Amino acid dipepetide frequency for Tipula oleracea nudivirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.23AlaAla: 1.23 ± 0.181
0.53AlaCys: 0.53 ± 0.118
1.35AlaAsp: 1.35 ± 0.173
1.326AlaGlu: 1.326 ± 0.224
1.23AlaPhe: 1.23 ± 0.172
0.651AlaGly: 0.651 ± 0.124
0.458AlaHis: 0.458 ± 0.098
2.17AlaIle: 2.17 ± 0.245
2.17AlaLys: 2.17 ± 0.21
1.953AlaLeu: 1.953 ± 0.25
0.699AlaMet: 0.699 ± 0.131
2.484AlaAsn: 2.484 ± 0.265
0.555AlaPro: 0.555 ± 0.142
0.844AlaGln: 0.844 ± 0.161
0.868AlaArg: 0.868 ± 0.153
1.833AlaSer: 1.833 ± 0.238
1.664AlaThr: 1.664 ± 0.255
1.664AlaVal: 1.664 ± 0.196
0.121AlaTrp: 0.121 ± 0.05
1.254AlaTyr: 1.254 ± 0.162
0.0AlaXaa: 0.0 ± 0.0
Cys
0.313CysAla: 0.313 ± 0.092
0.555CysCys: 0.555 ± 0.149
1.109CysAsp: 1.109 ± 0.155
0.965CysGlu: 0.965 ± 0.132
0.868CysPhe: 0.868 ± 0.155
0.603CysGly: 0.603 ± 0.146
0.169CysHis: 0.169 ± 0.085
1.616CysIle: 1.616 ± 0.239
2.05CysLys: 2.05 ± 0.297
1.471CysLeu: 1.471 ± 0.236
0.41CysMet: 0.41 ± 0.124
1.471CysAsn: 1.471 ± 0.18
0.506CysPro: 0.506 ± 0.132
0.41CysGln: 0.41 ± 0.096
0.627CysArg: 0.627 ± 0.133
0.989CysSer: 0.989 ± 0.166
0.844CysThr: 0.844 ± 0.154
0.916CysVal: 0.916 ± 0.151
0.048CysTrp: 0.048 ± 0.033
0.868CysTyr: 0.868 ± 0.149
0.0CysXaa: 0.0 ± 0.0
Asp
2.05AspAla: 2.05 ± 0.252
0.772AspCys: 0.772 ± 0.122
6.993AspAsp: 6.993 ± 0.72
5.425AspGlu: 5.425 ± 0.41
3.569AspPhe: 3.569 ± 0.267
2.025AspGly: 2.025 ± 0.237
1.013AspHis: 1.013 ± 0.171
6.993AspIle: 6.993 ± 0.41
3.882AspLys: 3.882 ± 0.331
4.292AspLeu: 4.292 ± 0.314
1.157AspMet: 1.157 ± 0.179
4.485AspAsn: 4.485 ± 0.352
1.254AspPro: 1.254 ± 0.214
1.64AspGln: 1.64 ± 0.187
1.206AspArg: 1.206 ± 0.136
3.882AspSer: 3.882 ± 0.276
3.014AspThr: 3.014 ± 0.328
3.858AspVal: 3.858 ± 0.253
0.169AspTrp: 0.169 ± 0.073
3.038AspTyr: 3.038 ± 0.309
0.0AspXaa: 0.0 ± 0.0
Glu
1.326GluAla: 1.326 ± 0.147
0.844GluCys: 0.844 ± 0.159
2.701GluAsp: 2.701 ± 0.268
3.665GluGlu: 3.665 ± 0.437
2.845GluPhe: 2.845 ± 0.256
0.892GluGly: 0.892 ± 0.158
1.471GluHis: 1.471 ± 0.189
6.004GluIle: 6.004 ± 0.436
4.895GluLys: 4.895 ± 0.447
6.414GluLeu: 6.414 ± 0.355
1.133GluMet: 1.133 ± 0.179
6.824GluAsn: 6.824 ± 0.466
2.484GluPro: 2.484 ± 0.349
2.267GluGln: 2.267 ± 0.309
1.326GluArg: 1.326 ± 0.212
4.051GluSer: 4.051 ± 0.314
2.556GluThr: 2.556 ± 0.255
2.652GluVal: 2.652 ± 0.263
0.241GluTrp: 0.241 ± 0.089
4.34GluTyr: 4.34 ± 0.359
0.0GluXaa: 0.0 ± 0.0
Phe
1.157PheAla: 1.157 ± 0.14
0.772PheCys: 0.772 ± 0.129
3.979PheAsp: 3.979 ± 0.298
3.954PheGlu: 3.954 ± 0.327
2.315PhePhe: 2.315 ± 0.273
1.254PheGly: 1.254 ± 0.168
0.868PheHis: 0.868 ± 0.162
6.318PheIle: 6.318 ± 0.377
4.967PheLys: 4.967 ± 0.363
4.027PheLeu: 4.027 ± 0.359
0.94PheMet: 0.94 ± 0.128
6.101PheAsn: 6.101 ± 0.456
0.916PhePro: 0.916 ± 0.136
1.712PheGln: 1.712 ± 0.199
1.423PheArg: 1.423 ± 0.164
3.183PheSer: 3.183 ± 0.249
2.99PheThr: 2.99 ± 0.3
1.953PheVal: 1.953 ± 0.222
0.169PheTrp: 0.169 ± 0.059
2.701PheTyr: 2.701 ± 0.237
0.0PheXaa: 0.0 ± 0.0
Gly
0.603GlyAla: 0.603 ± 0.123
0.603GlyCys: 0.603 ± 0.102
1.833GlyAsp: 1.833 ± 0.186
1.374GlyGlu: 1.374 ± 0.167
1.784GlyPhe: 1.784 ± 0.253
1.206GlyGly: 1.206 ± 0.206
0.434GlyHis: 0.434 ± 0.109
2.363GlyIle: 2.363 ± 0.256
1.447GlyLys: 1.447 ± 0.192
1.953GlyLeu: 1.953 ± 0.258
0.41GlyMet: 0.41 ± 0.108
1.881GlyAsn: 1.881 ± 0.222
0.627GlyPro: 0.627 ± 0.105
0.506GlyGln: 0.506 ± 0.106
0.723GlyArg: 0.723 ± 0.133
2.122GlySer: 2.122 ± 0.256
1.037GlyThr: 1.037 ± 0.153
2.146GlyVal: 2.146 ± 0.225
0.169GlyTrp: 0.169 ± 0.057
1.302GlyTyr: 1.302 ± 0.199
0.0GlyXaa: 0.0 ± 0.0
His
0.651HisAla: 0.651 ± 0.121
0.338HisCys: 0.338 ± 0.09
1.182HisAsp: 1.182 ± 0.171
0.82HisGlu: 0.82 ± 0.139
0.675HisPhe: 0.675 ± 0.113
0.482HisGly: 0.482 ± 0.11
0.555HisHis: 0.555 ± 0.119
2.122HisIle: 2.122 ± 0.204
1.543HisLys: 1.543 ± 0.209
1.495HisLeu: 1.495 ± 0.191
0.313HisMet: 0.313 ± 0.069
2.025HisAsn: 2.025 ± 0.211
0.434HisPro: 0.434 ± 0.102
0.747HisGln: 0.747 ± 0.114
0.579HisArg: 0.579 ± 0.128
1.399HisSer: 1.399 ± 0.154
1.037HisThr: 1.037 ± 0.152
0.772HisVal: 0.772 ± 0.121
0.145HisTrp: 0.145 ± 0.049
1.23HisTyr: 1.23 ± 0.174
0.0HisXaa: 0.0 ± 0.0
Ile
2.725IleAla: 2.725 ± 0.255
1.471IleCys: 1.471 ± 0.231
7.041IleAsp: 7.041 ± 0.42
6.51IleGlu: 6.51 ± 0.498
6.462IlePhe: 6.462 ± 0.415
2.869IleGly: 2.869 ± 0.282
2.508IleHis: 2.508 ± 0.269
11.357IleIle: 11.357 ± 0.508
9.742IleLys: 9.742 ± 0.563
9.5IleLeu: 9.5 ± 0.484
1.664IleMet: 1.664 ± 0.188
11.309IleAsn: 11.309 ± 0.579
4.581IlePro: 4.581 ± 0.384
4.196IleGln: 4.196 ± 0.332
2.677IleArg: 2.677 ± 0.284
7.861IleSer: 7.861 ± 0.384
6.824IleThr: 6.824 ± 0.428
4.702IleVal: 4.702 ± 0.378
0.458IleTrp: 0.458 ± 0.102
5.064IleTyr: 5.064 ± 0.403
0.0IleXaa: 0.0 ± 0.0
Lys
1.013LysAla: 1.013 ± 0.158
1.736LysCys: 1.736 ± 0.228
3.038LysAsp: 3.038 ± 0.267
3.93LysGlu: 3.93 ± 0.369
3.81LysPhe: 3.81 ± 0.257
1.302LysGly: 1.302 ± 0.155
1.929LysHis: 1.929 ± 0.218
11.14LysIle: 11.14 ± 0.583
9.766LysLys: 9.766 ± 0.727
8.56LysLeu: 8.56 ± 0.531
2.17LysMet: 2.17 ± 0.248
10.778LysAsn: 10.778 ± 0.557
2.701LysPro: 2.701 ± 0.457
3.376LysGln: 3.376 ± 0.288
3.062LysArg: 3.062 ± 0.303
6.607LysSer: 6.607 ± 0.386
4.75LysThr: 4.75 ± 0.297
3.303LysVal: 3.303 ± 0.276
0.217LysTrp: 0.217 ± 0.076
6.318LysTyr: 6.318 ± 0.407
0.0LysXaa: 0.0 ± 0.0
Leu
2.146LeuAla: 2.146 ± 0.256
1.447LeuCys: 1.447 ± 0.198
4.485LeuAsp: 4.485 ± 0.287
4.702LeuGlu: 4.702 ± 0.337
5.064LeuPhe: 5.064 ± 0.327
1.712LeuGly: 1.712 ± 0.171
1.712LeuHis: 1.712 ± 0.197
9.356LeuIle: 9.356 ± 0.569
8.078LeuLys: 8.078 ± 0.474
8.56LeuLeu: 8.56 ± 0.476
2.315LeuMet: 2.315 ± 0.219
9.187LeuAsn: 9.187 ± 0.472
3.328LeuPro: 3.328 ± 0.263
3.255LeuGln: 3.255 ± 0.248
1.977LeuArg: 1.977 ± 0.239
5.811LeuSer: 5.811 ± 0.449
5.666LeuThr: 5.666 ± 0.298
3.496LeuVal: 3.496 ± 0.317
0.482LeuTrp: 0.482 ± 0.107
5.353LeuTyr: 5.353 ± 0.346
0.0LeuXaa: 0.0 ± 0.0
Met
0.651MetAla: 0.651 ± 0.138
0.362MetCys: 0.362 ± 0.113
1.712MetAsp: 1.712 ± 0.226
1.278MetGlu: 1.278 ± 0.219
1.254MetPhe: 1.254 ± 0.157
0.627MetGly: 0.627 ± 0.128
0.289MetHis: 0.289 ± 0.087
1.881MetIle: 1.881 ± 0.223
1.616MetLys: 1.616 ± 0.222
1.808MetLeu: 1.808 ± 0.181
0.53MetMet: 0.53 ± 0.111
2.194MetAsn: 2.194 ± 0.24
0.506MetPro: 0.506 ± 0.111
0.747MetGln: 0.747 ± 0.161
0.506MetArg: 0.506 ± 0.117
1.664MetSer: 1.664 ± 0.162
0.796MetThr: 0.796 ± 0.118
1.061MetVal: 1.061 ± 0.123
0.072MetTrp: 0.072 ± 0.04
1.495MetTyr: 1.495 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
2.291AsnAla: 2.291 ± 0.253
1.543AsnCys: 1.543 ± 0.193
6.125AsnAsp: 6.125 ± 0.41
6.51AsnGlu: 6.51 ± 0.406
5.232AsnPhe: 5.232 ± 0.356
2.484AsnGly: 2.484 ± 0.303
1.519AsnHis: 1.519 ± 0.243
13.262AsnIle: 13.262 ± 0.77
9.983AsnLys: 9.983 ± 0.529
9.066AsnLeu: 9.066 ± 0.588
1.784AsnMet: 1.784 ± 0.183
12.249AsnAsn: 12.249 ± 0.763
2.435AsnPro: 2.435 ± 0.266
3.038AsnGln: 3.038 ± 0.279
2.797AsnArg: 2.797 ± 0.277
6.703AsnSer: 6.703 ± 0.453
6.076AsnThr: 6.076 ± 0.378
4.919AsnVal: 4.919 ± 0.384
0.434AsnTrp: 0.434 ± 0.101
5.305AsnTyr: 5.305 ± 0.379
0.0AsnXaa: 0.0 ± 0.0
Pro
0.747ProAla: 0.747 ± 0.112
0.555ProCys: 0.555 ± 0.116
1.399ProAsp: 1.399 ± 0.186
2.001ProGlu: 2.001 ± 0.292
1.567ProPhe: 1.567 ± 0.173
0.603ProGly: 0.603 ± 0.124
0.506ProHis: 0.506 ± 0.098
3.737ProIle: 3.737 ± 0.39
2.218ProLys: 2.218 ± 0.219
2.894ProLeu: 2.894 ± 0.234
0.555ProMet: 0.555 ± 0.102
2.869ProAsn: 2.869 ± 0.295
1.567ProPro: 1.567 ± 0.258
1.736ProGln: 1.736 ± 0.25
0.555ProArg: 0.555 ± 0.13
2.701ProSer: 2.701 ± 0.322
2.363ProThr: 2.363 ± 0.342
1.423ProVal: 1.423 ± 0.301
0.169ProTrp: 0.169 ± 0.063
1.833ProTyr: 1.833 ± 0.152
0.0ProXaa: 0.0 ± 0.0
Gln
0.699GlnAla: 0.699 ± 0.122
0.579GlnCys: 0.579 ± 0.112
1.495GlnAsp: 1.495 ± 0.18
1.399GlnGlu: 1.399 ± 0.198
1.736GlnPhe: 1.736 ± 0.228
0.41GlnGly: 0.41 ± 0.097
0.94GlnHis: 0.94 ± 0.155
3.689GlnIle: 3.689 ± 0.253
3.086GlnLys: 3.086 ± 0.253
3.81GlnLeu: 3.81 ± 0.36
0.699GlnMet: 0.699 ± 0.144
3.81GlnAsn: 3.81 ± 0.314
1.905GlnPro: 1.905 ± 0.396
2.387GlnGln: 2.387 ± 0.457
0.892GlnArg: 0.892 ± 0.15
2.291GlnSer: 2.291 ± 0.237
2.194GlnThr: 2.194 ± 0.283
0.94GlnVal: 0.94 ± 0.121
0.048GlnTrp: 0.048 ± 0.031
2.315GlnTyr: 2.315 ± 0.252
0.0GlnXaa: 0.0 ± 0.0
Arg
0.94ArgAla: 0.94 ± 0.164
0.458ArgCys: 0.458 ± 0.11
1.109ArgAsp: 1.109 ± 0.126
1.591ArgGlu: 1.591 ± 0.204
1.133ArgPhe: 1.133 ± 0.146
0.892ArgGly: 0.892 ± 0.154
0.338ArgHis: 0.338 ± 0.095
2.58ArgIle: 2.58 ± 0.24
2.074ArgLys: 2.074 ± 0.227
2.604ArgLeu: 2.604 ± 0.269
0.723ArgMet: 0.723 ± 0.139
2.484ArgAsn: 2.484 ± 0.253
0.675ArgPro: 0.675 ± 0.144
1.013ArgGln: 1.013 ± 0.143
1.326ArgArg: 1.326 ± 0.283
2.604ArgSer: 2.604 ± 0.416
1.278ArgThr: 1.278 ± 0.183
1.061ArgVal: 1.061 ± 0.144
0.096ArgTrp: 0.096 ± 0.046
1.977ArgTyr: 1.977 ± 0.187
0.0ArgXaa: 0.0 ± 0.0
Ser
2.001SerAla: 2.001 ± 0.235
0.989SerCys: 0.989 ± 0.158
4.437SerAsp: 4.437 ± 0.392
4.075SerGlu: 4.075 ± 0.278
3.472SerPhe: 3.472 ± 0.329
1.881SerGly: 1.881 ± 0.231
1.133SerHis: 1.133 ± 0.164
8.005SerIle: 8.005 ± 0.379
6.848SerLys: 6.848 ± 0.453
5.594SerLeu: 5.594 ± 0.339
1.471SerMet: 1.471 ± 0.209
7.113SerAsn: 7.113 ± 0.442
1.905SerPro: 1.905 ± 0.243
2.05SerGln: 2.05 ± 0.219
1.688SerArg: 1.688 ± 0.316
5.329SerSer: 5.329 ± 0.367
5.594SerThr: 5.594 ± 0.403
3.52SerVal: 3.52 ± 0.299
0.313SerTrp: 0.313 ± 0.084
3.569SerTyr: 3.569 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
1.616ThrAla: 1.616 ± 0.269
1.037ThrCys: 1.037 ± 0.222
3.086ThrAsp: 3.086 ± 0.238
2.894ThrGlu: 2.894 ± 0.307
2.58ThrPhe: 2.58 ± 0.247
1.543ThrGly: 1.543 ± 0.206
1.061ThrHis: 1.061 ± 0.187
6.125ThrIle: 6.125 ± 0.4
5.715ThrLys: 5.715 ± 0.426
5.16ThrLeu: 5.16 ± 0.406
1.64ThrMet: 1.64 ± 0.204
4.871ThrAsn: 4.871 ± 0.358
2.701ThrPro: 2.701 ± 0.363
2.315ThrGln: 2.315 ± 0.279
1.495ThrArg: 1.495 ± 0.184
4.485ThrSer: 4.485 ± 0.345
4.774ThrThr: 4.774 ± 0.562
2.725ThrVal: 2.725 ± 0.279
0.362ThrTrp: 0.362 ± 0.109
2.821ThrTyr: 2.821 ± 0.241
0.0ThrXaa: 0.0 ± 0.0
Val
1.35ValAla: 1.35 ± 0.184
1.061ValCys: 1.061 ± 0.186
3.545ValAsp: 3.545 ± 0.329
3.231ValGlu: 3.231 ± 0.348
2.628ValPhe: 2.628 ± 0.253
1.302ValGly: 1.302 ± 0.182
0.506ValHis: 0.506 ± 0.126
4.413ValIle: 4.413 ± 0.375
3.954ValLys: 3.954 ± 0.357
4.437ValLeu: 4.437 ± 0.291
0.796ValMet: 0.796 ± 0.143
4.871ValAsn: 4.871 ± 0.354
1.254ValPro: 1.254 ± 0.163
1.254ValGln: 1.254 ± 0.175
1.326ValArg: 1.326 ± 0.193
2.869ValSer: 2.869 ± 0.273
2.242ValThr: 2.242 ± 0.205
2.556ValVal: 2.556 ± 0.245
0.241ValTrp: 0.241 ± 0.071
2.459ValTyr: 2.459 ± 0.238
0.0ValXaa: 0.0 ± 0.0
Trp
0.145TrpAla: 0.145 ± 0.052
0.072TrpCys: 0.072 ± 0.035
0.313TrpAsp: 0.313 ± 0.093
0.193TrpGlu: 0.193 ± 0.072
0.193TrpPhe: 0.193 ± 0.058
0.193TrpGly: 0.193 ± 0.069
0.145TrpHis: 0.145 ± 0.06
0.338TrpIle: 0.338 ± 0.105
0.289TrpLys: 0.289 ± 0.088
0.434TrpLeu: 0.434 ± 0.098
0.145TrpMet: 0.145 ± 0.05
0.482TrpAsn: 0.482 ± 0.102
0.072TrpPro: 0.072 ± 0.04
0.072TrpGln: 0.072 ± 0.037
0.193TrpArg: 0.193 ± 0.08
0.145TrpSer: 0.145 ± 0.068
0.338TrpThr: 0.338 ± 0.084
0.169TrpVal: 0.169 ± 0.063
0.048TrpTrp: 0.048 ± 0.036
0.241TrpTyr: 0.241 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.399TyrAla: 1.399 ± 0.179
1.085TyrCys: 1.085 ± 0.159
3.786TyrAsp: 3.786 ± 0.317
3.086TyrGlu: 3.086 ± 0.226
3.279TyrPhe: 3.279 ± 0.285
1.591TyrGly: 1.591 ± 0.18
0.989TyrHis: 0.989 ± 0.149
6.052TyrIle: 6.052 ± 0.442
5.208TyrLys: 5.208 ± 0.435
4.099TyrLeu: 4.099 ± 0.292
1.471TyrMet: 1.471 ± 0.189
6.269TyrAsn: 6.269 ± 0.363
1.591TyrPro: 1.591 ± 0.161
1.76TyrGln: 1.76 ± 0.234
1.712TyrArg: 1.712 ± 0.191
4.461TyrSer: 4.461 ± 0.357
2.966TyrThr: 2.966 ± 0.274
2.459TyrVal: 2.459 ± 0.239
0.217TyrTrp: 0.217 ± 0.072
3.496TyrTyr: 3.496 ± 0.352
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 131 proteins (41473 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski