Amino acid dipepetide frequency for Halomicrobium zhouii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.146AlaAla: 13.146 ± 0.158
0.67AlaCys: 0.67 ± 0.025
10.121AlaAsp: 10.121 ± 0.09
8.071AlaGlu: 8.071 ± 0.106
3.963AlaPhe: 3.963 ± 0.068
9.656AlaGly: 9.656 ± 0.11
1.823AlaHis: 1.823 ± 0.039
4.682AlaIle: 4.682 ± 0.082
1.719AlaLys: 1.719 ± 0.038
10.197AlaLeu: 10.197 ± 0.122
2.059AlaMet: 2.059 ± 0.045
2.536AlaAsn: 2.536 ± 0.051
3.936AlaPro: 3.936 ± 0.065
2.274AlaGln: 2.274 ± 0.054
5.948AlaArg: 5.948 ± 0.071
5.897AlaSer: 5.897 ± 0.074
7.477AlaThr: 7.477 ± 0.094
11.019AlaVal: 11.019 ± 0.125
1.179AlaTrp: 1.179 ± 0.033
2.661AlaTyr: 2.661 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.558CysAla: 0.558 ± 0.024
0.09CysCys: 0.09 ± 0.009
0.591CysAsp: 0.591 ± 0.025
0.611CysGlu: 0.611 ± 0.027
0.205CysPhe: 0.205 ± 0.015
0.797CysGly: 0.797 ± 0.028
0.182CysHis: 0.182 ± 0.013
0.228CysIle: 0.228 ± 0.014
0.108CysLys: 0.108 ± 0.009
0.525CysLeu: 0.525 ± 0.022
0.102CysMet: 0.102 ± 0.01
0.163CysAsn: 0.163 ± 0.013
0.487CysPro: 0.487 ± 0.02
0.191CysGln: 0.191 ± 0.014
0.425CysArg: 0.425 ± 0.019
0.436CysSer: 0.436 ± 0.022
0.376CysThr: 0.376 ± 0.021
0.482CysVal: 0.482 ± 0.02
0.09CysTrp: 0.09 ± 0.009
0.195CysTyr: 0.195 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
10.372AspAla: 10.372 ± 0.118
0.657AspCys: 0.657 ± 0.025
8.634AspAsp: 8.634 ± 0.116
8.343AspGlu: 8.343 ± 0.12
1.964AspPhe: 1.964 ± 0.044
9.296AspGly: 9.296 ± 0.135
2.042AspHis: 2.042 ± 0.046
2.368AspIle: 2.368 ± 0.045
0.859AspLys: 0.859 ± 0.031
7.086AspLeu: 7.086 ± 0.084
1.236AspMet: 1.236 ± 0.033
1.352AspAsn: 1.352 ± 0.043
4.796AspPro: 4.796 ± 0.073
2.233AspGln: 2.233 ± 0.052
6.437AspArg: 6.437 ± 0.075
4.013AspSer: 4.013 ± 0.072
3.928AspThr: 3.928 ± 0.095
9.499AspVal: 9.499 ± 0.094
1.139AspTrp: 1.139 ± 0.032
1.977AspTyr: 1.977 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
8.311GluAla: 8.311 ± 0.108
0.523GluCys: 0.523 ± 0.021
5.95GluAsp: 5.95 ± 0.095
6.437GluGlu: 6.437 ± 0.103
2.953GluPhe: 2.953 ± 0.05
5.493GluGly: 5.493 ± 0.068
1.891GluHis: 1.891 ± 0.041
3.335GluIle: 3.335 ± 0.062
1.703GluLys: 1.703 ± 0.05
7.007GluLeu: 7.007 ± 0.096
1.851GluMet: 1.851 ± 0.038
2.366GluAsn: 2.366 ± 0.053
3.775GluPro: 3.775 ± 0.062
2.754GluGln: 2.754 ± 0.064
7.507GluArg: 7.507 ± 0.109
5.268GluSer: 5.268 ± 0.074
6.652GluThr: 6.652 ± 0.15
5.477GluVal: 5.477 ± 0.075
1.249GluTrp: 1.249 ± 0.035
2.628GluTyr: 2.628 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.716PheAla: 3.716 ± 0.069
0.261PheCys: 0.261 ± 0.014
3.462PheAsp: 3.462 ± 0.058
3.126PheGlu: 3.126 ± 0.055
1.071PhePhe: 1.071 ± 0.033
3.169PheGly: 3.169 ± 0.052
0.68PheHis: 0.68 ± 0.02
0.812PheIle: 0.812 ± 0.031
0.44PheLys: 0.44 ± 0.021
3.008PheLeu: 3.008 ± 0.059
0.492PheMet: 0.492 ± 0.02
0.667PheAsn: 0.667 ± 0.026
1.357PhePro: 1.357 ± 0.035
0.877PheGln: 0.877 ± 0.028
1.808PheArg: 1.808 ± 0.047
1.718PheSer: 1.718 ± 0.04
1.842PheThr: 1.842 ± 0.039
3.55PheVal: 3.55 ± 0.061
0.435PheTrp: 0.435 ± 0.021
0.865PheTyr: 0.865 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
8.332GlyAla: 8.332 ± 0.091
0.711GlyCys: 0.711 ± 0.029
7.6GlyAsp: 7.6 ± 0.095
7.318GlyGlu: 7.318 ± 0.09
3.092GlyPhe: 3.092 ± 0.052
7.828GlyGly: 7.828 ± 0.121
1.734GlyHis: 1.734 ± 0.043
3.768GlyIle: 3.768 ± 0.063
1.779GlyLys: 1.779 ± 0.052
7.432GlyLeu: 7.432 ± 0.103
1.701GlyMet: 1.701 ± 0.042
2.146GlyAsn: 2.146 ± 0.05
3.578GlyPro: 3.578 ± 0.056
2.229GlyGln: 2.229 ± 0.047
4.724GlyArg: 4.724 ± 0.075
5.452GlySer: 5.452 ± 0.087
6.059GlyThr: 6.059 ± 0.084
7.775GlyVal: 7.775 ± 0.103
1.196GlyTrp: 1.196 ± 0.037
2.556GlyTyr: 2.556 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
2.028HisAla: 2.028 ± 0.045
0.199HisCys: 0.199 ± 0.013
1.891HisAsp: 1.891 ± 0.043
1.708HisGlu: 1.708 ± 0.04
0.585HisPhe: 0.585 ± 0.02
1.905HisGly: 1.905 ± 0.048
0.541HisHis: 0.541 ± 0.026
0.527HisIle: 0.527 ± 0.024
0.26HisLys: 0.26 ± 0.015
1.741HisLeu: 1.741 ± 0.04
0.267HisMet: 0.267 ± 0.016
0.429HisAsn: 0.429 ± 0.02
1.217HisPro: 1.217 ± 0.033
0.508HisGln: 0.508 ± 0.022
1.347HisArg: 1.347 ± 0.034
0.913HisSer: 0.913 ± 0.032
0.961HisThr: 0.961 ± 0.028
2.116HisVal: 2.116 ± 0.05
0.276HisTrp: 0.276 ± 0.012
0.589HisTyr: 0.589 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
4.137IleAla: 4.137 ± 0.068
0.229IleCys: 0.229 ± 0.014
3.503IleAsp: 3.503 ± 0.057
3.606IleGlu: 3.606 ± 0.056
0.867IlePhe: 0.867 ± 0.031
3.348IleGly: 3.348 ± 0.051
0.749IleHis: 0.749 ± 0.025
1.099IleIle: 1.099 ± 0.039
0.589IleLys: 0.589 ± 0.025
2.823IleLeu: 2.823 ± 0.057
0.442IleMet: 0.442 ± 0.019
0.815IleAsn: 0.815 ± 0.027
1.855IlePro: 1.855 ± 0.045
1.106IleGln: 1.106 ± 0.03
2.252IleArg: 2.252 ± 0.045
1.986IleSer: 1.986 ± 0.044
2.103IleThr: 2.103 ± 0.04
3.323IleVal: 3.323 ± 0.063
0.303IleTrp: 0.303 ± 0.015
0.85IleTyr: 0.85 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
1.552LysAla: 1.552 ± 0.041
0.101LysCys: 0.101 ± 0.01
0.944LysAsp: 0.944 ± 0.035
1.175LysGlu: 1.175 ± 0.034
0.518LysPhe: 0.518 ± 0.019
1.265LysGly: 1.265 ± 0.037
0.428LysHis: 0.428 ± 0.023
0.669LysIle: 0.669 ± 0.027
0.425LysLys: 0.425 ± 0.025
1.589LysLeu: 1.589 ± 0.041
0.332LysMet: 0.332 ± 0.018
0.473LysAsn: 0.473 ± 0.023
0.798LysPro: 0.798 ± 0.026
0.697LysGln: 0.697 ± 0.03
1.436LysArg: 1.436 ± 0.038
1.046LysSer: 1.046 ± 0.033
1.143LysThr: 1.143 ± 0.034
1.138LysVal: 1.138 ± 0.029
0.235LysTrp: 0.235 ± 0.015
0.526LysTyr: 0.526 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
11.307LeuAla: 11.307 ± 0.142
0.522LeuCys: 0.522 ± 0.023
7.6LeuAsp: 7.6 ± 0.085
6.359LeuGlu: 6.359 ± 0.09
3.269LeuPhe: 3.269 ± 0.064
7.487LeuGly: 7.487 ± 0.088
1.501LeuHis: 1.501 ± 0.034
2.563LeuIle: 2.563 ± 0.05
1.28LeuLys: 1.28 ± 0.036
8.393LeuLeu: 8.393 ± 0.126
1.199LeuMet: 1.199 ± 0.029
1.703LeuAsn: 1.703 ± 0.041
4.11LeuPro: 4.11 ± 0.06
2.213LeuGln: 2.213 ± 0.046
5.29LeuArg: 5.29 ± 0.063
5.317LeuSer: 5.317 ± 0.07
5.281LeuThr: 5.281 ± 0.063
9.045LeuVal: 9.045 ± 0.116
0.908LeuTrp: 0.908 ± 0.025
2.214LeuTyr: 2.214 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
1.94MetAla: 1.94 ± 0.046
0.108MetCys: 0.108 ± 0.01
1.293MetAsp: 1.293 ± 0.039
1.059MetGlu: 1.059 ± 0.031
0.491MetPhe: 0.491 ± 0.019
1.489MetGly: 1.489 ± 0.037
0.321MetHis: 0.321 ± 0.018
0.621MetIle: 0.621 ± 0.023
0.409MetLys: 0.409 ± 0.018
1.417MetLeu: 1.417 ± 0.035
0.28MetMet: 0.28 ± 0.016
0.572MetAsn: 0.572 ± 0.022
0.815MetPro: 0.815 ± 0.027
0.481MetGln: 0.481 ± 0.02
1.043MetArg: 1.043 ± 0.029
1.349MetSer: 1.349 ± 0.034
1.512MetThr: 1.512 ± 0.036
1.327MetVal: 1.327 ± 0.032
0.161MetTrp: 0.161 ± 0.011
0.345MetTyr: 0.345 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.474AsnAla: 2.474 ± 0.046
0.196AsnCys: 0.196 ± 0.015
1.853AsnAsp: 1.853 ± 0.049
1.967AsnGlu: 1.967 ± 0.057
0.674AsnPhe: 0.674 ± 0.023
2.113AsnGly: 2.113 ± 0.054
0.525AsnHis: 0.525 ± 0.022
0.724AsnIle: 0.724 ± 0.026
0.353AsnLys: 0.353 ± 0.019
1.915AsnLeu: 1.915 ± 0.041
0.395AsnMet: 0.395 ± 0.019
0.521AsnAsn: 0.521 ± 0.024
1.451AsnPro: 1.451 ± 0.036
0.7AsnGln: 0.7 ± 0.029
1.532AsnArg: 1.532 ± 0.041
1.042AsnSer: 1.042 ± 0.036
1.189AsnThr: 1.189 ± 0.033
2.439AsnVal: 2.439 ± 0.055
0.362AsnTrp: 0.362 ± 0.02
0.721AsnTyr: 0.721 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
4.862ProAla: 4.862 ± 0.062
0.239ProCys: 0.239 ± 0.014
4.887ProAsp: 4.887 ± 0.064
4.276ProGlu: 4.276 ± 0.06
1.623ProPhe: 1.623 ± 0.04
4.052ProGly: 4.052 ± 0.063
0.828ProHis: 0.828 ± 0.026
1.682ProIle: 1.682 ± 0.036
0.73ProLys: 0.73 ± 0.025
3.671ProLeu: 3.671 ± 0.072
0.824ProMet: 0.824 ± 0.028
1.082ProAsn: 1.082 ± 0.027
2.232ProPro: 2.232 ± 0.051
1.031ProGln: 1.031 ± 0.033
2.323ProArg: 2.323 ± 0.041
2.742ProSer: 2.742 ± 0.054
3.213ProThr: 3.213 ± 0.051
4.383ProVal: 4.383 ± 0.066
0.566ProTrp: 0.566 ± 0.023
1.122ProTyr: 1.122 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.689GlnAla: 2.689 ± 0.053
0.191GlnCys: 0.191 ± 0.013
1.58GlnAsp: 1.58 ± 0.043
1.868GlnGlu: 1.868 ± 0.05
1.151GlnPhe: 1.151 ± 0.029
1.789GlnGly: 1.789 ± 0.041
0.563GlnHis: 0.563 ± 0.021
1.173GlnIle: 1.173 ± 0.031
0.544GlnLys: 0.544 ± 0.024
2.299GlnLeu: 2.299 ± 0.047
0.55GlnMet: 0.55 ± 0.022
0.784GlnAsn: 0.784 ± 0.031
1.19GlnPro: 1.19 ± 0.033
1.109GlnGln: 1.109 ± 0.041
2.185GlnArg: 2.185 ± 0.046
1.827GlnSer: 1.827 ± 0.055
1.826GlnThr: 1.826 ± 0.043
2.057GlnVal: 2.057 ± 0.042
0.435GlnTrp: 0.435 ± 0.019
0.868GlnTyr: 0.868 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.212ArgAla: 6.212 ± 0.078
0.467ArgCys: 0.467 ± 0.021
5.337ArgAsp: 5.337 ± 0.076
6.333ArgGlu: 6.333 ± 0.083
2.347ArgPhe: 2.347 ± 0.044
4.24ArgGly: 4.24 ± 0.058
1.256ArgHis: 1.256 ± 0.035
2.767ArgIle: 2.767 ± 0.053
1.318ArgLys: 1.318 ± 0.037
5.813ArgLeu: 5.813 ± 0.072
1.248ArgMet: 1.248 ± 0.031
1.634ArgAsn: 1.634 ± 0.039
2.666ArgPro: 2.666 ± 0.054
1.947ArgGln: 1.947 ± 0.041
4.912ArgArg: 4.912 ± 0.076
3.685ArgSer: 3.685 ± 0.062
3.909ArgThr: 3.909 ± 0.061
5.308ArgVal: 5.308 ± 0.073
0.851ArgTrp: 0.851 ± 0.026
2.007ArgTyr: 2.007 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.466SerAla: 5.466 ± 0.078
0.308SerCys: 0.308 ± 0.015
4.782SerAsp: 4.782 ± 0.088
4.331SerGlu: 4.331 ± 0.064
1.993SerPhe: 1.993 ± 0.041
5.613SerGly: 5.613 ± 0.074
1.099SerHis: 1.099 ± 0.033
2.292SerIle: 2.292 ± 0.046
1.11SerLys: 1.11 ± 0.035
5.034SerLeu: 5.034 ± 0.071
1.105SerMet: 1.105 ± 0.028
1.382SerAsn: 1.382 ± 0.034
2.692SerPro: 2.692 ± 0.051
1.515SerGln: 1.515 ± 0.041
3.182SerArg: 3.182 ± 0.056
3.193SerSer: 3.193 ± 0.062
3.695SerThr: 3.695 ± 0.059
5.204SerVal: 5.204 ± 0.074
0.669SerTrp: 0.669 ± 0.024
1.458SerTyr: 1.458 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
7.001ThrAla: 7.001 ± 0.101
0.388ThrCys: 0.388 ± 0.02
5.913ThrAsp: 5.913 ± 0.103
4.97ThrGlu: 4.97 ± 0.141
2.226ThrPhe: 2.226 ± 0.047
5.925ThrGly: 5.925 ± 0.088
1.155ThrHis: 1.155 ± 0.031
2.744ThrIle: 2.744 ± 0.051
0.927ThrLys: 0.927 ± 0.029
5.548ThrLeu: 5.548 ± 0.081
1.034ThrMet: 1.034 ± 0.031
1.495ThrAsn: 1.495 ± 0.037
3.168ThrPro: 3.168 ± 0.063
1.393ThrGln: 1.393 ± 0.039
3.254ThrArg: 3.254 ± 0.049
3.095ThrSer: 3.095 ± 0.051
4.406ThrThr: 4.406 ± 0.074
7.36ThrVal: 7.36 ± 0.097
0.709ThrTrp: 0.709 ± 0.025
1.753ThrTyr: 1.753 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
11.166ValAla: 11.166 ± 0.124
0.647ValCys: 0.647 ± 0.025
8.722ValAsp: 8.722 ± 0.099
8.256ValGlu: 8.256 ± 0.093
3.006ValPhe: 3.006 ± 0.059
8.32ValGly: 8.32 ± 0.109
1.744ValHis: 1.744 ± 0.038
2.781ValIle: 2.781 ± 0.06
1.288ValLys: 1.288 ± 0.038
8.366ValLeu: 8.366 ± 0.104
1.31ValMet: 1.31 ± 0.035
2.001ValAsn: 2.001 ± 0.042
4.498ValPro: 4.498 ± 0.07
2.168ValGln: 2.168 ± 0.046
5.69ValArg: 5.69 ± 0.072
5.184ValSer: 5.184 ± 0.07
6.706ValThr: 6.706 ± 0.093
10.195ValVal: 10.195 ± 0.12
0.907ValTrp: 0.907 ± 0.029
2.224ValTyr: 2.224 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.024TrpAla: 1.024 ± 0.033
0.092TrpCys: 0.092 ± 0.01
0.88TrpAsp: 0.88 ± 0.027
0.92TrpGlu: 0.92 ± 0.03
0.489TrpPhe: 0.489 ± 0.019
0.929TrpGly: 0.929 ± 0.027
0.284TrpHis: 0.284 ± 0.017
0.536TrpIle: 0.536 ± 0.019
0.266TrpLys: 0.266 ± 0.015
1.306TrpLeu: 1.306 ± 0.042
0.22TrpMet: 0.22 ± 0.014
0.416TrpAsn: 0.416 ± 0.019
0.49TrpPro: 0.49 ± 0.022
0.448TrpGln: 0.448 ± 0.02
0.995TrpArg: 0.995 ± 0.035
0.645TrpSer: 0.645 ± 0.027
0.836TrpThr: 0.836 ± 0.025
0.906TrpVal: 0.906 ± 0.027
0.221TrpTrp: 0.221 ± 0.014
0.368TrpTyr: 0.368 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.743TyrAla: 2.743 ± 0.051
0.242TyrCys: 0.242 ± 0.015
2.687TyrAsp: 2.687 ± 0.049
2.395TyrGlu: 2.395 ± 0.045
0.868TyrPhe: 0.868 ± 0.027
2.296TyrGly: 2.296 ± 0.04
0.661TyrHis: 0.661 ± 0.024
0.615TyrIle: 0.615 ± 0.021
0.383TyrLys: 0.383 ± 0.02
2.393TyrLeu: 2.393 ± 0.043
0.385TyrMet: 0.385 ± 0.019
0.609TyrAsn: 0.609 ± 0.023
1.257TyrPro: 1.257 ± 0.033
0.803TyrGln: 0.803 ± 0.025
1.968TyrArg: 1.968 ± 0.045
1.315TyrSer: 1.315 ± 0.036
1.352TyrThr: 1.352 ± 0.035
2.576TyrVal: 2.576 ± 0.056
0.378TyrTrp: 0.378 ± 0.018
0.904TyrTyr: 0.904 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4091 proteins (1202276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski