Amino acid dipepetide frequency for Asbolus verrucosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.6AlaAla: 4.6 ± 0.04	1.079AlaCys: 1.079 ± 0.016	2.79AlaAsp: 2.79 ± 0.023	3.672AlaGlu: 3.672 ± 0.033	2.383AlaPhe: 2.383 ± 0.026	3.095AlaGly: 3.095 ± 0.03	1.303AlaHis: 1.303 ± 0.016	3.558AlaIle: 3.558 ± 0.028	3.754AlaLys: 3.754 ± 0.033	5.619AlaLeu: 5.619 ± 0.045	1.286AlaMet: 1.286 ± 0.016	2.678AlaAsn: 2.678 ± 0.024	2.609AlaPro: 2.609 ± 0.031	2.239AlaGln: 2.239 ± 0.023	2.644AlaArg: 2.644 ± 0.029	4.133AlaSer: 4.133 ± 0.034	3.391AlaThr: 3.391 ± 0.027	4.052AlaVal: 4.052 ± 0.033	0.594AlaTrp: 0.594 ± 0.011	1.642AlaTyr: 1.642 ± 0.015	0.003AlaXaa: 0.003 ± 0.001
Cys	1.054CysAla: 1.054 ± 0.016	0.494CysCys: 0.494 ± 0.01	1.271CysAsp: 1.271 ± 0.018	1.273CysGlu: 1.273 ± 0.024	0.862CysPhe: 0.862 ± 0.013	1.38CysGly: 1.38 ± 0.027	0.502CysHis: 0.502 ± 0.011	1.189CysIle: 1.189 ± 0.02	1.279CysLys: 1.279 ± 0.018	1.844CysLeu: 1.844 ± 0.024	0.406CysMet: 0.406 ± 0.008	1.037CysAsn: 1.037 ± 0.017	1.022CysPro: 1.022 ± 0.025	0.774CysGln: 0.774 ± 0.014	0.985CysArg: 0.985 ± 0.018	1.59CysSer: 1.59 ± 0.024	1.065CysThr: 1.065 ± 0.018	1.299CysVal: 1.299 ± 0.02	0.246CysTrp: 0.246 ± 0.007	0.68CysTyr: 0.68 ± 0.014	0.001CysXaa: 0.001 ± 0.0
Asp	2.738AspAla: 2.738 ± 0.029	1.092AspCys: 1.092 ± 0.017	3.58AspAsp: 3.58 ± 0.034	4.122AspGlu: 4.122 ± 0.033	2.516AspPhe: 2.516 ± 0.021	3.002AspGly: 3.002 ± 0.029	1.162AspHis: 1.162 ± 0.016	3.691AspIle: 3.691 ± 0.029	3.478AspLys: 3.478 ± 0.033	5.137AspLeu: 5.137 ± 0.035	1.188AspMet: 1.188 ± 0.016	2.834AspAsn: 2.834 ± 0.025	2.406AspPro: 2.406 ± 0.025	1.674AspGln: 1.674 ± 0.017	2.36AspArg: 2.36 ± 0.026	3.967AspSer: 3.967 ± 0.037	2.547AspThr: 2.547 ± 0.022	3.715AspVal: 3.715 ± 0.027	0.655AspTrp: 0.655 ± 0.012	2.005AspTyr: 2.005 ± 0.02	0.002AspXaa: 0.002 ± 0.001
Glu	3.886GluAla: 3.886 ± 0.036	1.251GluCys: 1.251 ± 0.025	4.153GluAsp: 4.153 ± 0.032	6.378GluGlu: 6.378 ± 0.064	2.483GluPhe: 2.483 ± 0.022	3.026GluGly: 3.026 ± 0.035	1.494GluHis: 1.494 ± 0.02	4.632GluIle: 4.632 ± 0.038	5.513GluLys: 5.513 ± 0.052	5.842GluLeu: 5.842 ± 0.044	1.612GluMet: 1.612 ± 0.018	4.221GluAsn: 4.221 ± 0.034	2.452GluPro: 2.452 ± 0.032	2.566GluGln: 2.566 ± 0.029	3.354GluArg: 3.354 ± 0.036	4.304GluSer: 4.304 ± 0.034	3.743GluThr: 3.743 ± 0.037	4.107GluVal: 4.107 ± 0.031	0.67GluTrp: 0.67 ± 0.013	2.036GluTyr: 2.036 ± 0.024	0.002GluXaa: 0.002 ± 0.0
Phe	2.301PheAla: 2.301 ± 0.024	0.949PheCys: 0.949 ± 0.013	2.443PheAsp: 2.443 ± 0.021	2.544PheGlu: 2.544 ± 0.026	2.014PhePhe: 2.014 ± 0.026	2.57PheGly: 2.57 ± 0.028	1.046PheHis: 1.046 ± 0.015	2.68PheIle: 2.68 ± 0.027	2.703PheLys: 2.703 ± 0.024	4.224PheLeu: 4.224 ± 0.037	0.98PheMet: 0.98 ± 0.013	2.199PheAsn: 2.199 ± 0.023	1.751PhePro: 1.751 ± 0.019	1.735PheGln: 1.735 ± 0.016	1.965PheArg: 1.965 ± 0.019	3.226PheSer: 3.226 ± 0.03	2.437PheThr: 2.437 ± 0.021	2.84PheVal: 2.84 ± 0.029	0.553PheTrp: 0.553 ± 0.012	1.703PheTyr: 1.703 ± 0.021	0.002PheXaa: 0.002 ± 0.001
Gly	3.12GlyAla: 3.12 ± 0.031	1.006GlyCys: 1.006 ± 0.017	2.866GlyAsp: 2.866 ± 0.028	3.116GlyGlu: 3.116 ± 0.032	2.353GlyPhe: 2.353 ± 0.024	3.806GlyGly: 3.806 ± 0.057	1.416GlyHis: 1.416 ± 0.021	3.278GlyIle: 3.278 ± 0.032	3.543GlyLys: 3.543 ± 0.032	4.579GlyLeu: 4.579 ± 0.035	1.099GlyMet: 1.099 ± 0.017	2.642GlyAsn: 2.642 ± 0.026	2.186GlyPro: 2.186 ± 0.039	1.946GlyGln: 1.946 ± 0.024	2.636GlyArg: 2.636 ± 0.026	3.989GlySer: 3.989 ± 0.03	2.917GlyThr: 2.917 ± 0.029	3.363GlyVal: 3.363 ± 0.029	0.644GlyTrp: 0.644 ± 0.012	2.04GlyTyr: 2.04 ± 0.026	0.004GlyXaa: 0.004 ± 0.001
His	1.17HisAla: 1.17 ± 0.018	0.588HisCys: 0.588 ± 0.012	1.054HisAsp: 1.054 ± 0.014	1.328HisGlu: 1.328 ± 0.017	1.125HisPhe: 1.125 ± 0.014	1.261HisGly: 1.261 ± 0.017	0.905HisHis: 0.905 ± 0.019	1.557HisIle: 1.557 ± 0.019	1.558HisLys: 1.558 ± 0.023	2.54HisLeu: 2.54 ± 0.025	0.611HisMet: 0.611 ± 0.01	1.236HisAsn: 1.236 ± 0.016	1.261HisPro: 1.261 ± 0.016	1.056HisGln: 1.056 ± 0.016	1.281HisArg: 1.281 ± 0.018	1.775HisSer: 1.775 ± 0.022	1.327HisThr: 1.327 ± 0.021	1.55HisVal: 1.55 ± 0.02	0.291HisTrp: 0.291 ± 0.008	0.917HisTyr: 0.917 ± 0.014	0.001HisXaa: 0.001 ± 0.0
Ile	3.63IleAla: 3.63 ± 0.03	1.423IleCys: 1.423 ± 0.022	3.401IleAsp: 3.401 ± 0.028	3.96IleGlu: 3.96 ± 0.029	2.991IlePhe: 2.991 ± 0.037	3.034IleGly: 3.034 ± 0.025	1.475IleHis: 1.475 ± 0.018	4.083IleIle: 4.083 ± 0.036	4.425IleLys: 4.425 ± 0.032	6.294IleLeu: 6.294 ± 0.054	1.326IleMet: 1.326 ± 0.02	3.501IleAsn: 3.501 ± 0.03	3.015IlePro: 3.015 ± 0.026	2.437IleGln: 2.437 ± 0.023	2.832IleArg: 2.832 ± 0.023	4.659IleSer: 4.659 ± 0.029	3.703IleThr: 3.703 ± 0.031	3.95IleVal: 3.95 ± 0.031	0.654IleTrp: 0.654 ± 0.011	2.154IleTyr: 2.154 ± 0.023	0.002IleXaa: 0.002 ± 0.001
Lys	3.579LysAla: 3.579 ± 0.031	1.468LysCys: 1.468 ± 0.021	3.559LysAsp: 3.559 ± 0.03	5.205LysGlu: 5.205 ± 0.049	2.771LysPhe: 2.771 ± 0.026	2.96LysGly: 2.96 ± 0.03	1.771LysHis: 1.771 ± 0.023	4.965LysIle: 4.965 ± 0.031	6.23LysLys: 6.23 ± 0.058	6.447LysLeu: 6.447 ± 0.043	1.674LysMet: 1.674 ± 0.019	4.226LysAsn: 4.226 ± 0.031	3.246LysPro: 3.246 ± 0.042	2.882LysGln: 2.882 ± 0.026	3.703LysArg: 3.703 ± 0.031	5.053LysSer: 5.053 ± 0.042	4.082LysThr: 4.082 ± 0.03	3.995LysVal: 3.995 ± 0.03	0.811LysTrp: 0.811 ± 0.014	2.517LysTyr: 2.517 ± 0.025	0.004LysXaa: 0.004 ± 0.001
Leu	5.556LeuAla: 5.556 ± 0.04	1.818LeuCys: 1.818 ± 0.022	4.839LeuAsp: 4.839 ± 0.032	6.295LeuGlu: 6.295 ± 0.049	3.736LeuPhe: 3.736 ± 0.036	4.655LeuGly: 4.655 ± 0.036	2.423LeuHis: 2.423 ± 0.024	5.503LeuIle: 5.503 ± 0.044	7.19LeuLys: 7.19 ± 0.044	8.968LeuLeu: 8.968 ± 0.066	2.109LeuMet: 2.109 ± 0.022	4.922LeuAsn: 4.922 ± 0.035	4.523LeuPro: 4.523 ± 0.034	4.511LeuGln: 4.511 ± 0.038	4.72LeuArg: 4.72 ± 0.033	6.884LeuSer: 6.884 ± 0.04	5.372LeuThr: 5.372 ± 0.036	5.388LeuVal: 5.388 ± 0.037	0.974LeuTrp: 0.974 ± 0.015	2.971LeuTyr: 2.971 ± 0.026	0.004LeuXaa: 0.004 ± 0.001
Met	1.509MetAla: 1.509 ± 0.018	0.434MetCys: 0.434 ± 0.01	1.206MetAsp: 1.206 ± 0.014	1.6MetGlu: 1.6 ± 0.018	1.0MetPhe: 1.0 ± 0.016	1.155MetGly: 1.155 ± 0.015	0.479MetHis: 0.479 ± 0.009	1.218MetIle: 1.218 ± 0.017	1.712MetLys: 1.712 ± 0.018	1.985MetLeu: 1.985 ± 0.02	0.624MetMet: 0.624 ± 0.011	1.119MetAsn: 1.119 ± 0.016	0.903MetPro: 0.903 ± 0.014	0.888MetGln: 0.888 ± 0.012	1.068MetArg: 1.068 ± 0.015	1.643MetSer: 1.643 ± 0.018	1.233MetThr: 1.233 ± 0.016	1.367MetVal: 1.367 ± 0.018	0.25MetTrp: 0.25 ± 0.007	0.748MetTyr: 0.748 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	2.73AsnAla: 2.73 ± 0.028	1.134AsnCys: 1.134 ± 0.017	2.703AsnAsp: 2.703 ± 0.026	3.525AsnGlu: 3.525 ± 0.027	2.54AsnPhe: 2.54 ± 0.027	2.953AsnGly: 2.953 ± 0.033	1.202AsnHis: 1.202 ± 0.018	3.739AsnIle: 3.739 ± 0.031	3.744AsnLys: 3.744 ± 0.033	5.332AsnLeu: 5.332 ± 0.039	1.26AsnMet: 1.26 ± 0.017	3.398AsnAsn: 3.398 ± 0.034	2.462AsnPro: 2.462 ± 0.024	2.023AsnGln: 2.023 ± 0.02	2.402AsnArg: 2.402 ± 0.023	4.179AsnSer: 4.179 ± 0.034	2.773AsnThr: 2.773 ± 0.024	3.585AsnVal: 3.585 ± 0.024	0.61AsnTrp: 0.61 ± 0.01	2.034AsnTyr: 2.034 ± 0.022	0.002AsnXaa: 0.002 ± 0.001
Pro	2.628ProAla: 2.628 ± 0.028	0.75ProCys: 0.75 ± 0.018	2.516ProAsp: 2.516 ± 0.021	3.5ProGlu: 3.5 ± 0.036	1.875ProPhe: 1.875 ± 0.021	2.465ProGly: 2.465 ± 0.054	1.146ProHis: 1.146 ± 0.017	2.602ProIle: 2.602 ± 0.024	3.264ProLys: 3.264 ± 0.032	4.082ProLeu: 4.082 ± 0.029	0.86ProMet: 0.86 ± 0.013	2.464ProAsn: 2.464 ± 0.025	3.717ProPro: 3.717 ± 0.064	2.09ProGln: 2.09 ± 0.027	2.117ProArg: 2.117 ± 0.024	3.798ProSer: 3.798 ± 0.038	2.787ProThr: 2.787 ± 0.03	3.245ProVal: 3.245 ± 0.035	0.475ProTrp: 0.475 ± 0.01	1.616ProTyr: 1.616 ± 0.022	0.002ProXaa: 0.002 ± 0.0
Gln	2.216GlnAla: 2.216 ± 0.024	0.858GlnCys: 0.858 ± 0.018	1.87GlnAsp: 1.87 ± 0.019	2.83GlnGlu: 2.83 ± 0.029	1.704GlnPhe: 1.704 ± 0.019	1.763GlnGly: 1.763 ± 0.019	1.087GlnHis: 1.087 ± 0.017	2.666GlnIle: 2.666 ± 0.024	2.895GlnLys: 2.895 ± 0.026	3.878GlnLeu: 3.878 ± 0.034	0.981GlnMet: 0.981 ± 0.014	2.493GlnAsn: 2.493 ± 0.025	1.86GlnPro: 1.86 ± 0.027	2.421GlnGln: 2.421 ± 0.039	2.03GlnArg: 2.03 ± 0.02	2.62GlnSer: 2.62 ± 0.025	2.201GlnThr: 2.201 ± 0.023	2.37GlnVal: 2.37 ± 0.024	0.485GlnTrp: 0.485 ± 0.01	1.376GlnTyr: 1.376 ± 0.016	0.001GlnXaa: 0.001 ± 0.0
Arg	2.518ArgAla: 2.518 ± 0.026	0.918ArgCys: 0.918 ± 0.018	2.525ArgAsp: 2.525 ± 0.025	3.091ArgGlu: 3.091 ± 0.032	1.999ArgPhe: 1.999 ± 0.022	2.383ArgGly: 2.383 ± 0.026	1.353ArgHis: 1.353 ± 0.016	2.96ArgIle: 2.96 ± 0.022	3.868ArgLys: 3.868 ± 0.035	4.388ArgLeu: 4.388 ± 0.034	1.04ArgMet: 1.04 ± 0.013	2.785ArgAsn: 2.785 ± 0.026	2.24ArgPro: 2.24 ± 0.03	2.085ArgGln: 2.085 ± 0.021	3.338ArgArg: 3.338 ± 0.034	3.557ArgSer: 3.557 ± 0.034	2.535ArgThr: 2.535 ± 0.024	2.64ArgVal: 2.64 ± 0.025	0.527ArgTrp: 0.527 ± 0.011	1.629ArgTyr: 1.629 ± 0.016	0.002ArgXaa: 0.002 ± 0.001
Ser	4.076SerAla: 4.076 ± 0.033	1.441SerCys: 1.441 ± 0.022	4.26SerAsp: 4.26 ± 0.033	4.783SerGlu: 4.783 ± 0.036	3.071SerPhe: 3.071 ± 0.029	4.257SerGly: 4.257 ± 0.033	1.707SerHis: 1.707 ± 0.023	4.099SerIle: 4.099 ± 0.025	4.886SerLys: 4.886 ± 0.038	6.866SerLeu: 6.866 ± 0.045	1.497SerMet: 1.497 ± 0.014	3.875SerAsn: 3.875 ± 0.034	4.03SerPro: 4.03 ± 0.045	2.878SerGln: 2.878 ± 0.022	3.456SerArg: 3.456 ± 0.031	7.036SerSer: 7.036 ± 0.078	4.406SerThr: 4.406 ± 0.04	4.793SerVal: 4.793 ± 0.033	0.795SerTrp: 0.795 ± 0.012	2.44SerTyr: 2.44 ± 0.022	0.003SerXaa: 0.003 ± 0.001
Thr	3.491ThrAla: 3.491 ± 0.026	1.137ThrCys: 1.137 ± 0.02	2.846ThrAsp: 2.846 ± 0.027	3.628ThrGlu: 3.628 ± 0.044	2.42ThrPhe: 2.42 ± 0.024	3.07ThrGly: 3.07 ± 0.033	1.266ThrHis: 1.266 ± 0.017	3.673ThrIle: 3.673 ± 0.032	3.66ThrLys: 3.66 ± 0.03	5.233ThrLeu: 5.233 ± 0.03	1.135ThrMet: 1.135 ± 0.014	2.943ThrAsn: 2.943 ± 0.026	3.239ThrPro: 3.239 ± 0.037	2.082ThrGln: 2.082 ± 0.023	2.36ThrArg: 2.36 ± 0.022	4.469ThrSer: 4.469 ± 0.037	3.808ThrThr: 3.808 ± 0.063	3.936ThrVal: 3.936 ± 0.034	0.571ThrTrp: 0.571 ± 0.011	1.862ThrTyr: 1.862 ± 0.018	0.004ThrXaa: 0.004 ± 0.001
Val	4.032ValAla: 4.032 ± 0.032	1.387ValCys: 1.387 ± 0.021	3.503ValAsp: 3.503 ± 0.027	4.185ValGlu: 4.185 ± 0.034	2.718ValPhe: 2.718 ± 0.027	3.138ValGly: 3.138 ± 0.031	1.507ValHis: 1.507 ± 0.02	4.026ValIle: 4.026 ± 0.032	4.362ValLys: 4.362 ± 0.029	5.815ValLeu: 5.815 ± 0.044	1.38ValMet: 1.38 ± 0.019	3.236ValAsn: 3.236 ± 0.027	3.082ValPro: 3.082 ± 0.028	2.511ValGln: 2.511 ± 0.024	2.814ValArg: 2.814 ± 0.024	4.488ValSer: 4.488 ± 0.034	3.967ValThr: 3.967 ± 0.036	4.396ValVal: 4.396 ± 0.037	0.699ValTrp: 0.699 ± 0.012	2.065ValTyr: 2.065 ± 0.021	0.003ValXaa: 0.003 ± 0.001
Trp	0.558TrpAla: 0.558 ± 0.011	0.234TrpCys: 0.234 ± 0.006	0.6TrpAsp: 0.6 ± 0.012	0.617TrpGlu: 0.617 ± 0.012	0.564TrpPhe: 0.564 ± 0.013	0.609TrpGly: 0.609 ± 0.013	0.25TrpHis: 0.25 ± 0.007	0.727TrpIle: 0.727 ± 0.012	0.838TrpLys: 0.838 ± 0.015	1.072TrpLeu: 1.072 ± 0.016	0.296TrpMet: 0.296 ± 0.008	0.618TrpAsn: 0.618 ± 0.011	0.45TrpPro: 0.45 ± 0.01	0.424TrpGln: 0.424 ± 0.009	0.609TrpArg: 0.609 ± 0.011	0.823TrpSer: 0.823 ± 0.014	0.627TrpThr: 0.627 ± 0.011	0.597TrpVal: 0.597 ± 0.012	0.17TrpTrp: 0.17 ± 0.005	0.412TrpTyr: 0.412 ± 0.009	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.73TyrAla: 1.73 ± 0.02	0.795TyrCys: 0.795 ± 0.012	1.882TyrAsp: 1.882 ± 0.022	2.069TyrGlu: 2.069 ± 0.02	1.738TyrPhe: 1.738 ± 0.02	1.967TyrGly: 1.967 ± 0.023	0.901TyrHis: 0.901 ± 0.014	2.099TyrIle: 2.099 ± 0.022	2.243TyrLys: 2.243 ± 0.023	3.211TyrLeu: 3.211 ± 0.025	0.776TyrMet: 0.776 ± 0.012	1.897TyrAsn: 1.897 ± 0.021	1.544TyrPro: 1.544 ± 0.02	1.383TyrGln: 1.383 ± 0.021	1.704TyrArg: 1.704 ± 0.019	2.458TyrSer: 2.458 ± 0.024	1.908TyrThr: 1.908 ± 0.021	2.12TyrVal: 2.12 ± 0.022	0.421TyrTrp: 0.421 ± 0.01	1.404TyrTyr: 1.404 ± 0.02	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.002XaaGly: 0.002 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.004XaaIle: 0.004 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.005XaaLeu: 0.005 ± 0.001	0.003XaaMet: 0.003 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.003XaaSer: 0.003 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.12XaaXaa: 0.12 ± 0.018

Statistics based on 15225 proteins (5816570 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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