Amino acid dipepetide frequency for Jeotgalibacillus proteolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.926AlaAla: 6.926 ± 0.106	0.581AlaCys: 0.581 ± 0.023	3.516AlaAsp: 3.516 ± 0.067	5.209AlaGlu: 5.209 ± 0.074	3.617AlaPhe: 3.617 ± 0.072	6.161AlaGly: 6.161 ± 0.072	1.398AlaHis: 1.398 ± 0.035	5.857AlaIle: 5.857 ± 0.078	4.36AlaLys: 4.36 ± 0.069	7.694AlaLeu: 7.694 ± 0.092	2.144AlaMet: 2.144 ± 0.046	2.518AlaAsn: 2.518 ± 0.05	2.232AlaPro: 2.232 ± 0.045	2.424AlaGln: 2.424 ± 0.046	2.745AlaArg: 2.745 ± 0.057	4.545AlaSer: 4.545 ± 0.065	3.114AlaThr: 3.114 ± 0.052	6.003AlaVal: 6.003 ± 0.072	0.698AlaTrp: 0.698 ± 0.025	2.278AlaTyr: 2.278 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.4CysAla: 0.4 ± 0.022	0.08CysCys: 0.08 ± 0.009	0.36CysAsp: 0.36 ± 0.018	0.433CysGlu: 0.433 ± 0.023	0.283CysPhe: 0.283 ± 0.016	0.575CysGly: 0.575 ± 0.022	0.194CysHis: 0.194 ± 0.01	0.447CysIle: 0.447 ± 0.021	0.291CysLys: 0.291 ± 0.016	0.638CysLeu: 0.638 ± 0.027	0.152CysMet: 0.152 ± 0.013	0.243CysAsn: 0.243 ± 0.014	0.31CysPro: 0.31 ± 0.017	0.213CysGln: 0.213 ± 0.013	0.296CysArg: 0.296 ± 0.017	0.49CysSer: 0.49 ± 0.022	0.351CysThr: 0.351 ± 0.016	0.356CysVal: 0.356 ± 0.018	0.065CysTrp: 0.065 ± 0.008	0.204CysTyr: 0.204 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.389AspAla: 3.389 ± 0.063	0.327AspCys: 0.327 ± 0.018	2.413AspAsp: 2.413 ± 0.056	4.5AspGlu: 4.5 ± 0.073	2.429AspPhe: 2.429 ± 0.047	3.514AspGly: 3.514 ± 0.066	1.302AspHis: 1.302 ± 0.036	3.711AspIle: 3.711 ± 0.058	2.768AspLys: 2.768 ± 0.049	5.251AspLeu: 5.251 ± 0.062	1.255AspMet: 1.255 ± 0.033	1.74AspAsn: 1.74 ± 0.039	2.209AspPro: 2.209 ± 0.041	2.313AspGln: 2.313 ± 0.053	2.586AspArg: 2.586 ± 0.052	2.908AspSer: 2.908 ± 0.058	2.387AspThr: 2.387 ± 0.044	3.531AspVal: 3.531 ± 0.072	0.682AspTrp: 0.682 ± 0.024	2.129AspTyr: 2.129 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.181GluAla: 6.181 ± 0.079	0.361GluCys: 0.361 ± 0.018	4.239GluAsp: 4.239 ± 0.066	8.2GluGlu: 8.2 ± 0.104	2.644GluPhe: 2.644 ± 0.053	4.929GluGly: 4.929 ± 0.068	1.503GluHis: 1.503 ± 0.041	5.461GluIle: 5.461 ± 0.073	6.248GluLys: 6.248 ± 0.083	7.596GluLeu: 7.596 ± 0.082	2.346GluMet: 2.346 ± 0.045	3.641GluAsn: 3.641 ± 0.056	2.1GluPro: 2.1 ± 0.043	3.313GluGln: 3.313 ± 0.052	3.692GluArg: 3.692 ± 0.061	3.799GluSer: 3.799 ± 0.057	3.775GluThr: 3.775 ± 0.056	5.171GluVal: 5.171 ± 0.063	0.99GluTrp: 0.99 ± 0.029	2.155GluTyr: 2.155 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.084PheAla: 3.084 ± 0.06	0.323PheCys: 0.323 ± 0.015	2.355PheAsp: 2.355 ± 0.05	2.935PheGlu: 2.935 ± 0.055	2.289PhePhe: 2.289 ± 0.052	3.321PheGly: 3.321 ± 0.067	0.955PheHis: 0.955 ± 0.029	3.88PheIle: 3.88 ± 0.072	2.435PheLys: 2.435 ± 0.048	4.582PheLeu: 4.582 ± 0.087	1.221PheMet: 1.221 ± 0.034	1.974PheAsn: 1.974 ± 0.043	1.697PhePro: 1.697 ± 0.034	1.482PheGln: 1.482 ± 0.032	1.57PheArg: 1.57 ± 0.04	3.55PheSer: 3.55 ± 0.054	2.791PheThr: 2.791 ± 0.053	3.0PheVal: 3.0 ± 0.048	0.525PheTrp: 0.525 ± 0.023	1.721PheTyr: 1.721 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	5.302GlyAla: 5.302 ± 0.076	0.572GlyCys: 0.572 ± 0.023	3.397GlyAsp: 3.397 ± 0.058	4.94GlyGlu: 4.94 ± 0.074	3.6GlyPhe: 3.6 ± 0.063	5.127GlyGly: 5.127 ± 0.083	1.391GlyHis: 1.391 ± 0.036	5.856GlyIle: 5.856 ± 0.085	4.587GlyLys: 4.587 ± 0.072	6.906GlyLeu: 6.906 ± 0.083	2.211GlyMet: 2.211 ± 0.042	2.576GlyAsn: 2.576 ± 0.054	1.847GlyPro: 1.847 ± 0.044	2.178GlyGln: 2.178 ± 0.038	2.858GlyArg: 2.858 ± 0.049	4.383GlySer: 4.383 ± 0.067	4.037GlyThr: 4.037 ± 0.062	5.191GlyVal: 5.191 ± 0.075	0.873GlyTrp: 0.873 ± 0.029	2.776GlyTyr: 2.776 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.434HisAla: 1.434 ± 0.036	0.172HisCys: 0.172 ± 0.013	1.044HisAsp: 1.044 ± 0.028	1.487HisGlu: 1.487 ± 0.035	1.076HisPhe: 1.076 ± 0.031	1.41HisGly: 1.41 ± 0.041	0.629HisHis: 0.629 ± 0.024	1.355HisIle: 1.355 ± 0.033	1.013HisLys: 1.013 ± 0.03	2.172HisLeu: 2.172 ± 0.045	0.505HisMet: 0.505 ± 0.02	0.732HisAsn: 0.732 ± 0.025	1.123HisPro: 1.123 ± 0.032	0.862HisGln: 0.862 ± 0.029	0.901HisArg: 0.901 ± 0.024	1.414HisSer: 1.414 ± 0.031	1.1HisThr: 1.1 ± 0.032	1.361HisVal: 1.361 ± 0.034	0.225HisTrp: 0.225 ± 0.013	0.879HisTyr: 0.879 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.913IleAla: 5.913 ± 0.086	0.541IleCys: 0.541 ± 0.022	4.242IleAsp: 4.242 ± 0.065	5.766IleGlu: 5.766 ± 0.075	3.077IlePhe: 3.077 ± 0.067	5.814IleGly: 5.814 ± 0.09	1.65IleHis: 1.65 ± 0.037	5.559IleIle: 5.559 ± 0.096	4.321IleLys: 4.321 ± 0.064	6.834IleLeu: 6.834 ± 0.106	1.785IleMet: 1.785 ± 0.043	3.123IleAsn: 3.123 ± 0.057	3.305IlePro: 3.305 ± 0.058	2.93IleGln: 2.93 ± 0.051	3.167IleArg: 3.167 ± 0.057	4.902IleSer: 4.902 ± 0.07	4.256IleThr: 4.256 ± 0.062	5.191IleVal: 5.191 ± 0.072	0.672IleTrp: 0.672 ± 0.026	2.23IleTyr: 2.23 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.601LysAla: 4.601 ± 0.074	0.257LysCys: 0.257 ± 0.014	3.549LysAsp: 3.549 ± 0.051	6.686LysGlu: 6.686 ± 0.073	1.685LysPhe: 1.685 ± 0.034	4.373LysGly: 4.373 ± 0.068	1.237LysHis: 1.237 ± 0.033	4.154LysIle: 4.154 ± 0.062	5.733LysLys: 5.733 ± 0.088	5.271LysLeu: 5.271 ± 0.08	1.942LysMet: 1.942 ± 0.043	3.029LysAsn: 3.029 ± 0.051	2.153LysPro: 2.153 ± 0.045	2.626LysGln: 2.626 ± 0.044	3.328LysArg: 3.328 ± 0.049	3.415LysSer: 3.415 ± 0.057	3.368LysThr: 3.368 ± 0.055	4.016LysVal: 4.016 ± 0.059	0.83LysTrp: 0.83 ± 0.025	1.65LysTyr: 1.65 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	7.495LeuAla: 7.495 ± 0.084	0.629LeuCys: 0.629 ± 0.024	4.778LeuAsp: 4.778 ± 0.077	6.793LeuGlu: 6.793 ± 0.091	5.0LeuPhe: 5.0 ± 0.09	6.468LeuGly: 6.468 ± 0.086	2.007LeuHis: 2.007 ± 0.043	7.437LeuIle: 7.437 ± 0.112	6.272LeuLys: 6.272 ± 0.08	10.589LeuLeu: 10.589 ± 0.128	2.626LeuMet: 2.626 ± 0.05	4.246LeuAsn: 4.246 ± 0.062	4.047LeuPro: 4.047 ± 0.058	3.513LeuGln: 3.513 ± 0.052	3.626LeuArg: 3.626 ± 0.062	7.212LeuSer: 7.212 ± 0.08	6.03LeuThr: 6.03 ± 0.077	6.122LeuVal: 6.122 ± 0.086	0.867LeuTrp: 0.867 ± 0.031	3.141LeuTyr: 3.141 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.13MetAla: 2.13 ± 0.047	0.13MetCys: 0.13 ± 0.011	1.574MetAsp: 1.574 ± 0.039	1.984MetGlu: 1.984 ± 0.043	0.949MetPhe: 0.949 ± 0.032	1.771MetGly: 1.771 ± 0.042	0.456MetHis: 0.456 ± 0.019	2.207MetIle: 2.207 ± 0.05	2.351MetLys: 2.351 ± 0.042	2.583MetLeu: 2.583 ± 0.048	0.851MetMet: 0.851 ± 0.028	1.543MetAsn: 1.543 ± 0.038	1.049MetPro: 1.049 ± 0.03	0.86MetGln: 0.86 ± 0.026	1.125MetArg: 1.125 ± 0.031	1.683MetSer: 1.683 ± 0.04	1.761MetThr: 1.761 ± 0.035	1.829MetVal: 1.829 ± 0.045	0.19MetTrp: 0.19 ± 0.014	0.7MetTyr: 0.7 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.791AsnAla: 2.791 ± 0.052	0.242AsnCys: 0.242 ± 0.014	2.158AsnAsp: 2.158 ± 0.038	3.692AsnGlu: 3.692 ± 0.056	1.499AsnPhe: 1.499 ± 0.04	3.42AsnGly: 3.42 ± 0.065	1.007AsnHis: 1.007 ± 0.031	2.76AsnIle: 2.76 ± 0.053	2.52AsnLys: 2.52 ± 0.046	3.62AsnLeu: 3.62 ± 0.063	1.075AsnMet: 1.075 ± 0.029	1.756AsnAsn: 1.756 ± 0.041	2.008AsnPro: 2.008 ± 0.047	1.849AsnGln: 1.849 ± 0.049	2.038AsnArg: 2.038 ± 0.04	2.258AsnSer: 2.258 ± 0.048	2.005AsnThr: 2.005 ± 0.04	2.766AsnVal: 2.766 ± 0.049	0.523AsnTrp: 0.523 ± 0.02	1.413AsnTyr: 1.413 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.712ProAla: 2.712 ± 0.049	0.201ProCys: 0.201 ± 0.012	2.207ProAsp: 2.207 ± 0.049	3.294ProGlu: 3.294 ± 0.063	2.069ProPhe: 2.069 ± 0.042	2.509ProGly: 2.509 ± 0.058	0.817ProHis: 0.817 ± 0.028	2.664ProIle: 2.664 ± 0.049	1.951ProLys: 1.951 ± 0.039	3.709ProLeu: 3.709 ± 0.064	0.837ProMet: 0.837 ± 0.024	1.425ProAsn: 1.425 ± 0.036	1.087ProPro: 1.087 ± 0.034	1.124ProGln: 1.124 ± 0.033	1.096ProArg: 1.096 ± 0.029	2.568ProSer: 2.568 ± 0.055	1.738ProThr: 1.738 ± 0.036	3.092ProVal: 3.092 ± 0.05	0.369ProTrp: 0.369 ± 0.021	1.427ProTyr: 1.427 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.944GlnAla: 2.944 ± 0.052	0.189GlnCys: 0.189 ± 0.011	1.767GlnAsp: 1.767 ± 0.041	2.952GlnGlu: 2.952 ± 0.051	1.651GlnPhe: 1.651 ± 0.035	2.247GlnGly: 2.247 ± 0.046	0.736GlnHis: 0.736 ± 0.024	2.372GlnIle: 2.372 ± 0.041	2.545GlnLys: 2.545 ± 0.049	3.907GlnLeu: 3.907 ± 0.053	1.119GlnMet: 1.119 ± 0.031	1.579GlnAsn: 1.579 ± 0.039	1.263GlnPro: 1.263 ± 0.034	1.712GlnGln: 1.712 ± 0.045	1.517GlnArg: 1.517 ± 0.036	2.348GlnSer: 2.348 ± 0.049	2.066GlnThr: 2.066 ± 0.042	2.23GlnVal: 2.23 ± 0.047	0.442GlnTrp: 0.442 ± 0.022	1.266GlnTyr: 1.266 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.652ArgAla: 2.652 ± 0.051	0.254ArgCys: 0.254 ± 0.016	2.178ArgAsp: 2.178 ± 0.047	3.486ArgGlu: 3.486 ± 0.064	2.089ArgPhe: 2.089 ± 0.046	2.416ArgGly: 2.416 ± 0.042	0.821ArgHis: 0.821 ± 0.024	3.102ArgIle: 3.102 ± 0.053	3.058ArgLys: 3.058 ± 0.057	4.137ArgLeu: 4.137 ± 0.067	1.33ArgMet: 1.33 ± 0.033	1.831ArgAsn: 1.831 ± 0.043	1.372ArgPro: 1.372 ± 0.032	1.613ArgGln: 1.613 ± 0.038	1.838ArgArg: 1.838 ± 0.045	2.577ArgSer: 2.577 ± 0.044	2.133ArgThr: 2.133 ± 0.044	2.743ArgVal: 2.743 ± 0.053	0.454ArgTrp: 0.454 ± 0.02	1.526ArgTyr: 1.526 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.251SerAla: 4.251 ± 0.064	0.392SerCys: 0.392 ± 0.018	2.892SerAsp: 2.892 ± 0.051	4.073SerGlu: 4.073 ± 0.058	3.544SerPhe: 3.544 ± 0.06	4.803SerGly: 4.803 ± 0.072	1.306SerHis: 1.306 ± 0.034	5.299SerIle: 5.299 ± 0.069	3.644SerLys: 3.644 ± 0.058	6.627SerLeu: 6.627 ± 0.085	1.837SerMet: 1.837 ± 0.037	2.4SerAsn: 2.4 ± 0.044	2.352SerPro: 2.352 ± 0.044	2.15SerGln: 2.15 ± 0.044	2.59SerArg: 2.59 ± 0.046	4.604SerSer: 4.604 ± 0.075	3.318SerThr: 3.318 ± 0.053	4.368SerVal: 4.368 ± 0.058	0.738SerTrp: 0.738 ± 0.025	2.282SerTyr: 2.282 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.347ThrAla: 4.347 ± 0.062	0.309ThrCys: 0.309 ± 0.017	2.752ThrAsp: 2.752 ± 0.057	3.727ThrGlu: 3.727 ± 0.059	2.632ThrPhe: 2.632 ± 0.049	4.233ThrGly: 4.233 ± 0.058	1.09ThrHis: 1.09 ± 0.029	4.436ThrIle: 4.436 ± 0.055	2.938ThrLys: 2.938 ± 0.05	5.23ThrLeu: 5.23 ± 0.065	1.327ThrMet: 1.327 ± 0.033	2.223ThrAsn: 2.223 ± 0.046	2.334ThrPro: 2.334 ± 0.049	1.437ThrGln: 1.437 ± 0.035	1.912ThrArg: 1.912 ± 0.041	3.269ThrSer: 3.269 ± 0.059	2.731ThrThr: 2.731 ± 0.06	4.209ThrVal: 4.209 ± 0.058	0.577ThrTrp: 0.577 ± 0.023	1.823ThrTyr: 1.823 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	4.725ValAla: 4.725 ± 0.069	0.498ValCys: 0.498 ± 0.02	3.529ValAsp: 3.529 ± 0.058	4.935ValGlu: 4.935 ± 0.066	3.22ValPhe: 3.22 ± 0.051	4.372ValGly: 4.372 ± 0.068	1.388ValHis: 1.388 ± 0.039	5.576ValIle: 5.576 ± 0.074	4.317ValLys: 4.317 ± 0.068	6.935ValLeu: 6.935 ± 0.08	1.944ValMet: 1.944 ± 0.044	3.001ValAsn: 3.001 ± 0.052	2.702ValPro: 2.702 ± 0.054	2.464ValGln: 2.464 ± 0.049	2.704ValArg: 2.704 ± 0.05	4.551ValSer: 4.551 ± 0.066	4.153ValThr: 4.153 ± 0.059	4.741ValVal: 4.741 ± 0.069	0.714ValTrp: 0.714 ± 0.025	2.194ValTyr: 2.194 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.669TrpAla: 0.669 ± 0.023	0.061TrpCys: 0.061 ± 0.007	0.561TrpAsp: 0.561 ± 0.021	0.747TrpGlu: 0.747 ± 0.029	0.515TrpPhe: 0.515 ± 0.022	0.755TrpGly: 0.755 ± 0.028	0.207TrpHis: 0.207 ± 0.015	0.885TrpIle: 0.885 ± 0.026	0.746TrpLys: 0.746 ± 0.024	1.204TrpLeu: 1.204 ± 0.034	0.401TrpMet: 0.401 ± 0.016	0.555TrpAsn: 0.555 ± 0.021	0.292TrpPro: 0.292 ± 0.016	0.389TrpGln: 0.389 ± 0.017	0.45TrpArg: 0.45 ± 0.021	0.709TrpSer: 0.709 ± 0.025	0.643TrpThr: 0.643 ± 0.025	0.703TrpVal: 0.703 ± 0.029	0.163TrpTrp: 0.163 ± 0.013	0.352TrpTyr: 0.352 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.075TyrAla: 2.075 ± 0.044	0.262TyrCys: 0.262 ± 0.015	1.832TyrAsp: 1.832 ± 0.041	2.506TyrGlu: 2.506 ± 0.052	1.822TyrPhe: 1.822 ± 0.038	2.388TyrGly: 2.388 ± 0.053	0.799TyrHis: 0.799 ± 0.028	2.26TyrIle: 2.26 ± 0.053	1.806TyrLys: 1.806 ± 0.042	3.414TyrLeu: 3.414 ± 0.056	0.814TyrMet: 0.814 ± 0.026	1.265TyrAsn: 1.265 ± 0.032	1.412TyrPro: 1.412 ± 0.035	1.404TyrGln: 1.404 ± 0.038	1.571TyrArg: 1.571 ± 0.033	2.287TyrSer: 2.287 ± 0.045	1.779TyrThr: 1.779 ± 0.034	2.041TyrVal: 2.041 ± 0.041	0.409TyrTrp: 0.409 ± 0.018	1.332TyrTyr: 1.332 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4022 proteins (1171169 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---