr: 0.595 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
13.737LeuAla: 13.737 ± 0.119
0.911LeuCys: 0.911 ± 0.025
6.141LeuAsp: 6.141 ± 0.075
5.505LeuGlu: 5.505 ± 0.069
3.548LeuPhe: 3.548 ± 0.054
8.358LeuGly: 8.358 ± 0.075
1.905LeuHis: 1.905 ± 0.039
4.627LeuIle: 4.627 ± 0.064
3.006LeuLys: 3.006 ± 0.046
9.163LeuLeu: 9.163 ± 0.114
2.128LeuMet: 2.128 ± 0.042
2.365LeuAsn: 2.365 ± 0.039
5.582LeuPro: 5.582 ± 0.06
2.654LeuGln: 2.654 ± 0.041
7.013LeuArg: 7.013 ± 0.076
6.33LeuSer: 6.33 ± 0.068
5.326LeuThr: 5.326 ± 0.064
7.128LeuVal: 7.128 ± 0.079
1.098LeuTrp: 1.098 ± 0.023
1.869LeuTyr: 1.869 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
3.481MetAla: 3.481 ± 0.048
0.181MetCys: 0.181 ± 0.011
1.242MetAsp: 1.242 ± 0.029
1.211MetGlu: 1.211 ± 0.026
0.728MetPhe: 0.728 ± 0.022
1.929MetGly: 1.929 ± 0.038
0.526MetHis: 0.526 ± 0.019
1.413MetIle: 1.413 ± 0.03
0.966MetLys: 0.966 ± 0.026
2.662MetLeu: 2.662 ± 0.04
0.712MetMet: 0.712 ± 0.024
0.725MetAsn: 0.725 ± 0.02
1.567MetPro: 1.567 ± 0.029
0.858MetGln: 0.858 ± 0.023
1.89MetArg: 1.89 ± 0.035
1.591MetSer: 1.591 ± 0.034
1.736MetThr: 1.736 ± 0.038
1.671MetVal: 1.671 ± 0.037
0.236MetTrp: 0.236 ± 0.013
0.279MetTyr: 0.279 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.258AsnAla: 3.258 ± 0.055
0.268AsnCys: 0.268 ± 0.015
1.483AsnAsp: 1.483 ± 0.034
1.236AsnGlu: 1.236 ± 0.029
0.98AsnPhe: 0.98 ± 0.028
2.487AsnGly: 2.487 ± 0.044
0.483AsnHis: 0.483 ± 0.017
1.285AsnIle: 1.285 ± 0.031
0.616AsnLys: 0.616 ± 0.022
2.6AsnLeu: 2.6 ± 0.049
0.593AsnMet: 0.593 ± 0.02
0.629AsnAsn: 0.629 ± 0.024
1.774AsnPro: 1.774 ± 0.036
0.712AsnGln: 0.712 ± 0.022
1.965AsnArg: 1.965 ± 0.038
1.301AsnSer: 1.301 ± 0.031
1.128AsnThr: 1.128 ± 0.033
1.883AsnVal: 1.883 ± 0.039
0.47AsnTrp: 0.47 ± 0.02
0.732AsnTyr: 0.732 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.329ProAla: 6.329 ± 0.079
0.409ProCys: 0.409 ± 0.014
3.663ProAsp: 3.663 ± 0.047
3.892ProGlu: 3.892 ± 0.058
1.92ProPhe: 1.92 ± 0.035
4.743ProGly: 4.743 ± 0.063
1.068ProHis: 1.068 ± 0.028
2.398ProIle: 2.398 ± 0.038
1.497ProLys: 1.497 ± 0.033
4.84ProLeu: 4.84 ± 0.06
1.271ProMet: 1.271 ± 0.031
1.249ProAsn: 1.249 ± 0.029
2.497ProPro: 2.497 ± 0.055
1.803ProGln: 1.803 ± 0.032
3.129ProArg: 3.129 ± 0.054
2.875ProSer: 2.875 ± 0.04
2.325ProThr: 2.325 ± 0.039
4.25ProVal: 4.25 ± 0.051
0.683ProTrp: 0.683 ± 0.021
1.067ProTyr: 1.067 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
4.254GlnAla: 4.254 ± 0.063
0.264GlnCys: 0.264 ± 0.015
1.579GlnAsp: 1.579 ± 0.036
1.58GlnGlu: 1.58 ± 0.031
1.191GlnPhe: 1.191 ± 0.025
2.547GlnGly: 2.547 ± 0.041
0.633GlnHis: 0.633 ± 0.022
1.779GlnIle: 1.779 ± 0.035
0.943GlnLys: 0.943 ± 0.026
3.156GlnLeu: 3.156 ± 0.04
0.91GlnMet: 0.91 ± 0.025
0.781GlnAsn: 0.781 ± 0.024
1.73GlnPro: 1.73 ± 0.033
1.129GlnGln: 1.129 ± 0.03
2.453GlnArg: 2.453 ± 0.048
1.815GlnSer: 1.815 ± 0.039
1.604GlnThr: 1.604 ± 0.036
2.563GlnVal: 2.563 ± 0.044
0.48GlnTrp: 0.48 ± 0.016
0.648GlnTyr: 0.648 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
7.948ArgAla: 7.948 ± 0.084
0.572ArgCys: 0.572 ± 0.02
4.187ArgAsp: 4.187 ± 0.057
4.674ArgGlu: 4.674 ± 0.062
3.104ArgPhe: 3.104 ± 0.042
4.886ArgGly: 4.886 ± 0.053
1.812ArgHis: 1.812 ± 0.04
4.297ArgIle: 4.297 ± 0.05
2.677ArgLys: 2.677 ± 0.044
7.818ArgLeu: 7.818 ± 0.095
1.921ArgMet: 1.921 ± 0.037
2.05ArgAsn: 2.05 ± 0.04
3.547ArgPro: 3.547 ± 0.053
2.664ArgGln: 2.664 ± 0.042
5.731ArgArg: 5.731 ± 0.087
4.109ArgSer: 4.109 ± 0.056
3.493ArgThr: 3.493 ± 0.044
4.557ArgVal: 4.557 ± 0.054
1.105ArgTrp: 1.105 ± 0.028
1.811ArgTyr: 1.811 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.672SerAla: 6.672 ± 0.077
0.553SerCys: 0.553 ± 0.02
3.356SerAsp: 3.356 ± 0.048
3.107SerGlu: 3.107 ± 0.044
2.19SerPhe: 2.19 ± 0.039
5.791SerGly: 5.791 ± 0.071
1.131SerHis: 1.131 ± 0.027
2.78SerIle: 2.78 ± 0.038
1.6SerLys: 1.6 ± 0.039
5.623SerLeu: 5.623 ± 0.066
1.394SerMet: 1.394 ± 0.03
1.461SerAsn: 1.461 ± 0.036
2.942SerPro: 2.942 ± 0.041
1.901SerGln: 1.901 ± 0.04
3.943SerArg: 3.943 ± 0.048
3.234SerSer: 3.234 ± 0.057
2.7SerThr: 2.7 ± 0.045
3.812SerVal: 3.812 ± 0.05
0.842SerTrp: 0.842 ± 0.024
1.431SerTyr: 1.431 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
5.931ThrAla: 5.931 ± 0.075
0.5ThrCys: 0.5 ± 0.017
2.825ThrAsp: 2.825 ± 0.046
2.458ThrGlu: 2.458 ± 0.04
1.848ThrPhe: 1.848 ± 0.033
5.126ThrGly: 5.126 ± 0.085
0.913ThrHis: 0.913 ± 0.027
2.88ThrIle: 2.88 ± 0.044
1.292ThrLys: 1.292 ± 0.032
5.228ThrLeu: 5.228 ± 0.059
1.287ThrMet: 1.287 ± 0.03
1.246ThrAsn: 1.246 ± 0.037
3.078ThrPro: 3.078 ± 0.039
1.412ThrGln: 1.412 ± 0.03
3.429ThrArg: 3.429 ± 0.048
2.859ThrSer: 2.859 ± 0.053
2.425ThrThr: 2.425 ± 0.046
3.999ThrVal: 3.999 ± 0.052
0.66ThrTrp: 0.66 ± 0.02
1.186ThrTyr: 1.186 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
8.713ValAla: 8.713 ± 0.078
0.632ValCys: 0.632 ± 0.022
4.231ValAsp: 4.231 ± 0.05
4.627ValGlu: 4.627 ± 0.056
2.377ValPhe: 2.377 ± 0.043
5.335ValGly: 5.335 ± 0.057
1.382ValHis: 1.382 ± 0.032
3.804ValIle: 3.804 ± 0.051
1.974ValLys: 1.974 ± 0.041
6.899ValLeu: 6.899 ± 0.078
1.7ValMet: 1.7 ± 0.036
1.966ValAsn: 1.966 ± 0.043
3.986ValPro: 3.986 ± 0.045
1.993ValGln: 1.993 ± 0.037
5.009ValArg: 5.009 ± 0.057
4.357ValSer: 4.357 ± 0.055
4.308ValThr: 4.308 ± 0.063
5.126ValVal: 5.126 ± 0.066
0.865ValTrp: 0.865 ± 0.024
1.342ValTyr: 1.342 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.304TrpAla: 1.304 ± 0.034
0.164TrpCys: 0.164 ± 0.01
0.719TrpAsp: 0.719 ± 0.023
0.623TrpGlu: 0.623 ± 0.021
0.574TrpPhe: 0.574 ± 0.022
0.953TrpGly: 0.953 ± 0.029
0.372TrpHis: 0.372 ± 0.016
0.742TrpIle: 0.742 ± 0.022
0.537TrpLys: 0.537 ± 0.018
1.767TrpLeu: 1.767 ± 0.037
0.386TrpMet: 0.386 ± 0.016
0.51TrpAsn: 0.51 ± 0.017
0.689TrpPro: 0.689 ± 0.019
0.637TrpGln: 0.637 ± 0.019
1.278TrpArg: 1.278 ± 0.028
0.928TrpSer: 0.928 ± 0.024
0.765TrpThr: 0.765 ± 0.02
0.761TrpVal: 0.761 ± 0.024
0.237TrpTrp: 0.237 ± 0.014
0.306TrpTyr: 0.306 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.572TyrAla: 2.572 ± 0.043
0.271TyrCys: 0.271 ± 0.014
1.462TyrAsp: 1.462 ± 0.031
1.226TyrGlu: 1.226 ± 0.027
0.867TyrPhe: 0.867 ± 0.024
2.074TyrGly: 2.074 ± 0.044
0.492TyrHis: 0.492 ± 0.018
0.91TyrIle: 0.91 ± 0.021
0.631TyrLys: 0.631 ± 0.024
2.209TyrLeu: 2.209 ± 0.039
0.442TyrMet: 0.442 ± 0.017
0.652TyrAsn: 0.652 ± 0.021
1.043TyrPro: 1.043 ± 0.026
0.676TyrGln: 0.676 ± 0.02
1.864TyrArg: 1.864 ± 0.036
1.286TyrSer: 1.286 ± 0.03
1.066TyrThr: 1.066 ± 0.029
1.517TyrVal: 1.517 ± 0.032
0.376TyrTrp: 0.376 ± 0.015
0.636TyrTyr: 0.636 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5229 proteins (1570680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski