Amino acid dipepetide frequency for Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.275AlaAla: 8.275 ± 0.06	0.934AlaCys: 0.934 ± 0.016	3.901AlaAsp: 3.901 ± 0.03	5.001AlaGlu: 5.001 ± 0.044	2.805AlaPhe: 2.805 ± 0.026	5.437AlaGly: 5.437 ± 0.04	1.668AlaHis: 1.668 ± 0.019	4.019AlaIle: 4.019 ± 0.032	3.908AlaLys: 3.908 ± 0.035	6.976AlaLeu: 6.976 ± 0.048	1.733AlaMet: 1.733 ± 0.02	2.813AlaAsn: 2.813 ± 0.026	4.441AlaPro: 4.441 ± 0.037	3.133AlaGln: 3.133 ± 0.031	4.767AlaArg: 4.767 ± 0.03	7.003AlaSer: 7.003 ± 0.048	5.027AlaThr: 5.027 ± 0.032	4.87AlaVal: 4.87 ± 0.037	0.928AlaTrp: 0.928 ± 0.016	1.844AlaTyr: 1.844 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.855CysAla: 0.855 ± 0.015	0.255CysCys: 0.255 ± 0.008	0.614CysAsp: 0.614 ± 0.014	0.632CysGlu: 0.632 ± 0.013	0.506CysPhe: 0.506 ± 0.01	0.951CysGly: 0.951 ± 0.017	0.342CysHis: 0.342 ± 0.01	0.742CysIle: 0.742 ± 0.013	0.53CysLys: 0.53 ± 0.014	1.265CysLeu: 1.265 ± 0.018	0.268CysMet: 0.268 ± 0.008	0.42CysAsn: 0.42 ± 0.01	0.706CysPro: 0.706 ± 0.015	0.462CysGln: 0.462 ± 0.012	0.796CysArg: 0.796 ± 0.013	0.978CysSer: 0.978 ± 0.018	0.669CysThr: 0.669 ± 0.013	0.712CysVal: 0.712 ± 0.012	0.189CysTrp: 0.189 ± 0.007	0.346CysTyr: 0.346 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.173AspAla: 4.173 ± 0.036	0.614AspCys: 0.614 ± 0.011	4.328AspAsp: 4.328 ± 0.054	4.389AspGlu: 4.389 ± 0.039	2.128AspPhe: 2.128 ± 0.019	4.062AspGly: 4.062 ± 0.033	1.218AspHis: 1.218 ± 0.018	3.312AspIle: 3.312 ± 0.031	2.363AspLys: 2.363 ± 0.026	4.749AspLeu: 4.749 ± 0.037	1.251AspMet: 1.251 ± 0.016	2.032AspAsn: 2.032 ± 0.024	3.214AspPro: 3.214 ± 0.028	1.793AspGln: 1.793 ± 0.021	3.128AspArg: 3.128 ± 0.033	4.29AspSer: 4.29 ± 0.04	2.891AspThr: 2.891 ± 0.027	3.427AspVal: 3.427 ± 0.033	0.801AspTrp: 0.801 ± 0.019	1.495AspTyr: 1.495 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	4.93GluAla: 4.93 ± 0.042	0.667GluCys: 0.667 ± 0.012	4.121GluAsp: 4.121 ± 0.038	5.541GluGlu: 5.541 ± 0.055	1.983GluPhe: 1.983 ± 0.022	3.741GluGly: 3.741 ± 0.032	1.434GluHis: 1.434 ± 0.018	3.312GluIle: 3.312 ± 0.031	4.137GluLys: 4.137 ± 0.043	5.23GluLeu: 5.23 ± 0.041	1.538GluMet: 1.538 ± 0.02	2.547GluAsn: 2.547 ± 0.024	2.947GluPro: 2.947 ± 0.046	2.463GluGln: 2.463 ± 0.026	4.265GluArg: 4.265 ± 0.041	4.414GluSer: 4.414 ± 0.038	3.401GluThr: 3.401 ± 0.03	3.422GluVal: 3.422 ± 0.029	0.828GluTrp: 0.828 ± 0.014	1.699GluTyr: 1.699 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	2.685PheAla: 2.685 ± 0.024	0.555PheCys: 0.555 ± 0.011	2.188PheAsp: 2.188 ± 0.026	2.19PheGlu: 2.19 ± 0.024	1.482PhePhe: 1.482 ± 0.021	2.609PheGly: 2.609 ± 0.03	0.928PheHis: 0.928 ± 0.015	1.767PheIle: 1.767 ± 0.022	1.541PheLys: 1.541 ± 0.02	3.376PheLeu: 3.376 ± 0.034	0.719PheMet: 0.719 ± 0.014	1.468PheAsn: 1.468 ± 0.021	2.021PhePro: 2.021 ± 0.022	1.405PheGln: 1.405 ± 0.019	2.034PheArg: 2.034 ± 0.02	3.209PheSer: 3.209 ± 0.025	2.114PheThr: 2.114 ± 0.022	2.24PheVal: 2.24 ± 0.023	0.56PheTrp: 0.56 ± 0.011	1.029PheTyr: 1.029 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	4.832GlyAla: 4.832 ± 0.042	0.817GlyCys: 0.817 ± 0.014	3.677GlyAsp: 3.677 ± 0.032	3.841GlyGlu: 3.841 ± 0.028	2.619GlyPhe: 2.619 ± 0.028	6.153GlyGly: 6.153 ± 0.061	1.634GlyHis: 1.634 ± 0.021	3.425GlyIle: 3.425 ± 0.033	3.531GlyLys: 3.531 ± 0.033	5.554GlyLeu: 5.554 ± 0.035	1.648GlyMet: 1.648 ± 0.019	2.644GlyAsn: 2.644 ± 0.03	3.25GlyPro: 3.25 ± 0.034	2.445GlyGln: 2.445 ± 0.023	4.312GlyArg: 4.312 ± 0.038	5.811GlySer: 5.811 ± 0.043	3.764GlyThr: 3.764 ± 0.031	4.154GlyVal: 4.154 ± 0.034	1.048GlyTrp: 1.048 ± 0.016	2.002GlyTyr: 2.002 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.817HisAla: 1.817 ± 0.022	0.344HisCys: 0.344 ± 0.009	1.304HisAsp: 1.304 ± 0.017	1.268HisGlu: 1.268 ± 0.019	0.973HisPhe: 0.973 ± 0.013	1.677HisGly: 1.677 ± 0.023	0.99HisHis: 0.99 ± 0.02	1.278HisIle: 1.278 ± 0.018	0.931HisLys: 0.931 ± 0.015	2.273HisLeu: 2.273 ± 0.024	0.483HisMet: 0.483 ± 0.011	0.963HisAsn: 0.963 ± 0.014	1.886HisPro: 1.886 ± 0.022	1.177HisGln: 1.177 ± 0.019	1.7HisArg: 1.7 ± 0.022	2.179HisSer: 2.179 ± 0.024	1.315HisThr: 1.315 ± 0.018	1.401HisVal: 1.401 ± 0.02	0.298HisTrp: 0.298 ± 0.008	0.676HisTyr: 0.676 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	3.835IleAla: 3.835 ± 0.032	0.771IleCys: 0.771 ± 0.013	2.934IleAsp: 2.934 ± 0.029	2.995IleGlu: 2.995 ± 0.028	2.075IlePhe: 2.075 ± 0.025	3.011IleGly: 3.011 ± 0.027	1.272IleHis: 1.272 ± 0.017	2.728IleIle: 2.728 ± 0.028	2.263IleLys: 2.263 ± 0.026	4.779IleLeu: 4.779 ± 0.037	1.012IleMet: 1.012 ± 0.015	1.89IleAsn: 1.89 ± 0.018	3.448IlePro: 3.448 ± 0.031	2.003IleGln: 2.003 ± 0.02	2.979IleArg: 2.979 ± 0.023	4.458IleSer: 4.458 ± 0.033	2.903IleThr: 2.903 ± 0.027	2.939IleVal: 2.939 ± 0.027	0.7IleTrp: 0.7 ± 0.014	1.425IleTyr: 1.425 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	3.972LysAla: 3.972 ± 0.034	0.585LysCys: 0.585 ± 0.013	2.694LysAsp: 2.694 ± 0.026	3.547LysGlu: 3.547 ± 0.032	1.557LysPhe: 1.557 ± 0.02	2.99LysGly: 2.99 ± 0.026	1.157LysHis: 1.157 ± 0.016	2.51LysIle: 2.51 ± 0.025	3.738LysLys: 3.738 ± 0.059	4.34LysLeu: 4.34 ± 0.036	1.102LysMet: 1.102 ± 0.015	1.969LysAsn: 1.969 ± 0.022	2.989LysPro: 2.989 ± 0.029	2.02LysGln: 2.02 ± 0.022	3.769LysArg: 3.769 ± 0.033	3.87LysSer: 3.87 ± 0.033	2.764LysThr: 2.764 ± 0.024	2.701LysVal: 2.701 ± 0.028	0.643LysTrp: 0.643 ± 0.015	1.435LysTyr: 1.435 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	7.141LeuAla: 7.141 ± 0.047	1.193LeuCys: 1.193 ± 0.015	4.948LeuAsp: 4.948 ± 0.033	5.538LeuGlu: 5.538 ± 0.042	3.346LeuPhe: 3.346 ± 0.034	5.553LeuGly: 5.553 ± 0.044	2.328LeuHis: 2.328 ± 0.024	3.953LeuIle: 3.953 ± 0.033	4.47LeuLys: 4.47 ± 0.037	8.367LeuLeu: 8.367 ± 0.067	1.71LeuMet: 1.71 ± 0.021	3.284LeuAsn: 3.284 ± 0.025	5.485LeuPro: 5.485 ± 0.04	3.867LeuGln: 3.867 ± 0.037	5.804LeuArg: 5.804 ± 0.042	7.645LeuSer: 7.645 ± 0.043	4.728LeuThr: 4.728 ± 0.037	4.925LeuVal: 4.925 ± 0.04	1.094LeuTrp: 1.094 ± 0.019	2.257LeuTyr: 2.257 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	1.988MetAla: 1.988 ± 0.021	0.232MetCys: 0.232 ± 0.007	1.232MetAsp: 1.232 ± 0.017	1.434MetGlu: 1.434 ± 0.022	0.682MetPhe: 0.682 ± 0.013	1.479MetGly: 1.479 ± 0.019	0.467MetHis: 0.467 ± 0.01	1.018MetIle: 1.018 ± 0.015	1.147MetLys: 1.147 ± 0.017	1.751MetLeu: 1.751 ± 0.022	0.569MetMet: 0.569 ± 0.011	0.855MetAsn: 0.855 ± 0.014	1.183MetPro: 1.183 ± 0.017	0.851MetGln: 0.851 ± 0.013	1.298MetArg: 1.298 ± 0.018	1.844MetSer: 1.844 ± 0.019	1.249MetThr: 1.249 ± 0.016	1.228MetVal: 1.228 ± 0.017	0.248MetTrp: 0.248 ± 0.007	0.48MetTyr: 0.48 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.97AsnAla: 2.97 ± 0.026	0.462AsnCys: 0.462 ± 0.015	2.116AsnAsp: 2.116 ± 0.024	2.234AsnGlu: 2.234 ± 0.022	1.363AsnPhe: 1.363 ± 0.015	3.032AsnGly: 3.032 ± 0.033	0.966AsnHis: 0.966 ± 0.014	2.281AsnIle: 2.281 ± 0.024	1.702AsnLys: 1.702 ± 0.021	3.466AsnLeu: 3.466 ± 0.03	0.838AsnMet: 0.838 ± 0.012	2.039AsnAsn: 2.039 ± 0.031	2.74AsnPro: 2.74 ± 0.027	1.461AsnGln: 1.461 ± 0.022	2.242AsnArg: 2.242 ± 0.024	3.257AsnSer: 3.257 ± 0.031	2.319AsnThr: 2.319 ± 0.025	2.213AsnVal: 2.213 ± 0.025	0.498AsnTrp: 0.498 ± 0.011	1.055AsnTyr: 1.055 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.107ProAla: 5.107 ± 0.048	0.555ProCys: 0.555 ± 0.012	3.16ProAsp: 3.16 ± 0.025	3.833ProGlu: 3.833 ± 0.038	2.07ProPhe: 2.07 ± 0.024	3.919ProGly: 3.919 ± 0.038	1.575ProHis: 1.575 ± 0.022	2.722ProIle: 2.722 ± 0.028	2.711ProLys: 2.711 ± 0.025	4.934ProLeu: 4.934 ± 0.035	1.023ProMet: 1.023 ± 0.015	2.434ProAsn: 2.434 ± 0.025	6.143ProPro: 6.143 ± 0.073	2.715ProGln: 2.715 ± 0.033	3.635ProArg: 3.635 ± 0.034	6.756ProSer: 6.756 ± 0.055	4.385ProThr: 4.385 ± 0.039	3.478ProVal: 3.478 ± 0.03	0.648ProTrp: 0.648 ± 0.012	1.528ProTyr: 1.528 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.167GlnAla: 3.167 ± 0.029	0.471GlnCys: 0.471 ± 0.011	1.959GlnAsp: 1.959 ± 0.023	2.389GlnGlu: 2.389 ± 0.026	1.321GlnPhe: 1.321 ± 0.017	2.317GlnGly: 2.317 ± 0.025	1.224GlnHis: 1.224 ± 0.02	1.977GlnIle: 1.977 ± 0.021	2.164GlnLys: 2.164 ± 0.022	3.495GlnLeu: 3.495 ± 0.032	0.885GlnMet: 0.885 ± 0.014	1.848GlnAsn: 1.848 ± 0.024	2.864GlnPro: 2.864 ± 0.035	3.046GlnGln: 3.046 ± 0.067	2.869GlnArg: 2.869 ± 0.028	3.258GlnSer: 3.258 ± 0.032	2.222GlnThr: 2.222 ± 0.024	1.996GlnVal: 1.996 ± 0.022	0.49GlnTrp: 0.49 ± 0.012	1.083GlnTyr: 1.083 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	4.603ArgAla: 4.603 ± 0.034	0.768ArgCys: 0.768 ± 0.013	3.492ArgAsp: 3.492 ± 0.031	4.185ArgGlu: 4.185 ± 0.04	2.183ArgPhe: 2.183 ± 0.023	4.166ArgGly: 4.166 ± 0.04	1.652ArgHis: 1.652 ± 0.019	3.06ArgIle: 3.06 ± 0.029	3.773ArgLys: 3.773 ± 0.031	5.531ArgLeu: 5.531 ± 0.039	1.339ArgMet: 1.339 ± 0.02	2.563ArgAsn: 2.563 ± 0.025	3.674ArgPro: 3.674 ± 0.032	2.753ArgGln: 2.753 ± 0.025	5.676ArgArg: 5.676 ± 0.049	5.362ArgSer: 5.362 ± 0.054	3.395ArgThr: 3.395 ± 0.031	3.39ArgVal: 3.39 ± 0.027	0.942ArgTrp: 0.942 ± 0.017	1.684ArgTyr: 1.684 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.619SerAla: 6.619 ± 0.041	0.896SerCys: 0.896 ± 0.016	4.214SerAsp: 4.214 ± 0.034	4.387SerGlu: 4.387 ± 0.038	3.154SerPhe: 3.154 ± 0.028	5.692SerGly: 5.692 ± 0.04	2.246SerHis: 2.246 ± 0.026	4.232SerIle: 4.232 ± 0.033	4.066SerLys: 4.066 ± 0.039	7.473SerLeu: 7.473 ± 0.046	1.795SerMet: 1.795 ± 0.023	3.462SerAsn: 3.462 ± 0.033	6.285SerPro: 6.285 ± 0.057	3.61SerGln: 3.61 ± 0.036	5.692SerArg: 5.692 ± 0.049	10.388SerSer: 10.388 ± 0.083	6.122SerThr: 6.122 ± 0.042	4.515SerVal: 4.515 ± 0.033	1.007SerTrp: 1.007 ± 0.016	2.087SerTyr: 2.087 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.124ThrAla: 5.124 ± 0.038	0.719ThrCys: 0.719 ± 0.014	2.785ThrAsp: 2.785 ± 0.023	3.115ThrGlu: 3.115 ± 0.028	2.12ThrPhe: 2.12 ± 0.019	3.939ThrGly: 3.939 ± 0.031	1.349ThrHis: 1.349 ± 0.017	3.084ThrIle: 3.084 ± 0.029	2.617ThrLys: 2.617 ± 0.028	5.111ThrLeu: 5.111 ± 0.038	1.173ThrMet: 1.173 ± 0.017	2.208ThrAsn: 2.208 ± 0.023	4.581ThrPro: 4.581 ± 0.041	2.135ThrGln: 2.135 ± 0.025	3.306ThrArg: 3.306 ± 0.029	5.702ThrSer: 5.702 ± 0.044	4.881ThrThr: 4.881 ± 0.049	3.521ThrVal: 3.521 ± 0.029	0.682ThrTrp: 0.682 ± 0.012	1.526ThrTyr: 1.526 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	4.537ValAla: 4.537 ± 0.035	0.752ValCys: 0.752 ± 0.013	3.568ValAsp: 3.568 ± 0.032	3.84ValGlu: 3.84 ± 0.033	2.177ValPhe: 2.177 ± 0.025	3.782ValGly: 3.782 ± 0.035	1.371ValHis: 1.371 ± 0.02	2.863ValIle: 2.863 ± 0.03	2.872ValLys: 2.872 ± 0.029	5.174ValLeu: 5.174 ± 0.037	1.23ValMet: 1.23 ± 0.019	2.182ValAsn: 2.182 ± 0.022	3.368ValPro: 3.368 ± 0.026	2.145ValGln: 2.145 ± 0.024	3.38ValArg: 3.38 ± 0.028	4.514ValSer: 4.514 ± 0.034	3.246ValThr: 3.246 ± 0.028	3.871ValVal: 3.871 ± 0.036	0.812ValTrp: 0.812 ± 0.014	1.564ValTyr: 1.564 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	0.972TrpAla: 0.972 ± 0.016	0.256TrpCys: 0.256 ± 0.015	0.798TrpAsp: 0.798 ± 0.023	0.805TrpGlu: 0.805 ± 0.013	0.445TrpPhe: 0.445 ± 0.01	0.804TrpGly: 0.804 ± 0.015	0.331TrpHis: 0.331 ± 0.008	0.696TrpIle: 0.696 ± 0.013	0.824TrpLys: 0.824 ± 0.017	1.23TrpLeu: 1.23 ± 0.017	0.315TrpMet: 0.315 ± 0.008	0.567TrpAsn: 0.567 ± 0.012	0.523TrpPro: 0.523 ± 0.011	0.484TrpGln: 0.484 ± 0.01	0.921TrpArg: 0.921 ± 0.014	0.931TrpSer: 0.931 ± 0.016	0.78TrpThr: 0.78 ± 0.013	0.749TrpVal: 0.749 ± 0.014	0.236TrpTrp: 0.236 ± 0.008	0.344TrpTyr: 0.344 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.884TyrAla: 1.884 ± 0.022	0.392TyrCys: 0.392 ± 0.01	1.627TyrAsp: 1.627 ± 0.022	1.456TyrGlu: 1.456 ± 0.018	1.136TyrPhe: 1.136 ± 0.016	1.849TyrGly: 1.849 ± 0.023	0.78TyrHis: 0.78 ± 0.014	1.44TyrIle: 1.44 ± 0.017	1.064TyrLys: 1.064 ± 0.016	2.562TyrLeu: 2.562 ± 0.028	0.601TyrMet: 0.601 ± 0.012	1.067TyrAsn: 1.067 ± 0.017	1.579TyrPro: 1.579 ± 0.03	1.078TyrGln: 1.078 ± 0.016	1.62TyrArg: 1.62 ± 0.02	2.071TyrSer: 2.071 ± 0.025	1.5TyrThr: 1.5 ± 0.019	1.497TyrVal: 1.497 ± 0.022	0.355TyrTrp: 0.355 ± 0.009	0.879TyrTyr: 0.879 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10398 proteins (4587642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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