Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA833K04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.104AlaAla: 5.104 ± 0.396
0.581AlaCys: 0.581 ± 0.122
3.58AlaAsp: 3.58 ± 0.306
5.951AlaGlu: 5.951 ± 0.433
2.903AlaPhe: 2.903 ± 0.287
5.564AlaGly: 5.564 ± 0.39
1.234AlaHis: 1.234 ± 0.183
5.781AlaIle: 5.781 ± 0.466
5.322AlaLys: 5.322 ± 0.384
7.136AlaLeu: 7.136 ± 0.479
1.669AlaMet: 1.669 ± 0.194
1.79AlaAsn: 1.79 ± 0.203
2.492AlaPro: 2.492 ± 0.234
1.863AlaGln: 1.863 ± 0.235
4.475AlaArg: 4.475 ± 0.349
4.451AlaSer: 4.451 ± 0.299
3.314AlaThr: 3.314 ± 0.287
4.862AlaVal: 4.862 ± 0.353
0.822AlaTrp: 0.822 ± 0.133
1.669AlaTyr: 1.669 ± 0.197
0.0AlaXaa: 0.0 ± 0.0
Cys
0.605CysAla: 0.605 ± 0.146
0.073CysCys: 0.073 ± 0.037
0.411CysAsp: 0.411 ± 0.106
1.04CysGlu: 1.04 ± 0.137
0.218CysPhe: 0.218 ± 0.075
1.209CysGly: 1.209 ± 0.222
0.121CysHis: 0.121 ± 0.067
0.435CysIle: 0.435 ± 0.095
0.556CysLys: 0.556 ± 0.152
0.46CysLeu: 0.46 ± 0.103
0.073CysMet: 0.073 ± 0.043
0.218CysAsn: 0.218 ± 0.066
0.581CysPro: 0.581 ± 0.154
0.218CysGln: 0.218 ± 0.064
0.46CysArg: 0.46 ± 0.095
0.46CysSer: 0.46 ± 0.098
0.435CysThr: 0.435 ± 0.107
0.629CysVal: 0.629 ± 0.144
0.194CysTrp: 0.194 ± 0.068
0.266CysTyr: 0.266 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
3.29AspAla: 3.29 ± 0.362
0.363AspCys: 0.363 ± 0.086
2.201AspAsp: 2.201 ± 0.266
5.056AspGlu: 5.056 ± 0.412
2.346AspPhe: 2.346 ± 0.254
3.725AspGly: 3.725 ± 0.312
0.822AspHis: 0.822 ± 0.167
3.58AspIle: 3.58 ± 0.341
3.145AspLys: 3.145 ± 0.254
6.023AspLeu: 6.023 ± 0.38
1.258AspMet: 1.258 ± 0.18
1.669AspAsn: 1.669 ± 0.232
2.733AspPro: 2.733 ± 0.269
1.524AspGln: 1.524 ± 0.161
2.709AspArg: 2.709 ± 0.316
2.467AspSer: 2.467 ± 0.21
2.419AspThr: 2.419 ± 0.287
4.548AspVal: 4.548 ± 0.337
0.774AspTrp: 0.774 ± 0.146
1.959AspTyr: 1.959 ± 0.226
0.0AspXaa: 0.0 ± 0.0
Glu
6.918GluAla: 6.918 ± 0.512
0.822GluCys: 0.822 ± 0.169
4.886GluAsp: 4.886 ± 0.326
12.337GluGlu: 12.337 ± 0.901
3.096GluPhe: 3.096 ± 0.307
6.144GluGly: 6.144 ± 0.396
1.33GluHis: 1.33 ± 0.194
6.821GluIle: 6.821 ± 0.491
8.37GluLys: 8.37 ± 0.478
9.579GluLeu: 9.579 ± 0.608
2.492GluMet: 2.492 ± 0.274
4.064GluAsn: 4.064 ± 0.404
2.467GluPro: 2.467 ± 0.293
1.427GluGln: 1.427 ± 0.212
5.757GluArg: 5.757 ± 0.414
4.79GluSer: 4.79 ± 0.333
3.556GluThr: 3.556 ± 0.263
7.813GluVal: 7.813 ± 0.465
0.774GluTrp: 0.774 ± 0.134
2.032GluTyr: 2.032 ± 0.245
0.0GluXaa: 0.0 ± 0.0
Phe
2.25PheAla: 2.25 ± 0.226
0.363PheCys: 0.363 ± 0.096
2.564PheAsp: 2.564 ± 0.236
3.048PheGlu: 3.048 ± 0.252
1.379PhePhe: 1.379 ± 0.2
3.096PheGly: 3.096 ± 0.253
0.605PheHis: 0.605 ± 0.117
1.959PheIle: 1.959 ± 0.241
2.371PheLys: 2.371 ± 0.254
3.628PheLeu: 3.628 ± 0.336
0.677PheMet: 0.677 ± 0.119
0.992PheAsn: 0.992 ± 0.179
1.064PhePro: 1.064 ± 0.167
0.701PheGln: 0.701 ± 0.128
2.08PheArg: 2.08 ± 0.217
2.322PheSer: 2.322 ± 0.323
1.887PheThr: 1.887 ± 0.224
2.25PheVal: 2.25 ± 0.244
0.387PheTrp: 0.387 ± 0.1
0.701PheTyr: 0.701 ± 0.128
0.0PheXaa: 0.0 ± 0.0
Gly
5.394GlyAla: 5.394 ± 0.465
0.605GlyCys: 0.605 ± 0.131
4.499GlyAsp: 4.499 ± 0.34
6.967GlyGlu: 6.967 ± 0.441
3.096GlyPhe: 3.096 ± 0.26
5.564GlyGly: 5.564 ± 0.407
1.403GlyHis: 1.403 ± 0.172
6.265GlyIle: 6.265 ± 0.403
6.047GlyLys: 6.047 ± 0.428
6.41GlyLeu: 6.41 ± 0.454
1.717GlyMet: 1.717 ± 0.22
2.008GlyAsn: 2.008 ± 0.222
1.814GlyPro: 1.814 ± 0.205
1.597GlyGln: 1.597 ± 0.173
4.572GlyArg: 4.572 ± 0.353
4.403GlySer: 4.403 ± 0.337
4.112GlyThr: 4.112 ± 0.383
6.362GlyVal: 6.362 ± 0.404
0.968GlyTrp: 0.968 ± 0.157
2.104GlyTyr: 2.104 ± 0.249
0.0GlyXaa: 0.0 ± 0.0
His
1.209HisAla: 1.209 ± 0.158
0.145HisCys: 0.145 ± 0.054
1.064HisAsp: 1.064 ± 0.144
1.427HisGlu: 1.427 ± 0.221
0.532HisPhe: 0.532 ± 0.099
1.137HisGly: 1.137 ± 0.193
0.363HisHis: 0.363 ± 0.093
0.992HisIle: 0.992 ± 0.156
0.774HisLys: 0.774 ± 0.14
1.717HisLeu: 1.717 ± 0.196
0.314HisMet: 0.314 ± 0.09
0.363HisAsn: 0.363 ± 0.097
1.04HisPro: 1.04 ± 0.175
0.629HisGln: 0.629 ± 0.128
1.161HisArg: 1.161 ± 0.174
1.089HisSer: 1.089 ± 0.194
0.822HisThr: 0.822 ± 0.158
1.33HisVal: 1.33 ± 0.186
0.218HisTrp: 0.218 ± 0.066
0.581HisTyr: 0.581 ± 0.123
0.0HisXaa: 0.0 ± 0.0
Ile
5.177IleAla: 5.177 ± 0.378
0.701IleCys: 0.701 ± 0.149
3.895IleAsp: 3.895 ± 0.313
6.434IleGlu: 6.434 ± 0.372
2.443IlePhe: 2.443 ± 0.311
5.902IleGly: 5.902 ± 0.401
1.403IleHis: 1.403 ± 0.186
5.128IleIle: 5.128 ± 0.45
4.572IleLys: 4.572 ± 0.367
6.918IleLeu: 6.918 ± 0.431
1.451IleMet: 1.451 ± 0.209
2.129IleAsn: 2.129 ± 0.212
3.604IlePro: 3.604 ± 0.311
2.177IleGln: 2.177 ± 0.244
4.499IleArg: 4.499 ± 0.35
4.814IleSer: 4.814 ± 0.402
3.435IleThr: 3.435 ± 0.308
4.499IleVal: 4.499 ± 0.328
0.508IleTrp: 0.508 ± 0.109
1.693IleTyr: 1.693 ± 0.183
0.0IleXaa: 0.0 ± 0.0
Lys
5.951LysAla: 5.951 ± 0.394
0.653LysCys: 0.653 ± 0.167
3.725LysAsp: 3.725 ± 0.356
6.918LysGlu: 6.918 ± 0.406
2.516LysPhe: 2.516 ± 0.255
5.031LysGly: 5.031 ± 0.362
1.234LysHis: 1.234 ± 0.163
6.313LysIle: 6.313 ± 0.409
6.604LysLys: 6.604 ± 0.491
7.571LysLeu: 7.571 ± 0.573
1.887LysMet: 1.887 ± 0.206
2.637LysAsn: 2.637 ± 0.223
2.903LysPro: 2.903 ± 0.268
1.5LysGln: 1.5 ± 0.194
4.886LysArg: 4.886 ± 0.413
4.717LysSer: 4.717 ± 0.388
3.87LysThr: 3.87 ± 0.301
5.418LysVal: 5.418 ± 0.398
0.822LysTrp: 0.822 ± 0.147
1.645LysTyr: 1.645 ± 0.201
0.0LysXaa: 0.0 ± 0.0
Leu
7.329LeuAla: 7.329 ± 0.378
0.847LeuCys: 0.847 ± 0.156
5.491LeuAsp: 5.491 ± 0.377
10.281LeuGlu: 10.281 ± 0.615
2.782LeuPhe: 2.782 ± 0.361
7.209LeuGly: 7.209 ± 0.507
1.355LeuHis: 1.355 ± 0.179
6.12LeuIle: 6.12 ± 0.453
7.692LeuLys: 7.692 ± 0.507
7.329LeuLeu: 7.329 ± 0.541
1.717LeuMet: 1.717 ± 0.196
3.266LeuAsn: 3.266 ± 0.269
4.499LeuPro: 4.499 ± 0.438
2.588LeuGln: 2.588 ± 0.251
5.878LeuArg: 5.878 ± 0.387
6.531LeuSer: 6.531 ± 0.441
4.862LeuThr: 4.862 ± 0.315
6.531LeuVal: 6.531 ± 0.4
0.919LeuTrp: 0.919 ± 0.158
2.104LeuTyr: 2.104 ± 0.232
0.0LeuXaa: 0.0 ± 0.0
Met
2.056MetAla: 2.056 ± 0.249
0.169MetCys: 0.169 ± 0.059
1.209MetAsp: 1.209 ± 0.16
1.645MetGlu: 1.645 ± 0.217
0.314MetPhe: 0.314 ± 0.096
1.863MetGly: 1.863 ± 0.213
0.194MetHis: 0.194 ± 0.06
1.621MetIle: 1.621 ± 0.204
2.129MetLys: 2.129 ± 0.221
1.597MetLeu: 1.597 ± 0.186
0.605MetMet: 0.605 ± 0.128
1.089MetAsn: 1.089 ± 0.143
1.04MetPro: 1.04 ± 0.166
0.46MetGln: 0.46 ± 0.107
1.379MetArg: 1.379 ± 0.193
1.597MetSer: 1.597 ± 0.183
1.621MetThr: 1.621 ± 0.188
1.427MetVal: 1.427 ± 0.179
0.194MetTrp: 0.194 ± 0.071
0.314MetTyr: 0.314 ± 0.087
0.0MetXaa: 0.0 ± 0.0
Asn
2.129AsnAla: 2.129 ± 0.234
0.363AsnCys: 0.363 ± 0.093
1.427AsnAsp: 1.427 ± 0.182
2.443AsnGlu: 2.443 ± 0.281
1.306AsnPhe: 1.306 ± 0.192
1.597AsnGly: 1.597 ± 0.209
0.46AsnHis: 0.46 ± 0.102
2.322AsnIle: 2.322 ± 0.258
2.177AsnLys: 2.177 ± 0.244
4.088AsnLeu: 4.088 ± 0.262
0.701AsnMet: 0.701 ± 0.129
0.726AsnAsn: 0.726 ± 0.144
2.056AsnPro: 2.056 ± 0.198
1.234AsnGln: 1.234 ± 0.182
1.766AsnArg: 1.766 ± 0.193
1.959AsnSer: 1.959 ± 0.235
1.427AsnThr: 1.427 ± 0.199
2.492AsnVal: 2.492 ± 0.237
0.532AsnTrp: 0.532 ± 0.13
1.306AsnTyr: 1.306 ± 0.176
0.0AsnXaa: 0.0 ± 0.0
Pro
2.225ProAla: 2.225 ± 0.206
0.387ProCys: 0.387 ± 0.101
2.564ProAsp: 2.564 ± 0.259
5.152ProGlu: 5.152 ± 0.485
1.33ProPhe: 1.33 ± 0.173
2.83ProGly: 2.83 ± 0.295
0.822ProHis: 0.822 ± 0.147
2.83ProIle: 2.83 ± 0.271
3.241ProLys: 3.241 ± 0.271
3.145ProLeu: 3.145 ± 0.294
0.919ProMet: 0.919 ± 0.157
1.161ProAsn: 1.161 ± 0.181
1.742ProPro: 1.742 ± 0.179
1.04ProGln: 1.04 ± 0.167
2.346ProArg: 2.346 ± 0.289
2.443ProSer: 2.443 ± 0.223
1.742ProThr: 1.742 ± 0.19
2.661ProVal: 2.661 ± 0.331
0.435ProTrp: 0.435 ± 0.099
1.306ProTyr: 1.306 ± 0.176
0.0ProXaa: 0.0 ± 0.0
Gln
2.008GlnAla: 2.008 ± 0.231
0.073GlnCys: 0.073 ± 0.035
1.79GlnAsp: 1.79 ± 0.226
2.395GlnGlu: 2.395 ± 0.273
0.653GlnPhe: 0.653 ± 0.13
1.717GlnGly: 1.717 ± 0.193
0.435GlnHis: 0.435 ± 0.107
1.935GlnIle: 1.935 ± 0.181
2.08GlnLys: 2.08 ± 0.226
2.274GlnLeu: 2.274 ± 0.241
0.581GlnMet: 0.581 ± 0.116
1.185GlnAsn: 1.185 ± 0.168
0.798GlnPro: 0.798 ± 0.114
0.605GlnGln: 0.605 ± 0.122
1.79GlnArg: 1.79 ± 0.218
1.306GlnSer: 1.306 ± 0.179
1.597GlnThr: 1.597 ± 0.216
2.008GlnVal: 2.008 ± 0.241
0.145GlnTrp: 0.145 ± 0.066
0.581GlnTyr: 0.581 ± 0.111
0.0GlnXaa: 0.0 ± 0.0
Arg
3.895ArgAla: 3.895 ± 0.348
0.46ArgCys: 0.46 ± 0.11
3.145ArgAsp: 3.145 ± 0.341
6.072ArgGlu: 6.072 ± 0.44
1.814ArgPhe: 1.814 ± 0.26
5.225ArgGly: 5.225 ± 0.289
1.064ArgHis: 1.064 ± 0.171
4.644ArgIle: 4.644 ± 0.315
5.467ArgLys: 5.467 ± 0.381
5.951ArgLeu: 5.951 ± 0.336
1.548ArgMet: 1.548 ± 0.205
1.524ArgAsn: 1.524 ± 0.209
1.863ArgPro: 1.863 ± 0.196
1.597ArgGln: 1.597 ± 0.182
4.62ArgArg: 4.62 ± 0.366
3.072ArgSer: 3.072 ± 0.278
2.782ArgThr: 2.782 ± 0.252
4.378ArgVal: 4.378 ± 0.44
0.701ArgTrp: 0.701 ± 0.138
1.742ArgTyr: 1.742 ± 0.2
0.0ArgXaa: 0.0 ± 0.0
Ser
3.483SerAla: 3.483 ± 0.31
0.532SerCys: 0.532 ± 0.114
2.588SerAsp: 2.588 ± 0.251
5.83SerGlu: 5.83 ± 0.367
2.395SerPhe: 2.395 ± 0.277
5.66SerGly: 5.66 ± 0.416
1.282SerHis: 1.282 ± 0.18
3.677SerIle: 3.677 ± 0.37
4.886SerLys: 4.886 ± 0.352
5.66SerLeu: 5.66 ± 0.379
1.5SerMet: 1.5 ± 0.208
1.717SerAsn: 1.717 ± 0.239
2.588SerPro: 2.588 ± 0.271
2.08SerGln: 2.08 ± 0.234
3.604SerArg: 3.604 ± 0.347
3.483SerSer: 3.483 ± 0.29
3.145SerThr: 3.145 ± 0.292
4.161SerVal: 4.161 ± 0.38
0.943SerTrp: 0.943 ± 0.132
1.645SerTyr: 1.645 ± 0.219
0.0SerXaa: 0.0 ± 0.0
Thr
3.29ThrAla: 3.29 ± 0.278
0.363ThrCys: 0.363 ± 0.089
1.838ThrAsp: 1.838 ± 0.25
3.338ThrGlu: 3.338 ± 0.304
1.282ThrPhe: 1.282 ± 0.185
3.919ThrGly: 3.919 ± 0.363
1.137ThrHis: 1.137 ± 0.146
4.403ThrIle: 4.403 ± 0.308
3.096ThrLys: 3.096 ± 0.295
5.273ThrLeu: 5.273 ± 0.39
1.089ThrMet: 1.089 ± 0.155
1.572ThrAsn: 1.572 ± 0.196
2.661ThrPro: 2.661 ± 0.256
1.451ThrGln: 1.451 ± 0.208
2.927ThrArg: 2.927 ± 0.262
3.072ThrSer: 3.072 ± 0.274
2.685ThrThr: 2.685 ± 0.277
3.435ThrVal: 3.435 ± 0.326
0.387ThrTrp: 0.387 ± 0.1
1.524ThrTyr: 1.524 ± 0.182
0.0ThrXaa: 0.0 ± 0.0
Val
5.612ValAla: 5.612 ± 0.453
0.847ValCys: 0.847 ± 0.139
4.088ValAsp: 4.088 ± 0.321
6.144ValGlu: 6.144 ± 0.37
2.225ValPhe: 2.225 ± 0.255
5.709ValGly: 5.709 ± 0.438
1.089ValHis: 1.089 ± 0.161
5.031ValIle: 5.031 ± 0.347
5.806ValLys: 5.806 ± 0.37
6.894ValLeu: 6.894 ± 0.454
1.597ValMet: 1.597 ± 0.2
2.927ValAsn: 2.927 ± 0.271
2.854ValPro: 2.854 ± 0.321
1.959ValGln: 1.959 ± 0.233
3.846ValArg: 3.846 ± 0.308
5.298ValSer: 5.298 ± 0.349
3.58ValThr: 3.58 ± 0.289
4.838ValVal: 4.838 ± 0.436
0.653ValTrp: 0.653 ± 0.119
1.548ValTyr: 1.548 ± 0.211
0.0ValXaa: 0.0 ± 0.0
Trp
0.605TrpAla: 0.605 ± 0.125
0.097TrpCys: 0.097 ± 0.05
0.363TrpAsp: 0.363 ± 0.104
0.701TrpGlu: 0.701 ± 0.119
0.677TrpPhe: 0.677 ± 0.14
0.75TrpGly: 0.75 ± 0.144
0.169TrpHis: 0.169 ± 0.066
0.726TrpIle: 0.726 ± 0.138
0.871TrpLys: 0.871 ± 0.143
1.064TrpLeu: 1.064 ± 0.178
0.242TrpMet: 0.242 ± 0.082
0.605TrpAsn: 0.605 ± 0.133
0.556TrpPro: 0.556 ± 0.128
0.29TrpGln: 0.29 ± 0.071
0.677TrpArg: 0.677 ± 0.13
0.968TrpSer: 0.968 ± 0.15
0.363TrpThr: 0.363 ± 0.092
0.919TrpVal: 0.919 ± 0.155
0.121TrpTrp: 0.121 ± 0.049
0.363TrpTyr: 0.363 ± 0.104
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.032TyrAla: 2.032 ± 0.214
0.218TyrCys: 0.218 ± 0.068
1.282TyrAsp: 1.282 ± 0.188
2.298TyrGlu: 2.298 ± 0.249
1.016TyrPhe: 1.016 ± 0.137
2.056TyrGly: 2.056 ± 0.242
0.387TyrHis: 0.387 ± 0.083
0.798TyrIle: 0.798 ± 0.151
1.597TyrLys: 1.597 ± 0.199
2.637TyrLeu: 2.637 ± 0.316
0.46TyrMet: 0.46 ± 0.106
0.871TyrAsn: 0.871 ± 0.137
0.968TyrPro: 0.968 ± 0.121
1.016TyrGln: 1.016 ± 0.136
2.129TyrArg: 2.129 ± 0.228
1.621TyrSer: 1.621 ± 0.169
1.089TyrThr: 1.089 ± 0.166
1.984TyrVal: 1.984 ± 0.227
0.629TyrTrp: 0.629 ± 0.126
0.798TyrTyr: 0.798 ± 0.138
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 196 proteins (41341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski