Amino acid dipepetide frequency for Friedmanniomyces endolithicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.746AlaAla: 10.746 ± 0.048	1.028AlaCys: 1.028 ± 0.011	4.809AlaAsp: 4.809 ± 0.026	6.189AlaGlu: 6.189 ± 0.04	3.287AlaPhe: 3.287 ± 0.023	7.2AlaGly: 7.2 ± 0.033	2.033AlaHis: 2.033 ± 0.016	3.995AlaIle: 3.995 ± 0.025	4.498AlaLys: 4.498 ± 0.03	8.364AlaLeu: 8.364 ± 0.037	2.236AlaMet: 2.236 ± 0.016	3.1AlaAsn: 3.1 ± 0.019	5.438AlaPro: 5.438 ± 0.04	3.999AlaGln: 3.999 ± 0.025	5.701AlaArg: 5.701 ± 0.033	7.863AlaSer: 7.863 ± 0.036	6.019AlaThr: 6.019 ± 0.032	6.136AlaVal: 6.136 ± 0.03	1.227AlaTrp: 1.227 ± 0.013	2.388AlaTyr: 2.388 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	0.917CysAla: 0.917 ± 0.01	0.207CysCys: 0.207 ± 0.005	0.579CysAsp: 0.579 ± 0.008	0.593CysGlu: 0.593 ± 0.008	0.469CysPhe: 0.469 ± 0.007	0.894CysGly: 0.894 ± 0.013	0.294CysHis: 0.294 ± 0.006	0.576CysIle: 0.576 ± 0.008	0.447CysLys: 0.447 ± 0.008	1.094CysLeu: 1.094 ± 0.012	0.238CysMet: 0.238 ± 0.006	0.362CysAsn: 0.362 ± 0.007	0.564CysPro: 0.564 ± 0.008	0.373CysGln: 0.373 ± 0.007	0.66CysArg: 0.66 ± 0.009	0.744CysSer: 0.744 ± 0.01	0.621CysThr: 0.621 ± 0.009	0.727CysVal: 0.727 ± 0.011	0.174CysTrp: 0.174 ± 0.004	0.339CysTyr: 0.339 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.286AspAla: 5.286 ± 0.027	0.57AspCys: 0.57 ± 0.008	4.382AspAsp: 4.382 ± 0.037	4.807AspGlu: 4.807 ± 0.034	2.18AspPhe: 2.18 ± 0.017	4.519AspGly: 4.519 ± 0.027	1.244AspHis: 1.244 ± 0.013	2.542AspIle: 2.542 ± 0.017	2.051AspLys: 2.051 ± 0.018	5.001AspLeu: 5.001 ± 0.026	1.281AspMet: 1.281 ± 0.014	1.548AspAsn: 1.548 ± 0.015	3.228AspPro: 3.228 ± 0.021	1.789AspGln: 1.789 ± 0.015	3.153AspArg: 3.153 ± 0.021	3.764AspSer: 3.764 ± 0.022	2.986AspThr: 2.986 ± 0.02	3.982AspVal: 3.982 ± 0.027	0.835AspTrp: 0.835 ± 0.011	1.518AspTyr: 1.518 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	6.168GluAla: 6.168 ± 0.035	0.582GluCys: 0.582 ± 0.009	4.433GluAsp: 4.433 ± 0.028	5.832GluGlu: 5.832 ± 0.042	1.627GluPhe: 1.627 ± 0.016	4.739GluGly: 4.739 ± 0.034	1.564GluHis: 1.564 ± 0.013	2.596GluIle: 2.596 ± 0.018	3.448GluLys: 3.448 ± 0.026	5.261GluLeu: 5.261 ± 0.036	1.669GluMet: 1.669 ± 0.013	1.768GluAsn: 1.768 ± 0.016	2.76GluPro: 2.76 ± 0.021	2.804GluGln: 2.804 ± 0.021	4.68GluArg: 4.68 ± 0.032	4.0GluSer: 4.0 ± 0.025	3.412GluThr: 3.412 ± 0.023	4.11GluVal: 4.11 ± 0.026	0.867GluTrp: 0.867 ± 0.011	1.615GluTyr: 1.615 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.303PheAla: 3.303 ± 0.021	0.472PheCys: 0.472 ± 0.007	2.146PheAsp: 2.146 ± 0.017	2.015PheGlu: 2.015 ± 0.016	1.332PhePhe: 1.332 ± 0.014	2.853PheGly: 2.853 ± 0.023	0.807PheHis: 0.807 ± 0.009	1.346PheIle: 1.346 ± 0.015	1.247PheLys: 1.247 ± 0.012	2.971PheLeu: 2.971 ± 0.022	0.731PheMet: 0.731 ± 0.009	1.219PheAsn: 1.219 ± 0.013	1.678PhePro: 1.678 ± 0.015	1.164PheGln: 1.164 ± 0.013	1.834PheArg: 1.834 ± 0.015	2.448PheSer: 2.448 ± 0.017	2.044PheThr: 2.044 ± 0.016	2.27PheVal: 2.27 ± 0.017	0.545PheTrp: 0.545 ± 0.009	0.952PheTyr: 0.952 ± 0.011	0.0PheXaa: 0.0 ± 0.0
Gly	6.342GlyAla: 6.342 ± 0.033	0.801GlyCys: 0.801 ± 0.012	3.929GlyAsp: 3.929 ± 0.021	4.65GlyGlu: 4.65 ± 0.028	2.757GlyPhe: 2.757 ± 0.019	7.935GlyGly: 7.935 ± 0.069	1.745GlyHis: 1.745 ± 0.014	3.192GlyIle: 3.192 ± 0.023	3.815GlyLys: 3.815 ± 0.025	6.349GlyLeu: 6.349 ± 0.032	2.134GlyMet: 2.134 ± 0.02	2.456GlyAsn: 2.456 ± 0.019	3.356GlyPro: 3.356 ± 0.026	2.751GlyGln: 2.751 ± 0.019	4.739GlyArg: 4.739 ± 0.028	6.082GlySer: 6.082 ± 0.04	4.299GlyThr: 4.299 ± 0.026	5.028GlyVal: 5.028 ± 0.026	1.206GlyTrp: 1.206 ± 0.012	2.215GlyTyr: 2.215 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	2.194HisAla: 2.194 ± 0.017	0.303HisCys: 0.303 ± 0.006	1.447HisAsp: 1.447 ± 0.015	1.449HisGlu: 1.449 ± 0.014	0.906HisPhe: 0.906 ± 0.011	1.833HisGly: 1.833 ± 0.016	0.904HisHis: 0.904 ± 0.012	1.059HisIle: 1.059 ± 0.011	0.867HisLys: 0.867 ± 0.01	2.24HisLeu: 2.24 ± 0.015	0.498HisMet: 0.498 ± 0.008	0.795HisAsn: 0.795 ± 0.011	1.655HisPro: 1.655 ± 0.017	0.999HisGln: 0.999 ± 0.011	1.525HisArg: 1.525 ± 0.014	1.809HisSer: 1.809 ± 0.016	1.371HisThr: 1.371 ± 0.014	1.494HisVal: 1.494 ± 0.013	0.342HisTrp: 0.342 ± 0.007	0.679HisTyr: 0.679 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	4.131IleAla: 4.131 ± 0.023	0.604IleCys: 0.604 ± 0.009	2.523IleAsp: 2.523 ± 0.016	2.529IleGlu: 2.529 ± 0.017	1.548IlePhe: 1.548 ± 0.014	2.918IleGly: 2.918 ± 0.023	0.986IleHis: 0.986 ± 0.012	1.895IleIle: 1.895 ± 0.017	1.762IleLys: 1.762 ± 0.014	3.745IleLeu: 3.745 ± 0.025	0.875IleMet: 0.875 ± 0.01	1.469IleAsn: 1.469 ± 0.012	2.533IlePro: 2.533 ± 0.018	1.475IleGln: 1.475 ± 0.014	2.476IleArg: 2.476 ± 0.017	3.091IleSer: 3.091 ± 0.019	2.639IleThr: 2.639 ± 0.016	2.808IleVal: 2.808 ± 0.024	0.603IleTrp: 0.603 ± 0.008	1.176IleTyr: 1.176 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.562LysAla: 4.562 ± 0.026	0.391LysCys: 0.391 ± 0.007	2.543LysAsp: 2.543 ± 0.019	3.084LysGlu: 3.084 ± 0.024	1.125LysPhe: 1.125 ± 0.011	3.158LysGly: 3.158 ± 0.022	1.164LysHis: 1.164 ± 0.012	1.788LysIle: 1.788 ± 0.015	2.937LysLys: 2.937 ± 0.031	3.84LysLeu: 3.84 ± 0.025	1.025LysMet: 1.025 ± 0.01	1.289LysAsn: 1.289 ± 0.012	2.674LysPro: 2.674 ± 0.023	1.933LysGln: 1.933 ± 0.017	3.733LysArg: 3.733 ± 0.027	2.992LysSer: 2.992 ± 0.021	2.681LysThr: 2.681 ± 0.018	2.794LysVal: 2.794 ± 0.018	0.6LysTrp: 0.6 ± 0.008	1.199LysTyr: 1.199 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	8.539LeuAla: 8.539 ± 0.038	1.088LeuCys: 1.088 ± 0.012	5.05LeuAsp: 5.05 ± 0.031	5.407LeuGlu: 5.407 ± 0.034	2.933LeuPhe: 2.933 ± 0.024	6.027LeuGly: 6.027 ± 0.033	2.304LeuHis: 2.304 ± 0.02	3.357LeuIle: 3.357 ± 0.024	3.824LeuLys: 3.824 ± 0.024	8.25LeuLeu: 8.25 ± 0.048	1.772LeuMet: 1.772 ± 0.015	2.785LeuAsn: 2.785 ± 0.018	5.707LeuPro: 5.707 ± 0.026	3.928LeuGln: 3.928 ± 0.028	6.017LeuArg: 6.017 ± 0.035	6.555LeuSer: 6.555 ± 0.036	4.885LeuThr: 4.885 ± 0.026	5.315LeuVal: 5.315 ± 0.038	1.119LeuTrp: 1.119 ± 0.013	2.166LeuTyr: 2.166 ± 0.018	0.0LeuXaa: 0.0 ± 0.0
Met	2.429MetAla: 2.429 ± 0.016	0.243MetCys: 0.243 ± 0.006	1.273MetAsp: 1.273 ± 0.011	1.387MetGlu: 1.387 ± 0.012	0.705MetPhe: 0.705 ± 0.009	1.702MetGly: 1.702 ± 0.018	0.542MetHis: 0.542 ± 0.008	0.852MetIle: 0.852 ± 0.01	0.973MetLys: 0.973 ± 0.011	2.032MetLeu: 2.032 ± 0.015	0.617MetMet: 0.617 ± 0.009	0.755MetAsn: 0.755 ± 0.01	1.456MetPro: 1.456 ± 0.017	1.065MetGln: 1.065 ± 0.011	1.469MetArg: 1.469 ± 0.011	1.895MetSer: 1.895 ± 0.017	1.274MetThr: 1.274 ± 0.013	1.355MetVal: 1.355 ± 0.014	0.251MetTrp: 0.251 ± 0.006	0.554MetTyr: 0.554 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.219AsnAla: 3.219 ± 0.019	0.34AsnCys: 0.34 ± 0.007	1.792AsnAsp: 1.792 ± 0.015	1.788AsnGlu: 1.788 ± 0.013	1.151AsnPhe: 1.151 ± 0.012	3.22AsnGly: 3.22 ± 0.025	0.74AsnHis: 0.74 ± 0.01	1.575AsnIle: 1.575 ± 0.016	1.295AsnLys: 1.295 ± 0.014	2.775AsnLeu: 2.775 ± 0.018	0.727AsnMet: 0.727 ± 0.01	1.23AsnAsn: 1.23 ± 0.014	2.107AsnPro: 2.107 ± 0.017	1.083AsnGln: 1.083 ± 0.012	1.665AsnArg: 1.665 ± 0.013	2.208AsnSer: 2.208 ± 0.019	2.086AsnThr: 2.086 ± 0.015	2.167AsnVal: 2.167 ± 0.017	0.44AsnTrp: 0.44 ± 0.008	0.913AsnTyr: 0.913 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	6.089ProAla: 6.089 ± 0.045	0.442ProCys: 0.442 ± 0.006	3.132ProAsp: 3.132 ± 0.018	3.626ProGlu: 3.626 ± 0.023	1.865ProPhe: 1.865 ± 0.013	4.104ProGly: 4.104 ± 0.025	1.408ProHis: 1.408 ± 0.013	2.276ProIle: 2.276 ± 0.018	2.495ProLys: 2.495 ± 0.02	4.693ProLeu: 4.693 ± 0.028	1.154ProMet: 1.154 ± 0.013	2.019ProAsn: 2.019 ± 0.016	5.653ProPro: 5.653 ± 0.057	2.6ProGln: 2.6 ± 0.026	3.469ProArg: 3.469 ± 0.021	5.931ProSer: 5.931 ± 0.041	4.284ProThr: 4.284 ± 0.029	3.526ProVal: 3.526 ± 0.025	0.685ProTrp: 0.685 ± 0.009	1.502ProTyr: 1.502 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	4.014GlnAla: 4.014 ± 0.026	0.422GlnCys: 0.422 ± 0.007	2.053GlnAsp: 2.053 ± 0.015	2.315GlnGlu: 2.315 ± 0.019	1.078GlnPhe: 1.078 ± 0.01	2.553GlnGly: 2.553 ± 0.02	1.336GlnHis: 1.336 ± 0.013	1.669GlnIle: 1.669 ± 0.016	1.805GlnLys: 1.805 ± 0.016	3.468GlnLeu: 3.468 ± 0.022	0.973GlnMet: 0.973 ± 0.013	1.306GlnAsn: 1.306 ± 0.013	2.8GlnPro: 2.8 ± 0.028	3.275GlnGln: 3.275 ± 0.045	3.073GlnArg: 3.073 ± 0.02	3.048GlnSer: 3.048 ± 0.023	2.498GlnThr: 2.498 ± 0.017	2.162GlnVal: 2.162 ± 0.017	0.556GlnTrp: 0.556 ± 0.009	1.258GlnTyr: 1.258 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	5.358ArgAla: 5.358 ± 0.026	0.646ArgCys: 0.646 ± 0.01	3.53ArgAsp: 3.53 ± 0.024	4.402ArgGlu: 4.402 ± 0.033	2.02ArgPhe: 2.02 ± 0.016	4.169ArgGly: 4.169 ± 0.025	1.609ArgHis: 1.609 ± 0.017	2.648ArgIle: 2.648 ± 0.02	3.72ArgLys: 3.72 ± 0.023	5.574ArgLeu: 5.574 ± 0.031	1.531ArgMet: 1.531 ± 0.013	2.09ArgAsn: 2.09 ± 0.017	3.664ArgPro: 3.664 ± 0.028	2.929ArgGln: 2.929 ± 0.021	5.537ArgArg: 5.537 ± 0.037	4.91ArgSer: 4.91 ± 0.032	3.641ArgThr: 3.641 ± 0.022	3.648ArgVal: 3.648 ± 0.021	0.926ArgTrp: 0.926 ± 0.011	1.657ArgTyr: 1.657 ± 0.013	0.0ArgXaa: 0.0 ± 0.0
Ser	7.461SerAla: 7.461 ± 0.039	0.687SerCys: 0.687 ± 0.01	3.921SerAsp: 3.921 ± 0.024	4.046SerGlu: 4.046 ± 0.026	2.482SerPhe: 2.482 ± 0.018	5.984SerGly: 5.984 ± 0.036	1.821SerHis: 1.821 ± 0.015	3.307SerIle: 3.307 ± 0.02	3.277SerLys: 3.277 ± 0.024	6.483SerLeu: 6.483 ± 0.031	1.746SerMet: 1.746 ± 0.016	2.622SerAsn: 2.622 ± 0.018	5.384SerPro: 5.384 ± 0.042	3.047SerGln: 3.047 ± 0.02	4.774SerArg: 4.774 ± 0.033	7.989SerSer: 7.989 ± 0.066	5.683SerThr: 5.683 ± 0.035	4.44SerVal: 4.44 ± 0.024	0.94SerTrp: 0.94 ± 0.011	1.945SerTyr: 1.945 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	6.219ThrAla: 6.219 ± 0.028	0.68ThrCys: 0.68 ± 0.01	2.869ThrAsp: 2.869 ± 0.019	3.048ThrGlu: 3.048 ± 0.021	2.149ThrPhe: 2.149 ± 0.016	4.395ThrGly: 4.395 ± 0.026	1.388ThrHis: 1.388 ± 0.013	2.791ThrIle: 2.791 ± 0.019	2.47ThrLys: 2.47 ± 0.018	5.45ThrLeu: 5.45 ± 0.029	1.224ThrMet: 1.224 ± 0.013	2.112ThrAsn: 2.112 ± 0.018	4.625ThrPro: 4.625 ± 0.029	2.225ThrGln: 2.225 ± 0.014	3.202ThrArg: 3.202 ± 0.021	5.39ThrSer: 5.39 ± 0.039	4.738ThrThr: 4.738 ± 0.036	3.816ThrVal: 3.816 ± 0.024	0.769ThrTrp: 0.769 ± 0.011	1.61ThrTyr: 1.61 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.835ValAla: 5.835 ± 0.028	0.797ValCys: 0.797 ± 0.01	3.77ValAsp: 3.77 ± 0.024	4.401ValGlu: 4.401 ± 0.028	2.221ValPhe: 2.221 ± 0.019	4.55ValGly: 4.55 ± 0.025	1.425ValHis: 1.425 ± 0.013	2.51ValIle: 2.51 ± 0.019	2.939ValLys: 2.939 ± 0.021	5.675ValLeu: 5.675 ± 0.035	1.44ValMet: 1.44 ± 0.015	2.081ValAsn: 2.081 ± 0.014	3.643ValPro: 3.643 ± 0.02	2.509ValGln: 2.509 ± 0.02	3.919ValArg: 3.919 ± 0.026	4.436ValSer: 4.436 ± 0.028	3.52ValThr: 3.52 ± 0.026	4.571ValVal: 4.571 ± 0.031	0.865ValTrp: 0.865 ± 0.011	1.665ValTyr: 1.665 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	1.068TrpAla: 1.068 ± 0.012	0.19TrpCys: 0.19 ± 0.004	0.813TrpAsp: 0.813 ± 0.012	0.807TrpGlu: 0.807 ± 0.011	0.48TrpPhe: 0.48 ± 0.009	0.845TrpGly: 0.845 ± 0.011	0.357TrpHis: 0.357 ± 0.007	0.622TrpIle: 0.622 ± 0.009	0.667TrpLys: 0.667 ± 0.008	1.311TrpLeu: 1.311 ± 0.014	0.371TrpMet: 0.371 ± 0.007	0.496TrpAsn: 0.496 ± 0.008	0.589TrpPro: 0.589 ± 0.008	0.635TrpGln: 0.635 ± 0.008	1.015TrpArg: 1.015 ± 0.011	1.004TrpSer: 1.004 ± 0.012	0.866TrpThr: 0.866 ± 0.011	0.824TrpVal: 0.824 ± 0.01	0.252TrpTrp: 0.252 ± 0.005	0.397TrpTyr: 0.397 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.375TyrAla: 2.375 ± 0.019	0.38TyrCys: 0.38 ± 0.007	1.674TyrAsp: 1.674 ± 0.016	1.558TyrGlu: 1.558 ± 0.013	1.063TyrPhe: 1.063 ± 0.013	2.186TyrGly: 2.186 ± 0.021	0.695TyrHis: 0.695 ± 0.009	1.189TyrIle: 1.189 ± 0.011	0.975TyrLys: 0.975 ± 0.014	2.453TyrLeu: 2.453 ± 0.02	0.589TyrMet: 0.589 ± 0.007	1.017TyrAsn: 1.017 ± 0.011	1.438TyrPro: 1.438 ± 0.015	1.08TyrGln: 1.08 ± 0.012	1.567TyrArg: 1.567 ± 0.015	1.879TyrSer: 1.879 ± 0.016	1.624TyrThr: 1.624 ± 0.014	1.601TyrVal: 1.601 ± 0.016	0.405TyrTrp: 0.405 ± 0.007	0.912TyrTyr: 0.912 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 17901 proteins (8776224 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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