Amino acid dipepetide frequency for Thiorhodospira sibirica ATCC 700588

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.393AlaAla: 11.393 ± 0.164	1.283AlaCys: 1.283 ± 0.042	5.362AlaAsp: 5.362 ± 0.083	6.343AlaGlu: 6.343 ± 0.124	3.562AlaPhe: 3.562 ± 0.084	7.154AlaGly: 7.154 ± 0.099	3.293AlaHis: 3.293 ± 0.07	5.409AlaIle: 5.409 ± 0.086	3.448AlaLys: 3.448 ± 0.065	14.245AlaLeu: 14.245 ± 0.183	2.89AlaMet: 2.89 ± 0.063	2.848AlaAsn: 2.848 ± 0.066	4.7AlaPro: 4.7 ± 0.094	7.07AlaGln: 7.07 ± 0.11	7.448AlaArg: 7.448 ± 0.112	5.337AlaSer: 5.337 ± 0.084	4.908AlaThr: 4.908 ± 0.079	7.315AlaVal: 7.315 ± 0.095	1.562AlaTrp: 1.562 ± 0.047	2.677AlaTyr: 2.677 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.201CysAla: 1.201 ± 0.039	0.152CysCys: 0.152 ± 0.015	0.508CysAsp: 0.508 ± 0.025	0.664CysGlu: 0.664 ± 0.028	0.373CysPhe: 0.373 ± 0.017	0.959CysGly: 0.959 ± 0.038	0.376CysHis: 0.376 ± 0.023	0.528CysIle: 0.528 ± 0.025	0.337CysLys: 0.337 ± 0.02	1.247CysLeu: 1.247 ± 0.035	0.245CysMet: 0.245 ± 0.014	0.237CysAsn: 0.237 ± 0.015	0.595CysPro: 0.595 ± 0.031	0.51CysGln: 0.51 ± 0.023	0.655CysArg: 0.655 ± 0.028	0.567CysSer: 0.567 ± 0.027	0.495CysThr: 0.495 ± 0.024	0.81CysVal: 0.81 ± 0.038	0.133CysTrp: 0.133 ± 0.011	0.258CysTyr: 0.258 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.588AspAla: 5.588 ± 0.089	0.521AspCys: 0.521 ± 0.025	2.598AspAsp: 2.598 ± 0.054	3.187AspGlu: 3.187 ± 0.057	2.125AspPhe: 2.125 ± 0.048	3.795AspGly: 3.795 ± 0.065	1.324AspHis: 1.324 ± 0.04	3.13AspIle: 3.13 ± 0.064	1.513AspLys: 1.513 ± 0.049	5.609AspLeu: 5.609 ± 0.079	1.203AspMet: 1.203 ± 0.038	1.415AspAsn: 1.415 ± 0.047	3.009AspPro: 3.009 ± 0.061	2.273AspGln: 2.273 ± 0.053	3.056AspArg: 3.056 ± 0.054	2.473AspSer: 2.473 ± 0.051	2.912AspThr: 2.912 ± 0.058	3.185AspVal: 3.185 ± 0.069	0.845AspTrp: 0.845 ± 0.032	1.656AspTyr: 1.656 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.813GluAla: 6.813 ± 0.112	0.434GluCys: 0.434 ± 0.024	2.868GluAsp: 2.868 ± 0.054	3.095GluGlu: 3.095 ± 0.079	1.753GluPhe: 1.753 ± 0.046	3.784GluGly: 3.784 ± 0.071	1.909GluHis: 1.909 ± 0.051	3.596GluIle: 3.596 ± 0.067	1.941GluLys: 1.941 ± 0.049	6.186GluLeu: 6.186 ± 0.085	1.548GluMet: 1.548 ± 0.048	1.64GluAsn: 1.64 ± 0.041	2.3GluPro: 2.3 ± 0.059	4.024GluGln: 4.024 ± 0.08	5.138GluArg: 5.138 ± 0.098	2.602GluSer: 2.602 ± 0.059	3.036GluThr: 3.036 ± 0.055	4.142GluVal: 4.142 ± 0.078	0.59GluTrp: 0.59 ± 0.022	1.366GluTyr: 1.366 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.059PheAla: 4.059 ± 0.073	0.445PheCys: 0.445 ± 0.021	2.047PheAsp: 2.047 ± 0.043	1.97PheGlu: 1.97 ± 0.047	1.507PhePhe: 1.507 ± 0.037	2.645PheGly: 2.645 ± 0.058	0.78PheHis: 0.78 ± 0.03	2.005PheIle: 2.005 ± 0.058	1.248PheLys: 1.248 ± 0.04	3.303PheLeu: 3.303 ± 0.067	0.879PheMet: 0.879 ± 0.029	1.269PheAsn: 1.269 ± 0.045	1.415PhePro: 1.415 ± 0.035	1.112PheGln: 1.112 ± 0.032	1.832PheArg: 1.832 ± 0.04	2.376PheSer: 2.376 ± 0.055	1.829PheThr: 1.829 ± 0.05	2.349PheVal: 2.349 ± 0.057	0.548PheTrp: 0.548 ± 0.026	1.102PheTyr: 1.102 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	6.279GlyAla: 6.279 ± 0.102	1.041GlyCys: 1.041 ± 0.037	3.327GlyAsp: 3.327 ± 0.058	4.413GlyGlu: 4.413 ± 0.072	3.07GlyPhe: 3.07 ± 0.063	4.91GlyGly: 4.91 ± 0.094	1.939GlyHis: 1.939 ± 0.049	4.406GlyIle: 4.406 ± 0.069	2.51GlyLys: 2.51 ± 0.061	8.424GlyLeu: 8.424 ± 0.116	1.982GlyMet: 1.982 ± 0.046	1.866GlyAsn: 1.866 ± 0.06	2.302GlyPro: 2.302 ± 0.054	3.515GlyGln: 3.515 ± 0.058	4.922GlyArg: 4.922 ± 0.073	3.484GlySer: 3.484 ± 0.062	3.432GlyThr: 3.432 ± 0.077	5.343GlyVal: 5.343 ± 0.085	1.018GlyTrp: 1.018 ± 0.034	2.441GlyTyr: 2.441 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	3.032HisAla: 3.032 ± 0.068	0.44HisCys: 0.44 ± 0.021	1.565HisAsp: 1.565 ± 0.037	1.585HisGlu: 1.585 ± 0.045	1.117HisPhe: 1.117 ± 0.033	2.199HisGly: 2.199 ± 0.048	1.036HisHis: 1.036 ± 0.038	1.6HisIle: 1.6 ± 0.038	0.77HisLys: 0.77 ± 0.028	3.382HisLeu: 3.382 ± 0.061	0.463HisMet: 0.463 ± 0.024	0.749HisAsn: 0.749 ± 0.032	2.053HisPro: 2.053 ± 0.05	1.316HisGln: 1.316 ± 0.039	1.839HisArg: 1.839 ± 0.052	1.638HisSer: 1.638 ± 0.043	1.753HisThr: 1.753 ± 0.05	1.408HisVal: 1.408 ± 0.039	0.529HisTrp: 0.529 ± 0.024	1.048HisTyr: 1.048 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.073IleAla: 6.073 ± 0.09	0.547IleCys: 0.547 ± 0.025	3.205IleAsp: 3.205 ± 0.061	3.79IleGlu: 3.79 ± 0.071	1.68IlePhe: 1.68 ± 0.045	4.045IleGly: 4.045 ± 0.069	1.473IleHis: 1.473 ± 0.041	2.745IleIle: 2.745 ± 0.063	1.96IleLys: 1.96 ± 0.048	5.176IleLeu: 5.176 ± 0.09	1.08IleMet: 1.08 ± 0.033	2.012IleAsn: 2.012 ± 0.052	2.801IlePro: 2.801 ± 0.054	2.09IleGln: 2.09 ± 0.047	3.371IleArg: 3.371 ± 0.068	3.095IleSer: 3.095 ± 0.062	3.182IleThr: 3.182 ± 0.06	3.139IleVal: 3.139 ± 0.068	0.584IleTrp: 0.584 ± 0.024	1.374IleTyr: 1.374 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.664LysAla: 3.664 ± 0.064	0.185LysCys: 0.185 ± 0.015	1.682LysAsp: 1.682 ± 0.05	1.711LysGlu: 1.711 ± 0.05	0.704LysPhe: 0.704 ± 0.033	2.167LysGly: 2.167 ± 0.057	0.908LysHis: 0.908 ± 0.033	1.627LysIle: 1.627 ± 0.044	1.395LysLys: 1.395 ± 0.05	2.953LysLeu: 2.953 ± 0.068	0.601LysMet: 0.601 ± 0.028	1.103LysAsn: 1.103 ± 0.039	1.865LysPro: 1.865 ± 0.05	1.612LysGln: 1.612 ± 0.045	2.426LysArg: 2.426 ± 0.049	1.571LysSer: 1.571 ± 0.046	1.988LysThr: 1.988 ± 0.045	1.946LysVal: 1.946 ± 0.052	0.246LysTrp: 0.246 ± 0.019	0.62LysTyr: 0.62 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	13.392LeuAla: 13.392 ± 0.168	1.288LeuCys: 1.288 ± 0.042	6.376LeuAsp: 6.376 ± 0.085	7.034LeuGlu: 7.034 ± 0.089	3.802LeuPhe: 3.802 ± 0.08	8.332LeuGly: 8.332 ± 0.108	3.434LeuHis: 3.434 ± 0.067	5.751LeuIle: 5.751 ± 0.082	3.819LeuLys: 3.819 ± 0.066	13.348LeuLeu: 13.348 ± 0.185	2.552LeuMet: 2.552 ± 0.052	3.698LeuAsn: 3.698 ± 0.074	6.083LeuPro: 6.083 ± 0.094	5.569LeuGln: 5.569 ± 0.088	8.16LeuArg: 8.16 ± 0.115	7.603LeuSer: 7.603 ± 0.106	5.484LeuThr: 5.484 ± 0.083	6.905LeuVal: 6.905 ± 0.103	1.439LeuTrp: 1.439 ± 0.044	2.642LeuTyr: 2.642 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.609MetAla: 2.609 ± 0.061	0.158MetCys: 0.158 ± 0.013	1.325MetAsp: 1.325 ± 0.041	1.222MetGlu: 1.222 ± 0.038	0.571MetPhe: 0.571 ± 0.021	1.574MetGly: 1.574 ± 0.045	0.69MetHis: 0.69 ± 0.023	1.25MetIle: 1.25 ± 0.039	0.728MetLys: 0.728 ± 0.027	2.575MetLeu: 2.575 ± 0.063	0.597MetMet: 0.597 ± 0.026	0.756MetAsn: 0.756 ± 0.028	1.394MetPro: 1.394 ± 0.041	1.37MetGln: 1.37 ± 0.038	1.717MetArg: 1.717 ± 0.043	1.563MetSer: 1.563 ± 0.043	1.291MetThr: 1.291 ± 0.04	1.609MetVal: 1.609 ± 0.041	0.159MetTrp: 0.159 ± 0.014	0.452MetTyr: 0.452 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.276AsnAla: 3.276 ± 0.057	0.247AsnCys: 0.247 ± 0.019	1.421AsnAsp: 1.421 ± 0.041	1.555AsnGlu: 1.555 ± 0.045	0.933AsnPhe: 0.933 ± 0.036	1.93AsnGly: 1.93 ± 0.055	0.769AsnHis: 0.769 ± 0.029	1.587AsnIle: 1.587 ± 0.046	0.776AsnLys: 0.776 ± 0.033	3.196AsnLeu: 3.196 ± 0.065	0.646AsnMet: 0.646 ± 0.025	0.797AsnAsn: 0.797 ± 0.033	2.159AsnPro: 2.159 ± 0.056	1.391AsnGln: 1.391 ± 0.039	1.902AsnArg: 1.902 ± 0.045	1.282AsnSer: 1.282 ± 0.045	1.832AsnThr: 1.832 ± 0.045	1.593AsnVal: 1.593 ± 0.048	0.348AsnTrp: 0.348 ± 0.021	0.7AsnTyr: 0.7 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.547ProAla: 5.547 ± 0.11	0.458ProCys: 0.458 ± 0.022	2.997ProAsp: 2.997 ± 0.064	3.591ProGlu: 3.591 ± 0.064	1.712ProPhe: 1.712 ± 0.041	3.776ProGly: 3.776 ± 0.072	1.474ProHis: 1.474 ± 0.043	2.218ProIle: 2.218 ± 0.048	1.519ProLys: 1.519 ± 0.042	5.68ProLeu: 5.68 ± 0.1	1.159ProMet: 1.159 ± 0.034	1.203ProAsn: 1.203 ± 0.042	3.145ProPro: 3.145 ± 0.088	2.611ProGln: 2.611 ± 0.057	2.726ProArg: 2.726 ± 0.06	2.681ProSer: 2.681 ± 0.065	2.468ProThr: 2.468 ± 0.055	3.884ProVal: 3.884 ± 0.076	0.831ProTrp: 0.831 ± 0.028	1.281ProTyr: 1.281 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	7.372GlnAla: 7.372 ± 0.113	0.516GlnCys: 0.516 ± 0.024	2.259GlnAsp: 2.259 ± 0.058	2.562GlnGlu: 2.562 ± 0.062	1.317GlnPhe: 1.317 ± 0.035	3.929GlnGly: 3.929 ± 0.069	1.784GlnHis: 1.784 ± 0.05	2.568GlnIle: 2.568 ± 0.05	1.305GlnLys: 1.305 ± 0.041	5.143GlnLeu: 5.143 ± 0.087	1.182GlnMet: 1.182 ± 0.038	1.246GlnAsn: 1.246 ± 0.039	2.445GlnPro: 2.445 ± 0.058	3.354GlnGln: 3.354 ± 0.091	4.786GlnArg: 4.786 ± 0.072	2.43GlnSer: 2.43 ± 0.046	2.905GlnThr: 2.905 ± 0.064	3.154GlnVal: 3.154 ± 0.059	0.813GlnTrp: 0.813 ± 0.029	1.054GlnTyr: 1.054 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	6.285ArgAla: 6.285 ± 0.094	0.817ArgCys: 0.817 ± 0.034	3.382ArgAsp: 3.382 ± 0.067	4.493ArgGlu: 4.493 ± 0.078	2.934ArgPhe: 2.934 ± 0.054	3.879ArgGly: 3.879 ± 0.062	2.264ArgHis: 2.264 ± 0.06	4.276ArgIle: 4.276 ± 0.073	2.044ArgLys: 2.044 ± 0.045	9.291ArgLeu: 9.291 ± 0.119	1.874ArgMet: 1.874 ± 0.05	1.809ArgAsn: 1.809 ± 0.045	3.157ArgPro: 3.157 ± 0.065	3.734ArgGln: 3.734 ± 0.064	4.978ArgArg: 4.978 ± 0.092	3.183ArgSer: 3.183 ± 0.073	3.153ArgThr: 3.153 ± 0.058	4.604ArgVal: 4.604 ± 0.07	1.093ArgTrp: 1.093 ± 0.036	2.313ArgTyr: 2.313 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.764SerAla: 5.764 ± 0.08	0.566SerCys: 0.566 ± 0.025	2.548SerAsp: 2.548 ± 0.055	3.022SerGlu: 3.022 ± 0.059	1.906SerPhe: 1.906 ± 0.053	4.563SerGly: 4.563 ± 0.086	1.482SerHis: 1.482 ± 0.042	2.607SerIle: 2.607 ± 0.062	1.558SerLys: 1.558 ± 0.045	6.214SerLeu: 6.214 ± 0.089	1.265SerMet: 1.265 ± 0.038	1.343SerAsn: 1.343 ± 0.045	2.898SerPro: 2.898 ± 0.06	2.38SerGln: 2.38 ± 0.057	3.446SerArg: 3.446 ± 0.061	2.951SerSer: 2.951 ± 0.073	2.796SerThr: 2.796 ± 0.065	3.655SerVal: 3.655 ± 0.06	0.665SerTrp: 0.665 ± 0.025	1.298SerTyr: 1.298 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.509ThrAla: 5.509 ± 0.07	0.416ThrCys: 0.416 ± 0.02	2.508ThrAsp: 2.508 ± 0.06	2.714ThrGlu: 2.714 ± 0.062	1.549ThrPhe: 1.549 ± 0.043	4.043ThrGly: 4.043 ± 0.072	1.682ThrHis: 1.682 ± 0.045	2.201ThrIle: 2.201 ± 0.056	1.086ThrLys: 1.086 ± 0.037	7.388ThrLeu: 7.388 ± 0.091	0.88ThrMet: 0.88 ± 0.032	1.101ThrAsn: 1.101 ± 0.041	3.702ThrPro: 3.702 ± 0.077	2.975ThrGln: 2.975 ± 0.061	3.376ThrArg: 3.376 ± 0.066	2.222ThrSer: 2.222 ± 0.054	2.555ThrThr: 2.555 ± 0.072	3.693ThrVal: 3.693 ± 0.068	0.563ThrTrp: 0.563 ± 0.023	1.113ThrTyr: 1.113 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.683ValAla: 6.683 ± 0.095	0.843ValCys: 0.843 ± 0.029	3.61ValAsp: 3.61 ± 0.062	3.776ValGlu: 3.776 ± 0.073	2.574ValPhe: 2.574 ± 0.054	4.252ValGly: 4.252 ± 0.076	1.698ValHis: 1.698 ± 0.05	4.075ValIle: 4.075 ± 0.068	2.026ValLys: 2.026 ± 0.053	8.043ValLeu: 8.043 ± 0.109	1.772ValMet: 1.772 ± 0.046	2.225ValAsn: 2.225 ± 0.046	2.755ValPro: 2.755 ± 0.06	2.703ValGln: 2.703 ± 0.05	4.587ValArg: 4.587 ± 0.067	3.933ValSer: 3.933 ± 0.064	3.26ValThr: 3.26 ± 0.064	5.05ValVal: 5.05 ± 0.087	0.776ValTrp: 0.776 ± 0.03	1.718ValTyr: 1.718 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.933TrpAla: 0.933 ± 0.033	0.155TrpCys: 0.155 ± 0.013	0.567TrpAsp: 0.567 ± 0.025	0.707TrpGlu: 0.707 ± 0.032	0.547TrpPhe: 0.547 ± 0.024	0.771TrpGly: 0.771 ± 0.032	0.412TrpHis: 0.412 ± 0.024	0.72TrpIle: 0.72 ± 0.029	0.342TrpLys: 0.342 ± 0.02	2.146TrpLeu: 2.146 ± 0.051	0.346TrpMet: 0.346 ± 0.02	0.346TrpAsn: 0.346 ± 0.02	0.665TrpPro: 0.665 ± 0.028	0.935TrpGln: 0.935 ± 0.033	1.04TrpArg: 1.04 ± 0.033	0.647TrpSer: 0.647 ± 0.025	0.472TrpThr: 0.472 ± 0.022	1.001TrpVal: 1.001 ± 0.038	0.226TrpTrp: 0.226 ± 0.02	0.347TrpTyr: 0.347 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.775TyrAla: 2.775 ± 0.06	0.338TyrCys: 0.338 ± 0.022	1.263TyrAsp: 1.263 ± 0.039	1.334TyrGlu: 1.334 ± 0.04	0.983TyrPhe: 0.983 ± 0.033	1.918TyrGly: 1.918 ± 0.045	0.793TyrHis: 0.793 ± 0.028	1.123TyrIle: 1.123 ± 0.038	0.647TyrLys: 0.647 ± 0.027	3.16TyrLeu: 3.16 ± 0.066	0.447TyrMet: 0.447 ± 0.021	0.677TyrAsn: 0.677 ± 0.027	1.519TyrPro: 1.519 ± 0.045	1.581TyrGln: 1.581 ± 0.045	2.157TyrArg: 2.157 ± 0.051	1.289TyrSer: 1.289 ± 0.041	1.525TyrThr: 1.525 ± 0.038	1.573TyrVal: 1.573 ± 0.041	0.356TyrTrp: 0.356 ± 0.019	0.796TyrTyr: 0.796 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2933 proteins (923034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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