Amino acid dipepetide frequency for Hericium alpestre

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.762AlaAla: 9.762 ± 0.066
1.149AlaCys: 1.149 ± 0.017
4.945AlaAsp: 4.945 ± 0.04
5.622AlaGlu: 5.622 ± 0.047
3.42AlaPhe: 3.42 ± 0.034
5.808AlaGly: 5.808 ± 0.041
2.34AlaHis: 2.34 ± 0.025
4.228AlaIle: 4.228 ± 0.035
4.295AlaLys: 4.295 ± 0.039
8.894AlaLeu: 8.894 ± 0.053
2.14AlaMet: 2.14 ± 0.024
2.751AlaAsn: 2.751 ± 0.025
5.694AlaPro: 5.694 ± 0.051
3.599AlaGln: 3.599 ± 0.031
5.662AlaArg: 5.662 ± 0.043
7.609AlaSer: 7.609 ± 0.053
5.081AlaThr: 5.081 ± 0.039
5.785AlaVal: 5.785 ± 0.038
1.228AlaTrp: 1.228 ± 0.017
2.268AlaTyr: 2.268 ± 0.025
0.122AlaXaa: 0.122 ± 0.007
Cys
0.992CysAla: 0.992 ± 0.017
0.226CysCys: 0.226 ± 0.008
0.665CysAsp: 0.665 ± 0.012
0.594CysGlu: 0.594 ± 0.013
0.5CysPhe: 0.5 ± 0.011
0.812CysGly: 0.812 ± 0.018
0.349CysHis: 0.349 ± 0.009
0.669CysIle: 0.669 ± 0.012
0.546CysLys: 0.546 ± 0.011
1.16CysLeu: 1.16 ± 0.017
0.312CysMet: 0.312 ± 0.008
0.392CysAsn: 0.392 ± 0.01
0.699CysPro: 0.699 ± 0.015
0.449CysGln: 0.449 ± 0.011
0.724CysArg: 0.724 ± 0.014
0.891CysSer: 0.891 ± 0.016
0.703CysThr: 0.703 ± 0.015
0.763CysVal: 0.763 ± 0.016
0.19CysTrp: 0.19 ± 0.007
0.305CysTyr: 0.305 ± 0.009
0.018CysXaa: 0.018 ± 0.002
Asp
5.724AspAla: 5.724 ± 0.038
0.639AspCys: 0.639 ± 0.013
4.522AspAsp: 4.522 ± 0.047
4.837AspGlu: 4.837 ± 0.049
2.206AspPhe: 2.206 ± 0.023
4.079AspGly: 4.079 ± 0.031
1.311AspHis: 1.311 ± 0.019
3.211AspIle: 3.211 ± 0.026
2.38AspLys: 2.38 ± 0.028
5.386AspLeu: 5.386 ± 0.039
1.405AspMet: 1.405 ± 0.019
1.737AspAsn: 1.737 ± 0.022
3.602AspPro: 3.602 ± 0.032
1.699AspGln: 1.699 ± 0.022
2.976AspArg: 2.976 ± 0.029
3.961AspSer: 3.961 ± 0.033
3.048AspThr: 3.048 ± 0.028
4.438AspVal: 4.438 ± 0.033
0.966AspTrp: 0.966 ± 0.015
1.489AspTyr: 1.489 ± 0.017
0.087AspXaa: 0.087 ± 0.006
Glu
5.561GluAla: 5.561 ± 0.042
0.612GluCys: 0.612 ± 0.014
4.618GluAsp: 4.618 ± 0.046
5.822GluGlu: 5.822 ± 0.068
2.004GluPhe: 2.004 ± 0.023
3.879GluGly: 3.879 ± 0.037
1.655GluHis: 1.655 ± 0.02
2.79GluIle: 2.79 ± 0.03
3.324GluLys: 3.324 ± 0.034
5.603GluLeu: 5.603 ± 0.045
1.467GluMet: 1.467 ± 0.018
1.877GluAsn: 1.877 ± 0.023
2.943GluPro: 2.943 ± 0.031
2.53GluGln: 2.53 ± 0.027
4.035GluArg: 4.035 ± 0.041
3.775GluSer: 3.775 ± 0.035
3.049GluThr: 3.049 ± 0.027
3.767GluVal: 3.767 ± 0.031
0.95GluTrp: 0.95 ± 0.014
1.57GluTyr: 1.57 ± 0.021
0.073GluXaa: 0.073 ± 0.005
Phe
3.268PheAla: 3.268 ± 0.03
0.544PheCys: 0.544 ± 0.012
2.412PheAsp: 2.412 ± 0.022
2.102PheGlu: 2.102 ± 0.022
1.585PhePhe: 1.585 ± 0.024
2.673PheGly: 2.673 ± 0.028
0.94PheHis: 0.94 ± 0.014
1.848PheIle: 1.848 ± 0.021
1.534PheLys: 1.534 ± 0.021
3.487PheLeu: 3.487 ± 0.031
0.864PheMet: 0.864 ± 0.015
1.365PheAsn: 1.365 ± 0.018
1.966PhePro: 1.966 ± 0.024
1.216PheGln: 1.216 ± 0.016
1.931PheArg: 1.931 ± 0.018
2.991PheSer: 2.991 ± 0.03
2.137PheThr: 2.137 ± 0.023
2.606PheVal: 2.606 ± 0.026
0.589PheTrp: 0.589 ± 0.011
1.058PheTyr: 1.058 ± 0.016
0.046PheXaa: 0.046 ± 0.004
Gly
5.278GlyAla: 5.278 ± 0.037
0.752GlyCys: 0.752 ± 0.015
3.547GlyAsp: 3.547 ± 0.033
3.551GlyGlu: 3.551 ± 0.03
2.511GlyPhe: 2.511 ± 0.024
5.096GlyGly: 5.096 ± 0.064
1.693GlyHis: 1.693 ± 0.022
3.172GlyIle: 3.172 ± 0.03
3.458GlyLys: 3.458 ± 0.031
5.662GlyLeu: 5.662 ± 0.043
1.522GlyMet: 1.522 ± 0.022
2.062GlyAsn: 2.062 ± 0.024
3.415GlyPro: 3.415 ± 0.03
2.312GlyGln: 2.312 ± 0.027
3.923GlyArg: 3.923 ± 0.031
5.121GlySer: 5.121 ± 0.043
3.729GlyThr: 3.729 ± 0.031
4.083GlyVal: 4.083 ± 0.036
1.067GlyTrp: 1.067 ± 0.015
1.799GlyTyr: 1.799 ± 0.024
0.093GlyXaa: 0.093 ± 0.006
His
2.477HisAla: 2.477 ± 0.027
0.335HisCys: 0.335 ± 0.009
1.442HisAsp: 1.442 ± 0.017
1.441HisGlu: 1.441 ± 0.018
1.063HisPhe: 1.063 ± 0.016
1.728HisGly: 1.728 ± 0.017
0.794HisHis: 0.794 ± 0.015
1.416HisIle: 1.416 ± 0.019
0.984HisLys: 0.984 ± 0.016
2.603HisLeu: 2.603 ± 0.028
0.556HisMet: 0.556 ± 0.012
0.799HisAsn: 0.799 ± 0.013
1.921HisPro: 1.921 ± 0.02
0.847HisGln: 0.847 ± 0.015
1.6HisArg: 1.6 ± 0.02
1.822HisSer: 1.822 ± 0.023
1.437HisThr: 1.437 ± 0.018
1.891HisVal: 1.891 ± 0.022
0.388HisTrp: 0.388 ± 0.01
0.683HisTyr: 0.683 ± 0.013
0.03HisXaa: 0.03 ± 0.003
Ile
4.254IleAla: 4.254 ± 0.033
0.719IleCys: 0.719 ± 0.013
2.895IleAsp: 2.895 ± 0.027
2.689IleGlu: 2.689 ± 0.027
1.909IlePhe: 1.909 ± 0.022
2.884IleGly: 2.884 ± 0.028
1.262IleHis: 1.262 ± 0.016
2.443IleIle: 2.443 ± 0.027
2.055IleLys: 2.055 ± 0.023
4.457IleLeu: 4.457 ± 0.037
1.013IleMet: 1.013 ± 0.017
1.616IleAsn: 1.616 ± 0.019
3.138IlePro: 3.138 ± 0.027
1.759IleGln: 1.759 ± 0.019
2.71IleArg: 2.71 ± 0.024
3.623IleSer: 3.623 ± 0.031
2.719IleThr: 2.719 ± 0.027
3.376IleVal: 3.376 ± 0.03
0.683IleTrp: 0.683 ± 0.012
1.283IleTyr: 1.283 ± 0.021
0.058IleXaa: 0.058 ± 0.005
Lys
4.713LysAla: 4.713 ± 0.049
0.485LysCys: 0.485 ± 0.012
2.75LysAsp: 2.75 ± 0.028
3.316LysGlu: 3.316 ± 0.032
1.381LysPhe: 1.381 ± 0.019
2.967LysGly: 2.967 ± 0.031
1.207LysHis: 1.207 ± 0.016
2.035LysIle: 2.035 ± 0.023
3.236LysLys: 3.236 ± 0.047
3.979LysLeu: 3.979 ± 0.028
0.962LysMet: 0.962 ± 0.016
1.491LysAsn: 1.491 ± 0.022
2.679LysPro: 2.679 ± 0.025
1.769LysGln: 1.769 ± 0.023
3.36LysArg: 3.36 ± 0.035
3.029LysSer: 3.029 ± 0.033
2.603LysThr: 2.603 ± 0.029
2.805LysVal: 2.805 ± 0.026
0.69LysTrp: 0.69 ± 0.014
1.262LysTyr: 1.262 ± 0.019
0.074LysXaa: 0.074 ± 0.005
Leu
8.349LeuAla: 8.349 ± 0.049
1.23LeuCys: 1.23 ± 0.02
5.571LeuAsp: 5.571 ± 0.041
5.612LeuGlu: 5.612 ± 0.046
3.41LeuPhe: 3.41 ± 0.032
5.388LeuGly: 5.388 ± 0.035
2.597LeuHis: 2.597 ± 0.027
3.85LeuIle: 3.85 ± 0.034
4.247LeuLys: 4.247 ± 0.035
8.616LeuLeu: 8.616 ± 0.06
1.829LeuMet: 1.829 ± 0.02
3.05LeuAsn: 3.05 ± 0.027
6.125LeuPro: 6.125 ± 0.037
3.817LeuGln: 3.817 ± 0.034
6.089LeuArg: 6.089 ± 0.042
7.524LeuSer: 7.524 ± 0.044
5.216LeuThr: 5.216 ± 0.037
5.687LeuVal: 5.687 ± 0.044
1.216LeuTrp: 1.216 ± 0.017
2.355LeuTyr: 2.355 ± 0.025
0.117LeuXaa: 0.117 ± 0.008
Met
2.05MetAla: 2.05 ± 0.021
0.25MetCys: 0.25 ± 0.007
1.34MetAsp: 1.34 ± 0.02
1.275MetGlu: 1.275 ± 0.015
0.776MetPhe: 0.776 ± 0.015
1.257MetGly: 1.257 ± 0.02
0.653MetHis: 0.653 ± 0.012
0.943MetIle: 0.943 ± 0.016
0.99MetLys: 0.99 ± 0.018
2.101MetLeu: 2.101 ± 0.023
0.556MetMet: 0.556 ± 0.013
0.71MetAsn: 0.71 ± 0.015
1.512MetPro: 1.512 ± 0.021
1.006MetGln: 1.006 ± 0.017
1.38MetArg: 1.38 ± 0.018
2.007MetSer: 2.007 ± 0.023
1.266MetThr: 1.266 ± 0.018
1.227MetVal: 1.227 ± 0.017
0.263MetTrp: 0.263 ± 0.008
0.533MetTyr: 0.533 ± 0.013
0.031MetXaa: 0.031 ± 0.003
Asn
3.166AsnAla: 3.166 ± 0.028
0.346AsnCys: 0.346 ± 0.01
1.754AsnAsp: 1.754 ± 0.022
1.801AsnGlu: 1.801 ± 0.023
1.266AsnPhe: 1.266 ± 0.017
2.497AsnGly: 2.497 ± 0.027
0.773AsnHis: 0.773 ± 0.014
1.795AsnIle: 1.795 ± 0.02
1.332AsnLys: 1.332 ± 0.019
2.966AsnLeu: 2.966 ± 0.028
0.747AsnMet: 0.747 ± 0.012
1.147AsnAsn: 1.147 ± 0.019
2.116AsnPro: 2.116 ± 0.023
1.024AsnGln: 1.024 ± 0.015
1.61AsnArg: 1.61 ± 0.018
2.171AsnSer: 2.171 ± 0.024
1.87AsnThr: 1.87 ± 0.022
2.427AsnVal: 2.427 ± 0.021
0.492AsnTrp: 0.492 ± 0.011
0.894AsnTyr: 0.894 ± 0.014
0.046AsnXaa: 0.046 ± 0.004
Pro
6.319ProAla: 6.319 ± 0.056
0.526ProCys: 0.526 ± 0.012
3.588ProAsp: 3.588 ± 0.028
3.863ProGlu: 3.863 ± 0.029
2.233ProPhe: 2.233 ± 0.023
3.732ProGly: 3.732 ± 0.033
1.606ProHis: 1.606 ± 0.021
2.681ProIle: 2.681 ± 0.027
2.507ProLys: 2.507 ± 0.027
5.13ProLeu: 5.13 ± 0.039
1.172ProMet: 1.172 ± 0.017
2.008ProAsn: 2.008 ± 0.022
5.927ProPro: 5.927 ± 0.073
2.287ProGln: 2.287 ± 0.03
3.406ProArg: 3.406 ± 0.034
6.773ProSer: 6.773 ± 0.06
4.084ProThr: 4.084 ± 0.045
3.912ProVal: 3.912 ± 0.034
0.738ProTrp: 0.738 ± 0.014
1.517ProTyr: 1.517 ± 0.023
0.095ProXaa: 0.095 ± 0.007
Gln
3.574GlnAla: 3.574 ± 0.031
0.431GlnCys: 0.431 ± 0.01
2.101GlnAsp: 2.101 ± 0.025
2.265GlnGlu: 2.265 ± 0.026
1.284GlnPhe: 1.284 ± 0.02
2.168GlnGly: 2.168 ± 0.023
1.116GlnHis: 1.116 ± 0.019
1.765GlnIle: 1.765 ± 0.02
1.748GlnLys: 1.748 ± 0.022
3.475GlnLeu: 3.475 ± 0.028
0.862GlnMet: 0.862 ± 0.018
1.256GlnAsn: 1.256 ± 0.019
2.403GlnPro: 2.403 ± 0.031
1.949GlnGln: 1.949 ± 0.036
2.441GlnArg: 2.441 ± 0.024
2.751GlnSer: 2.751 ± 0.03
2.152GlnThr: 2.152 ± 0.021
2.131GlnVal: 2.131 ± 0.023
0.549GlnTrp: 0.549 ± 0.012
1.086GlnTyr: 1.086 ± 0.015
0.048GlnXaa: 0.048 ± 0.004
Arg
5.502ArgAla: 5.502 ± 0.042
0.718ArgCys: 0.718 ± 0.016
3.412ArgAsp: 3.412 ± 0.031
3.796ArgGlu: 3.796 ± 0.035
2.068ArgPhe: 2.068 ± 0.023
3.501ArgGly: 3.501 ± 0.034
1.655ArgHis: 1.655 ± 0.02
2.995ArgIle: 2.995 ± 0.026
3.303ArgLys: 3.303 ± 0.03
5.617ArgLeu: 5.617 ± 0.041
1.411ArgMet: 1.411 ± 0.019
1.923ArgAsn: 1.923 ± 0.02
3.515ArgPro: 3.515 ± 0.037
2.31ArgGln: 2.31 ± 0.024
4.957ArgArg: 4.957 ± 0.046
4.547ArgSer: 4.547 ± 0.039
3.433ArgThr: 3.433 ± 0.028
3.672ArgVal: 3.672 ± 0.03
0.946ArgTrp: 0.946 ± 0.015
1.546ArgTyr: 1.546 ± 0.018
0.09ArgXaa: 0.09 ± 0.006
Ser
7.183SerAla: 7.183 ± 0.049
0.85SerCys: 0.85 ± 0.015
4.427SerAsp: 4.427 ± 0.038
4.002SerGlu: 4.002 ± 0.035
2.944SerPhe: 2.944 ± 0.026
5.093SerGly: 5.093 ± 0.043
1.934SerHis: 1.934 ± 0.025
3.715SerIle: 3.715 ± 0.029
3.447SerLys: 3.447 ± 0.038
7.135SerLeu: 7.135 ± 0.044
1.772SerMet: 1.772 ± 0.022
2.474SerAsn: 2.474 ± 0.028
5.735SerPro: 5.735 ± 0.056
2.944SerGln: 2.944 ± 0.032
4.618SerArg: 4.618 ± 0.038
8.509SerSer: 8.509 ± 0.076
5.238SerThr: 5.238 ± 0.046
4.855SerVal: 4.855 ± 0.036
1.009SerTrp: 1.009 ± 0.016
1.899SerTyr: 1.899 ± 0.021
0.102SerXaa: 0.102 ± 0.006
Thr
5.164ThrAla: 5.164 ± 0.034
0.707ThrCys: 0.707 ± 0.014
2.904ThrAsp: 2.904 ± 0.029
2.865ThrGlu: 2.865 ± 0.028
2.359ThrPhe: 2.359 ± 0.026
3.771ThrGly: 3.771 ± 0.027
1.485ThrHis: 1.485 ± 0.019
2.897ThrIle: 2.897 ± 0.026
2.377ThrLys: 2.377 ± 0.025
5.481ThrLeu: 5.481 ± 0.044
1.211ThrMet: 1.211 ± 0.016
1.818ThrAsn: 1.818 ± 0.021
4.331ThrPro: 4.331 ± 0.038
1.95ThrGln: 1.95 ± 0.025
3.145ThrArg: 3.145 ± 0.025
5.116ThrSer: 5.116 ± 0.039
3.693ThrThr: 3.693 ± 0.037
3.728ThrVal: 3.728 ± 0.027
0.801ThrTrp: 0.801 ± 0.015
1.55ThrTyr: 1.55 ± 0.019
0.076ThrXaa: 0.076 ± 0.006
Val
5.514ValAla: 5.514 ± 0.038
0.842ValCys: 0.842 ± 0.017
4.093ValAsp: 4.093 ± 0.034
4.035ValGlu: 4.035 ± 0.035
2.558ValPhe: 2.558 ± 0.029
3.76ValGly: 3.76 ± 0.033
1.732ValHis: 1.732 ± 0.02
2.979ValIle: 2.979 ± 0.028
3.096ValLys: 3.096 ± 0.031
6.198ValLeu: 6.198 ± 0.048
1.332ValMet: 1.332 ± 0.018
2.188ValAsn: 2.188 ± 0.026
4.126ValPro: 4.126 ± 0.032
2.597ValGln: 2.597 ± 0.025
3.795ValArg: 3.795 ± 0.03
4.73ValSer: 4.73 ± 0.037
3.472ValThr: 3.472 ± 0.03
4.491ValVal: 4.491 ± 0.039
0.937ValTrp: 0.937 ± 0.017
1.727ValTyr: 1.727 ± 0.022
0.091ValXaa: 0.091 ± 0.006
Trp
1.128TrpAla: 1.128 ± 0.017
0.2TrpCys: 0.2 ± 0.007
0.957TrpAsp: 0.957 ± 0.015
0.834TrpGlu: 0.834 ± 0.014
0.547TrpPhe: 0.547 ± 0.013
0.841TrpGly: 0.841 ± 0.016
0.406TrpHis: 0.406 ± 0.01
0.742TrpIle: 0.742 ± 0.013
0.798TrpLys: 0.798 ± 0.016
1.303TrpLeu: 1.303 ± 0.017
0.373TrpMet: 0.373 ± 0.01
0.589TrpAsn: 0.589 ± 0.012
0.652TrpPro: 0.652 ± 0.012
0.531TrpGln: 0.531 ± 0.011
0.966TrpArg: 0.966 ± 0.015
1.062TrpSer: 1.062 ± 0.019
0.908TrpThr: 0.908 ± 0.014
0.837TrpVal: 0.837 ± 0.015
0.262TrpTrp: 0.262 ± 0.008
0.421TrpTyr: 0.421 ± 0.009
0.015TrpXaa: 0.015 ± 0.002
Tyr
2.285TyrAla: 2.285 ± 0.026
0.379TyrCys: 0.379 ± 0.01
1.667TyrAsp: 1.667 ± 0.02
1.493TyrGlu: 1.493 ± 0.017
1.094TyrPhe: 1.094 ± 0.016
1.82TyrGly: 1.82 ± 0.025
0.71TyrHis: 0.71 ± 0.012
1.318TyrIle: 1.318 ± 0.019
1.07TyrLys: 1.07 ± 0.018
2.515TyrLeu: 2.515 ± 0.024
0.594TyrMet: 0.594 ± 0.012
0.958TyrAsn: 0.958 ± 0.016
1.512TyrPro: 1.512 ± 0.021
0.908TyrGln: 0.908 ± 0.014
1.509TyrArg: 1.509 ± 0.021
1.777TyrSer: 1.777 ± 0.021
1.523TyrThr: 1.523 ± 0.022
1.719TyrVal: 1.719 ± 0.024
0.387TyrTrp: 0.387 ± 0.009
0.82TyrTyr: 0.82 ± 0.015
0.037TyrXaa: 0.037 ± 0.003
Xaa
0.139XaaAla: 0.139 ± 0.008
0.018XaaCys: 0.018 ± 0.003
0.094XaaAsp: 0.094 ± 0.006
0.088XaaGlu: 0.088 ± 0.007
0.045XaaPhe: 0.045 ± 0.004
0.093XaaGly: 0.093 ± 0.006
0.038XaaHis: 0.038 ± 0.003
0.054XaaIle: 0.054 ± 0.004
0.063XaaLys: 0.063 ± 0.006
0.126XaaLeu: 0.126 ± 0.009
0.027XaaMet: 0.027 ± 0.003
0.031XaaAsn: 0.031 ± 0.003
0.091XaaPro: 0.091 ± 0.007
0.05XaaGln: 0.05 ± 0.004
0.079XaaArg: 0.079 ± 0.006
0.099XaaSer: 0.099 ± 0.006
0.07XaaThr: 0.07 ± 0.005
0.091XaaVal: 0.091 ± 0.006
0.021XaaTrp: 0.021 ± 0.002
0.029XaaTyr: 0.029 ± 0.003
0.173XaaXaa: 0.173 ± 0.014
Statistics based on 11000 proteins (4291909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski