Amino acid dipepetide frequency for Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.75AlaAla: 3.75 ± 0.078	0.601AlaCys: 0.601 ± 0.017	2.32AlaAsp: 2.32 ± 0.028	3.013AlaGlu: 3.013 ± 0.054	2.083AlaPhe: 2.083 ± 0.032	2.779AlaGly: 2.779 ± 0.038	0.891AlaHis: 0.891 ± 0.019	3.713AlaIle: 3.713 ± 0.044	3.688AlaLys: 3.688 ± 0.049	4.509AlaLeu: 4.509 ± 0.049	1.024AlaMet: 1.024 ± 0.019	2.868AlaAsn: 2.868 ± 0.031	2.314AlaPro: 2.314 ± 0.053	1.855AlaGln: 1.855 ± 0.037	2.028AlaArg: 2.028 ± 0.026	4.575AlaSer: 4.575 ± 0.087	3.595AlaThr: 3.595 ± 0.057	2.887AlaVal: 2.887 ± 0.04	0.44AlaTrp: 0.44 ± 0.014	1.573AlaTyr: 1.573 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.513CysAla: 0.513 ± 0.015	0.252CysCys: 0.252 ± 0.012	0.623CysAsp: 0.623 ± 0.014	0.562CysGlu: 0.562 ± 0.018	0.617CysPhe: 0.617 ± 0.015	0.774CysGly: 0.774 ± 0.019	0.276CysHis: 0.276 ± 0.011	0.866CysIle: 0.866 ± 0.018	0.664CysLys: 0.664 ± 0.015	1.142CysLeu: 1.142 ± 0.023	0.218CysMet: 0.218 ± 0.009	0.58CysAsn: 0.58 ± 0.015	0.481CysPro: 0.481 ± 0.017	0.406CysGln: 0.406 ± 0.012	0.404CysArg: 0.404 ± 0.013	0.875CysSer: 0.875 ± 0.02	0.557CysThr: 0.557 ± 0.015	0.64CysVal: 0.64 ± 0.015	0.149CysTrp: 0.149 ± 0.007	0.411CysTyr: 0.411 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	2.795AspAla: 2.795 ± 0.041	0.589AspCys: 0.589 ± 0.016	5.612AspAsp: 5.612 ± 0.089	5.626AspGlu: 5.626 ± 0.068	2.738AspPhe: 2.738 ± 0.038	2.901AspGly: 2.901 ± 0.04	1.126AspHis: 1.126 ± 0.023	4.227AspIle: 4.227 ± 0.044	3.945AspLys: 3.945 ± 0.041	5.622AspLeu: 5.622 ± 0.05	1.031AspMet: 1.031 ± 0.019	3.484AspAsn: 3.484 ± 0.035	2.369AspPro: 2.369 ± 0.032	2.017AspGln: 2.017 ± 0.029	1.79AspArg: 1.79 ± 0.025	4.886AspSer: 4.886 ± 0.063	2.746AspThr: 2.746 ± 0.037	3.317AspVal: 3.317 ± 0.035	0.587AspTrp: 0.587 ± 0.014	2.419AspTyr: 2.419 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	3.053GluAla: 3.053 ± 0.039	0.617GluCys: 0.617 ± 0.014	4.692GluAsp: 4.692 ± 0.069	7.205GluGlu: 7.205 ± 0.12	3.09GluPhe: 3.09 ± 0.036	2.602GluGly: 2.602 ± 0.034	1.129GluHis: 1.129 ± 0.021	4.842GluIle: 4.842 ± 0.043	5.038GluLys: 5.038 ± 0.058	6.635GluLeu: 6.635 ± 0.061	1.312GluMet: 1.312 ± 0.026	4.007GluAsn: 4.007 ± 0.044	2.172GluPro: 2.172 ± 0.043	2.79GluGln: 2.79 ± 0.048	2.433GluArg: 2.433 ± 0.032	5.671GluSer: 5.671 ± 0.094	3.609GluThr: 3.609 ± 0.058	3.634GluVal: 3.634 ± 0.04	0.58GluTrp: 0.58 ± 0.014	2.481GluTyr: 2.481 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	2.309PheAla: 2.309 ± 0.028	0.526PheCys: 0.526 ± 0.015	2.884PheAsp: 2.884 ± 0.032	2.843PheGlu: 2.843 ± 0.032	2.108PhePhe: 2.108 ± 0.035	2.743PheGly: 2.743 ± 0.044	0.961PheHis: 0.961 ± 0.021	3.356PheIle: 3.356 ± 0.041	3.335PheLys: 3.335 ± 0.039	3.904PheLeu: 3.904 ± 0.05	0.925PheMet: 0.925 ± 0.016	3.036PheAsn: 3.036 ± 0.031	1.888PhePro: 1.888 ± 0.031	1.802PheGln: 1.802 ± 0.029	1.525PheArg: 1.525 ± 0.024	3.342PheSer: 3.342 ± 0.037	2.644PheThr: 2.644 ± 0.033	2.607PheVal: 2.607 ± 0.031	0.531PheTrp: 0.531 ± 0.022	1.642PheTyr: 1.642 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	2.849GlyAla: 2.849 ± 0.043	0.678GlyCys: 0.678 ± 0.02	2.903GlyAsp: 2.903 ± 0.036	2.951GlyGlu: 2.951 ± 0.037	2.538GlyPhe: 2.538 ± 0.036	3.705GlyGly: 3.705 ± 0.066	1.016GlyHis: 1.016 ± 0.021	3.656GlyIle: 3.656 ± 0.041	3.52GlyLys: 3.52 ± 0.045	4.542GlyLeu: 4.542 ± 0.043	0.928GlyMet: 0.928 ± 0.02	2.967GlyAsn: 2.967 ± 0.042	1.565GlyPro: 1.565 ± 0.036	1.59GlyGln: 1.59 ± 0.024	1.895GlyArg: 1.895 ± 0.032	4.78GlySer: 4.78 ± 0.076	2.925GlyThr: 2.925 ± 0.045	3.238GlyVal: 3.238 ± 0.039	0.596GlyTrp: 0.596 ± 0.016	2.067GlyTyr: 2.067 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	0.891HisAla: 0.891 ± 0.016	0.255HisCys: 0.255 ± 0.01	1.196HisAsp: 1.196 ± 0.02	1.343HisGlu: 1.343 ± 0.021	0.887HisPhe: 0.887 ± 0.021	1.119HisGly: 1.119 ± 0.022	0.984HisHis: 0.984 ± 0.032	1.351HisIle: 1.351 ± 0.021	1.283HisLys: 1.283 ± 0.022	1.925HisLeu: 1.925 ± 0.03	0.351HisMet: 0.351 ± 0.011	1.266HisAsn: 1.266 ± 0.023	1.117HisPro: 1.117 ± 0.022	1.122HisGln: 1.122 ± 0.025	0.866HisArg: 0.866 ± 0.018	1.677HisSer: 1.677 ± 0.032	0.997HisThr: 0.997 ± 0.018	1.075HisVal: 1.075 ± 0.026	0.23HisTrp: 0.23 ± 0.015	0.78HisTyr: 0.78 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.646IleAla: 3.646 ± 0.039	0.834IleCys: 0.834 ± 0.019	4.661IleAsp: 4.661 ± 0.046	4.607IleGlu: 4.607 ± 0.054	3.023IlePhe: 3.023 ± 0.042	3.517IleGly: 3.517 ± 0.039	1.522IleHis: 1.522 ± 0.02	5.118IleIle: 5.118 ± 0.051	5.086IleLys: 5.086 ± 0.055	6.247IleLeu: 6.247 ± 0.057	1.338IleMet: 1.338 ± 0.022	4.665IleAsn: 4.665 ± 0.052	3.7IlePro: 3.7 ± 0.04	2.695IleGln: 2.695 ± 0.034	2.653IleArg: 2.653 ± 0.033	6.05IleSer: 6.05 ± 0.055	4.139IleThr: 4.139 ± 0.044	4.013IleVal: 4.013 ± 0.04	0.742IleTrp: 0.742 ± 0.018	2.381IleTyr: 2.381 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.149LysAla: 3.149 ± 0.044	0.707LysCys: 0.707 ± 0.018	4.071LysAsp: 4.071 ± 0.047	5.168LysGlu: 5.168 ± 0.064	3.497LysPhe: 3.497 ± 0.041	2.692LysGly: 2.692 ± 0.035	1.445LysHis: 1.445 ± 0.022	4.987LysIle: 4.987 ± 0.05	6.536LysLys: 6.536 ± 0.074	7.634LysLeu: 7.634 ± 0.069	1.263LysMet: 1.263 ± 0.022	4.284LysAsn: 4.284 ± 0.041	3.071LysPro: 3.071 ± 0.043	3.172LysGln: 3.172 ± 0.042	3.349LysArg: 3.349 ± 0.04	6.133LysSer: 6.133 ± 0.054	3.588LysThr: 3.588 ± 0.038	3.864LysVal: 3.864 ± 0.042	0.698LysTrp: 0.698 ± 0.016	2.912LysTyr: 2.912 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	4.863LeuAla: 4.863 ± 0.05	1.034LeuCys: 1.034 ± 0.018	5.167LeuAsp: 5.167 ± 0.045	5.756LeuGlu: 5.756 ± 0.054	4.032LeuPhe: 4.032 ± 0.043	4.446LeuGly: 4.446 ± 0.042	1.875LeuHis: 1.875 ± 0.033	6.575LeuIle: 6.575 ± 0.068	6.942LeuLys: 6.942 ± 0.052	8.471LeuLeu: 8.471 ± 0.073	1.83LeuMet: 1.83 ± 0.027	5.865LeuAsn: 5.865 ± 0.056	4.511LeuPro: 4.511 ± 0.041	3.98LeuGln: 3.98 ± 0.046	3.676LeuArg: 3.676 ± 0.039	7.983LeuSer: 7.983 ± 0.07	5.321LeuThr: 5.321 ± 0.053	5.266LeuVal: 5.266 ± 0.051	0.772LeuTrp: 0.772 ± 0.019	3.038LeuTyr: 3.038 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	1.136MetAla: 1.136 ± 0.019	0.202MetCys: 0.202 ± 0.008	1.064MetAsp: 1.064 ± 0.025	1.089MetGlu: 1.089 ± 0.021	0.877MetPhe: 0.877 ± 0.019	0.997MetGly: 0.997 ± 0.021	0.283MetHis: 0.283 ± 0.01	1.39MetIle: 1.39 ± 0.026	1.471MetLys: 1.471 ± 0.024	1.55MetLeu: 1.55 ± 0.023	0.499MetMet: 0.499 ± 0.016	1.327MetAsn: 1.327 ± 0.026	0.707MetPro: 0.707 ± 0.017	0.598MetGln: 0.598 ± 0.016	0.67MetArg: 0.67 ± 0.018	1.915MetSer: 1.915 ± 0.022	1.119MetThr: 1.119 ± 0.018	1.132MetVal: 1.132 ± 0.023	0.153MetTrp: 0.153 ± 0.008	0.636MetTyr: 0.636 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.696AsnAla: 2.696 ± 0.031	0.654AsnCys: 0.654 ± 0.018	4.051AsnAsp: 4.051 ± 0.045	4.17AsnGlu: 4.17 ± 0.039	2.745AsnPhe: 2.745 ± 0.034	3.522AsnGly: 3.522 ± 0.05	1.44AsnHis: 1.44 ± 0.026	4.034AsnIle: 4.034 ± 0.04	4.428AsnLys: 4.428 ± 0.046	5.712AsnLeu: 5.712 ± 0.054	1.066AsnMet: 1.066 ± 0.021	5.235AsnAsn: 5.235 ± 0.082	2.823AsnPro: 2.823 ± 0.046	2.688AsnGln: 2.688 ± 0.036	2.082AsnArg: 2.082 ± 0.028	5.737AsnSer: 5.737 ± 0.065	3.298AsnThr: 3.298 ± 0.045	3.096AsnVal: 3.096 ± 0.035	0.7AsnTrp: 0.7 ± 0.016	2.515AsnTyr: 2.515 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	2.274ProAla: 2.274 ± 0.049	0.351ProCys: 0.351 ± 0.012	2.29ProAsp: 2.29 ± 0.032	3.152ProGlu: 3.152 ± 0.041	1.839ProPhe: 1.839 ± 0.025	2.034ProGly: 2.034 ± 0.032	0.938ProHis: 0.938 ± 0.019	3.244ProIle: 3.244 ± 0.035	3.117ProLys: 3.117 ± 0.037	3.542ProLeu: 3.542 ± 0.039	0.778ProMet: 0.778 ± 0.019	2.684ProAsn: 2.684 ± 0.034	3.241ProPro: 3.241 ± 0.079	2.269ProGln: 2.269 ± 0.048	1.649ProArg: 1.649 ± 0.024	4.28ProSer: 4.28 ± 0.062	3.156ProThr: 3.156 ± 0.055	2.91ProVal: 2.91 ± 0.048	0.369ProTrp: 0.369 ± 0.012	1.417ProTyr: 1.417 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	1.991GlnAla: 1.991 ± 0.037	0.379GlnCys: 0.379 ± 0.012	2.201GlnAsp: 2.201 ± 0.028	3.02GlnGlu: 3.02 ± 0.043	1.877GlnPhe: 1.877 ± 0.026	1.747GlnGly: 1.747 ± 0.031	1.012GlnHis: 1.012 ± 0.021	2.602GlnIle: 2.602 ± 0.03	2.489GlnLys: 2.489 ± 0.032	4.138GlnLeu: 4.138 ± 0.047	0.79GlnMet: 0.79 ± 0.027	2.08GlnAsn: 2.08 ± 0.031	2.213GlnPro: 2.213 ± 0.042	4.892GlnGln: 4.892 ± 0.145	1.694GlnArg: 1.694 ± 0.035	3.484GlnSer: 3.484 ± 0.042	2.025GlnThr: 2.025 ± 0.028	2.253GlnVal: 2.253 ± 0.031	0.366GlnTrp: 0.366 ± 0.012	1.467GlnTyr: 1.467 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	1.882ArgAla: 1.882 ± 0.027	0.422ArgCys: 0.422 ± 0.013	2.046ArgAsp: 2.046 ± 0.024	2.317ArgGlu: 2.317 ± 0.035	1.781ArgPhe: 1.781 ± 0.027	1.838ArgGly: 1.838 ± 0.035	0.85ArgHis: 0.85 ± 0.017	2.746ArgIle: 2.746 ± 0.039	3.194ArgLys: 3.194 ± 0.037	3.629ArgLeu: 3.629 ± 0.035	0.793ArgMet: 0.793 ± 0.019	2.333ArgAsn: 2.333 ± 0.031	1.475ArgPro: 1.475 ± 0.025	1.594ArgGln: 1.594 ± 0.027	2.28ArgArg: 2.28 ± 0.038	3.184ArgSer: 3.184 ± 0.038	2.006ArgThr: 2.006 ± 0.026	2.04ArgVal: 2.04 ± 0.028	0.389ArgTrp: 0.389 ± 0.013	1.411ArgTyr: 1.411 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	4.268SerAla: 4.268 ± 0.09	0.873SerCys: 0.873 ± 0.02	4.663SerAsp: 4.663 ± 0.06	4.872SerGlu: 4.872 ± 0.069	3.86SerPhe: 3.86 ± 0.042	4.743SerGly: 4.743 ± 0.081	1.763SerHis: 1.763 ± 0.028	6.632SerIle: 6.632 ± 0.058	6.343SerLys: 6.343 ± 0.054	7.73SerLeu: 7.73 ± 0.063	1.672SerMet: 1.672 ± 0.023	6.021SerAsn: 6.021 ± 0.064	3.965SerPro: 3.965 ± 0.052	3.446SerGln: 3.446 ± 0.042	3.405SerArg: 3.405 ± 0.043	11.453SerSer: 11.453 ± 0.186	6.69SerThr: 6.69 ± 0.095	4.664SerVal: 4.664 ± 0.062	0.8SerTrp: 0.8 ± 0.018	2.737SerTyr: 2.737 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	3.109ThrAla: 3.109 ± 0.04	0.642ThrCys: 0.642 ± 0.016	2.889ThrAsp: 2.889 ± 0.047	3.276ThrGlu: 3.276 ± 0.06	2.426ThrPhe: 2.426 ± 0.038	3.288ThrGly: 3.288 ± 0.051	1.059ThrHis: 1.059 ± 0.019	4.347ThrIle: 4.347 ± 0.045	4.064ThrLys: 4.064 ± 0.04	4.78ThrLeu: 4.78 ± 0.044	1.031ThrMet: 1.031 ± 0.02	3.868ThrAsn: 3.868 ± 0.047	3.436ThrPro: 3.436 ± 0.054	1.921ThrGln: 1.921 ± 0.026	2.154ThrArg: 2.154 ± 0.033	6.095ThrSer: 6.095 ± 0.096	5.758ThrThr: 5.758 ± 0.145	3.391ThrVal: 3.391 ± 0.073	0.589ThrTrp: 0.589 ± 0.02	1.8ThrTyr: 1.8 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	3.254ValAla: 3.254 ± 0.042	0.643ValCys: 0.643 ± 0.016	3.603ValAsp: 3.603 ± 0.044	3.928ValGlu: 3.928 ± 0.051	2.54ValPhe: 2.54 ± 0.034	2.944ValGly: 2.944 ± 0.044	1.108ValHis: 1.108 ± 0.023	3.826ValIle: 3.826 ± 0.041	3.837ValLys: 3.837 ± 0.041	5.11ValLeu: 5.11 ± 0.046	1.094ValMet: 1.094 ± 0.023	3.174ValAsn: 3.174 ± 0.038	2.74ValPro: 2.74 ± 0.044	1.987ValGln: 1.987 ± 0.03	1.894ValArg: 1.894 ± 0.025	4.837ValSer: 4.837 ± 0.053	3.37ValThr: 3.37 ± 0.057	3.797ValVal: 3.797 ± 0.056	0.55ValTrp: 0.55 ± 0.014	1.99ValTyr: 1.99 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	0.457TrpAla: 0.457 ± 0.015	0.202TrpCys: 0.202 ± 0.009	0.6TrpAsp: 0.6 ± 0.018	0.559TrpGlu: 0.559 ± 0.015	0.545TrpPhe: 0.545 ± 0.014	0.522TrpGly: 0.522 ± 0.015	0.175TrpHis: 0.175 ± 0.009	0.736TrpIle: 0.736 ± 0.018	0.797TrpLys: 0.797 ± 0.018	0.946TrpLeu: 0.946 ± 0.022	0.21TrpMet: 0.21 ± 0.008	0.656TrpAsn: 0.656 ± 0.017	0.275TrpPro: 0.275 ± 0.01	0.309TrpGln: 0.309 ± 0.01	0.433TrpArg: 0.433 ± 0.013	0.787TrpSer: 0.787 ± 0.017	0.519TrpThr: 0.519 ± 0.018	0.547TrpVal: 0.547 ± 0.015	0.174TrpTrp: 0.174 ± 0.009	0.394TrpTyr: 0.394 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.618TyrAla: 1.618 ± 0.026	0.55TyrCys: 0.55 ± 0.014	2.29TyrAsp: 2.29 ± 0.033	2.134TyrGlu: 2.134 ± 0.028	1.807TyrPhe: 1.807 ± 0.032	1.994TyrGly: 1.994 ± 0.037	0.865TyrHis: 0.865 ± 0.019	2.387TyrIle: 2.387 ± 0.031	2.444TyrLys: 2.444 ± 0.031	3.633TyrLeu: 3.633 ± 0.043	0.663TyrMet: 0.663 ± 0.017	2.293TyrAsn: 2.293 ± 0.031	1.471TyrPro: 1.471 ± 0.024	1.587TyrGln: 1.587 ± 0.024	1.331TyrArg: 1.331 ± 0.022	2.856TyrSer: 2.856 ± 0.034	1.863TyrThr: 1.863 ± 0.03	1.856TyrVal: 1.856 ± 0.026	0.43TyrTrp: 0.43 ± 0.012	1.638TyrTyr: 1.638 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6226 proteins (3018650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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