Amino acid dipepetide frequency for Pterula gracilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.72AlaAla: 8.72 ± 0.084
1.121AlaCys: 1.121 ± 0.015
4.072AlaAsp: 4.072 ± 0.03
4.702AlaGlu: 4.702 ± 0.031
3.21AlaPhe: 3.21 ± 0.027
5.785AlaGly: 5.785 ± 0.043
2.144AlaHis: 2.144 ± 0.021
3.859AlaIle: 3.859 ± 0.03
3.693AlaLys: 3.693 ± 0.034
8.331AlaLeu: 8.331 ± 0.045
1.969AlaMet: 1.969 ± 0.018
2.79AlaAsn: 2.79 ± 0.023
5.313AlaPro: 5.313 ± 0.045
3.444AlaGln: 3.444 ± 0.034
4.965AlaArg: 4.965 ± 0.033
8.141AlaSer: 8.141 ± 0.046
5.034AlaThr: 5.034 ± 0.037
5.484AlaVal: 5.484 ± 0.036
1.105AlaTrp: 1.105 ± 0.016
2.144AlaTyr: 2.144 ± 0.021
0.0AlaXaa: 0.0 ± 0.0
Cys
1.008CysAla: 1.008 ± 0.015
0.278CysCys: 0.278 ± 0.009
0.655CysAsp: 0.655 ± 0.013
0.564CysGlu: 0.564 ± 0.01
0.553CysPhe: 0.553 ± 0.011
0.916CysGly: 0.916 ± 0.018
0.334CysHis: 0.334 ± 0.008
0.685CysIle: 0.685 ± 0.012
0.532CysLys: 0.532 ± 0.01
1.276CysLeu: 1.276 ± 0.017
0.314CysMet: 0.314 ± 0.008
0.468CysAsn: 0.468 ± 0.012
0.781CysPro: 0.781 ± 0.013
0.464CysGln: 0.464 ± 0.011
0.804CysArg: 0.804 ± 0.014
1.148CysSer: 1.148 ± 0.016
0.828CysThr: 0.828 ± 0.016
0.868CysVal: 0.868 ± 0.013
0.209CysTrp: 0.209 ± 0.007
0.344CysTyr: 0.344 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
4.84AspAla: 4.84 ± 0.034
0.623AspCys: 0.623 ± 0.01
4.122AspAsp: 4.122 ± 0.045
4.199AspGlu: 4.199 ± 0.036
2.029AspPhe: 2.029 ± 0.021
3.906AspGly: 3.906 ± 0.03
1.279AspHis: 1.279 ± 0.016
2.674AspIle: 2.674 ± 0.028
2.016AspLys: 2.016 ± 0.022
4.892AspLeu: 4.892 ± 0.036
1.173AspMet: 1.173 ± 0.017
1.604AspAsn: 1.604 ± 0.019
3.297AspPro: 3.297 ± 0.023
1.647AspGln: 1.647 ± 0.018
2.775AspArg: 2.775 ± 0.025
4.168AspSer: 4.168 ± 0.032
2.987AspThr: 2.987 ± 0.022
3.93AspVal: 3.93 ± 0.027
0.861AspTrp: 0.861 ± 0.015
1.443AspTyr: 1.443 ± 0.018
0.0AspXaa: 0.0 ± 0.0
Glu
4.799GluAla: 4.799 ± 0.035
0.628GluCys: 0.628 ± 0.012
4.074GluAsp: 4.074 ± 0.036
5.353GluGlu: 5.353 ± 0.047
1.817GluPhe: 1.817 ± 0.022
3.883GluGly: 3.883 ± 0.034
1.409GluHis: 1.409 ± 0.016
2.501GluIle: 2.501 ± 0.022
3.055GluLys: 3.055 ± 0.03
5.064GluLeu: 5.064 ± 0.039
1.363GluMet: 1.363 ± 0.016
1.77GluAsn: 1.77 ± 0.021
2.527GluPro: 2.527 ± 0.024
2.221GluGln: 2.221 ± 0.023
3.835GluArg: 3.835 ± 0.034
3.997GluSer: 3.997 ± 0.032
2.916GluThr: 2.916 ± 0.025
3.608GluVal: 3.608 ± 0.03
0.854GluTrp: 0.854 ± 0.014
1.478GluTyr: 1.478 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.101PheAla: 3.101 ± 0.024
0.564PheCys: 0.564 ± 0.012
2.174PheAsp: 2.174 ± 0.021
1.921PheGlu: 1.921 ± 0.021
1.629PhePhe: 1.629 ± 0.023
2.764PheGly: 2.764 ± 0.03
0.963PheHis: 0.963 ± 0.013
1.785PheIle: 1.785 ± 0.019
1.453PheLys: 1.453 ± 0.016
3.566PheLeu: 3.566 ± 0.031
0.799PheMet: 0.799 ± 0.014
1.362PheAsn: 1.362 ± 0.016
2.121PhePro: 2.121 ± 0.024
1.27PheGln: 1.27 ± 0.016
1.9PheArg: 1.9 ± 0.022
3.37PheSer: 3.37 ± 0.029
2.324PheThr: 2.324 ± 0.021
2.5PheVal: 2.5 ± 0.024
0.578PheTrp: 0.578 ± 0.012
1.049PheTyr: 1.049 ± 0.013
0.0PheXaa: 0.0 ± 0.0
Gly
5.436GlyAla: 5.436 ± 0.044
0.915GlyCys: 0.915 ± 0.016
3.472GlyAsp: 3.472 ± 0.03
3.701GlyGlu: 3.701 ± 0.031
2.599GlyPhe: 2.599 ± 0.026
6.38GlyGly: 6.38 ± 0.069
1.678GlyHis: 1.678 ± 0.021
3.018GlyIle: 3.018 ± 0.024
3.376GlyLys: 3.376 ± 0.031
5.751GlyLeu: 5.751 ± 0.038
1.653GlyMet: 1.653 ± 0.022
2.285GlyAsn: 2.285 ± 0.025
3.31GlyPro: 3.31 ± 0.029
2.339GlyGln: 2.339 ± 0.028
4.116GlyArg: 4.116 ± 0.032
6.111GlySer: 6.111 ± 0.039
4.027GlyThr: 4.027 ± 0.032
4.535GlyVal: 4.535 ± 0.031
1.137GlyTrp: 1.137 ± 0.016
2.012GlyTyr: 2.012 ± 0.03
0.0GlyXaa: 0.0 ± 0.0
His
2.112HisAla: 2.112 ± 0.021
0.376HisCys: 0.376 ± 0.009
1.327HisAsp: 1.327 ± 0.017
1.265HisGlu: 1.265 ± 0.019
0.976HisPhe: 0.976 ± 0.015
1.726HisGly: 1.726 ± 0.018
1.068HisHis: 1.068 ± 0.02
1.28HisIle: 1.28 ± 0.016
0.88HisLys: 0.88 ± 0.012
2.708HisLeu: 2.708 ± 0.027
0.48HisMet: 0.48 ± 0.01
0.835HisAsn: 0.835 ± 0.013
2.101HisPro: 2.101 ± 0.024
1.012HisGln: 1.012 ± 0.016
1.742HisArg: 1.742 ± 0.019
2.323HisSer: 2.323 ± 0.026
1.586HisThr: 1.586 ± 0.018
1.586HisVal: 1.586 ± 0.018
0.343HisTrp: 0.343 ± 0.008
0.684HisTyr: 0.684 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
3.987IleAla: 3.987 ± 0.032
0.699IleCys: 0.699 ± 0.013
2.52IleAsp: 2.52 ± 0.022
2.345IleGlu: 2.345 ± 0.02
1.812IlePhe: 1.812 ± 0.02
2.854IleGly: 2.854 ± 0.027
1.247IleHis: 1.247 ± 0.016
2.293IleIle: 2.293 ± 0.024
1.844IleLys: 1.844 ± 0.025
4.373IleLeu: 4.373 ± 0.032
0.936IleMet: 0.936 ± 0.016
1.542IleAsn: 1.542 ± 0.02
3.073IlePro: 3.073 ± 0.028
1.709IleGln: 1.709 ± 0.019
2.691IleArg: 2.691 ± 0.026
3.858IleSer: 3.858 ± 0.028
2.818IleThr: 2.818 ± 0.026
3.037IleVal: 3.037 ± 0.025
0.666IleTrp: 0.666 ± 0.014
1.212IleTyr: 1.212 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
3.956LysAla: 3.956 ± 0.038
0.474LysCys: 0.474 ± 0.011
2.443LysAsp: 2.443 ± 0.026
2.973LysGlu: 2.973 ± 0.028
1.354LysPhe: 1.354 ± 0.019
2.868LysGly: 2.868 ± 0.028
1.136LysHis: 1.136 ± 0.014
1.89LysIle: 1.89 ± 0.021
2.885LysLys: 2.885 ± 0.041
3.886LysLeu: 3.886 ± 0.033
0.953LysMet: 0.953 ± 0.015
1.455LysAsn: 1.455 ± 0.019
2.517LysPro: 2.517 ± 0.025
1.666LysGln: 1.666 ± 0.017
3.233LysArg: 3.233 ± 0.029
3.219LysSer: 3.219 ± 0.026
2.514LysThr: 2.514 ± 0.022
2.604LysVal: 2.604 ± 0.026
0.601LysTrp: 0.601 ± 0.011
1.195LysTyr: 1.195 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
8.131LeuAla: 8.131 ± 0.046
1.354LeuCys: 1.354 ± 0.02
5.198LeuAsp: 5.198 ± 0.036
5.303LeuGlu: 5.303 ± 0.045
3.481LeuPhe: 3.481 ± 0.032
5.819LeuGly: 5.819 ± 0.039
2.589LeuHis: 2.589 ± 0.024
3.92LeuIle: 3.92 ± 0.032
3.957LeuLys: 3.957 ± 0.034
9.074LeuLeu: 9.074 ± 0.063
1.767LeuMet: 1.767 ± 0.018
3.056LeuAsn: 3.056 ± 0.026
6.151LeuPro: 6.151 ± 0.04
3.665LeuGln: 3.665 ± 0.029
5.992LeuArg: 5.992 ± 0.039
8.218LeuSer: 8.218 ± 0.046
5.314LeuThr: 5.314 ± 0.034
5.928LeuVal: 5.928 ± 0.037
1.185LeuTrp: 1.185 ± 0.015
2.302LeuTyr: 2.302 ± 0.025
0.0LeuXaa: 0.0 ± 0.0
Met
1.842MetAla: 1.842 ± 0.022
0.254MetCys: 0.254 ± 0.007
1.287MetAsp: 1.287 ± 0.018
1.227MetGlu: 1.227 ± 0.016
0.82MetPhe: 0.82 ± 0.014
1.469MetGly: 1.469 ± 0.02
0.557MetHis: 0.557 ± 0.011
0.969MetIle: 0.969 ± 0.014
0.995MetLys: 0.995 ± 0.014
1.922MetLeu: 1.922 ± 0.019
0.575MetMet: 0.575 ± 0.011
0.767MetAsn: 0.767 ± 0.012
1.231MetPro: 1.231 ± 0.015
0.841MetGln: 0.841 ± 0.013
1.325MetArg: 1.325 ± 0.017
2.038MetSer: 2.038 ± 0.021
1.237MetThr: 1.237 ± 0.018
1.234MetVal: 1.234 ± 0.017
0.288MetTrp: 0.288 ± 0.007
0.606MetTyr: 0.606 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.127AsnAla: 3.127 ± 0.026
0.402AsnCys: 0.402 ± 0.01
1.735AsnAsp: 1.735 ± 0.022
1.664AsnGlu: 1.664 ± 0.018
1.24AsnPhe: 1.24 ± 0.016
2.647AsnGly: 2.647 ± 0.028
0.862AsnHis: 0.862 ± 0.015
1.692AsnIle: 1.692 ± 0.02
1.275AsnLys: 1.275 ± 0.018
3.031AsnLeu: 3.031 ± 0.026
0.728AsnMet: 0.728 ± 0.011
1.333AsnAsn: 1.333 ± 0.024
2.324AsnPro: 2.324 ± 0.023
1.155AsnGln: 1.155 ± 0.016
1.756AsnArg: 1.756 ± 0.02
2.654AsnSer: 2.654 ± 0.027
2.125AsnThr: 2.125 ± 0.022
2.362AsnVal: 2.362 ± 0.024
0.483AsnTrp: 0.483 ± 0.01
0.895AsnTyr: 0.895 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
5.562ProAla: 5.562 ± 0.046
0.592ProCys: 0.592 ± 0.011
3.03ProAsp: 3.03 ± 0.024
3.436ProGlu: 3.436 ± 0.027
2.208ProPhe: 2.208 ± 0.022
3.915ProGly: 3.915 ± 0.033
1.705ProHis: 1.705 ± 0.022
2.616ProIle: 2.616 ± 0.025
2.454ProLys: 2.454 ± 0.027
5.338ProLeu: 5.338 ± 0.037
1.126ProMet: 1.126 ± 0.013
2.15ProAsn: 2.15 ± 0.021
6.395ProPro: 6.395 ± 0.086
2.374ProGln: 2.374 ± 0.026
3.636ProArg: 3.636 ± 0.034
7.591ProSer: 7.591 ± 0.063
4.696ProThr: 4.696 ± 0.036
3.733ProVal: 3.733 ± 0.033
0.727ProTrp: 0.727 ± 0.013
1.514ProTyr: 1.514 ± 0.019
0.0ProXaa: 0.0 ± 0.0
Gln
3.349GlnAla: 3.349 ± 0.031
0.495GlnCys: 0.495 ± 0.01
1.953GlnAsp: 1.953 ± 0.02
2.157GlnGlu: 2.157 ± 0.025
1.214GlnPhe: 1.214 ± 0.014
2.244GlnGly: 2.244 ± 0.021
1.147GlnHis: 1.147 ± 0.017
1.64GlnIle: 1.64 ± 0.018
1.58GlnLys: 1.58 ± 0.02
3.53GlnLeu: 3.53 ± 0.031
0.836GlnMet: 0.836 ± 0.013
1.26GlnAsn: 1.26 ± 0.019
2.407GlnPro: 2.407 ± 0.028
2.096GlnGln: 2.096 ± 0.04
2.502GlnArg: 2.502 ± 0.024
3.185GlnSer: 3.185 ± 0.029
2.206GlnThr: 2.206 ± 0.022
2.203GlnVal: 2.203 ± 0.023
0.528GlnTrp: 0.528 ± 0.011
1.027GlnTyr: 1.027 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
4.893ArgAla: 4.893 ± 0.034
0.886ArgCys: 0.886 ± 0.015
3.084ArgAsp: 3.084 ± 0.03
3.518ArgGlu: 3.518 ± 0.03
2.185ArgPhe: 2.185 ± 0.019
3.772ArgGly: 3.772 ± 0.04
1.599ArgHis: 1.599 ± 0.017
2.814ArgIle: 2.814 ± 0.024
3.18ArgLys: 3.18 ± 0.03
5.553ArgLeu: 5.553 ± 0.039
1.431ArgMet: 1.431 ± 0.016
2.018ArgAsn: 2.018 ± 0.019
3.6ArgPro: 3.6 ± 0.032
2.306ArgGln: 2.306 ± 0.022
5.218ArgArg: 5.218 ± 0.044
5.409ArgSer: 5.409 ± 0.044
3.663ArgThr: 3.663 ± 0.03
3.733ArgVal: 3.733 ± 0.029
0.965ArgTrp: 0.965 ± 0.015
1.622ArgTyr: 1.622 ± 0.016
0.0ArgXaa: 0.0 ± 0.0
Ser
7.47SerAla: 7.47 ± 0.043
1.064SerCys: 1.064 ± 0.016
4.263SerAsp: 4.263 ± 0.031
4.041SerGlu: 4.041 ± 0.03
3.398SerPhe: 3.398 ± 0.029
5.886SerGly: 5.886 ± 0.04
2.328SerHis: 2.328 ± 0.026
4.07SerIle: 4.07 ± 0.032
3.645SerLys: 3.645 ± 0.03
8.165SerLeu: 8.165 ± 0.056
1.86SerMet: 1.86 ± 0.02
2.991SerAsn: 2.991 ± 0.028
6.762SerPro: 6.762 ± 0.069
3.305SerGln: 3.305 ± 0.031
5.48SerArg: 5.48 ± 0.045
11.761SerSer: 11.761 ± 0.097
6.688SerThr: 6.688 ± 0.046
5.204SerVal: 5.204 ± 0.035
1.114SerTrp: 1.114 ± 0.018
2.109SerTyr: 2.109 ± 0.018
0.0SerXaa: 0.0 ± 0.0
Thr
5.196ThrAla: 5.196 ± 0.034
0.8ThrCys: 0.8 ± 0.014
2.649ThrAsp: 2.649 ± 0.023
2.802ThrGlu: 2.802 ± 0.025
2.427ThrPhe: 2.427 ± 0.024
4.02ThrGly: 4.02 ± 0.032
1.622ThrHis: 1.622 ± 0.019
2.945ThrIle: 2.945 ± 0.027
2.407ThrLys: 2.407 ± 0.021
5.958ThrLeu: 5.958 ± 0.037
1.244ThrMet: 1.244 ± 0.016
2.071ThrAsn: 2.071 ± 0.02
4.863ThrPro: 4.863 ± 0.036
2.138ThrGln: 2.138 ± 0.022
3.43ThrArg: 3.43 ± 0.03
6.299ThrSer: 6.299 ± 0.045
4.641ThrThr: 4.641 ± 0.05
3.869ThrVal: 3.869 ± 0.029
0.804ThrTrp: 0.804 ± 0.013
1.584ThrTyr: 1.584 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
5.276ValAla: 5.276 ± 0.033
0.91ValCys: 0.91 ± 0.015
3.954ValAsp: 3.954 ± 0.03
3.831ValGlu: 3.831 ± 0.029
2.573ValPhe: 2.573 ± 0.027
4.152ValGly: 4.152 ± 0.035
1.634ValHis: 1.634 ± 0.019
2.905ValIle: 2.905 ± 0.026
2.869ValLys: 2.869 ± 0.026
6.257ValLeu: 6.257 ± 0.047
1.358ValMet: 1.358 ± 0.016
2.141ValAsn: 2.141 ± 0.021
3.841ValPro: 3.841 ± 0.028
2.431ValGln: 2.431 ± 0.022
3.521ValArg: 3.521 ± 0.027
4.961ValSer: 4.961 ± 0.029
3.515ValThr: 3.515 ± 0.031
4.794ValVal: 4.794 ± 0.041
0.945ValTrp: 0.945 ± 0.017
1.823ValTyr: 1.823 ± 0.019
0.0ValXaa: 0.0 ± 0.0
Trp
1.069TrpAla: 1.069 ± 0.017
0.207TrpCys: 0.207 ± 0.007
0.878TrpAsp: 0.878 ± 0.015
0.804TrpGlu: 0.804 ± 0.013
0.573TrpPhe: 0.573 ± 0.01
0.921TrpGly: 0.921 ± 0.015
0.333TrpHis: 0.333 ± 0.009
0.706TrpIle: 0.706 ± 0.011
0.76TrpLys: 0.76 ± 0.012
1.207TrpLeu: 1.207 ± 0.017
0.363TrpMet: 0.363 ± 0.008
0.593TrpAsn: 0.593 ± 0.012
0.599TrpPro: 0.599 ± 0.011
0.464TrpGln: 0.464 ± 0.01
0.993TrpArg: 0.993 ± 0.016
1.089TrpSer: 1.089 ± 0.017
0.933TrpThr: 0.933 ± 0.014
0.88TrpVal: 0.88 ± 0.012
0.266TrpTrp: 0.266 ± 0.008
0.395TrpTyr: 0.395 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.151TyrAla: 2.151 ± 0.021
0.389TyrCys: 0.389 ± 0.009
1.573TyrAsp: 1.573 ± 0.016
1.345TyrGlu: 1.345 ± 0.018
1.094TyrPhe: 1.094 ± 0.015
1.923TyrGly: 1.923 ± 0.027
0.777TyrHis: 0.777 ± 0.013
1.25TyrIle: 1.25 ± 0.017
0.965TyrLys: 0.965 ± 0.014
2.525TyrLeu: 2.525 ± 0.022
0.555TyrMet: 0.555 ± 0.012
1.0TyrAsn: 1.0 ± 0.015
1.584TyrPro: 1.584 ± 0.024
1.015TyrGln: 1.015 ± 0.014
1.535TyrArg: 1.535 ± 0.019
2.06TyrSer: 2.06 ± 0.021
1.719TyrThr: 1.719 ± 0.02
1.602TyrVal: 1.602 ± 0.02
0.375TyrTrp: 0.375 ± 0.008
0.817TyrTyr: 0.817 ± 0.013
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.002
Statistics based on 12852 proteins (5104399 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski