Amino acid dipepetide frequency for Novosphingobium malaysiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.078AlaAla: 16.078 ± 0.17	1.242AlaCys: 1.242 ± 0.03	7.135AlaAsp: 7.135 ± 0.071	7.733AlaGlu: 7.733 ± 0.082	4.23AlaPhe: 4.23 ± 0.054	10.719AlaGly: 10.719 ± 0.107	2.328AlaHis: 2.328 ± 0.043	6.296AlaIle: 6.296 ± 0.08	4.11AlaLys: 4.11 ± 0.072	12.612AlaLeu: 12.612 ± 0.125	4.096AlaMet: 4.096 ± 0.056	3.114AlaAsn: 3.114 ± 0.05	5.67AlaPro: 5.67 ± 0.08	4.216AlaGln: 4.216 ± 0.059	8.775AlaArg: 8.775 ± 0.099	6.673AlaSer: 6.673 ± 0.073	5.76AlaThr: 5.76 ± 0.069	8.228AlaVal: 8.228 ± 0.088	1.618AlaTrp: 1.618 ± 0.035	2.634AlaTyr: 2.634 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.091CysAla: 1.091 ± 0.03	0.108CysCys: 0.108 ± 0.01	0.656CysAsp: 0.656 ± 0.026	0.586CysGlu: 0.586 ± 0.022	0.322CysPhe: 0.322 ± 0.017	1.004CysGly: 1.004 ± 0.029	0.251CysHis: 0.251 ± 0.016	0.424CysIle: 0.424 ± 0.019	0.247CysLys: 0.247 ± 0.014	0.768CysLeu: 0.768 ± 0.023	0.202CysMet: 0.202 ± 0.011	0.298CysAsn: 0.298 ± 0.014	0.517CysPro: 0.517 ± 0.02	0.278CysGln: 0.278 ± 0.015	0.677CysArg: 0.677 ± 0.024	0.553CysSer: 0.553 ± 0.019	0.473CysThr: 0.473 ± 0.023	0.664CysVal: 0.664 ± 0.022	0.127CysTrp: 0.127 ± 0.009	0.226CysTyr: 0.226 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.203AspAla: 7.203 ± 0.081	0.594AspCys: 0.594 ± 0.023	3.377AspAsp: 3.377 ± 0.06	3.818AspGlu: 3.818 ± 0.056	2.393AspPhe: 2.393 ± 0.044	5.447AspGly: 5.447 ± 0.077	1.355AspHis: 1.355 ± 0.031	2.888AspIle: 2.888 ± 0.052	2.013AspLys: 2.013 ± 0.046	6.076AspLeu: 6.076 ± 0.068	1.595AspMet: 1.595 ± 0.036	1.472AspAsn: 1.472 ± 0.035	3.903AspPro: 3.903 ± 0.053	1.654AspGln: 1.654 ± 0.035	4.322AspArg: 4.322 ± 0.065	2.457AspSer: 2.457 ± 0.045	2.812AspThr: 2.812 ± 0.048	4.376AspVal: 4.376 ± 0.061	1.19AspTrp: 1.19 ± 0.03	1.728AspTyr: 1.728 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.204GluAla: 8.204 ± 0.098	0.437GluCys: 0.437 ± 0.017	3.424GluAsp: 3.424 ± 0.056	3.761GluGlu: 3.761 ± 0.054	1.865GluPhe: 1.865 ± 0.039	5.086GluGly: 5.086 ± 0.065	1.356GluHis: 1.356 ± 0.032	3.217GluIle: 3.217 ± 0.049	2.456GluLys: 2.456 ± 0.045	5.302GluLeu: 5.302 ± 0.071	1.677GluMet: 1.677 ± 0.039	1.639GluAsn: 1.639 ± 0.035	2.924GluPro: 2.924 ± 0.043	2.2GluGln: 2.2 ± 0.042	4.921GluArg: 4.921 ± 0.072	2.572GluSer: 2.572 ± 0.044	3.523GluThr: 3.523 ± 0.056	4.036GluVal: 4.036 ± 0.055	0.913GluTrp: 0.913 ± 0.026	1.198GluTyr: 1.198 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.659PheAla: 4.659 ± 0.072	0.406PheCys: 0.406 ± 0.018	2.738PheAsp: 2.738 ± 0.047	2.273PheGlu: 2.273 ± 0.04	1.287PhePhe: 1.287 ± 0.037	3.769PheGly: 3.769 ± 0.058	0.81PheHis: 0.81 ± 0.023	1.427PheIle: 1.427 ± 0.033	0.97PheLys: 0.97 ± 0.027	3.136PheLeu: 3.136 ± 0.054	0.844PheMet: 0.844 ± 0.022	1.036PheAsn: 1.036 ± 0.031	1.596PhePro: 1.596 ± 0.035	0.901PheGln: 0.901 ± 0.024	2.094PheArg: 2.094 ± 0.04	2.242PheSer: 2.242 ± 0.047	2.127PheThr: 2.127 ± 0.047	2.676PheVal: 2.676 ± 0.047	0.562PheTrp: 0.562 ± 0.025	0.985PheTyr: 0.985 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.182GlyAla: 9.182 ± 0.09	0.932GlyCys: 0.932 ± 0.026	4.868GlyAsp: 4.868 ± 0.068	5.225GlyGlu: 5.225 ± 0.061	3.64GlyPhe: 3.64 ± 0.063	7.913GlyGly: 7.913 ± 0.108	1.906GlyHis: 1.906 ± 0.04	4.494GlyIle: 4.494 ± 0.061	3.85GlyLys: 3.85 ± 0.05	8.363GlyLeu: 8.363 ± 0.085	2.645GlyMet: 2.645 ± 0.041	2.475GlyAsn: 2.475 ± 0.048	3.83GlyPro: 3.83 ± 0.054	2.901GlyGln: 2.901 ± 0.046	5.928GlyArg: 5.928 ± 0.07	4.974GlySer: 4.974 ± 0.058	4.981GlyThr: 4.981 ± 0.075	6.113GlyVal: 6.113 ± 0.069	1.574GlyTrp: 1.574 ± 0.037	2.548GlyTyr: 2.548 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.43HisAla: 2.43 ± 0.045	0.285HisCys: 0.285 ± 0.014	1.241HisAsp: 1.241 ± 0.029	1.195HisGlu: 1.195 ± 0.031	0.969HisPhe: 0.969 ± 0.029	2.032HisGly: 2.032 ± 0.042	0.601HisHis: 0.601 ± 0.024	0.9HisIle: 0.9 ± 0.027	0.536HisLys: 0.536 ± 0.021	1.928HisLeu: 1.928 ± 0.039	0.549HisMet: 0.549 ± 0.019	0.503HisAsn: 0.503 ± 0.019	1.419HisPro: 1.419 ± 0.035	0.525HisGln: 0.525 ± 0.018	1.463HisArg: 1.463 ± 0.037	1.035HisSer: 1.035 ± 0.027	0.815HisThr: 0.815 ± 0.023	1.565HisVal: 1.565 ± 0.033	0.373HisTrp: 0.373 ± 0.016	0.664HisTyr: 0.664 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.072IleAla: 7.072 ± 0.079	0.516IleCys: 0.516 ± 0.02	3.892IleAsp: 3.892 ± 0.056	3.64IleGlu: 3.64 ± 0.054	1.498IlePhe: 1.498 ± 0.035	4.754IleGly: 4.754 ± 0.072	0.958IleHis: 0.958 ± 0.027	1.893IleIle: 1.893 ± 0.041	1.297IleLys: 1.297 ± 0.031	3.705IleLeu: 3.705 ± 0.052	0.973IleMet: 0.973 ± 0.026	1.382IleAsn: 1.382 ± 0.041	2.329IlePro: 2.329 ± 0.041	1.108IleGln: 1.108 ± 0.028	3.033IleArg: 3.033 ± 0.046	2.671IleSer: 2.671 ± 0.048	2.47IleThr: 2.47 ± 0.041	3.945IleVal: 3.945 ± 0.055	0.602IleTrp: 0.602 ± 0.023	1.1IleTyr: 1.1 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.416LysAla: 4.416 ± 0.073	0.206LysCys: 0.206 ± 0.014	1.842LysAsp: 1.842 ± 0.037	1.578LysGlu: 1.578 ± 0.041	0.988LysPhe: 0.988 ± 0.027	2.907LysGly: 2.907 ± 0.046	0.648LysHis: 0.648 ± 0.019	1.556LysIle: 1.556 ± 0.035	1.134LysLys: 1.134 ± 0.032	3.301LysLeu: 3.301 ± 0.056	0.846LysMet: 0.846 ± 0.029	0.798LysAsn: 0.798 ± 0.025	2.113LysPro: 2.113 ± 0.041	1.028LysGln: 1.028 ± 0.035	2.29LysArg: 2.29 ± 0.042	1.69LysSer: 1.69 ± 0.04	1.742LysThr: 1.742 ± 0.041	2.656LysVal: 2.656 ± 0.053	0.457LysTrp: 0.457 ± 0.019	0.714LysTyr: 0.714 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.255LeuAla: 13.255 ± 0.115	0.893LeuCys: 0.893 ± 0.025	6.161LeuAsp: 6.161 ± 0.063	5.557LeuGlu: 5.557 ± 0.066	3.384LeuPhe: 3.384 ± 0.061	8.165LeuGly: 8.165 ± 0.088	1.854LeuHis: 1.854 ± 0.036	4.266LeuIle: 4.266 ± 0.063	3.116LeuLys: 3.116 ± 0.057	8.47LeuLeu: 8.47 ± 0.106	2.177LeuMet: 2.177 ± 0.044	2.299LeuAsn: 2.299 ± 0.042	5.444LeuPro: 5.444 ± 0.06	2.636LeuGln: 2.636 ± 0.046	6.238LeuArg: 6.238 ± 0.076	5.944LeuSer: 5.944 ± 0.065	5.297LeuThr: 5.297 ± 0.061	7.084LeuVal: 7.084 ± 0.088	1.143LeuTrp: 1.143 ± 0.03	1.935LeuTyr: 1.935 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.52MetAla: 3.52 ± 0.051	0.199MetCys: 0.199 ± 0.012	1.333MetAsp: 1.333 ± 0.032	1.342MetGlu: 1.342 ± 0.031	0.783MetPhe: 0.783 ± 0.021	2.169MetGly: 2.169 ± 0.045	0.548MetHis: 0.548 ± 0.021	1.369MetIle: 1.369 ± 0.037	1.038MetLys: 1.038 ± 0.027	2.71MetLeu: 2.71 ± 0.045	0.749MetMet: 0.749 ± 0.027	0.767MetAsn: 0.767 ± 0.021	1.621MetPro: 1.621 ± 0.036	0.928MetGln: 0.928 ± 0.027	1.837MetArg: 1.837 ± 0.033	1.573MetSer: 1.573 ± 0.032	1.842MetThr: 1.842 ± 0.034	1.748MetVal: 1.748 ± 0.037	0.25MetTrp: 0.25 ± 0.014	0.317MetTyr: 0.317 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.304AsnAla: 3.304 ± 0.054	0.314AsnCys: 0.314 ± 0.018	1.405AsnAsp: 1.405 ± 0.036	1.284AsnGlu: 1.284 ± 0.035	1.097AsnPhe: 1.097 ± 0.031	2.419AsnGly: 2.419 ± 0.05	0.49AsnHis: 0.49 ± 0.019	1.278AsnIle: 1.278 ± 0.033	0.672AsnLys: 0.672 ± 0.024	2.623AsnLeu: 2.623 ± 0.052	0.642AsnMet: 0.642 ± 0.02	0.715AsnAsn: 0.715 ± 0.024	1.84AsnPro: 1.84 ± 0.042	0.738AsnGln: 0.738 ± 0.02	1.793AsnArg: 1.793 ± 0.039	1.394AsnSer: 1.394 ± 0.034	1.263AsnThr: 1.263 ± 0.032	2.112AsnVal: 2.112 ± 0.05	0.464AsnTrp: 0.464 ± 0.021	0.777AsnTyr: 0.777 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.295ProAla: 6.295 ± 0.084	0.379ProCys: 0.379 ± 0.017	3.975ProAsp: 3.975 ± 0.056	4.214ProGlu: 4.214 ± 0.053	1.978ProPhe: 1.978 ± 0.039	4.891ProGly: 4.891 ± 0.065	1.111ProHis: 1.111 ± 0.029	2.247ProIle: 2.247 ± 0.037	1.618ProLys: 1.618 ± 0.034	4.726ProLeu: 4.726 ± 0.06	1.338ProMet: 1.338 ± 0.031	1.313ProAsn: 1.313 ± 0.034	2.581ProPro: 2.581 ± 0.066	1.766ProGln: 1.766 ± 0.037	3.0ProArg: 3.0 ± 0.051	2.857ProSer: 2.857 ± 0.041	2.409ProThr: 2.409 ± 0.044	4.346ProVal: 4.346 ± 0.062	0.696ProTrp: 0.696 ± 0.025	1.156ProTyr: 1.156 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.997GlnAla: 3.997 ± 0.065	0.263GlnCys: 0.263 ± 0.013	1.674GlnAsp: 1.674 ± 0.031	1.567GlnGlu: 1.567 ± 0.032	1.132GlnPhe: 1.132 ± 0.032	2.45GlnGly: 2.45 ± 0.045	0.645GlnHis: 0.645 ± 0.019	1.776GlnIle: 1.776 ± 0.039	0.976GlnLys: 0.976 ± 0.027	2.881GlnLeu: 2.881 ± 0.048	0.888GlnMet: 0.888 ± 0.026	0.765GlnAsn: 0.765 ± 0.024	1.728GlnPro: 1.728 ± 0.036	1.178GlnGln: 1.178 ± 0.032	2.241GlnArg: 2.241 ± 0.043	1.663GlnSer: 1.663 ± 0.035	1.601GlnThr: 1.601 ± 0.034	2.425GlnVal: 2.425 ± 0.048	0.458GlnTrp: 0.458 ± 0.02	0.701GlnTyr: 0.701 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	7.427ArgAla: 7.427 ± 0.074	0.543ArgCys: 0.543 ± 0.021	4.0ArgAsp: 4.0 ± 0.056	4.506ArgGlu: 4.506 ± 0.065	2.979ArgPhe: 2.979 ± 0.051	4.758ArgGly: 4.758 ± 0.061	1.681ArgHis: 1.681 ± 0.04	3.984ArgIle: 3.984 ± 0.061	2.508ArgLys: 2.508 ± 0.038	7.333ArgLeu: 7.333 ± 0.091	1.922ArgMet: 1.922 ± 0.04	1.894ArgAsn: 1.894 ± 0.043	3.256ArgPro: 3.256 ± 0.053	2.363ArgGln: 2.363 ± 0.046	5.006ArgArg: 5.006 ± 0.078	3.496ArgSer: 3.496 ± 0.057	3.366ArgThr: 3.366 ± 0.047	4.417ArgVal: 4.417 ± 0.059	1.086ArgTrp: 1.086 ± 0.031	1.887ArgTyr: 1.887 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.373SerAla: 6.373 ± 0.08	0.496SerCys: 0.496 ± 0.023	3.264SerAsp: 3.264 ± 0.05	3.049SerGlu: 3.049 ± 0.051	2.042SerPhe: 2.042 ± 0.041	5.702SerGly: 5.702 ± 0.066	1.035SerHis: 1.035 ± 0.025	2.567SerIle: 2.567 ± 0.047	1.575SerLys: 1.575 ± 0.034	5.272SerLeu: 5.272 ± 0.059	1.461SerMet: 1.461 ± 0.036	1.474SerAsn: 1.474 ± 0.035	2.915SerPro: 2.915 ± 0.05	1.711SerGln: 1.711 ± 0.038	3.57SerArg: 3.57 ± 0.056	3.042SerSer: 3.042 ± 0.051	2.673SerThr: 2.673 ± 0.052	3.803SerVal: 3.803 ± 0.052	0.804SerTrp: 0.804 ± 0.025	1.46SerTyr: 1.46 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.984ThrAla: 5.984 ± 0.067	0.49ThrCys: 0.49 ± 0.017	2.96ThrAsp: 2.96 ± 0.055	2.65ThrGlu: 2.65 ± 0.043	1.949ThrPhe: 1.949 ± 0.046	5.439ThrGly: 5.439 ± 0.069	1.026ThrHis: 1.026 ± 0.031	2.812ThrIle: 2.812 ± 0.049	1.344ThrLys: 1.344 ± 0.035	5.29ThrLeu: 5.29 ± 0.07	1.32ThrMet: 1.32 ± 0.03	1.351ThrAsn: 1.351 ± 0.038	3.261ThrPro: 3.261 ± 0.052	1.458ThrGln: 1.458 ± 0.034	3.336ThrArg: 3.336 ± 0.047	2.849ThrSer: 2.849 ± 0.054	2.592ThrThr: 2.592 ± 0.057	4.114ThrVal: 4.114 ± 0.058	0.747ThrTrp: 0.747 ± 0.025	1.336ThrTyr: 1.336 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.675ValAla: 8.675 ± 0.086	0.707ValCys: 0.707 ± 0.027	4.3ValAsp: 4.3 ± 0.056	4.615ValGlu: 4.615 ± 0.06	2.465ValPhe: 2.465 ± 0.048	5.436ValGly: 5.436 ± 0.077	1.461ValHis: 1.461 ± 0.033	3.769ValIle: 3.769 ± 0.055	2.173ValLys: 2.173 ± 0.043	6.888ValLeu: 6.888 ± 0.075	1.827ValMet: 1.827 ± 0.036	2.163ValAsn: 2.163 ± 0.045	4.078ValPro: 4.078 ± 0.051	2.055ValGln: 2.055 ± 0.04	4.854ValArg: 4.854 ± 0.067	4.36ValSer: 4.36 ± 0.06	4.51ValThr: 4.51 ± 0.064	5.463ValVal: 5.463 ± 0.064	0.942ValTrp: 0.942 ± 0.027	1.454ValTyr: 1.454 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.341TrpAla: 1.341 ± 0.034	0.165TrpCys: 0.165 ± 0.01	0.799TrpAsp: 0.799 ± 0.025	0.722TrpGlu: 0.722 ± 0.023	0.593TrpPhe: 0.593 ± 0.019	1.029TrpGly: 1.029 ± 0.03	0.384TrpHis: 0.384 ± 0.018	0.744TrpIle: 0.744 ± 0.025	0.565TrpLys: 0.565 ± 0.021	1.69TrpLeu: 1.69 ± 0.039	0.391TrpMet: 0.391 ± 0.016	0.514TrpAsn: 0.514 ± 0.018	0.708TrpPro: 0.708 ± 0.025	0.654TrpGln: 0.654 ± 0.024	1.204TrpArg: 1.204 ± 0.031	0.911TrpSer: 0.911 ± 0.028	0.812TrpThr: 0.812 ± 0.023	0.848TrpVal: 0.848 ± 0.027	0.27TrpTrp: 0.27 ± 0.014	0.326TrpTyr: 0.326 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.758TyrAla: 2.758 ± 0.049	0.298TyrCys: 0.298 ± 0.014	1.631TyrAsp: 1.631 ± 0.035	1.396TyrGlu: 1.396 ± 0.037	0.947TyrPhe: 0.947 ± 0.026	2.256TyrGly: 2.256 ± 0.046	0.579TyrHis: 0.579 ± 0.018	0.927TyrIle: 0.927 ± 0.025	0.712TyrLys: 0.712 ± 0.023	2.247TyrLeu: 2.247 ± 0.048	0.498TyrMet: 0.498 ± 0.015	0.653TyrAsn: 0.653 ± 0.027	1.164TyrPro: 1.164 ± 0.028	0.707TyrGln: 0.707 ± 0.024	1.829TyrArg: 1.829 ± 0.042	1.331TyrSer: 1.331 ± 0.037	1.24TyrThr: 1.24 ± 0.038	1.577TyrVal: 1.577 ± 0.032	0.397TyrTrp: 0.397 ± 0.019	0.717TyrTyr: 0.717 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4270 proteins (1374240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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