Amino acid dipepetide frequency for Cimex lectularius (Bed bug) (Acanthia lectularia)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.325AlaAla: 4.325 ± 0.045
1.106AlaCys: 1.106 ± 0.025
2.737AlaAsp: 2.737 ± 0.025
3.673AlaGlu: 3.673 ± 0.03
2.356AlaPhe: 2.356 ± 0.023
3.314AlaGly: 3.314 ± 0.031
1.366AlaHis: 1.366 ± 0.014
3.541AlaIle: 3.541 ± 0.029
3.879AlaLys: 3.879 ± 0.03
5.694AlaLeu: 5.694 ± 0.042
1.496AlaMet: 1.496 ± 0.02
2.515AlaAsn: 2.515 ± 0.024
2.6AlaPro: 2.6 ± 0.035
2.244AlaGln: 2.244 ± 0.026
2.771AlaArg: 2.771 ± 0.025
4.218AlaSer: 4.218 ± 0.032
3.196AlaThr: 3.196 ± 0.027
4.207AlaVal: 4.207 ± 0.036
0.593AlaTrp: 0.593 ± 0.011
1.751AlaTyr: 1.751 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
1.031CysAla: 1.031 ± 0.016
0.468CysCys: 0.468 ± 0.011
1.114CysAsp: 1.114 ± 0.025
1.168CysGlu: 1.168 ± 0.022
0.863CysPhe: 0.863 ± 0.013
1.358CysGly: 1.358 ± 0.034
0.535CysHis: 0.535 ± 0.011
1.176CysIle: 1.176 ± 0.023
1.258CysLys: 1.258 ± 0.024
1.968CysLeu: 1.968 ± 0.027
0.398CysMet: 0.398 ± 0.008
0.939CysAsn: 0.939 ± 0.021
1.074CysPro: 1.074 ± 0.035
0.777CysGln: 0.777 ± 0.022
1.028CysArg: 1.028 ± 0.031
1.631CysSer: 1.631 ± 0.032
1.094CysThr: 1.094 ± 0.021
1.205CysVal: 1.205 ± 0.028
0.241CysTrp: 0.241 ± 0.006
0.63CysTyr: 0.63 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
2.604AspAla: 2.604 ± 0.024
1.041AspCys: 1.041 ± 0.021
3.301AspAsp: 3.301 ± 0.035
4.038AspGlu: 4.038 ± 0.036
2.347AspPhe: 2.347 ± 0.024
3.073AspGly: 3.073 ± 0.031
1.142AspHis: 1.142 ± 0.018
3.533AspIle: 3.533 ± 0.029
3.498AspLys: 3.498 ± 0.034
4.907AspLeu: 4.907 ± 0.037
1.301AspMet: 1.301 ± 0.015
2.48AspAsn: 2.48 ± 0.025
2.424AspPro: 2.424 ± 0.034
1.632AspGln: 1.632 ± 0.018
2.423AspArg: 2.423 ± 0.029
3.9AspSer: 3.9 ± 0.032
2.559AspThr: 2.559 ± 0.024
3.588AspVal: 3.588 ± 0.03
0.675AspTrp: 0.675 ± 0.011
1.878AspTyr: 1.878 ± 0.021
0.0AspXaa: 0.0 ± 0.0
Glu
3.899GluAla: 3.899 ± 0.034
1.215GluCys: 1.215 ± 0.036
3.878GluAsp: 3.878 ± 0.033
6.273GluGlu: 6.273 ± 0.076
2.358GluPhe: 2.358 ± 0.022
3.527GluGly: 3.527 ± 0.03
1.399GluHis: 1.399 ± 0.019
4.08GluIle: 4.08 ± 0.028
5.738GluLys: 5.738 ± 0.049
5.887GluLeu: 5.887 ± 0.044
1.8GluMet: 1.8 ± 0.019
3.686GluAsn: 3.686 ± 0.029
2.528GluPro: 2.528 ± 0.033
2.49GluGln: 2.49 ± 0.028
3.842GluArg: 3.842 ± 0.041
4.356GluSer: 4.356 ± 0.037
3.536GluThr: 3.536 ± 0.034
4.149GluVal: 4.149 ± 0.038
0.701GluTrp: 0.701 ± 0.011
1.978GluTyr: 1.978 ± 0.019
0.0GluXaa: 0.0 ± 0.0
Phe
2.237PheAla: 2.237 ± 0.02
0.926PheCys: 0.926 ± 0.014
2.249PheAsp: 2.249 ± 0.023
2.362PheGlu: 2.362 ± 0.025
1.98PhePhe: 1.98 ± 0.022
2.607PheGly: 2.607 ± 0.036
1.088PheHis: 1.088 ± 0.013
2.607PheIle: 2.607 ± 0.025
2.6PheLys: 2.6 ± 0.024
4.11PheLeu: 4.11 ± 0.035
0.975PheMet: 0.975 ± 0.014
2.102PheAsn: 2.102 ± 0.022
1.915PhePro: 1.915 ± 0.02
1.574PheGln: 1.574 ± 0.017
1.942PheArg: 1.942 ± 0.02
3.455PheSer: 3.455 ± 0.033
2.419PheThr: 2.419 ± 0.021
2.709PheVal: 2.709 ± 0.03
0.479PheTrp: 0.479 ± 0.01
1.536PheTyr: 1.536 ± 0.017
0.0PheXaa: 0.0 ± 0.0
Gly
3.187GlyAla: 3.187 ± 0.034
1.076GlyCys: 1.076 ± 0.02
2.971GlyAsp: 2.971 ± 0.034
3.629GlyGlu: 3.629 ± 0.039
2.553GlyPhe: 2.553 ± 0.022
4.712GlyGly: 4.712 ± 0.121
1.558GlyHis: 1.558 ± 0.037
3.401GlyIle: 3.401 ± 0.028
4.064GlyLys: 4.064 ± 0.032
5.109GlyLeu: 5.109 ± 0.047
1.352GlyMet: 1.352 ± 0.017
2.697GlyAsn: 2.697 ± 0.029
2.398GlyPro: 2.398 ± 0.037
2.046GlyGln: 2.046 ± 0.026
3.059GlyArg: 3.059 ± 0.028
4.54GlySer: 4.54 ± 0.05
3.135GlyThr: 3.135 ± 0.029
3.87GlyVal: 3.87 ± 0.032
0.706GlyTrp: 0.706 ± 0.013
2.112GlyTyr: 2.112 ± 0.029
0.001GlyXaa: 0.001 ± 0.0
His
1.223HisAla: 1.223 ± 0.016
0.575HisCys: 0.575 ± 0.012
1.066HisAsp: 1.066 ± 0.016
1.292HisGlu: 1.292 ± 0.016
1.195HisPhe: 1.195 ± 0.017
1.469HisGly: 1.469 ± 0.032
0.909HisHis: 0.909 ± 0.023
1.526HisIle: 1.526 ± 0.016
1.492HisLys: 1.492 ± 0.018
2.515HisLeu: 2.515 ± 0.021
0.604HisMet: 0.604 ± 0.013
1.172HisAsn: 1.172 ± 0.015
1.357HisPro: 1.357 ± 0.02
0.986HisGln: 0.986 ± 0.016
1.276HisArg: 1.276 ± 0.019
1.935HisSer: 1.935 ± 0.025
1.363HisThr: 1.363 ± 0.02
1.512HisVal: 1.512 ± 0.019
0.304HisTrp: 0.304 ± 0.008
0.902HisTyr: 0.902 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
3.59IleAla: 3.59 ± 0.03
1.28IleCys: 1.28 ± 0.021
3.236IleAsp: 3.236 ± 0.029
3.82IleGlu: 3.82 ± 0.03
2.607IlePhe: 2.607 ± 0.03
3.286IleGly: 3.286 ± 0.03
1.451IleHis: 1.451 ± 0.018
3.75IleIle: 3.75 ± 0.033
4.128IleLys: 4.128 ± 0.029
5.57IleLeu: 5.57 ± 0.039
1.406IleMet: 1.406 ± 0.018
3.068IleAsn: 3.068 ± 0.028
2.962IlePro: 2.962 ± 0.024
2.255IleGln: 2.255 ± 0.025
2.765IleArg: 2.765 ± 0.023
4.592IleSer: 4.592 ± 0.037
3.396IleThr: 3.396 ± 0.03
3.823IleVal: 3.823 ± 0.033
0.648IleTrp: 0.648 ± 0.012
1.964IleTyr: 1.964 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.894LysAla: 3.894 ± 0.03
1.349LysCys: 1.349 ± 0.028
3.726LysAsp: 3.726 ± 0.034
5.677LysGlu: 5.677 ± 0.053
2.55LysPhe: 2.55 ± 0.025
3.577LysGly: 3.577 ± 0.046
1.682LysHis: 1.682 ± 0.018
4.207LysIle: 4.207 ± 0.033
6.167LysLys: 6.167 ± 0.069
6.339LysLeu: 6.339 ± 0.039
1.783LysMet: 1.783 ± 0.018
3.614LysAsn: 3.614 ± 0.035
3.209LysPro: 3.209 ± 0.053
2.764LysGln: 2.764 ± 0.026
3.913LysArg: 3.913 ± 0.031
4.814LysSer: 4.814 ± 0.037
3.918LysThr: 3.918 ± 0.031
4.164LysVal: 4.164 ± 0.032
0.741LysTrp: 0.741 ± 0.012
2.325LysTyr: 2.325 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
5.833LeuAla: 5.833 ± 0.04
1.861LeuCys: 1.861 ± 0.023
4.822LeuAsp: 4.822 ± 0.036
6.102LeuGlu: 6.102 ± 0.044
3.879LeuPhe: 3.879 ± 0.034
4.956LeuGly: 4.956 ± 0.033
2.328LeuHis: 2.328 ± 0.023
5.122LeuIle: 5.122 ± 0.04
6.867LeuLys: 6.867 ± 0.046
9.041LeuLeu: 9.041 ± 0.061
2.218LeuMet: 2.218 ± 0.021
4.581LeuAsn: 4.581 ± 0.029
4.696LeuPro: 4.696 ± 0.037
4.049LeuGln: 4.049 ± 0.036
4.841LeuArg: 4.841 ± 0.033
7.608LeuSer: 7.608 ± 0.06
5.243LeuThr: 5.243 ± 0.028
5.661LeuVal: 5.661 ± 0.036
0.952LeuTrp: 0.952 ± 0.016
2.949LeuTyr: 2.949 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
1.664MetAla: 1.664 ± 0.019
0.448MetCys: 0.448 ± 0.009
1.325MetAsp: 1.325 ± 0.017
1.674MetGlu: 1.674 ± 0.02
1.01MetPhe: 1.01 ± 0.016
1.306MetGly: 1.306 ± 0.016
0.501MetHis: 0.501 ± 0.01
1.303MetIle: 1.303 ± 0.019
1.81MetLys: 1.81 ± 0.019
2.092MetLeu: 2.092 ± 0.023
0.672MetMet: 0.672 ± 0.014
1.187MetAsn: 1.187 ± 0.016
1.1MetPro: 1.1 ± 0.014
0.883MetGln: 0.883 ± 0.012
1.202MetArg: 1.202 ± 0.015
1.889MetSer: 1.889 ± 0.018
1.408MetThr: 1.408 ± 0.016
1.492MetVal: 1.492 ± 0.018
0.256MetTrp: 0.256 ± 0.007
0.785MetTyr: 0.785 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.556AsnAla: 2.556 ± 0.026
1.033AsnCys: 1.033 ± 0.017
2.452AsnAsp: 2.452 ± 0.023
3.188AsnGlu: 3.188 ± 0.033
2.15AsnPhe: 2.15 ± 0.024
2.922AsnGly: 2.922 ± 0.028
1.179AsnHis: 1.179 ± 0.018
3.312AsnIle: 3.312 ± 0.03
3.463AsnLys: 3.463 ± 0.033
4.634AsnLeu: 4.634 ± 0.036
1.231AsnMet: 1.231 ± 0.016
2.736AsnAsn: 2.736 ± 0.031
2.338AsnPro: 2.338 ± 0.028
1.849AsnGln: 1.849 ± 0.025
2.243AsnArg: 2.243 ± 0.022
3.76AsnSer: 3.76 ± 0.03
2.577AsnThr: 2.577 ± 0.023
3.146AsnVal: 3.146 ± 0.025
0.582AsnTrp: 0.582 ± 0.011
1.781AsnTyr: 1.781 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
2.682ProAla: 2.682 ± 0.031
0.874ProCys: 0.874 ± 0.046
2.445ProAsp: 2.445 ± 0.021
3.303ProGlu: 3.303 ± 0.039
1.951ProPhe: 1.951 ± 0.021
2.906ProGly: 2.906 ± 0.068
1.237ProHis: 1.237 ± 0.019
2.613ProIle: 2.613 ± 0.024
3.042ProLys: 3.042 ± 0.034
4.26ProLeu: 4.26 ± 0.028
0.984ProMet: 0.984 ± 0.014
2.264ProAsn: 2.264 ± 0.023
4.058ProPro: 4.058 ± 0.064
2.123ProGln: 2.123 ± 0.033
2.206ProArg: 2.206 ± 0.021
4.119ProSer: 4.119 ± 0.044
2.98ProThr: 2.98 ± 0.031
3.529ProVal: 3.529 ± 0.042
0.533ProTrp: 0.533 ± 0.012
1.65ProTyr: 1.65 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
2.331GlnAla: 2.331 ± 0.025
0.733GlnCys: 0.733 ± 0.022
1.811GlnAsp: 1.811 ± 0.021
2.659GlnGlu: 2.659 ± 0.028
1.535GlnPhe: 1.535 ± 0.018
2.061GlnGly: 2.061 ± 0.024
1.059GlnHis: 1.059 ± 0.017
2.317GlnIle: 2.317 ± 0.022
2.609GlnLys: 2.609 ± 0.026
3.764GlnLeu: 3.764 ± 0.03
1.02GlnMet: 1.02 ± 0.017
2.021GlnAsn: 2.021 ± 0.026
1.969GlnPro: 1.969 ± 0.028
2.375GlnGln: 2.375 ± 0.058
2.02GlnArg: 2.02 ± 0.021
2.641GlnSer: 2.641 ± 0.031
2.105GlnThr: 2.105 ± 0.024
2.396GlnVal: 2.396 ± 0.023
0.443GlnTrp: 0.443 ± 0.01
1.302GlnTyr: 1.302 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
2.718ArgAla: 2.718 ± 0.025
0.952ArgCys: 0.952 ± 0.017
2.521ArgAsp: 2.521 ± 0.025
3.569ArgGlu: 3.569 ± 0.039
2.054ArgPhe: 2.054 ± 0.022
2.775ArgGly: 2.775 ± 0.031
1.324ArgHis: 1.324 ± 0.018
2.901ArgIle: 2.901 ± 0.024
3.92ArgLys: 3.92 ± 0.027
4.694ArgLeu: 4.694 ± 0.038
1.213ArgMet: 1.213 ± 0.016
2.436ArgAsn: 2.436 ± 0.021
2.444ArgPro: 2.444 ± 0.031
2.002ArgGln: 2.002 ± 0.022
3.409ArgArg: 3.409 ± 0.033
3.581ArgSer: 3.581 ± 0.029
2.632ArgThr: 2.632 ± 0.028
3.061ArgVal: 3.061 ± 0.026
0.568ArgTrp: 0.568 ± 0.011
1.644ArgTyr: 1.644 ± 0.023
0.001ArgXaa: 0.001 ± 0.0
Ser
4.127SerAla: 4.127 ± 0.031
1.53SerCys: 1.53 ± 0.03
4.058SerAsp: 4.058 ± 0.033
4.672SerGlu: 4.672 ± 0.033
3.247SerPhe: 3.247 ± 0.039
4.811SerGly: 4.811 ± 0.051
1.865SerHis: 1.865 ± 0.021
4.28SerIle: 4.28 ± 0.032
4.841SerLys: 4.841 ± 0.038
7.467SerLeu: 7.467 ± 0.048
1.701SerMet: 1.701 ± 0.02
3.634SerAsn: 3.634 ± 0.033
4.217SerPro: 4.217 ± 0.042
2.966SerGln: 2.966 ± 0.029
3.656SerArg: 3.656 ± 0.033
7.325SerSer: 7.325 ± 0.076
4.529SerThr: 4.529 ± 0.037
4.804SerVal: 4.804 ± 0.031
0.893SerTrp: 0.893 ± 0.013
2.419SerTyr: 2.419 ± 0.025
0.001SerXaa: 0.001 ± 0.0
Thr
3.336ThrAla: 3.336 ± 0.03
1.146ThrCys: 1.146 ± 0.025
2.802ThrAsp: 2.802 ± 0.023
3.381ThrGlu: 3.381 ± 0.028
2.365ThrPhe: 2.365 ± 0.023
3.388ThrGly: 3.388 ± 0.032
1.3ThrHis: 1.3 ± 0.02
3.37ThrIle: 3.37 ± 0.028
3.549ThrLys: 3.549 ± 0.033
5.263ThrLeu: 5.263 ± 0.034
1.251ThrMet: 1.251 ± 0.017
2.637ThrAsn: 2.637 ± 0.024
3.201ThrPro: 3.201 ± 0.03
2.018ThrGln: 2.018 ± 0.024
2.476ThrArg: 2.476 ± 0.021
4.597ThrSer: 4.597 ± 0.039
3.708ThrThr: 3.708 ± 0.056
3.923ThrVal: 3.923 ± 0.032
0.621ThrTrp: 0.621 ± 0.01
1.766ThrTyr: 1.766 ± 0.019
0.0ThrXaa: 0.0 ± 0.0
Val
4.018ValAla: 4.018 ± 0.04
1.367ValCys: 1.367 ± 0.025
3.447ValAsp: 3.447 ± 0.023
4.236ValGlu: 4.236 ± 0.038
2.749ValPhe: 2.749 ± 0.024
3.485ValGly: 3.485 ± 0.032
1.617ValHis: 1.617 ± 0.016
3.891ValIle: 3.891 ± 0.029
4.453ValLys: 4.453 ± 0.035
5.986ValLeu: 5.986 ± 0.034
1.529ValMet: 1.529 ± 0.018
3.038ValAsn: 3.038 ± 0.026
3.256ValPro: 3.256 ± 0.037
2.447ValGln: 2.447 ± 0.025
3.026ValArg: 3.026 ± 0.026
4.744ValSer: 4.744 ± 0.028
3.778ValThr: 3.778 ± 0.034
4.55ValVal: 4.55 ± 0.037
0.721ValTrp: 0.721 ± 0.012
2.061ValTyr: 2.061 ± 0.021
0.0ValXaa: 0.0 ± 0.0
Trp
0.619TrpAla: 0.619 ± 0.012
0.227TrpCys: 0.227 ± 0.006
0.636TrpAsp: 0.636 ± 0.011
0.694TrpGlu: 0.694 ± 0.013
0.493TrpPhe: 0.493 ± 0.01
0.617TrpGly: 0.617 ± 0.013
0.266TrpHis: 0.266 ± 0.008
0.667TrpIle: 0.667 ± 0.012
0.835TrpLys: 0.835 ± 0.011
1.104TrpLeu: 1.104 ± 0.015
0.289TrpMet: 0.289 ± 0.008
0.599TrpAsn: 0.599 ± 0.013
0.462TrpPro: 0.462 ± 0.009
0.434TrpGln: 0.434 ± 0.009
0.633TrpArg: 0.633 ± 0.01
0.85TrpSer: 0.85 ± 0.013
0.606TrpThr: 0.606 ± 0.01
0.664TrpVal: 0.664 ± 0.013
0.174TrpTrp: 0.174 ± 0.006
0.367TrpTyr: 0.367 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.706TyrAla: 1.706 ± 0.02
0.75TyrCys: 0.75 ± 0.013
1.747TyrAsp: 1.747 ± 0.022
1.913TyrGlu: 1.913 ± 0.022
1.631TyrPhe: 1.631 ± 0.017
2.022TyrGly: 2.022 ± 0.026
0.868TyrHis: 0.868 ± 0.013
2.0TyrIle: 2.0 ± 0.022
2.204TyrLys: 2.204 ± 0.019
3.204TyrLeu: 3.204 ± 0.031
0.783TyrMet: 0.783 ± 0.011
1.725TyrAsn: 1.725 ± 0.018
1.55TyrPro: 1.55 ± 0.026
1.26TyrGln: 1.26 ± 0.016
1.688TyrArg: 1.688 ± 0.017
2.485TyrSer: 2.485 ± 0.023
1.913TyrThr: 1.913 ± 0.021
1.946TyrVal: 1.946 ± 0.021
0.406TyrTrp: 0.406 ± 0.01
1.295TyrTyr: 1.295 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.001XaaLeu: 0.001 ± 0.0
0.001XaaMet: 0.001 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.085XaaXaa: 0.085 ± 0.017
Statistics based on 14152 proteins (5704716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski