Amino acid dipepetide frequency for Jiangella rhizosphaerae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.71AlaAla: 23.71 ± 0.196	0.879AlaCys: 0.879 ± 0.023	9.265AlaAsp: 9.265 ± 0.074	8.542AlaGlu: 8.542 ± 0.087	3.684AlaPhe: 3.684 ± 0.054	14.908AlaGly: 14.908 ± 0.11	2.489AlaHis: 2.489 ± 0.039	4.298AlaIle: 4.298 ± 0.06	1.864AlaLys: 1.864 ± 0.04	13.771AlaLeu: 13.771 ± 0.109	2.546AlaMet: 2.546 ± 0.041	2.0AlaAsn: 2.0 ± 0.035	6.597AlaPro: 6.597 ± 0.064	3.347AlaGln: 3.347 ± 0.04	10.023AlaArg: 10.023 ± 0.081	5.87AlaSer: 5.87 ± 0.061	7.738AlaThr: 7.738 ± 0.069	13.163AlaVal: 13.163 ± 0.115	2.049AlaTrp: 2.049 ± 0.038	2.573AlaTyr: 2.573 ± 0.036	0.001AlaXaa: 0.001 ± 0.001
Cys	0.782CysAla: 0.782 ± 0.02	0.084CysCys: 0.084 ± 0.007	0.423CysAsp: 0.423 ± 0.016	0.327CysGlu: 0.327 ± 0.014	0.187CysPhe: 0.187 ± 0.011	0.764CysGly: 0.764 ± 0.021	0.189CysHis: 0.189 ± 0.011	0.145CysIle: 0.145 ± 0.009	0.07CysLys: 0.07 ± 0.006	0.534CysLeu: 0.534 ± 0.019	0.095CysMet: 0.095 ± 0.007	0.111CysAsn: 0.111 ± 0.007	0.395CysPro: 0.395 ± 0.016	0.15CysGln: 0.15 ± 0.008	0.508CysArg: 0.508 ± 0.016	0.324CysSer: 0.324 ± 0.012	0.366CysThr: 0.366 ± 0.016	0.522CysVal: 0.522 ± 0.017	0.111CysTrp: 0.111 ± 0.008	0.13CysTyr: 0.13 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.76AspAla: 8.76 ± 0.073	0.33AspCys: 0.33 ± 0.014	5.54AspAsp: 5.54 ± 0.07	4.56AspGlu: 4.56 ± 0.056	1.523AspPhe: 1.523 ± 0.032	7.988AspGly: 7.988 ± 0.078	1.49AspHis: 1.49 ± 0.035	1.891AspIle: 1.891 ± 0.036	0.692AspLys: 0.692 ± 0.023	6.764AspLeu: 6.764 ± 0.065	0.696AspMet: 0.696 ± 0.018	0.907AspAsn: 0.907 ± 0.024	4.939AspPro: 4.939 ± 0.055	1.682AspGln: 1.682 ± 0.032	4.968AspArg: 4.968 ± 0.049	2.223AspSer: 2.223 ± 0.039	2.987AspThr: 2.987 ± 0.041	6.585AspVal: 6.585 ± 0.064	1.049AspTrp: 1.049 ± 0.024	1.279AspTyr: 1.279 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.175GluAla: 7.175 ± 0.072	0.31GluCys: 0.31 ± 0.013	2.675GluAsp: 2.675 ± 0.037	2.892GluGlu: 2.892 ± 0.052	1.622GluPhe: 1.622 ± 0.028	3.617GluGly: 3.617 ± 0.048	1.552GluHis: 1.552 ± 0.027	2.264GluIle: 2.264 ± 0.037	0.947GluLys: 0.947 ± 0.028	7.246GluLeu: 7.246 ± 0.078	0.799GluMet: 0.799 ± 0.021	1.075GluAsn: 1.075 ± 0.026	3.849GluPro: 3.849 ± 0.051	2.26GluGln: 2.26 ± 0.042	5.478GluArg: 5.478 ± 0.061	2.591GluSer: 2.591 ± 0.042	2.821GluThr: 2.821 ± 0.042	4.885GluVal: 4.885 ± 0.054	0.85GluTrp: 0.85 ± 0.023	1.198GluTyr: 1.198 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.906PheAla: 3.906 ± 0.045	0.207PheCys: 0.207 ± 0.011	2.223PheAsp: 2.223 ± 0.041	1.558PheGlu: 1.558 ± 0.031	0.83PhePhe: 0.83 ± 0.022	3.068PheGly: 3.068 ± 0.046	0.592PheHis: 0.592 ± 0.017	0.746PheIle: 0.746 ± 0.019	0.333PheLys: 0.333 ± 0.012	2.532PheLeu: 2.532 ± 0.044	0.38PheMet: 0.38 ± 0.013	0.552PheAsn: 0.552 ± 0.018	1.307PhePro: 1.307 ± 0.026	0.737PheGln: 0.737 ± 0.018	1.889PheArg: 1.889 ± 0.032	1.354PheSer: 1.354 ± 0.029	1.915PheThr: 1.915 ± 0.035	2.643PheVal: 2.643 ± 0.041	0.467PheTrp: 0.467 ± 0.018	0.625PheTyr: 0.625 ± 0.02	0.001PheXaa: 0.001 ± 0.001
Gly	11.198GlyAla: 11.198 ± 0.09	0.701GlyCys: 0.701 ± 0.023	6.233GlyAsp: 6.233 ± 0.074	5.157GlyGlu: 5.157 ± 0.057	2.856GlyPhe: 2.856 ± 0.041	8.84GlyGly: 8.84 ± 0.09	2.113GlyHis: 2.113 ± 0.038	3.435GlyIle: 3.435 ± 0.04	1.444GlyLys: 1.444 ± 0.032	9.721GlyLeu: 9.721 ± 0.085	1.879GlyMet: 1.879 ± 0.033	1.641GlyAsn: 1.641 ± 0.037	5.002GlyPro: 5.002 ± 0.053	2.374GlyGln: 2.374 ± 0.036	7.99GlyArg: 7.99 ± 0.066	5.061GlySer: 5.061 ± 0.057	5.906GlyThr: 5.906 ± 0.068	8.456GlyVal: 8.456 ± 0.077	1.854GlyTrp: 1.854 ± 0.037	2.337GlyTyr: 2.337 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.528HisAla: 2.528 ± 0.041	0.159HisCys: 0.159 ± 0.01	1.554HisAsp: 1.554 ± 0.031	1.217HisGlu: 1.217 ± 0.026	0.521HisPhe: 0.521 ± 0.016	2.12HisGly: 2.12 ± 0.038	0.646HisHis: 0.646 ± 0.021	0.544HisIle: 0.544 ± 0.018	0.231HisLys: 0.231 ± 0.011	2.201HisLeu: 2.201 ± 0.04	0.252HisMet: 0.252 ± 0.01	0.306HisAsn: 0.306 ± 0.013	1.586HisPro: 1.586 ± 0.033	0.571HisGln: 0.571 ± 0.016	1.927HisArg: 1.927 ± 0.032	0.782HisSer: 0.782 ± 0.022	1.055HisThr: 1.055 ± 0.022	2.0HisVal: 2.0 ± 0.031	0.344HisTrp: 0.344 ± 0.013	0.487HisTyr: 0.487 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.019IleAla: 5.019 ± 0.057	0.222IleCys: 0.222 ± 0.01	2.643IleAsp: 2.643 ± 0.039	2.254IleGlu: 2.254 ± 0.037	0.797IlePhe: 0.797 ± 0.023	3.607IleGly: 3.607 ± 0.046	0.535IleHis: 0.535 ± 0.016	0.971IleIle: 0.971 ± 0.027	0.495IleLys: 0.495 ± 0.019	2.57IleLeu: 2.57 ± 0.042	0.505IleMet: 0.505 ± 0.017	0.616IleAsn: 0.616 ± 0.02	1.78IlePro: 1.78 ± 0.028	0.704IleGln: 0.704 ± 0.019	2.272IleArg: 2.272 ± 0.037	1.537IleSer: 1.537 ± 0.027	2.097IleThr: 2.097 ± 0.034	3.465IleVal: 3.465 ± 0.048	0.425IleTrp: 0.425 ± 0.015	0.618IleTyr: 0.618 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	1.834LysAla: 1.834 ± 0.04	0.055LysCys: 0.055 ± 0.005	0.762LysAsp: 0.762 ± 0.02	0.695LysGlu: 0.695 ± 0.019	0.324LysPhe: 0.324 ± 0.016	1.028LysGly: 1.028 ± 0.029	0.348LysHis: 0.348 ± 0.015	0.579LysIle: 0.579 ± 0.018	0.371LysLys: 0.371 ± 0.019	1.4LysLeu: 1.4 ± 0.03	0.203LysMet: 0.203 ± 0.011	0.275LysAsn: 0.275 ± 0.013	0.875LysPro: 0.875 ± 0.029	0.461LysGln: 0.461 ± 0.018	1.079LysArg: 1.079 ± 0.028	0.705LysSer: 0.705 ± 0.021	0.861LysThr: 0.861 ± 0.021	1.312LysVal: 1.312 ± 0.029	0.172LysTrp: 0.172 ± 0.01	0.294LysTyr: 0.294 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.866LeuAla: 15.866 ± 0.127	0.594LeuCys: 0.594 ± 0.018	7.386LeuAsp: 7.386 ± 0.067	4.915LeuGlu: 4.915 ± 0.055	2.563LeuPhe: 2.563 ± 0.042	9.253LeuGly: 9.253 ± 0.086	1.971LeuHis: 1.971 ± 0.033	3.314LeuIle: 3.314 ± 0.052	1.22LeuLys: 1.22 ± 0.025	10.703LeuLeu: 10.703 ± 0.118	1.489LeuMet: 1.489 ± 0.029	1.547LeuAsn: 1.547 ± 0.029	6.227LeuPro: 6.227 ± 0.061	2.173LeuGln: 2.173 ± 0.036	8.602LeuArg: 8.602 ± 0.079	5.158LeuSer: 5.158 ± 0.056	6.683LeuThr: 6.683 ± 0.078	9.608LeuVal: 9.608 ± 0.092	1.241LeuTrp: 1.241 ± 0.027	1.789LeuTyr: 1.789 ± 0.031	0.001LeuXaa: 0.001 ± 0.001
Met	2.109MetAla: 2.109 ± 0.031	0.094MetCys: 0.094 ± 0.007	0.825MetAsp: 0.825 ± 0.022	0.628MetGlu: 0.628 ± 0.018	0.473MetPhe: 0.473 ± 0.017	1.163MetGly: 1.163 ± 0.027	0.312MetHis: 0.312 ± 0.012	0.708MetIle: 0.708 ± 0.02	0.29MetLys: 0.29 ± 0.013	1.677MetLeu: 1.677 ± 0.03	0.269MetMet: 0.269 ± 0.011	0.382MetAsn: 0.382 ± 0.013	1.03MetPro: 1.03 ± 0.023	0.383MetGln: 0.383 ± 0.016	1.415MetArg: 1.415 ± 0.025	1.217MetSer: 1.217 ± 0.027	1.642MetThr: 1.642 ± 0.03	1.371MetVal: 1.371 ± 0.028	0.193MetTrp: 0.193 ± 0.01	0.277MetTyr: 0.277 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.144AsnAla: 2.144 ± 0.037	0.114AsnCys: 0.114 ± 0.007	1.065AsnAsp: 1.065 ± 0.026	0.837AsnGlu: 0.837 ± 0.023	0.45AsnPhe: 0.45 ± 0.02	1.742AsnGly: 1.742 ± 0.039	0.36AsnHis: 0.36 ± 0.016	0.576AsnIle: 0.576 ± 0.02	0.23AsnLys: 0.23 ± 0.012	1.643AsnLeu: 1.643 ± 0.035	0.238AsnMet: 0.238 ± 0.011	0.362AsnAsn: 0.362 ± 0.015	1.372AsnPro: 1.372 ± 0.034	0.476AsnGln: 0.476 ± 0.016	1.229AsnArg: 1.229 ± 0.024	0.757AsnSer: 0.757 ± 0.02	1.023AsnThr: 1.023 ± 0.029	1.547AsnVal: 1.547 ± 0.032	0.281AsnTrp: 0.281 ± 0.013	0.413AsnTyr: 0.413 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.755ProAla: 8.755 ± 0.081	0.262ProCys: 0.262 ± 0.012	4.887ProAsp: 4.887 ± 0.053	4.034ProGlu: 4.034 ± 0.049	1.644ProPhe: 1.644 ± 0.032	6.464ProGly: 6.464 ± 0.07	1.176ProHis: 1.176 ± 0.028	1.621ProIle: 1.621 ± 0.028	0.756ProLys: 0.756 ± 0.023	5.071ProLeu: 5.071 ± 0.058	1.074ProMet: 1.074 ± 0.022	0.964ProAsn: 0.964 ± 0.022	3.725ProPro: 3.725 ± 0.059	1.265ProGln: 1.265 ± 0.027	3.798ProArg: 3.798 ± 0.057	3.424ProSer: 3.424 ± 0.04	3.098ProThr: 3.098 ± 0.053	5.705ProVal: 5.705 ± 0.058	0.973ProTrp: 0.973 ± 0.023	1.271ProTyr: 1.271 ± 0.027	0.003ProXaa: 0.003 ± 0.001
Gln	3.47GlnAla: 3.47 ± 0.049	0.139GlnCys: 0.139 ± 0.008	1.21GlnAsp: 1.21 ± 0.029	1.215GlnGlu: 1.215 ± 0.029	0.736GlnPhe: 0.736 ± 0.019	1.768GlnGly: 1.768 ± 0.031	0.629GlnHis: 0.629 ± 0.018	1.006GlnIle: 1.006 ± 0.023	0.349GlnLys: 0.349 ± 0.014	3.074GlnLeu: 3.074 ± 0.036	0.347GlnMet: 0.347 ± 0.012	0.514GlnAsn: 0.514 ± 0.019	1.707GlnPro: 1.707 ± 0.03	1.008GlnGln: 1.008 ± 0.026	2.474GlnArg: 2.474 ± 0.042	1.086GlnSer: 1.086 ± 0.029	1.31GlnThr: 1.31 ± 0.031	2.377GlnVal: 2.377 ± 0.037	0.451GlnTrp: 0.451 ± 0.016	0.594GlnTyr: 0.594 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.746ArgAla: 9.746 ± 0.077	0.488ArgCys: 0.488 ± 0.018	4.716ArgAsp: 4.716 ± 0.056	4.415ArgGlu: 4.415 ± 0.055	2.478ArgPhe: 2.478 ± 0.033	5.627ArgGly: 5.627 ± 0.058	1.939ArgHis: 1.939 ± 0.034	3.041ArgIle: 3.041 ± 0.038	1.131ArgLys: 1.131 ± 0.034	9.009ArgLeu: 9.009 ± 0.081	1.658ArgMet: 1.658 ± 0.03	1.264ArgAsn: 1.264 ± 0.023	5.142ArgPro: 5.142 ± 0.065	2.244ArgGln: 2.244 ± 0.033	8.533ArgArg: 8.533 ± 0.095	4.148ArgSer: 4.148 ± 0.052	4.721ArgThr: 4.721 ± 0.052	6.38ArgVal: 6.38 ± 0.053	1.562ArgTrp: 1.562 ± 0.035	1.927ArgTyr: 1.927 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.317SerAla: 6.317 ± 0.057	0.327SerCys: 0.327 ± 0.013	2.795SerAsp: 2.795 ± 0.037	2.246SerGlu: 2.246 ± 0.037	1.506SerPhe: 1.506 ± 0.029	5.515SerGly: 5.515 ± 0.058	0.877SerHis: 0.877 ± 0.024	1.749SerIle: 1.749 ± 0.03	0.681SerLys: 0.681 ± 0.02	4.632SerLeu: 4.632 ± 0.053	1.067SerMet: 1.067 ± 0.025	0.787SerAsn: 0.787 ± 0.02	2.986SerPro: 2.986 ± 0.041	1.102SerGln: 1.102 ± 0.028	3.602SerArg: 3.602 ± 0.046	2.709SerSer: 2.709 ± 0.047	3.103SerThr: 3.103 ± 0.048	4.366SerVal: 4.366 ± 0.046	0.964SerTrp: 0.964 ± 0.025	1.139SerTyr: 1.139 ± 0.029	0.001SerXaa: 0.001 ± 0.001
Thr	8.255ThrAla: 8.255 ± 0.079	0.367ThrCys: 0.367 ± 0.016	3.538ThrAsp: 3.538 ± 0.047	3.056ThrGlu: 3.056 ± 0.046	1.924ThrPhe: 1.924 ± 0.033	6.218ThrGly: 6.218 ± 0.073	1.1ThrHis: 1.1 ± 0.025	2.126ThrIle: 2.126 ± 0.039	0.839ThrLys: 0.839 ± 0.021	5.739ThrLeu: 5.739 ± 0.06	1.043ThrMet: 1.043 ± 0.026	1.02ThrAsn: 1.02 ± 0.03	3.935ThrPro: 3.935 ± 0.053	1.315ThrGln: 1.315 ± 0.026	3.695ThrArg: 3.695 ± 0.042	3.095ThrSer: 3.095 ± 0.044	4.052ThrThr: 4.052 ± 0.06	6.586ThrVal: 6.586 ± 0.078	1.039ThrTrp: 1.039 ± 0.024	1.332ThrTyr: 1.332 ± 0.029	0.001ThrXaa: 0.001 ± 0.001
Val	13.343ValAla: 13.343 ± 0.109	0.61ValCys: 0.61 ± 0.02	6.559ValAsp: 6.559 ± 0.06	5.515ValGlu: 5.515 ± 0.061	2.596ValPhe: 2.596 ± 0.039	7.348ValGly: 7.348 ± 0.064	1.894ValHis: 1.894 ± 0.033	3.067ValIle: 3.067 ± 0.049	1.208ValLys: 1.208 ± 0.03	9.966ValLeu: 9.966 ± 0.092	1.406ValMet: 1.406 ± 0.034	1.692ValAsn: 1.692 ± 0.032	5.479ValPro: 5.479 ± 0.054	2.097ValGln: 2.097 ± 0.037	7.365ValArg: 7.365 ± 0.065	4.501ValSer: 4.501 ± 0.049	6.598ValThr: 6.598 ± 0.07	10.611ValVal: 10.611 ± 0.107	1.232ValTrp: 1.232 ± 0.03	1.685ValTyr: 1.685 ± 0.034	0.002ValXaa: 0.002 ± 0.001
Trp	1.753TrpAla: 1.753 ± 0.033	0.132TrpCys: 0.132 ± 0.008	0.942TrpAsp: 0.942 ± 0.025	0.751TrpGlu: 0.751 ± 0.018	0.559TrpPhe: 0.559 ± 0.017	1.062TrpGly: 1.062 ± 0.025	0.398TrpHis: 0.398 ± 0.015	0.577TrpIle: 0.577 ± 0.018	0.24TrpLys: 0.24 ± 0.011	1.874TrpLeu: 1.874 ± 0.032	0.294TrpMet: 0.294 ± 0.014	0.444TrpAsn: 0.444 ± 0.015	0.92TrpPro: 0.92 ± 0.024	0.553TrpGln: 0.553 ± 0.016	1.389TrpArg: 1.389 ± 0.027	1.02TrpSer: 1.02 ± 0.023	1.131TrpThr: 1.131 ± 0.027	1.187TrpVal: 1.187 ± 0.029	0.396TrpTrp: 0.396 ± 0.016	0.407TrpTyr: 0.407 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.647TyrAla: 2.647 ± 0.039	0.142TyrCys: 0.142 ± 0.009	1.613TyrAsp: 1.613 ± 0.033	1.29TyrGlu: 1.29 ± 0.03	0.594TyrPhe: 0.594 ± 0.018	2.095TyrGly: 2.095 ± 0.032	0.422TyrHis: 0.422 ± 0.015	0.473TyrIle: 0.473 ± 0.016	0.241TyrLys: 0.241 ± 0.011	2.178TyrLeu: 2.178 ± 0.041	0.217TyrMet: 0.217 ± 0.011	0.398TyrAsn: 0.398 ± 0.014	1.117TyrPro: 1.117 ± 0.024	0.563TyrGln: 0.563 ± 0.018	1.93TyrArg: 1.93 ± 0.036	0.909TyrSer: 0.909 ± 0.023	1.168TyrThr: 1.168 ± 0.03	2.003TyrVal: 2.003 ± 0.032	0.375TyrTrp: 0.375 ± 0.015	0.491TyrTyr: 0.491 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6027 proteins (1902621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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