Human papillomavirus 122

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Betapapillomavirus; Betapapillomavirus 2

Average proteome isoelectric point is 6.01

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|D7P182|D7P182_9PAPI Replication protein E1 OS=Human papillomavirus 122 OX=765054 GN=E1 PE=3 SV=1
MM1 pKa = 7.6IGKK4 pKa = 8.88QPTIPDD10 pKa = 3.46VVLEE14 pKa = 4.15LQEE17 pKa = 4.85LVQPTDD23 pKa = 3.0LHH25 pKa = 7.68CYY27 pKa = 10.12EE28 pKa = 5.0EE29 pKa = 4.54LTEE32 pKa = 4.52EE33 pKa = 4.17PAEE36 pKa = 4.13EE37 pKa = 4.26EE38 pKa = 4.29QCLTPYY44 pKa = 10.38KK45 pKa = 10.38IIVACNCGTRR55 pKa = 11.84LRR57 pKa = 11.84LYY59 pKa = 10.95VFATDD64 pKa = 3.85LGIRR68 pKa = 11.84AQQEE72 pKa = 4.1LLLGEE77 pKa = 4.32VQLVCPEE84 pKa = 3.9CRR86 pKa = 11.84EE87 pKa = 3.77KK88 pKa = 10.94LRR90 pKa = 11.84RR91 pKa = 11.84HH92 pKa = 5.46EE93 pKa = 4.04

Molecular weight: 10.71 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|D7P184|D7P184_9PAPI Uncharacterized protein E4 OS=Human papillomavirus 122 OX=765054 GN=E4 PE=4 SV=1
MM1 pKa = 7.66EE2 pKa = 5.01SLSEE6 pKa = 4.14RR7 pKa = 11.84FNALQEE13 pKa = 4.29TLMDD17 pKa = 4.67LYY19 pKa = 11.24EE20 pKa = 4.58SGRR23 pKa = 11.84EE24 pKa = 3.93DD25 pKa = 3.48LQSQIDD31 pKa = 3.25HH32 pKa = 6.24WQTLRR37 pKa = 11.84QEE39 pKa = 4.07QVLLYY44 pKa = 8.8FARR47 pKa = 11.84KK48 pKa = 8.52HH49 pKa = 4.52GVMRR53 pKa = 11.84LGYY56 pKa = 10.22QPVPPLATSEE66 pKa = 4.58SKK68 pKa = 11.11AKK70 pKa = 10.42DD71 pKa = 3.66AIGMVLLLQSLQKK84 pKa = 10.42SSYY87 pKa = 9.35GQEE90 pKa = 3.58PWTLVQTSLEE100 pKa = 4.48TVRR103 pKa = 11.84SPPANCFKK111 pKa = 10.8KK112 pKa = 10.31GPQNIEE118 pKa = 3.67VMFDD122 pKa = 3.5GDD124 pKa = 3.96PEE126 pKa = 5.54NIMSYY131 pKa = 7.43TVWTYY136 pKa = 10.87IYY138 pKa = 10.27YY139 pKa = 8.22QTNNDD144 pKa = 2.67TWEE147 pKa = 4.16KK148 pKa = 11.19VEE150 pKa = 4.03GQVDD154 pKa = 3.85YY155 pKa = 11.2FGAYY159 pKa = 9.53YY160 pKa = 10.68FEE162 pKa = 5.01GTLKK166 pKa = 9.74TYY168 pKa = 10.3YY169 pKa = 10.23INFEE173 pKa = 3.61TDD175 pKa = 2.51AARR178 pKa = 11.84FSKK181 pKa = 8.53TNKK184 pKa = 9.23WEE186 pKa = 3.72VHH188 pKa = 4.32VNKK191 pKa = 10.35NIVFAPVTSSSPPTGDD207 pKa = 3.01GGEE210 pKa = 4.16ASSNTVSRR218 pKa = 11.84SRR220 pKa = 11.84SHH222 pKa = 6.67SPQLSAPTLSSVQQRR237 pKa = 11.84PLSTTSRR244 pKa = 11.84RR245 pKa = 11.84YY246 pKa = 9.32RR247 pKa = 11.84RR248 pKa = 11.84KK249 pKa = 9.88ASSPTSTRR257 pKa = 11.84QKK259 pKa = 9.94RR260 pKa = 11.84QRR262 pKa = 11.84QKK264 pKa = 9.17ATTRR268 pKa = 11.84RR269 pKa = 11.84SRR271 pKa = 11.84SRR273 pKa = 11.84SRR275 pKa = 11.84GRR277 pKa = 11.84TATEE281 pKa = 3.51RR282 pKa = 11.84GGRR285 pKa = 11.84GGRR288 pKa = 11.84ASSADD293 pKa = 3.5SDD295 pKa = 4.01SSTGRR300 pKa = 11.84RR301 pKa = 11.84RR302 pKa = 11.84GRR304 pKa = 11.84GGGRR308 pKa = 11.84GPTTRR313 pKa = 11.84SQSRR317 pKa = 11.84SRR319 pKa = 11.84SRR321 pKa = 11.84SRR323 pKa = 11.84SRR325 pKa = 11.84SQARR329 pKa = 11.84GSSTRR334 pKa = 11.84GGIAPASVGASVRR347 pKa = 11.84SVGRR351 pKa = 11.84EE352 pKa = 3.3HH353 pKa = 7.29HH354 pKa = 6.46GRR356 pKa = 11.84LEE358 pKa = 3.98RR359 pKa = 11.84LLAEE363 pKa = 4.55AQDD366 pKa = 3.93PPIVILRR373 pKa = 11.84GEE375 pKa = 4.18ANVLKK380 pKa = 10.18CYY382 pKa = 10.28RR383 pKa = 11.84YY384 pKa = 9.27RR385 pKa = 11.84ARR387 pKa = 11.84KK388 pKa = 8.56RR389 pKa = 11.84HH390 pKa = 5.73LGLVKK395 pKa = 10.46YY396 pKa = 10.85YY397 pKa = 9.25STTWSWVGGDD407 pKa = 3.25CCDD410 pKa = 2.91RR411 pKa = 11.84VGRR414 pKa = 11.84SRR416 pKa = 11.84MLLAFDD422 pKa = 4.07TYY424 pKa = 10.68KK425 pKa = 10.55QRR427 pKa = 11.84EE428 pKa = 4.05QFITTMKK435 pKa = 10.51LPPNVDD441 pKa = 2.49WSFGHH446 pKa = 7.68LDD448 pKa = 3.65DD449 pKa = 5.58LL450 pKa = 5.21

Molecular weight: 50.86 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2528

93

606

361.1

40.63

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.617 ± 0.311

2.057 ± 0.616

5.934 ± 0.435

6.646 ± 0.594

3.995 ± 0.592

6.843 ± 0.985

2.057 ± 0.167

4.786 ± 0.877

4.391 ± 0.634

8.703 ± 0.879

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.464 ± 0.282

3.837 ± 0.915

6.487 ± 1.546

5.498 ± 0.383

7.002 ± 1.048

7.595 ± 0.997

6.25 ± 0.673

6.29 ± 0.692

1.187 ± 0.304

3.362 ± 0.457
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski