Amino acid dipepetide frequency for Candidatus Altiarchaeales archaeon WOR_SM1_SCG

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.461AlaAla: 4.461 ± 0.107	1.003AlaCys: 1.003 ± 0.051	3.083AlaAsp: 3.083 ± 0.087	4.296AlaGlu: 4.296 ± 0.103	2.08AlaPhe: 2.08 ± 0.057	5.233AlaGly: 5.233 ± 0.11	0.985AlaHis: 0.985 ± 0.045	4.607AlaIle: 4.607 ± 0.111	4.634AlaLys: 4.634 ± 0.102	5.263AlaLeu: 5.263 ± 0.137	1.328AlaMet: 1.328 ± 0.044	2.574AlaAsn: 2.574 ± 0.086	1.481AlaPro: 1.481 ± 0.054	1.251AlaGln: 1.251 ± 0.051	2.453AlaArg: 2.453 ± 0.074	3.313AlaSer: 3.313 ± 0.081	2.489AlaThr: 2.489 ± 0.083	4.657AlaVal: 4.657 ± 0.104	0.513AlaTrp: 0.513 ± 0.032	1.85AlaTyr: 1.85 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.048	0.323CysCys: 0.323 ± 0.032	1.201CysAsp: 1.201 ± 0.079	1.254CysGlu: 1.254 ± 0.051	0.623CysPhe: 0.623 ± 0.037	1.629CysGly: 1.629 ± 0.075	0.256CysHis: 0.256 ± 0.02	1.177CysIle: 1.177 ± 0.056	1.085CysLys: 1.085 ± 0.047	1.025CysLeu: 1.025 ± 0.044	0.353CysMet: 0.353 ± 0.023	0.938CysAsn: 0.938 ± 0.085	0.932CysPro: 0.932 ± 0.049	0.297CysGln: 0.297 ± 0.025	0.594CysArg: 0.594 ± 0.031	1.111CysSer: 1.111 ± 0.089	0.913CysThr: 0.913 ± 0.063	0.959CysVal: 0.959 ± 0.045	0.149CysTrp: 0.149 ± 0.016	0.572CysTyr: 0.572 ± 0.039	0.0CysXaa: 0.0 ± 0.0
Asp	4.063AspAla: 4.063 ± 0.117	1.038AspCys: 1.038 ± 0.072	3.301AspAsp: 3.301 ± 0.1	5.003AspGlu: 5.003 ± 0.103	2.777AspPhe: 2.777 ± 0.076	3.579AspGly: 3.579 ± 0.156	0.642AspHis: 0.642 ± 0.033	5.443AspIle: 5.443 ± 0.104	4.828AspLys: 4.828 ± 0.106	4.672AspLeu: 4.672 ± 0.101	1.449AspMet: 1.449 ± 0.054	3.176AspAsn: 3.176 ± 0.118	1.88AspPro: 1.88 ± 0.059	0.603AspGln: 0.603 ± 0.036	1.968AspArg: 1.968 ± 0.054	3.337AspSer: 3.337 ± 0.09	2.718AspThr: 2.718 ± 0.097	4.167AspVal: 4.167 ± 0.094	0.677AspTrp: 0.677 ± 0.036	2.663AspTyr: 2.663 ± 0.07	0.0AspXaa: 0.0 ± 0.0
Glu	3.357GluAla: 3.357 ± 0.093	1.075GluCys: 1.075 ± 0.052	3.914GluAsp: 3.914 ± 0.088	6.425GluGlu: 6.425 ± 0.19	3.489GluPhe: 3.489 ± 0.085	4.188GluGly: 4.188 ± 0.095	1.347GluHis: 1.347 ± 0.054	8.751GluIle: 8.751 ± 0.161	9.177GluLys: 9.177 ± 0.189	7.059GluLeu: 7.059 ± 0.149	1.857GluMet: 1.857 ± 0.054	5.456GluAsn: 5.456 ± 0.101	1.987GluPro: 1.987 ± 0.066	1.661GluGln: 1.661 ± 0.062	3.228GluArg: 3.228 ± 0.08	3.838GluSer: 3.838 ± 0.086	3.835GluThr: 3.835 ± 0.1	4.659GluVal: 4.659 ± 0.093	0.72GluTrp: 0.72 ± 0.033	2.89GluTyr: 2.89 ± 0.083	0.0GluXaa: 0.0 ± 0.0
Phe	2.462PheAla: 2.462 ± 0.075	0.652PheCys: 0.652 ± 0.039	2.535PheAsp: 2.535 ± 0.065	3.144PheGlu: 3.144 ± 0.081	1.943PhePhe: 1.943 ± 0.066	2.908PheGly: 2.908 ± 0.079	0.722PheHis: 0.722 ± 0.036	3.794PheIle: 3.794 ± 0.084	3.444PheLys: 3.444 ± 0.096	3.972PheLeu: 3.972 ± 0.121	1.089PheMet: 1.089 ± 0.052	2.664PheAsn: 2.664 ± 0.076	1.518PhePro: 1.518 ± 0.053	0.813PheGln: 0.813 ± 0.04	1.672PheArg: 1.672 ± 0.058	2.882PheSer: 2.882 ± 0.075	2.089PheThr: 2.089 ± 0.068	2.731PheVal: 2.731 ± 0.076	0.449PheTrp: 0.449 ± 0.024	1.62PheTyr: 1.62 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.139GlyAla: 4.139 ± 0.095	1.306GlyCys: 1.306 ± 0.074	4.385GlyAsp: 4.385 ± 0.114	5.096GlyGlu: 5.096 ± 0.105	3.077GlyPhe: 3.077 ± 0.082	4.764GlyGly: 4.764 ± 0.123	1.066GlyHis: 1.066 ± 0.047	7.393GlyIle: 7.393 ± 0.15	6.253GlyLys: 6.253 ± 0.125	4.817GlyLeu: 4.817 ± 0.095	1.836GlyMet: 1.836 ± 0.062	3.914GlyAsn: 3.914 ± 0.124	1.242GlyPro: 1.242 ± 0.051	1.119GlyGln: 1.119 ± 0.038	2.637GlyArg: 2.637 ± 0.066	3.948GlySer: 3.948 ± 0.107	3.958GlyThr: 3.958 ± 0.115	4.677GlyVal: 4.677 ± 0.091	0.764GlyTrp: 0.764 ± 0.041	2.651GlyTyr: 2.651 ± 0.088	0.0GlyXaa: 0.0 ± 0.0
His	1.064HisAla: 1.064 ± 0.045	0.292HisCys: 0.292 ± 0.026	0.93HisAsp: 0.93 ± 0.036	1.299HisGlu: 1.299 ± 0.046	0.685HisPhe: 0.685 ± 0.034	1.154HisGly: 1.154 ± 0.048	0.368HisHis: 0.368 ± 0.026	1.328HisIle: 1.328 ± 0.049	1.232HisLys: 1.232 ± 0.046	1.457HisLeu: 1.457 ± 0.055	0.178HisMet: 0.178 ± 0.015	0.877HisAsn: 0.877 ± 0.035	0.863HisPro: 0.863 ± 0.041	0.311HisGln: 0.311 ± 0.023	0.833HisArg: 0.833 ± 0.04	0.924HisSer: 0.924 ± 0.037	0.875HisThr: 0.875 ± 0.036	0.789HisVal: 0.789 ± 0.037	0.148HisTrp: 0.148 ± 0.016	0.688HisTyr: 0.688 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.426IleAla: 5.426 ± 0.121	1.261IleCys: 1.261 ± 0.05	5.284IleAsp: 5.284 ± 0.114	7.018IleGlu: 7.018 ± 0.126	3.949IlePhe: 3.949 ± 0.094	5.997IleGly: 5.997 ± 0.13	1.504IleHis: 1.504 ± 0.049	8.323IleIle: 8.323 ± 0.162	8.25IleLys: 8.25 ± 0.139	8.268IleLeu: 8.268 ± 0.145	1.806IleMet: 1.806 ± 0.059	5.412IleAsn: 5.412 ± 0.119	4.022IlePro: 4.022 ± 0.099	1.67IleGln: 1.67 ± 0.053	3.371IleArg: 3.371 ± 0.083	6.068IleSer: 6.068 ± 0.094	5.121IleThr: 5.121 ± 0.125	5.006IleVal: 5.006 ± 0.086	0.769IleTrp: 0.769 ± 0.037	3.517IleTyr: 3.517 ± 0.115	0.0IleXaa: 0.0 ± 0.0
Lys	3.771LysAla: 3.771 ± 0.101	1.11LysCys: 1.11 ± 0.045	4.966LysAsp: 4.966 ± 0.131	8.113LysGlu: 8.113 ± 0.176	3.853LysPhe: 3.853 ± 0.102	4.509LysGly: 4.509 ± 0.112	1.504LysHis: 1.504 ± 0.05	10.255LysIle: 10.255 ± 0.172	9.307LysLys: 9.307 ± 0.196	7.687LysLeu: 7.687 ± 0.156	1.935LysMet: 1.935 ± 0.063	6.304LysAsn: 6.304 ± 0.103	2.742LysPro: 2.742 ± 0.078	2.137LysGln: 2.137 ± 0.078	3.518LysArg: 3.518 ± 0.086	4.628LysSer: 4.628 ± 0.105	4.709LysThr: 4.709 ± 0.098	4.473LysVal: 4.473 ± 0.094	0.766LysTrp: 0.766 ± 0.038	3.36LysTyr: 3.36 ± 0.079	0.0LysXaa: 0.0 ± 0.0
Leu	4.736LeuAla: 4.736 ± 0.109	1.352LeuCys: 1.352 ± 0.044	4.506LeuAsp: 4.506 ± 0.089	5.951LeuGlu: 5.951 ± 0.129	3.696LeuPhe: 3.696 ± 0.097	5.467LeuGly: 5.467 ± 0.141	1.264LeuHis: 1.264 ± 0.045	8.063LeuIle: 8.063 ± 0.15	8.952LeuLys: 8.952 ± 0.186	7.19LeuLeu: 7.19 ± 0.167	2.092LeuMet: 2.092 ± 0.057	5.505LeuAsn: 5.505 ± 0.119	2.888LeuPro: 2.888 ± 0.073	1.644LeuGln: 1.644 ± 0.059	3.296LeuArg: 3.296 ± 0.083	5.613LeuSer: 5.613 ± 0.104	4.57LeuThr: 4.57 ± 0.104	4.528LeuVal: 4.528 ± 0.102	0.725LeuTrp: 0.725 ± 0.036	2.55LeuTyr: 2.55 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	1.343MetAla: 1.343 ± 0.053	0.297MetCys: 0.297 ± 0.023	1.422MetAsp: 1.422 ± 0.052	1.78MetGlu: 1.78 ± 0.053	0.796MetPhe: 0.796 ± 0.037	1.472MetGly: 1.472 ± 0.055	0.448MetHis: 0.448 ± 0.027	1.614MetIle: 1.614 ± 0.054	2.413MetLys: 2.413 ± 0.065	1.926MetLeu: 1.926 ± 0.053	0.548MetMet: 0.548 ± 0.04	1.449MetAsn: 1.449 ± 0.043	0.926MetPro: 0.926 ± 0.049	0.732MetGln: 0.732 ± 0.033	1.043MetArg: 1.043 ± 0.047	1.262MetSer: 1.262 ± 0.054	1.166MetThr: 1.166 ± 0.041	1.314MetVal: 1.314 ± 0.05	0.177MetTrp: 0.177 ± 0.019	0.615MetTyr: 0.615 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.272AsnAla: 3.272 ± 0.082	1.187AsnCys: 1.187 ± 0.089	2.984AsnAsp: 2.984 ± 0.114	4.455AsnGlu: 4.455 ± 0.096	2.867AsnPhe: 2.867 ± 0.079	2.925AsnGly: 2.925 ± 0.117	0.74AsnHis: 0.74 ± 0.037	5.581AsnIle: 5.581 ± 0.136	5.124AsnLys: 5.124 ± 0.096	5.872AsnLeu: 5.872 ± 0.112	1.102AsnMet: 1.102 ± 0.038	4.453AsnAsn: 4.453 ± 0.334	2.483AsnPro: 2.483 ± 0.059	1.102AsnGln: 1.102 ± 0.05	1.99AsnArg: 1.99 ± 0.054	3.532AsnSer: 3.532 ± 0.141	3.122AsnThr: 3.122 ± 0.206	3.238AsnVal: 3.238 ± 0.111	0.668AsnTrp: 0.668 ± 0.044	2.676AsnTyr: 2.676 ± 0.099	0.0AsnXaa: 0.0 ± 0.0
Pro	2.136ProAla: 2.136 ± 0.065	0.458ProCys: 0.458 ± 0.027	2.51ProAsp: 2.51 ± 0.078	3.706ProGlu: 3.706 ± 0.084	1.427ProPhe: 1.427 ± 0.059	3.256ProGly: 3.256 ± 0.094	0.646ProHis: 0.646 ± 0.028	2.077ProIle: 2.077 ± 0.068	2.396ProLys: 2.396 ± 0.067	2.692ProLeu: 2.692 ± 0.07	0.665ProMet: 0.665 ± 0.036	1.191ProAsn: 1.191 ± 0.046	1.37ProPro: 1.37 ± 0.057	0.834ProGln: 0.834 ± 0.041	1.165ProArg: 1.165 ± 0.054	1.687ProSer: 1.687 ± 0.061	1.501ProThr: 1.501 ± 0.072	2.67ProVal: 2.67 ± 0.077	0.327ProTrp: 0.327 ± 0.023	1.299ProTyr: 1.299 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	1.096GlnAla: 1.096 ± 0.045	0.314GlnCys: 0.314 ± 0.024	1.069GlnAsp: 1.069 ± 0.047	1.697GlnGlu: 1.697 ± 0.066	0.798GlnPhe: 0.798 ± 0.034	1.34GlnGly: 1.34 ± 0.05	0.332GlnHis: 0.332 ± 0.027	1.734GlnIle: 1.734 ± 0.05	2.211GlnLys: 2.211 ± 0.077	1.547GlnLeu: 1.547 ± 0.051	0.553GlnMet: 0.553 ± 0.032	1.219GlnAsn: 1.219 ± 0.045	0.56GlnPro: 0.56 ± 0.031	0.6GlnGln: 0.6 ± 0.035	0.842GlnArg: 0.842 ± 0.034	1.017GlnSer: 1.017 ± 0.037	1.05GlnThr: 1.05 ± 0.047	1.376GlnVal: 1.376 ± 0.048	0.181GlnTrp: 0.181 ± 0.016	0.706GlnTyr: 0.706 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.092ArgAla: 2.092 ± 0.065	0.594ArgCys: 0.594 ± 0.031	2.486ArgAsp: 2.486 ± 0.072	3.815ArgGlu: 3.815 ± 0.099	1.627ArgPhe: 1.627 ± 0.051	2.722ArgGly: 2.722 ± 0.071	0.685ArgHis: 0.685 ± 0.034	3.534ArgIle: 3.534 ± 0.079	3.762ArgLys: 3.762 ± 0.084	2.839ArgLeu: 2.839 ± 0.079	1.075ArgMet: 1.075 ± 0.041	2.115ArgAsn: 2.115 ± 0.059	0.985ArgPro: 0.985 ± 0.045	0.964ArgGln: 0.964 ± 0.04	1.851ArgArg: 1.851 ± 0.074	1.714ArgSer: 1.714 ± 0.053	1.825ArgThr: 1.825 ± 0.064	2.495ArgVal: 2.495 ± 0.061	0.431ArgTrp: 0.431 ± 0.027	1.53ArgTyr: 1.53 ± 0.061	0.0ArgXaa: 0.0 ± 0.0
Ser	3.663SerAla: 3.663 ± 0.082	1.009SerCys: 1.009 ± 0.067	3.873SerAsp: 3.873 ± 0.11	4.5SerGlu: 4.5 ± 0.101	2.445SerPhe: 2.445 ± 0.072	5.749SerGly: 5.749 ± 0.15	0.959SerHis: 0.959 ± 0.035	4.552SerIle: 4.552 ± 0.1	4.273SerLys: 4.273 ± 0.093	4.38SerLeu: 4.38 ± 0.113	1.32SerMet: 1.32 ± 0.043	3.32SerAsn: 3.32 ± 0.197	2.07SerPro: 2.07 ± 0.068	1.245SerGln: 1.245 ± 0.044	2.376SerArg: 2.376 ± 0.073	3.923SerSer: 3.923 ± 0.164	2.616SerThr: 2.616 ± 0.084	3.82SerVal: 3.82 ± 0.081	0.563SerTrp: 0.563 ± 0.038	2.028SerTyr: 2.028 ± 0.066	0.002SerXaa: 0.002 ± 0.001
Thr	3.352ThrAla: 3.352 ± 0.111	0.897ThrCys: 0.897 ± 0.074	2.973ThrAsp: 2.973 ± 0.102	3.392ThrGlu: 3.392 ± 0.077	1.886ThrPhe: 1.886 ± 0.068	5.045ThrGly: 5.045 ± 0.144	0.933ThrHis: 0.933 ± 0.035	4.491ThrIle: 4.491 ± 0.106	3.602ThrLys: 3.602 ± 0.08	4.345ThrLeu: 4.345 ± 0.111	0.948ThrMet: 0.948 ± 0.039	2.507ThrAsn: 2.507 ± 0.13	2.276ThrPro: 2.276 ± 0.071	1.187ThrGln: 1.187 ± 0.052	1.9ThrArg: 1.9 ± 0.057	2.676ThrSer: 2.676 ± 0.071	2.85ThrThr: 2.85 ± 0.106	3.328ThrVal: 3.328 ± 0.107	0.434ThrTrp: 0.434 ± 0.029	1.821ThrTyr: 1.821 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	3.514ValAla: 3.514 ± 0.094	1.178ValCys: 1.178 ± 0.059	3.626ValAsp: 3.626 ± 0.079	4.646ValGlu: 4.646 ± 0.093	2.883ValPhe: 2.883 ± 0.075	3.715ValGly: 3.715 ± 0.085	1.025ValHis: 1.025 ± 0.041	5.634ValIle: 5.634 ± 0.113	5.169ValLys: 5.169 ± 0.101	5.362ValLeu: 5.362 ± 0.099	1.632ValMet: 1.632 ± 0.062	3.281ValAsn: 3.281 ± 0.101	2.198ValPro: 2.198 ± 0.064	1.114ValGln: 1.114 ± 0.039	2.562ValArg: 2.562 ± 0.1	4.319ValSer: 4.319 ± 0.111	3.11ValThr: 3.11 ± 0.123	4.732ValVal: 4.732 ± 0.101	0.539ValTrp: 0.539 ± 0.028	2.281ValTyr: 2.281 ± 0.083	0.0ValXaa: 0.0 ± 0.0
Trp	0.515TrpAla: 0.515 ± 0.034	0.163TrpCys: 0.163 ± 0.016	0.617TrpAsp: 0.617 ± 0.036	0.624TrpGlu: 0.624 ± 0.031	0.472TrpPhe: 0.472 ± 0.03	0.614TrpGly: 0.614 ± 0.034	0.192TrpHis: 0.192 ± 0.018	0.758TrpIle: 0.758 ± 0.035	0.85TrpLys: 0.85 ± 0.047	0.743TrpLeu: 0.743 ± 0.033	0.279TrpMet: 0.279 ± 0.022	0.764TrpAsn: 0.764 ± 0.049	0.145TrpPro: 0.145 ± 0.014	0.3TrpGln: 0.3 ± 0.02	0.355TrpArg: 0.355 ± 0.027	0.533TrpSer: 0.533 ± 0.035	0.477TrpThr: 0.477 ± 0.028	0.614TrpVal: 0.614 ± 0.031	0.178TrpTrp: 0.178 ± 0.018	0.387TrpTyr: 0.387 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.169TyrAla: 2.169 ± 0.06	0.805TyrCys: 0.805 ± 0.045	2.319TyrAsp: 2.319 ± 0.068	2.699TyrGlu: 2.699 ± 0.065	1.726TyrPhe: 1.726 ± 0.058	2.775TyrGly: 2.775 ± 0.109	0.677TyrHis: 0.677 ± 0.035	2.935TyrIle: 2.935 ± 0.079	2.687TyrLys: 2.687 ± 0.072	3.474TyrLeu: 3.474 ± 0.095	0.696TyrMet: 0.696 ± 0.03	2.253TyrAsn: 2.253 ± 0.09	1.443TyrPro: 1.443 ± 0.053	0.656TyrGln: 0.656 ± 0.036	1.487TyrArg: 1.487 ± 0.055	2.361TyrSer: 2.361 ± 0.086	1.85TyrThr: 1.85 ± 0.068	2.29TyrVal: 2.29 ± 0.079	0.397TyrTrp: 0.397 ± 0.031	1.673TyrTyr: 1.673 ± 0.066	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 2164 proteins (656850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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