Amino acid dipepetide frequency for Halorussus sp. MSC15.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.544AlaAla: 12.544 ± 0.177
0.609AlaCys: 0.609 ± 0.025
10.034AlaAsp: 10.034 ± 0.126
9.103AlaGlu: 9.103 ± 0.109
4.012AlaPhe: 4.012 ± 0.064
9.043AlaGly: 9.043 ± 0.093
1.62AlaHis: 1.62 ± 0.035
3.904AlaIle: 3.904 ± 0.067
2.049AlaLys: 2.049 ± 0.046
10.016AlaLeu: 10.016 ± 0.126
1.967AlaMet: 1.967 ± 0.042
2.585AlaAsn: 2.585 ± 0.059
3.915AlaPro: 3.915 ± 0.065
2.099AlaGln: 2.099 ± 0.049
6.065AlaArg: 6.065 ± 0.091
5.843AlaSer: 5.843 ± 0.085
7.099AlaThr: 7.099 ± 0.09
10.635AlaVal: 10.635 ± 0.113
1.099AlaTrp: 1.099 ± 0.033
2.679AlaTyr: 2.679 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.553CysAla: 0.553 ± 0.022
0.09CysCys: 0.09 ± 0.01
0.548CysAsp: 0.548 ± 0.02
0.588CysGlu: 0.588 ± 0.025
0.184CysPhe: 0.184 ± 0.013
0.777CysGly: 0.777 ± 0.026
0.174CysHis: 0.174 ± 0.012
0.234CysIle: 0.234 ± 0.013
0.105CysLys: 0.105 ± 0.009
0.479CysLeu: 0.479 ± 0.022
0.113CysMet: 0.113 ± 0.01
0.179CysAsn: 0.179 ± 0.013
0.501CysPro: 0.501 ± 0.026
0.156CysGln: 0.156 ± 0.012
0.451CysArg: 0.451 ± 0.021
0.409CysSer: 0.409 ± 0.019
0.337CysThr: 0.337 ± 0.017
0.477CysVal: 0.477 ± 0.021
0.092CysTrp: 0.092 ± 0.008
0.175CysTyr: 0.175 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
10.294AspAla: 10.294 ± 0.126
0.689AspCys: 0.689 ± 0.03
7.425AspAsp: 7.425 ± 0.118
8.193AspGlu: 8.193 ± 0.115
2.262AspPhe: 2.262 ± 0.046
7.777AspGly: 7.777 ± 0.114
1.859AspHis: 1.859 ± 0.039
2.71AspIle: 2.71 ± 0.058
1.107AspLys: 1.107 ± 0.034
6.847AspLeu: 6.847 ± 0.092
1.172AspMet: 1.172 ± 0.034
1.38AspAsn: 1.38 ± 0.044
4.538AspPro: 4.538 ± 0.075
1.523AspGln: 1.523 ± 0.042
6.274AspArg: 6.274 ± 0.095
4.156AspSer: 4.156 ± 0.062
3.835AspThr: 3.835 ± 0.069
7.415AspVal: 7.415 ± 0.084
1.135AspTrp: 1.135 ± 0.033
2.099AspTyr: 2.099 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
7.954GluAla: 7.954 ± 0.102
0.556GluCys: 0.556 ± 0.024
5.992GluAsp: 5.992 ± 0.098
7.025GluGlu: 7.025 ± 0.114
3.23GluPhe: 3.23 ± 0.056
5.75GluGly: 5.75 ± 0.075
1.585GluHis: 1.585 ± 0.043
3.516GluIle: 3.516 ± 0.064
2.119GluLys: 2.119 ± 0.046
7.194GluLeu: 7.194 ± 0.092
2.039GluMet: 2.039 ± 0.046
2.729GluAsn: 2.729 ± 0.053
3.11GluPro: 3.11 ± 0.056
2.836GluGln: 2.836 ± 0.052
7.891GluArg: 7.891 ± 0.103
5.849GluSer: 5.849 ± 0.083
7.046GluThr: 7.046 ± 0.099
6.439GluVal: 6.439 ± 0.08
1.169GluTrp: 1.169 ± 0.032
2.8GluTyr: 2.8 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.871PheAla: 3.871 ± 0.061
0.263PheCys: 0.263 ± 0.016
3.289PheAsp: 3.289 ± 0.059
3.4PheGlu: 3.4 ± 0.056
1.048PhePhe: 1.048 ± 0.031
3.404PheGly: 3.404 ± 0.06
0.675PheHis: 0.675 ± 0.024
0.837PheIle: 0.837 ± 0.032
0.507PheLys: 0.507 ± 0.021
2.926PheLeu: 2.926 ± 0.063
0.449PheMet: 0.449 ± 0.021
0.708PheAsn: 0.708 ± 0.028
1.392PhePro: 1.392 ± 0.039
0.808PheGln: 0.808 ± 0.025
2.029PheArg: 2.029 ± 0.043
1.816PheSer: 1.816 ± 0.039
1.905PheThr: 1.905 ± 0.044
3.594PheVal: 3.594 ± 0.059
0.429PheTrp: 0.429 ± 0.023
0.915PheTyr: 0.915 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
7.802GlyAla: 7.802 ± 0.104
0.646GlyCys: 0.646 ± 0.025
7.034GlyAsp: 7.034 ± 0.084
7.516GlyGlu: 7.516 ± 0.088
3.161GlyPhe: 3.161 ± 0.054
7.702GlyGly: 7.702 ± 0.131
1.588GlyHis: 1.588 ± 0.039
3.499GlyIle: 3.499 ± 0.063
2.056GlyLys: 2.056 ± 0.044
7.127GlyLeu: 7.127 ± 0.102
1.627GlyMet: 1.627 ± 0.037
2.264GlyAsn: 2.264 ± 0.054
3.344GlyPro: 3.344 ± 0.058
2.147GlyGln: 2.147 ± 0.047
4.978GlyArg: 4.978 ± 0.071
5.159GlySer: 5.159 ± 0.082
5.926GlyThr: 5.926 ± 0.088
8.226GlyVal: 8.226 ± 0.082
1.102GlyTrp: 1.102 ± 0.035
2.637GlyTyr: 2.637 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.9HisAla: 1.9 ± 0.048
0.18HisCys: 0.18 ± 0.013
1.698HisAsp: 1.698 ± 0.04
1.623HisGlu: 1.623 ± 0.038
0.646HisPhe: 0.646 ± 0.027
1.827HisGly: 1.827 ± 0.042
0.557HisHis: 0.557 ± 0.027
0.53HisIle: 0.53 ± 0.026
0.294HisLys: 0.294 ± 0.017
1.73HisLeu: 1.73 ± 0.037
0.259HisMet: 0.259 ± 0.015
0.457HisAsn: 0.457 ± 0.02
1.139HisPro: 1.139 ± 0.035
0.429HisGln: 0.429 ± 0.022
1.248HisArg: 1.248 ± 0.036
0.819HisSer: 0.819 ± 0.027
0.958HisThr: 0.958 ± 0.032
1.844HisVal: 1.844 ± 0.041
0.24HisTrp: 0.24 ± 0.015
0.568HisTyr: 0.568 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
3.829IleAla: 3.829 ± 0.056
0.212IleCys: 0.212 ± 0.015
3.251IleAsp: 3.251 ± 0.056
3.352IleGlu: 3.352 ± 0.066
0.832IlePhe: 0.832 ± 0.027
2.887IleGly: 2.887 ± 0.062
0.676IleHis: 0.676 ± 0.023
1.078IleIle: 1.078 ± 0.033
0.636IleLys: 0.636 ± 0.024
2.681IleLeu: 2.681 ± 0.052
0.4IleMet: 0.4 ± 0.022
0.832IleAsn: 0.832 ± 0.029
1.886IlePro: 1.886 ± 0.038
0.944IleGln: 0.944 ± 0.035
2.363IleArg: 2.363 ± 0.047
1.916IleSer: 1.916 ± 0.041
2.049IleThr: 2.049 ± 0.042
2.913IleVal: 2.913 ± 0.056
0.276IleTrp: 0.276 ± 0.016
0.817IleTyr: 0.817 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
1.95LysAla: 1.95 ± 0.048
0.144LysCys: 0.144 ± 0.011
1.189LysAsp: 1.189 ± 0.036
1.468LysGlu: 1.468 ± 0.035
0.682LysPhe: 0.682 ± 0.024
1.499LysGly: 1.499 ± 0.036
0.467LysHis: 0.467 ± 0.021
0.874LysIle: 0.874 ± 0.034
0.653LysLys: 0.653 ± 0.032
1.864LysLeu: 1.864 ± 0.041
0.449LysMet: 0.449 ± 0.024
0.683LysAsn: 0.683 ± 0.026
0.989LysPro: 0.989 ± 0.033
0.865LysGln: 0.865 ± 0.029
1.731LysArg: 1.731 ± 0.037
1.36LysSer: 1.36 ± 0.036
1.453LysThr: 1.453 ± 0.038
1.474LysVal: 1.474 ± 0.042
0.31LysTrp: 0.31 ± 0.016
0.745LysTyr: 0.745 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
10.904LeuAla: 10.904 ± 0.143
0.486LeuCys: 0.486 ± 0.021
7.572LeuAsp: 7.572 ± 0.088
5.768LeuGlu: 5.768 ± 0.086
3.057LeuPhe: 3.057 ± 0.078
7.663LeuGly: 7.663 ± 0.097
1.436LeuHis: 1.436 ± 0.037
2.078LeuIle: 2.078 ± 0.055
1.741LeuLys: 1.741 ± 0.041
8.55LeuLeu: 8.55 ± 0.141
1.214LeuMet: 1.214 ± 0.033
2.007LeuAsn: 2.007 ± 0.044
4.046LeuPro: 4.046 ± 0.059
1.975LeuGln: 1.975 ± 0.044
5.852LeuArg: 5.852 ± 0.072
5.697LeuSer: 5.697 ± 0.065
5.134LeuThr: 5.134 ± 0.075
8.438LeuVal: 8.438 ± 0.121
0.864LeuTrp: 0.864 ± 0.029
2.286LeuTyr: 2.286 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
1.804MetAla: 1.804 ± 0.039
0.091MetCys: 0.091 ± 0.01
1.24MetAsp: 1.24 ± 0.041
1.15MetGlu: 1.15 ± 0.031
0.496MetPhe: 0.496 ± 0.024
1.344MetGly: 1.344 ± 0.038
0.335MetHis: 0.335 ± 0.016
0.546MetIle: 0.546 ± 0.023
0.495MetLys: 0.495 ± 0.021
1.506MetLeu: 1.506 ± 0.039
0.297MetMet: 0.297 ± 0.016
0.681MetAsn: 0.681 ± 0.023
0.777MetPro: 0.777 ± 0.027
0.483MetGln: 0.483 ± 0.022
1.118MetArg: 1.118 ± 0.033
1.407MetSer: 1.407 ± 0.034
1.455MetThr: 1.455 ± 0.041
1.311MetVal: 1.311 ± 0.034
0.162MetTrp: 0.162 ± 0.012
0.399MetTyr: 0.399 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.725AsnAla: 2.725 ± 0.05
0.251AsnCys: 0.251 ± 0.014
1.876AsnAsp: 1.876 ± 0.041
1.905AsnGlu: 1.905 ± 0.049
0.834AsnPhe: 0.834 ± 0.029
2.135AsnGly: 2.135 ± 0.056
0.575AsnHis: 0.575 ± 0.023
0.835AsnIle: 0.835 ± 0.03
0.485AsnLys: 0.485 ± 0.02
2.308AsnLeu: 2.308 ± 0.042
0.416AsnMet: 0.416 ± 0.017
0.653AsnAsn: 0.653 ± 0.031
1.773AsnPro: 1.773 ± 0.039
0.777AsnGln: 0.777 ± 0.028
1.85AsnArg: 1.85 ± 0.04
1.272AsnSer: 1.272 ± 0.035
1.319AsnThr: 1.319 ± 0.037
2.719AsnVal: 2.719 ± 0.059
0.358AsnTrp: 0.358 ± 0.018
0.83AsnTyr: 0.83 ± 0.027
0.0AsnXaa: 0.0 ± 0.0
Pro
4.277ProAla: 4.277 ± 0.059
0.221ProCys: 0.221 ± 0.014
4.957ProAsp: 4.957 ± 0.078
4.852ProGlu: 4.852 ± 0.071
1.542ProPhe: 1.542 ± 0.039
3.624ProGly: 3.624 ± 0.064
0.895ProHis: 0.895 ± 0.027
1.538ProIle: 1.538 ± 0.042
1.026ProLys: 1.026 ± 0.03
3.351ProLeu: 3.351 ± 0.057
0.782ProMet: 0.782 ± 0.023
1.265ProAsn: 1.265 ± 0.031
2.098ProPro: 2.098 ± 0.047
0.921ProGln: 0.921 ± 0.029
2.379ProArg: 2.379 ± 0.045
2.723ProSer: 2.723 ± 0.055
3.223ProThr: 3.223 ± 0.057
3.983ProVal: 3.983 ± 0.058
0.513ProTrp: 0.513 ± 0.02
1.1ProTyr: 1.1 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.233GlnAla: 2.233 ± 0.05
0.155GlnCys: 0.155 ± 0.013
1.278GlnAsp: 1.278 ± 0.04
1.493GlnGlu: 1.493 ± 0.037
1.189GlnPhe: 1.189 ± 0.029
1.577GlnGly: 1.577 ± 0.047
0.529GlnHis: 0.529 ± 0.02
1.049GlnIle: 1.049 ± 0.031
0.753GlnLys: 0.753 ± 0.03
2.204GlnLeu: 2.204 ± 0.044
0.612GlnMet: 0.612 ± 0.024
0.935GlnAsn: 0.935 ± 0.035
0.978GlnPro: 0.978 ± 0.026
1.162GlnGln: 1.162 ± 0.044
1.979GlnArg: 1.979 ± 0.043
1.848GlnSer: 1.848 ± 0.046
1.853GlnThr: 1.853 ± 0.049
1.943GlnVal: 1.943 ± 0.04
0.352GlnTrp: 0.352 ± 0.016
0.833GlnTyr: 0.833 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.277ArgAla: 6.277 ± 0.085
0.409ArgCys: 0.409 ± 0.019
5.404ArgAsp: 5.404 ± 0.074
7.079ArgGlu: 7.079 ± 0.104
2.308ArgPhe: 2.308 ± 0.043
4.752ArgGly: 4.752 ± 0.075
1.273ArgHis: 1.273 ± 0.034
2.76ArgIle: 2.76 ± 0.055
1.713ArgLys: 1.713 ± 0.035
5.728ArgLeu: 5.728 ± 0.079
1.252ArgMet: 1.252 ± 0.03
1.934ArgAsn: 1.934 ± 0.048
2.745ArgPro: 2.745 ± 0.059
1.778ArgGln: 1.778 ± 0.041
5.279ArgArg: 5.279 ± 0.082
3.63ArgSer: 3.63 ± 0.059
4.443ArgThr: 4.443 ± 0.074
5.603ArgVal: 5.603 ± 0.074
0.884ArgTrp: 0.884 ± 0.032
1.847ArgTyr: 1.847 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
6.242SerAla: 6.242 ± 0.089
0.32SerCys: 0.32 ± 0.018
4.866SerAsp: 4.866 ± 0.074
4.719SerGlu: 4.719 ± 0.073
1.992SerPhe: 1.992 ± 0.048
5.959SerGly: 5.959 ± 0.087
1.028SerHis: 1.028 ± 0.031
2.089SerIle: 2.089 ± 0.046
1.421SerLys: 1.421 ± 0.035
4.974SerLeu: 4.974 ± 0.067
1.086SerMet: 1.086 ± 0.03
1.616SerAsn: 1.616 ± 0.042
2.805SerPro: 2.805 ± 0.055
1.483SerGln: 1.483 ± 0.039
3.232SerArg: 3.232 ± 0.053
3.484SerSer: 3.484 ± 0.074
3.324SerThr: 3.324 ± 0.057
5.659SerVal: 5.659 ± 0.086
0.706SerTrp: 0.706 ± 0.029
1.461SerTyr: 1.461 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.971ThrAla: 6.971 ± 0.095
0.347ThrCys: 0.347 ± 0.019
5.998ThrAsp: 5.998 ± 0.079
5.075ThrGlu: 5.075 ± 0.084
2.301ThrPhe: 2.301 ± 0.047
5.916ThrGly: 5.916 ± 0.075
1.145ThrHis: 1.145 ± 0.033
2.362ThrIle: 2.362 ± 0.044
1.255ThrLys: 1.255 ± 0.035
5.468ThrLeu: 5.468 ± 0.082
1.021ThrMet: 1.021 ± 0.031
1.592ThrAsn: 1.592 ± 0.044
3.297ThrPro: 3.297 ± 0.051
1.409ThrGln: 1.409 ± 0.039
3.366ThrArg: 3.366 ± 0.066
3.123ThrSer: 3.123 ± 0.065
5.117ThrThr: 5.117 ± 0.17
7.085ThrVal: 7.085 ± 0.106
0.654ThrTrp: 0.654 ± 0.027
1.865ThrTyr: 1.865 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
10.976ValAla: 10.976 ± 0.135
0.625ValCys: 0.625 ± 0.024
5.493ValAsp: 5.493 ± 0.084
9.14ValGlu: 9.14 ± 0.099
3.053ValPhe: 3.053 ± 0.058
8.631ValGly: 8.631 ± 0.119
1.65ValHis: 1.65 ± 0.041
2.402ValIle: 2.402 ± 0.05
1.633ValLys: 1.633 ± 0.042
8.01ValLeu: 8.01 ± 0.113
1.354ValMet: 1.354 ± 0.033
2.276ValAsn: 2.276 ± 0.051
4.196ValPro: 4.196 ± 0.063
2.062ValGln: 2.062 ± 0.051
6.044ValArg: 6.044 ± 0.076
5.895ValSer: 5.895 ± 0.089
6.559ValThr: 6.559 ± 0.101
9.843ValVal: 9.843 ± 0.131
0.919ValTrp: 0.919 ± 0.027
2.295ValTyr: 2.295 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.963TrpAla: 0.963 ± 0.03
0.088TrpCys: 0.088 ± 0.008
0.805TrpAsp: 0.805 ± 0.028
0.853TrpGlu: 0.853 ± 0.031
0.524TrpPhe: 0.524 ± 0.021
0.863TrpGly: 0.863 ± 0.028
0.238TrpHis: 0.238 ± 0.014
0.386TrpIle: 0.386 ± 0.016
0.333TrpLys: 0.333 ± 0.018
1.225TrpLeu: 1.225 ± 0.034
0.225TrpMet: 0.225 ± 0.015
0.402TrpAsn: 0.402 ± 0.016
0.455TrpPro: 0.455 ± 0.023
0.412TrpGln: 0.412 ± 0.017
0.904TrpArg: 0.904 ± 0.027
0.737TrpSer: 0.737 ± 0.025
0.892TrpThr: 0.892 ± 0.03
0.948TrpVal: 0.948 ± 0.032
0.2TrpTrp: 0.2 ± 0.013
0.402TrpTyr: 0.402 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.85TyrAla: 2.85 ± 0.049
0.238TyrCys: 0.238 ± 0.014
2.744TyrAsp: 2.744 ± 0.055
2.527TyrGlu: 2.527 ± 0.055
0.909TyrPhe: 0.909 ± 0.034
2.408TyrGly: 2.408 ± 0.048
0.643TyrHis: 0.643 ± 0.023
0.602TyrIle: 0.602 ± 0.026
0.469TyrLys: 0.469 ± 0.02
2.581TyrLeu: 2.581 ± 0.054
0.359TyrMet: 0.359 ± 0.018
0.722TyrAsn: 0.722 ± 0.027
1.284TyrPro: 1.284 ± 0.033
0.688TyrGln: 0.688 ± 0.022
2.064TyrArg: 2.064 ± 0.042
1.326TyrSer: 1.326 ± 0.035
1.44TyrThr: 1.44 ± 0.039
2.507TyrVal: 2.507 ± 0.052
0.391TyrTrp: 0.391 ± 0.018
0.932TyrTyr: 0.932 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4072 proteins (1157722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski