Amino acid dipepetide frequency for Toxocara canis (Canine roundworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.762AlaAla: 6.762 ± 0.057	1.405AlaCys: 1.405 ± 0.017	3.863AlaAsp: 3.863 ± 0.031	4.975AlaGlu: 4.975 ± 0.049	3.084AlaPhe: 3.084 ± 0.031	3.858AlaGly: 3.858 ± 0.043	1.86AlaHis: 1.86 ± 0.021	4.431AlaIle: 4.431 ± 0.041	4.04AlaLys: 4.04 ± 0.028	6.966AlaLeu: 6.966 ± 0.044	1.859AlaMet: 1.859 ± 0.018	3.231AlaAsn: 3.231 ± 0.025	3.387AlaPro: 3.387 ± 0.048	3.035AlaGln: 3.035 ± 0.027	4.04AlaArg: 4.04 ± 0.025	6.198AlaSer: 6.198 ± 0.039	4.289AlaThr: 4.289 ± 0.039	5.444AlaVal: 5.444 ± 0.041	0.647AlaTrp: 0.647 ± 0.013	1.996AlaTyr: 1.996 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	1.809CysAla: 1.809 ± 0.023	0.736CysCys: 0.736 ± 0.023	1.281CysAsp: 1.281 ± 0.024	1.429CysGlu: 1.429 ± 0.018	0.989CysPhe: 0.989 ± 0.022	1.471CysGly: 1.471 ± 0.017	0.516CysHis: 0.516 ± 0.012	1.258CysIle: 1.258 ± 0.019	1.034CysLys: 1.034 ± 0.018	1.853CysLeu: 1.853 ± 0.021	0.524CysMet: 0.524 ± 0.011	0.893CysAsn: 0.893 ± 0.015	1.117CysPro: 1.117 ± 0.022	0.733CysGln: 0.733 ± 0.016	1.374CysArg: 1.374 ± 0.017	2.029CysSer: 2.029 ± 0.032	1.208CysThr: 1.208 ± 0.02	1.611CysVal: 1.611 ± 0.034	0.259CysTrp: 0.259 ± 0.006	0.711CysTyr: 0.711 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.025AspAla: 4.025 ± 0.031	1.043AspCys: 1.043 ± 0.019	3.645AspAsp: 3.645 ± 0.03	4.845AspGlu: 4.845 ± 0.04	2.129AspPhe: 2.129 ± 0.022	3.651AspGly: 3.651 ± 0.036	1.106AspHis: 1.106 ± 0.016	2.701AspIle: 2.701 ± 0.026	2.418AspLys: 2.418 ± 0.024	4.276AspLeu: 4.276 ± 0.03	1.208AspMet: 1.208 ± 0.014	1.91AspAsn: 1.91 ± 0.026	2.152AspPro: 2.152 ± 0.022	1.669AspGln: 1.669 ± 0.017	3.033AspArg: 3.033 ± 0.031	4.045AspSer: 4.045 ± 0.042	2.366AspThr: 2.366 ± 0.021	3.769AspVal: 3.769 ± 0.033	0.611AspTrp: 0.611 ± 0.013	1.609AspTyr: 1.609 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	4.562GluAla: 4.562 ± 0.042	1.432GluCys: 1.432 ± 0.024	3.364GluAsp: 3.364 ± 0.033	5.775GluGlu: 5.775 ± 0.068	2.071GluPhe: 2.071 ± 0.028	3.383GluGly: 3.383 ± 0.033	1.65GluHis: 1.65 ± 0.018	3.267GluIle: 3.267 ± 0.032	4.536GluLys: 4.536 ± 0.048	5.794GluLeu: 5.794 ± 0.05	1.999GluMet: 1.999 ± 0.019	2.993GluAsn: 2.993 ± 0.027	2.527GluPro: 2.527 ± 0.041	3.197GluGln: 3.197 ± 0.032	4.911GluArg: 4.911 ± 0.043	4.636GluSer: 4.636 ± 0.041	3.385GluThr: 3.385 ± 0.034	3.832GluVal: 3.832 ± 0.046	0.892GluTrp: 0.892 ± 0.07	1.786GluTyr: 1.786 ± 0.019	0.001GluXaa: 0.001 ± 0.0
Phe	3.176PheAla: 3.176 ± 0.033	1.069PheCys: 1.069 ± 0.026	2.512PheAsp: 2.512 ± 0.022	2.423PheGlu: 2.423 ± 0.023	1.909PhePhe: 1.909 ± 0.027	2.718PheGly: 2.718 ± 0.026	0.989PheHis: 0.989 ± 0.016	2.461PheIle: 2.461 ± 0.023	1.654PheLys: 1.654 ± 0.018	3.578PheLeu: 3.578 ± 0.03	1.003PheMet: 1.003 ± 0.016	1.588PheAsn: 1.588 ± 0.019	1.692PhePro: 1.692 ± 0.021	1.206PheGln: 1.206 ± 0.014	2.228PheArg: 2.228 ± 0.02	3.197PheSer: 3.197 ± 0.026	2.224PheThr: 2.224 ± 0.023	3.069PheVal: 3.069 ± 0.027	0.508PheTrp: 0.508 ± 0.011	1.351PheTyr: 1.351 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	4.068GlyAla: 4.068 ± 0.036	1.277GlyCys: 1.277 ± 0.018	3.087GlyAsp: 3.087 ± 0.025	3.656GlyGlu: 3.656 ± 0.039	2.32GlyPhe: 2.32 ± 0.039	4.347GlyGly: 4.347 ± 0.079	1.318GlyHis: 1.318 ± 0.018	3.038GlyIle: 3.038 ± 0.027	3.013GlyLys: 3.013 ± 0.033	4.113GlyLeu: 4.113 ± 0.046	1.405GlyMet: 1.405 ± 0.018	2.335GlyAsn: 2.335 ± 0.027	2.563GlyPro: 2.563 ± 0.049	2.056GlyGln: 2.056 ± 0.041	3.688GlyArg: 3.688 ± 0.032	4.776GlySer: 4.776 ± 0.044	3.273GlyThr: 3.273 ± 0.033	3.735GlyVal: 3.735 ± 0.028	0.691GlyTrp: 0.691 ± 0.021	1.846GlyTyr: 1.846 ± 0.027	0.001GlyXaa: 0.001 ± 0.0
His	1.599HisAla: 1.599 ± 0.028	0.664HisCys: 0.664 ± 0.017	1.082HisAsp: 1.082 ± 0.014	1.451HisGlu: 1.451 ± 0.021	1.17HisPhe: 1.17 ± 0.014	1.291HisGly: 1.291 ± 0.018	0.753HisHis: 0.753 ± 0.014	1.367HisIle: 1.367 ± 0.018	1.103HisLys: 1.103 ± 0.015	2.348HisLeu: 2.348 ± 0.025	0.625HisMet: 0.625 ± 0.011	0.94HisAsn: 0.94 ± 0.012	1.207HisPro: 1.207 ± 0.015	0.918HisGln: 0.918 ± 0.017	1.675HisArg: 1.675 ± 0.023	2.111HisSer: 2.111 ± 0.02	1.217HisThr: 1.217 ± 0.018	1.496HisVal: 1.496 ± 0.02	0.319HisTrp: 0.319 ± 0.008	0.8HisTyr: 0.8 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.573IleAla: 4.573 ± 0.03	1.402IleCys: 1.402 ± 0.021	3.175IleAsp: 3.175 ± 0.03	3.46IleGlu: 3.46 ± 0.029	2.303IlePhe: 2.303 ± 0.023	3.24IleGly: 3.24 ± 0.032	1.206IleHis: 1.206 ± 0.013	2.893IleIle: 2.893 ± 0.028	2.43IleLys: 2.43 ± 0.024	4.418IleLeu: 4.418 ± 0.032	1.152IleMet: 1.152 ± 0.014	2.122IleAsn: 2.122 ± 0.02	2.565IlePro: 2.565 ± 0.027	1.744IleGln: 1.744 ± 0.02	3.374IleArg: 3.374 ± 0.023	4.51IleSer: 4.51 ± 0.032	3.036IleThr: 3.036 ± 0.03	3.935IleVal: 3.935 ± 0.035	0.639IleTrp: 0.639 ± 0.014	1.644IleTyr: 1.644 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.732LysAla: 3.732 ± 0.031	1.245LysCys: 1.245 ± 0.02	2.506LysAsp: 2.506 ± 0.027	4.065LysGlu: 4.065 ± 0.041	1.836LysPhe: 1.836 ± 0.018	2.722LysGly: 2.722 ± 0.029	1.248LysHis: 1.248 ± 0.015	2.641LysIle: 2.641 ± 0.024	4.188LysLys: 4.188 ± 0.054	4.721LysLeu: 4.721 ± 0.036	1.516LysMet: 1.516 ± 0.021	2.251LysAsn: 2.251 ± 0.024	2.388LysPro: 2.388 ± 0.049	2.367LysGln: 2.367 ± 0.026	4.175LysArg: 4.175 ± 0.033	3.707LysSer: 3.707 ± 0.028	2.899LysThr: 2.899 ± 0.027	3.092LysVal: 3.092 ± 0.031	0.694LysTrp: 0.694 ± 0.012	1.615LysTyr: 1.615 ± 0.017	0.001LysXaa: 0.001 ± 0.0
Leu	6.44LeuAla: 6.44 ± 0.047	2.172LeuCys: 2.172 ± 0.021	4.348LeuAsp: 4.348 ± 0.037	5.225LeuGlu: 5.225 ± 0.06	3.881LeuPhe: 3.881 ± 0.03	4.032LeuGly: 4.032 ± 0.028	2.32LeuHis: 2.32 ± 0.022	4.908LeuIle: 4.908 ± 0.038	4.97LeuLys: 4.97 ± 0.042	9.199LeuLeu: 9.199 ± 0.068	2.283LeuMet: 2.283 ± 0.019	3.924LeuAsn: 3.924 ± 0.026	4.721LeuPro: 4.721 ± 0.037	3.717LeuGln: 3.717 ± 0.032	6.001LeuArg: 6.001 ± 0.045	7.707LeuSer: 7.707 ± 0.057	4.737LeuThr: 4.737 ± 0.034	5.26LeuVal: 5.26 ± 0.034	0.979LeuTrp: 0.979 ± 0.015	2.492LeuTyr: 2.492 ± 0.022	0.001LeuXaa: 0.001 ± 0.0
Met	1.966MetAla: 1.966 ± 0.022	0.552MetCys: 0.552 ± 0.01	1.289MetAsp: 1.289 ± 0.025	1.608MetGlu: 1.608 ± 0.019	0.953MetPhe: 0.953 ± 0.014	1.341MetGly: 1.341 ± 0.02	0.663MetHis: 0.663 ± 0.011	1.254MetIle: 1.254 ± 0.016	1.478MetLys: 1.478 ± 0.016	2.449MetLeu: 2.449 ± 0.021	0.707MetMet: 0.707 ± 0.011	1.14MetAsn: 1.14 ± 0.014	1.298MetPro: 1.298 ± 0.019	1.168MetGln: 1.168 ± 0.018	1.796MetArg: 1.796 ± 0.019	1.983MetSer: 1.983 ± 0.017	1.31MetThr: 1.31 ± 0.019	1.532MetVal: 1.532 ± 0.018	0.264MetTrp: 0.264 ± 0.006	0.57MetTyr: 0.57 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.642AsnAla: 3.642 ± 0.027	0.928AsnCys: 0.928 ± 0.012	2.46AsnAsp: 2.46 ± 0.025	3.318AsnGlu: 3.318 ± 0.031	1.676AsnPhe: 1.676 ± 0.022	3.087AsnGly: 3.087 ± 0.033	0.809AsnHis: 0.809 ± 0.013	2.239AsnIle: 2.239 ± 0.021	1.994AsnLys: 1.994 ± 0.02	3.254AsnLeu: 3.254 ± 0.03	1.007AsnMet: 1.007 ± 0.014	1.842AsnAsn: 1.842 ± 0.024	1.756AsnPro: 1.756 ± 0.021	1.317AsnGln: 1.317 ± 0.017	2.487AsnArg: 2.487 ± 0.03	3.209AsnSer: 3.209 ± 0.022	2.129AsnThr: 2.129 ± 0.019	3.101AsnVal: 3.101 ± 0.024	0.48AsnTrp: 0.48 ± 0.01	1.204AsnTyr: 1.204 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	3.284ProAla: 3.284 ± 0.052	0.856ProCys: 0.856 ± 0.016	2.23ProAsp: 2.23 ± 0.028	2.818ProGlu: 2.818 ± 0.044	1.955ProPhe: 1.955 ± 0.018	2.776ProGly: 2.776 ± 0.067	1.13ProHis: 1.13 ± 0.014	2.509ProIle: 2.509 ± 0.025	2.375ProLys: 2.375 ± 0.023	4.326ProLeu: 4.326 ± 0.053	1.066ProMet: 1.066 ± 0.014	2.053ProAsn: 2.053 ± 0.024	3.939ProPro: 3.939 ± 0.056	2.036ProGln: 2.036 ± 0.028	2.52ProArg: 2.52 ± 0.026	4.781ProSer: 4.781 ± 0.044	3.006ProThr: 3.006 ± 0.065	3.046ProVal: 3.046 ± 0.035	0.45ProTrp: 0.45 ± 0.011	1.385ProTyr: 1.385 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	2.372GlnAla: 2.372 ± 0.023	0.989GlnCys: 0.989 ± 0.02	1.255GlnAsp: 1.255 ± 0.015	2.043GlnGlu: 2.043 ± 0.041	1.581GlnPhe: 1.581 ± 0.017	1.612GlnGly: 1.612 ± 0.021	1.083GlnHis: 1.083 ± 0.016	2.15GlnIle: 2.15 ± 0.02	2.318GlnLys: 2.318 ± 0.025	4.373GlnLeu: 4.373 ± 0.037	1.316GlnMet: 1.316 ± 0.021	1.638GlnAsn: 1.638 ± 0.017	2.236GlnPro: 2.236 ± 0.029	2.838GlnGln: 2.838 ± 0.058	2.954GlnArg: 2.954 ± 0.026	3.03GlnSer: 3.03 ± 0.027	2.101GlnThr: 2.101 ± 0.021	2.081GlnVal: 2.081 ± 0.027	0.517GlnTrp: 0.517 ± 0.014	1.139GlnTyr: 1.139 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.128ArgAla: 4.128 ± 0.03	1.568ArgCys: 1.568 ± 0.024	2.924ArgAsp: 2.924 ± 0.028	3.87ArgGlu: 3.87 ± 0.036	2.634ArgPhe: 2.634 ± 0.029	3.099ArgGly: 3.099 ± 0.031	1.671ArgHis: 1.671 ± 0.023	3.662ArgIle: 3.662 ± 0.028	3.987ArgLys: 3.987 ± 0.033	5.912ArgLeu: 5.912 ± 0.04	1.676ArgMet: 1.676 ± 0.019	2.902ArgAsn: 2.902 ± 0.025	2.868ArgPro: 2.868 ± 0.028	2.665ArgGln: 2.665 ± 0.024	5.563ArgArg: 5.563 ± 0.048	5.517ArgSer: 5.517 ± 0.043	3.459ArgThr: 3.459 ± 0.022	3.538ArgVal: 3.538 ± 0.031	0.787ArgTrp: 0.787 ± 0.014	1.918ArgTyr: 1.918 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.743SerAla: 6.743 ± 0.046	1.747SerCys: 1.747 ± 0.024	4.371SerAsp: 4.371 ± 0.045	5.141SerGlu: 5.141 ± 0.039	3.246SerPhe: 3.246 ± 0.024	4.984SerGly: 4.984 ± 0.043	1.796SerHis: 1.796 ± 0.025	4.122SerIle: 4.122 ± 0.033	4.07SerLys: 4.07 ± 0.037	7.207SerLeu: 7.207 ± 0.044	1.956SerMet: 1.956 ± 0.026	3.38SerAsn: 3.38 ± 0.029	4.158SerPro: 4.158 ± 0.045	2.958SerGln: 2.958 ± 0.023	4.903SerArg: 4.903 ± 0.044	9.163SerSer: 9.163 ± 0.077	5.449SerThr: 5.449 ± 0.054	5.452SerVal: 5.452 ± 0.035	0.809SerTrp: 0.809 ± 0.016	2.028SerTyr: 2.028 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	4.634ThrAla: 4.634 ± 0.038	1.154ThrCys: 1.154 ± 0.017	2.719ThrAsp: 2.719 ± 0.03	3.17ThrGlu: 3.17 ± 0.039	2.286ThrPhe: 2.286 ± 0.025	2.978ThrGly: 2.978 ± 0.043	1.254ThrHis: 1.254 ± 0.015	3.164ThrIle: 3.164 ± 0.028	2.72ThrLys: 2.72 ± 0.023	4.932ThrLeu: 4.932 ± 0.037	1.324ThrMet: 1.324 ± 0.016	2.356ThrAsn: 2.356 ± 0.025	3.031ThrPro: 3.031 ± 0.062	1.961ThrGln: 1.961 ± 0.023	2.922ThrArg: 2.922 ± 0.027	4.988ThrSer: 4.988 ± 0.043	4.095ThrThr: 4.095 ± 0.07	4.179ThrVal: 4.179 ± 0.035	0.52ThrTrp: 0.52 ± 0.016	1.443ThrTyr: 1.443 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.034ValAla: 5.034 ± 0.039	1.594ValCys: 1.594 ± 0.025	3.931ValAsp: 3.931 ± 0.035	4.325ValGlu: 4.325 ± 0.038	2.715ValPhe: 2.715 ± 0.028	3.511ValGly: 3.511 ± 0.032	1.733ValHis: 1.733 ± 0.028	3.631ValIle: 3.631 ± 0.025	3.237ValLys: 3.237 ± 0.037	5.914ValLeu: 5.914 ± 0.039	1.578ValMet: 1.578 ± 0.019	2.7ValAsn: 2.7 ± 0.027	3.157ValPro: 3.157 ± 0.04	2.568ValGln: 2.568 ± 0.033	3.915ValArg: 3.915 ± 0.032	4.96ValSer: 4.96 ± 0.033	3.542ValThr: 3.542 ± 0.031	4.999ValVal: 4.999 ± 0.13	0.765ValTrp: 0.765 ± 0.023	1.893ValTyr: 1.893 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	0.697TrpAla: 0.697 ± 0.012	0.248TrpCys: 0.248 ± 0.011	0.559TrpAsp: 0.559 ± 0.011	0.562TrpGlu: 0.562 ± 0.01	0.457TrpPhe: 0.457 ± 0.01	0.494TrpGly: 0.494 ± 0.035	0.301TrpHis: 0.301 ± 0.007	0.708TrpIle: 0.708 ± 0.012	0.723TrpLys: 0.723 ± 0.012	1.173TrpLeu: 1.173 ± 0.024	0.365TrpMet: 0.365 ± 0.007	0.607TrpAsn: 0.607 ± 0.012	0.505TrpPro: 0.505 ± 0.02	0.474TrpGln: 0.474 ± 0.009	0.817TrpArg: 0.817 ± 0.012	0.939TrpSer: 0.939 ± 0.03	0.668TrpThr: 0.668 ± 0.019	0.591TrpVal: 0.591 ± 0.037	0.173TrpTrp: 0.173 ± 0.006	0.337TrpTyr: 0.337 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.124TyrAla: 2.124 ± 0.025	0.752TyrCys: 0.752 ± 0.013	1.613TyrAsp: 1.613 ± 0.018	1.835TyrGlu: 1.835 ± 0.018	1.361TyrPhe: 1.361 ± 0.016	2.008TyrGly: 2.008 ± 0.028	0.727TyrHis: 0.727 ± 0.018	1.415TyrIle: 1.415 ± 0.019	1.323TyrLys: 1.323 ± 0.017	2.51TyrLeu: 2.51 ± 0.025	0.749TyrMet: 0.749 ± 0.01	1.134TyrAsn: 1.134 ± 0.016	1.27TyrPro: 1.27 ± 0.027	0.999TyrGln: 0.999 ± 0.017	1.968TyrArg: 1.968 ± 0.02	2.199TyrSer: 2.199 ± 0.022	1.439TyrThr: 1.439 ± 0.019	1.943TyrVal: 1.943 ± 0.027	0.397TyrTrp: 0.397 ± 0.009	1.05TyrTyr: 1.05 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.332XaaXaa: 0.332 ± 0.108

Statistics based on 18499 proteins (7137888 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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