Amino acid dipepetide frequency for Eimeria acervulina (Coccidian parasite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	67.217AlaAla: 67.217 ± 0.818	1.738AlaCys: 1.738 ± 0.026	5.01AlaAsp: 5.01 ± 0.047	8.191AlaGlu: 8.191 ± 0.072	2.768AlaPhe: 2.768 ± 0.034	7.718AlaGly: 7.718 ± 0.064	1.493AlaHis: 1.493 ± 0.019	2.236AlaIle: 2.236 ± 0.029	3.311AlaLys: 3.311 ± 0.04	8.776AlaLeu: 8.776 ± 0.064	1.105AlaMet: 1.105 ± 0.02	2.223AlaAsn: 2.223 ± 0.025	7.515AlaPro: 7.515 ± 0.088	3.535AlaGln: 3.535 ± 0.041	4.391AlaArg: 4.391 ± 0.033	8.729AlaSer: 8.729 ± 0.057	7.993AlaThr: 7.993 ± 0.082	6.975AlaVal: 6.975 ± 0.052	0.775AlaTrp: 0.775 ± 0.015	1.298AlaTyr: 1.298 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	1.366CysAla: 1.366 ± 0.022	1.753CysCys: 1.753 ± 0.045	0.536CysAsp: 0.536 ± 0.013	0.719CysGlu: 0.719 ± 0.014	0.696CysPhe: 0.696 ± 0.012	1.327CysGly: 1.327 ± 0.022	0.244CysHis: 0.244 ± 0.008	0.752CysIle: 0.752 ± 0.014	0.566CysLys: 0.566 ± 0.015	2.152CysLeu: 2.152 ± 0.026	0.441CysMet: 0.441 ± 0.01	0.505CysAsn: 0.505 ± 0.012	0.857CysPro: 0.857 ± 0.026	0.387CysGln: 0.387 ± 0.01	1.215CysArg: 1.215 ± 0.017	2.931CysSer: 2.931 ± 0.041	0.933CysThr: 0.933 ± 0.016	1.008CysVal: 1.008 ± 0.019	0.276CysTrp: 0.276 ± 0.009	0.317CysTyr: 0.317 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	4.815AspAla: 4.815 ± 0.047	0.75AspCys: 0.75 ± 0.014	1.896AspAsp: 1.896 ± 0.041	2.859AspGlu: 2.859 ± 0.042	1.197AspPhe: 1.197 ± 0.019	2.515AspGly: 2.515 ± 0.031	0.392AspHis: 0.392 ± 0.011	1.507AspIle: 1.507 ± 0.025	1.51AspLys: 1.51 ± 0.03	3.181AspLeu: 3.181 ± 0.032	0.648AspMet: 0.648 ± 0.013	0.884AspAsn: 0.884 ± 0.019	2.131AspPro: 2.131 ± 0.028	0.974AspGln: 0.974 ± 0.019	1.903AspArg: 1.903 ± 0.042	3.575AspSer: 3.575 ± 0.03	1.916AspThr: 1.916 ± 0.023	2.141AspVal: 2.141 ± 0.03	0.468AspTrp: 0.468 ± 0.01	0.603AspTyr: 0.603 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	8.731GluAla: 8.731 ± 0.074	0.802GluCys: 0.802 ± 0.019	3.1GluAsp: 3.1 ± 0.037	7.51GluGlu: 7.51 ± 0.102	1.224GluPhe: 1.224 ± 0.021	5.267GluGly: 5.267 ± 0.048	0.932GluHis: 0.932 ± 0.018	1.476GluIle: 1.476 ± 0.024	2.637GluLys: 2.637 ± 0.038	4.907GluLeu: 4.907 ± 0.041	0.964GluMet: 0.964 ± 0.016	1.164GluAsn: 1.164 ± 0.024	2.162GluPro: 2.162 ± 0.028	5.098GluGln: 5.098 ± 0.071	3.511GluArg: 3.511 ± 0.041	3.044GluSer: 3.044 ± 0.035	3.791GluThr: 3.791 ± 0.055	3.167GluVal: 3.167 ± 0.033	0.537GluTrp: 0.537 ± 0.013	0.781GluTyr: 0.781 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.802PheAla: 2.802 ± 0.025	0.76PheCys: 0.76 ± 0.014	1.116PheAsp: 1.116 ± 0.019	1.332PheGlu: 1.332 ± 0.02	1.15PhePhe: 1.15 ± 0.02	1.662PheGly: 1.662 ± 0.028	0.459PheHis: 0.459 ± 0.011	0.999PheIle: 0.999 ± 0.018	0.953PheLys: 0.953 ± 0.019	2.744PheLeu: 2.744 ± 0.031	0.419PheMet: 0.419 ± 0.011	0.697PheAsn: 0.697 ± 0.014	1.307PhePro: 1.307 ± 0.019	0.77PheGln: 0.77 ± 0.015	1.35PheArg: 1.35 ± 0.02	2.429PheSer: 2.429 ± 0.031	1.041PheThr: 1.041 ± 0.018	1.837PheVal: 1.837 ± 0.026	0.293PheTrp: 0.293 ± 0.008	0.58PheTyr: 0.58 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	8.512GlyAla: 8.512 ± 0.064	1.354GlyCys: 1.354 ± 0.018	3.193GlyAsp: 3.193 ± 0.036	3.905GlyGlu: 3.905 ± 0.041	1.79GlyPhe: 1.79 ± 0.024	7.56GlyGly: 7.56 ± 0.102	0.885GlyHis: 0.885 ± 0.017	1.702GlyIle: 1.702 ± 0.025	1.873GlyLys: 1.873 ± 0.029	5.022GlyLeu: 5.022 ± 0.047	0.828GlyMet: 0.828 ± 0.017	1.29GlyAsn: 1.29 ± 0.021	5.157GlyPro: 5.157 ± 0.112	1.799GlyGln: 1.799 ± 0.023	3.541GlyArg: 3.541 ± 0.038	6.309GlySer: 6.309 ± 0.063	2.641GlyThr: 2.641 ± 0.03	3.925GlyVal: 3.925 ± 0.037	0.632GlyTrp: 0.632 ± 0.012	0.935GlyTyr: 0.935 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	2.096HisAla: 2.096 ± 0.023	0.422HisCys: 0.422 ± 0.011	0.609HisAsp: 0.609 ± 0.012	1.211HisGlu: 1.211 ± 0.019	0.648HisPhe: 0.648 ± 0.013	1.062HisGly: 1.062 ± 0.018	0.855HisHis: 0.855 ± 0.025	0.668HisIle: 0.668 ± 0.013	0.823HisLys: 0.823 ± 0.013	2.404HisLeu: 2.404 ± 0.028	0.387HisMet: 0.387 ± 0.011	0.479HisAsn: 0.479 ± 0.011	1.422HisPro: 1.422 ± 0.019	2.228HisGln: 2.228 ± 0.038	1.477HisArg: 1.477 ± 0.017	1.633HisSer: 1.633 ± 0.02	0.932HisThr: 0.932 ± 0.013	0.932HisVal: 0.932 ± 0.017	0.247HisTrp: 0.247 ± 0.008	0.385HisTyr: 0.385 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.361IleAla: 2.361 ± 0.027	0.7IleCys: 0.7 ± 0.015	1.311IleAsp: 1.311 ± 0.02	1.663IleGlu: 1.663 ± 0.024	0.851IlePhe: 0.851 ± 0.017	1.499IleGly: 1.499 ± 0.023	0.642IleHis: 0.642 ± 0.012	0.941IleIle: 0.941 ± 0.024	1.172IleLys: 1.172 ± 0.024	2.111IleLeu: 2.111 ± 0.028	0.387IleMet: 0.387 ± 0.013	0.826IleAsn: 0.826 ± 0.018	1.433IlePro: 1.433 ± 0.019	1.091IleGln: 1.091 ± 0.019	1.623IleArg: 1.623 ± 0.022	2.404IleSer: 2.404 ± 0.033	1.169IleThr: 1.169 ± 0.02	1.389IleVal: 1.389 ± 0.024	0.264IleTrp: 0.264 ± 0.008	0.514IleTyr: 0.514 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	3.44LysAla: 3.44 ± 0.044	0.511LysCys: 0.511 ± 0.013	1.581LysAsp: 1.581 ± 0.027	3.319LysGlu: 3.319 ± 0.05	0.679LysPhe: 0.679 ± 0.015	2.614LysGly: 2.614 ± 0.038	0.829LysHis: 0.829 ± 0.016	1.017LysIle: 1.017 ± 0.017	2.238LysLys: 2.238 ± 0.039	2.794LysLeu: 2.794 ± 0.036	0.543LysMet: 0.543 ± 0.012	0.926LysAsn: 0.926 ± 0.017	1.746LysPro: 1.746 ± 0.027	3.44LysGln: 3.44 ± 0.042	2.666LysArg: 2.666 ± 0.032	1.93LysSer: 1.93 ± 0.03	1.901LysThr: 1.901 ± 0.032	1.542LysVal: 1.542 ± 0.024	0.322LysTrp: 0.322 ± 0.01	0.616LysTyr: 0.616 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	6.921LeuAla: 6.921 ± 0.063	1.793LeuCys: 1.793 ± 0.024	2.872LeuAsp: 2.872 ± 0.036	4.94LeuGlu: 4.94 ± 0.047	2.7LeuPhe: 2.7 ± 0.032	4.912LeuGly: 4.912 ± 0.041	2.882LeuHis: 2.882 ± 0.027	2.146LeuIle: 2.146 ± 0.029	3.539LeuLys: 3.539 ± 0.042	17.099LeuLeu: 17.099 ± 0.186	1.354LeuMet: 1.354 ± 0.02	1.98LeuAsn: 1.98 ± 0.026	6.09LeuPro: 6.09 ± 0.053	11.976LeuGln: 11.976 ± 0.151	6.775LeuArg: 6.775 ± 0.053	7.183LeuSer: 7.183 ± 0.05	3.233LeuThr: 3.233 ± 0.028	3.966LeuVal: 3.966 ± 0.042	1.061LeuTrp: 1.061 ± 0.019	1.515LeuTyr: 1.515 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	0.995MetAla: 0.995 ± 0.017	0.206MetCys: 0.206 ± 0.007	0.491MetAsp: 0.491 ± 0.012	0.864MetGlu: 0.864 ± 0.016	0.319MetPhe: 0.319 ± 0.008	0.956MetGly: 0.956 ± 0.018	0.484MetHis: 0.484 ± 0.01	0.33MetIle: 0.33 ± 0.012	0.643MetLys: 0.643 ± 0.014	1.584MetLeu: 1.584 ± 0.021	0.262MetMet: 0.262 ± 0.011	0.373MetAsn: 0.373 ± 0.011	0.796MetPro: 0.796 ± 0.014	1.637MetGln: 1.637 ± 0.024	1.014MetArg: 1.014 ± 0.016	0.821MetSer: 0.821 ± 0.014	0.526MetThr: 0.526 ± 0.011	0.553MetVal: 0.553 ± 0.013	0.161MetTrp: 0.161 ± 0.007	0.256MetTyr: 0.256 ± 0.007	0.0MetXaa: 0.0 ± 0.0
Asn	2.284AsnAla: 2.284 ± 0.022	0.562AsnCys: 0.562 ± 0.013	0.848AsnAsp: 0.848 ± 0.017	1.311AsnGlu: 1.311 ± 0.021	0.637AsnPhe: 0.637 ± 0.014	1.478AsnGly: 1.478 ± 0.023	0.354AsnHis: 0.354 ± 0.009	0.883AsnIle: 0.883 ± 0.016	1.186AsnLys: 1.186 ± 0.02	1.617AsnLeu: 1.617 ± 0.027	0.37AsnMet: 0.37 ± 0.009	1.507AsnAsn: 1.507 ± 0.037	1.366AsnPro: 1.366 ± 0.02	0.747AsnGln: 0.747 ± 0.017	1.342AsnArg: 1.342 ± 0.018	4.265AsnSer: 4.265 ± 0.056	1.275AsnThr: 1.275 ± 0.02	1.001AsnVal: 1.001 ± 0.02	0.224AsnTrp: 0.224 ± 0.009	0.415AsnTyr: 0.415 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.421ProAla: 7.421 ± 0.061	0.888ProCys: 0.888 ± 0.016	1.689ProAsp: 1.689 ± 0.02	3.075ProGlu: 3.075 ± 0.032	1.733ProPhe: 1.733 ± 0.023	3.045ProGly: 3.045 ± 0.043	1.57ProHis: 1.57 ± 0.024	1.245ProIle: 1.245 ± 0.017	1.791ProLys: 1.791 ± 0.029	6.472ProLeu: 6.472 ± 0.063	0.741ProMet: 0.741 ± 0.017	1.097ProAsn: 1.097 ± 0.016	6.245ProPro: 6.245 ± 0.09	4.346ProGln: 4.346 ± 0.054	3.007ProArg: 3.007 ± 0.036	5.579ProSer: 5.579 ± 0.058	2.832ProThr: 2.832 ± 0.032	2.889ProVal: 2.889 ± 0.029	0.649ProTrp: 0.649 ± 0.013	0.905ProTyr: 0.905 ± 0.017	0.0ProXaa: 0.0 ± 0.0
Gln	3.58GlnAla: 3.58 ± 0.033	0.573GlnCys: 0.573 ± 0.011	1.672GlnAsp: 1.672 ± 0.025	5.118GlnGlu: 5.118 ± 0.071	0.836GlnPhe: 0.836 ± 0.014	3.059GlnGly: 3.059 ± 0.032	3.738GlnHis: 3.738 ± 0.049	1.207GlnIle: 1.207 ± 0.019	2.775GlnLys: 2.775 ± 0.039	8.954GlnLeu: 8.954 ± 0.116	1.136GlnMet: 1.136 ± 0.022	0.994GlnAsn: 0.994 ± 0.016	3.583GlnPro: 3.583 ± 0.056	53.26GlnGln: 53.26 ± 0.828	5.272GlnArg: 5.272 ± 0.057	2.255GlnSer: 2.255 ± 0.024	2.325GlnThr: 2.325 ± 0.024	2.156GlnVal: 2.156 ± 0.024	0.535GlnTrp: 0.535 ± 0.014	0.658GlnTyr: 0.658 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.691ArgAla: 4.691 ± 0.038	1.481ArgCys: 1.481 ± 0.021	2.342ArgAsp: 2.342 ± 0.039	3.759ArgGlu: 3.759 ± 0.047	1.47ArgPhe: 1.47 ± 0.019	4.403ArgGly: 4.403 ± 0.048	1.458ArgHis: 1.458 ± 0.02	1.682ArgIle: 1.682 ± 0.022	2.386ArgLys: 2.386 ± 0.029	6.374ArgLeu: 6.374 ± 0.048	1.078ArgMet: 1.078 ± 0.015	1.351ArgAsn: 1.351 ± 0.018	2.644ArgPro: 2.644 ± 0.029	4.33ArgGln: 4.33 ± 0.044	5.981ArgArg: 5.981 ± 0.06	5.155ArgSer: 5.155 ± 0.044	2.142ArgThr: 2.142 ± 0.026	2.965ArgVal: 2.965 ± 0.03	0.73ArgTrp: 0.73 ± 0.014	0.912ArgTyr: 0.912 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	8.696SerAla: 8.696 ± 0.058	2.165SerCys: 2.165 ± 0.031	2.636SerAsp: 2.636 ± 0.026	3.51SerGlu: 3.51 ± 0.03	2.546SerPhe: 2.546 ± 0.031	5.454SerGly: 5.454 ± 0.057	1.253SerHis: 1.253 ± 0.021	2.387SerIle: 2.387 ± 0.032	3.085SerLys: 3.085 ± 0.035	7.525SerLeu: 7.525 ± 0.054	0.999SerMet: 0.999 ± 0.018	4.512SerAsn: 4.512 ± 0.063	5.431SerPro: 5.431 ± 0.048	2.486SerGln: 2.486 ± 0.036	5.484SerArg: 5.484 ± 0.045	30.152SerSer: 30.152 ± 0.386	4.223SerThr: 4.223 ± 0.045	3.996SerVal: 3.996 ± 0.056	0.82SerTrp: 0.82 ± 0.015	1.101SerTyr: 1.101 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	8.994ThrAla: 8.994 ± 0.078	0.703ThrCys: 0.703 ± 0.018	1.875ThrAsp: 1.875 ± 0.024	2.951ThrGlu: 2.951 ± 0.035	1.053ThrPhe: 1.053 ± 0.017	2.923ThrGly: 2.923 ± 0.033	0.854ThrHis: 0.854 ± 0.015	1.121ThrIle: 1.121 ± 0.022	1.524ThrLys: 1.524 ± 0.025	3.415ThrLeu: 3.415 ± 0.032	0.477ThrMet: 0.477 ± 0.01	1.218ThrAsn: 1.218 ± 0.02	3.608ThrPro: 3.608 ± 0.033	1.897ThrGln: 1.897 ± 0.025	2.171ThrArg: 2.171 ± 0.025	3.706ThrSer: 3.706 ± 0.042	3.008ThrThr: 3.008 ± 0.041	2.263ThrVal: 2.263 ± 0.033	0.365ThrTrp: 0.365 ± 0.008	0.625ThrTyr: 0.625 ± 0.015	0.0ThrXaa: 0.0 ± 0.0
Val	6.116ValAla: 6.116 ± 0.047	1.229ValCys: 1.229 ± 0.017	2.127ValAsp: 2.127 ± 0.026	3.138ValGlu: 3.138 ± 0.036	1.616ValPhe: 1.616 ± 0.025	3.286ValGly: 3.286 ± 0.035	1.115ValHis: 1.115 ± 0.017	1.193ValIle: 1.193 ± 0.022	1.629ValLys: 1.629 ± 0.026	5.218ValLeu: 5.218 ± 0.06	0.666ValMet: 0.666 ± 0.014	1.013ValAsn: 1.013 ± 0.017	2.578ValPro: 2.578 ± 0.032	2.571ValGln: 2.571 ± 0.029	2.601ValArg: 2.601 ± 0.031	4.455ValSer: 4.455 ± 0.049	1.647ValThr: 1.647 ± 0.027	3.077ValVal: 3.077 ± 0.04	0.577ValTrp: 0.577 ± 0.012	1.273ValTyr: 1.273 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	0.733TrpAla: 0.733 ± 0.014	0.203TrpCys: 0.203 ± 0.006	0.336TrpAsp: 0.336 ± 0.009	0.567TrpGlu: 0.567 ± 0.014	0.238TrpPhe: 0.238 ± 0.008	1.131TrpGly: 1.131 ± 0.02	0.194TrpHis: 0.194 ± 0.007	0.27TrpIle: 0.27 ± 0.008	0.394TrpLys: 0.394 ± 0.011	1.096TrpLeu: 1.096 ± 0.018	0.179TrpMet: 0.179 ± 0.007	0.224TrpAsn: 0.224 ± 0.008	0.391TrpPro: 0.391 ± 0.01	0.554TrpGln: 0.554 ± 0.013	0.949TrpArg: 0.949 ± 0.019	0.653TrpSer: 0.653 ± 0.012	0.352TrpThr: 0.352 ± 0.009	0.534TrpVal: 0.534 ± 0.013	0.151TrpTrp: 0.151 ± 0.005	0.118TrpTyr: 0.118 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.225TyrAla: 1.225 ± 0.019	0.39TyrCys: 0.39 ± 0.013	0.622TyrAsp: 0.622 ± 0.015	0.862TyrGlu: 0.862 ± 0.015	0.551TyrPhe: 0.551 ± 0.011	0.984TyrGly: 0.984 ± 0.017	0.285TyrHis: 0.285 ± 0.008	0.586TyrIle: 0.586 ± 0.014	0.621TyrLys: 0.621 ± 0.013	1.492TyrLeu: 1.492 ± 0.022	0.283TyrMet: 0.283 ± 0.008	0.411TyrAsn: 0.411 ± 0.012	0.756TyrPro: 0.756 ± 0.016	0.563TyrGln: 0.563 ± 0.012	1.065TyrArg: 1.065 ± 0.017	1.251TyrSer: 1.251 ± 0.02	0.872TyrThr: 0.872 ± 0.014	0.806TyrVal: 0.806 ± 0.015	0.18TyrTrp: 0.18 ± 0.005	0.347TyrTyr: 0.347 ± 0.01	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6867 proteins (4597400 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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