Amino acid dipepetide frequency for Thermoplasmatales archaeon (strain BRNA1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.45AlaAla: 8.45 ± 0.235
1.182AlaCys: 1.182 ± 0.052
6.025AlaAsp: 6.025 ± 0.126
6.269AlaGlu: 6.269 ± 0.175
3.192AlaPhe: 3.192 ± 0.096
6.758AlaGly: 6.758 ± 0.158
1.216AlaHis: 1.216 ± 0.06
5.613AlaIle: 5.613 ± 0.121
5.236AlaLys: 5.236 ± 0.144
7.038AlaLeu: 7.038 ± 0.158
2.906AlaMet: 2.906 ± 0.086
2.472AlaAsn: 2.472 ± 0.085
2.79AlaPro: 2.79 ± 0.097
2.089AlaGln: 2.089 ± 0.076
3.95AlaArg: 3.95 ± 0.09
4.715AlaSer: 4.715 ± 0.125
3.885AlaThr: 3.885 ± 0.12
7.559AlaVal: 7.559 ± 0.15
0.695AlaTrp: 0.695 ± 0.045
2.633AlaTyr: 2.633 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
1.259CysAla: 1.259 ± 0.065
0.365CysCys: 0.365 ± 0.036
1.062CysAsp: 1.062 ± 0.047
0.952CysGlu: 0.952 ± 0.053
0.614CysPhe: 0.614 ± 0.04
1.866CysGly: 1.866 ± 0.076
0.329CysHis: 0.329 ± 0.031
0.959CysIle: 0.959 ± 0.052
0.702CysLys: 0.702 ± 0.04
1.182CysLeu: 1.182 ± 0.057
0.523CysMet: 0.523 ± 0.031
0.471CysAsn: 0.471 ± 0.034
1.076CysPro: 1.076 ± 0.062
0.402CysGln: 0.402 ± 0.028
1.081CysArg: 1.081 ± 0.055
1.072CysSer: 1.072 ± 0.048
0.95CysThr: 0.95 ± 0.05
1.141CysVal: 1.141 ± 0.051
0.129CysTrp: 0.129 ± 0.018
0.521CysTyr: 0.521 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
5.89AspAla: 5.89 ± 0.125
1.072AspCys: 1.072 ± 0.055
4.279AspAsp: 4.279 ± 0.107
4.649AspGlu: 4.649 ± 0.117
2.675AspPhe: 2.675 ± 0.073
5.737AspGly: 5.737 ± 0.142
1.038AspHis: 1.038 ± 0.044
5.22AspIle: 5.22 ± 0.109
2.779AspLys: 2.779 ± 0.089
5.854AspLeu: 5.854 ± 0.109
2.301AspMet: 2.301 ± 0.072
2.008AspAsn: 2.008 ± 0.064
3.253AspPro: 3.253 ± 0.082
1.281AspGln: 1.281 ± 0.051
3.986AspArg: 3.986 ± 0.098
4.076AspSer: 4.076 ± 0.114
3.174AspThr: 3.174 ± 0.082
5.378AspVal: 5.378 ± 0.111
0.699AspTrp: 0.699 ± 0.036
2.536AspTyr: 2.536 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
5.561GluAla: 5.561 ± 0.152
1.044GluCys: 1.044 ± 0.051
4.514GluAsp: 4.514 ± 0.117
5.319GluGlu: 5.319 ± 0.153
2.472GluPhe: 2.472 ± 0.071
4.83GluGly: 4.83 ± 0.117
1.182GluHis: 1.182 ± 0.053
5.017GluIle: 5.017 ± 0.12
4.891GluLys: 4.891 ± 0.127
5.017GluLeu: 5.017 ± 0.114
2.515GluMet: 2.515 ± 0.084
2.671GluAsn: 2.671 ± 0.08
2.287GluPro: 2.287 ± 0.078
1.753GluGln: 1.753 ± 0.065
3.562GluArg: 3.562 ± 0.096
3.506GluSer: 3.506 ± 0.097
3.318GluThr: 3.318 ± 0.091
4.604GluVal: 4.604 ± 0.113
0.665GluTrp: 0.665 ± 0.039
2.443GluTyr: 2.443 ± 0.085
0.0GluXaa: 0.0 ± 0.0
Phe
3.025PheAla: 3.025 ± 0.107
0.697PheCys: 0.697 ± 0.041
2.892PheAsp: 2.892 ± 0.088
2.355PheGlu: 2.355 ± 0.077
1.541PhePhe: 1.541 ± 0.067
3.488PheGly: 3.488 ± 0.092
0.605PheHis: 0.605 ± 0.035
2.513PheIle: 2.513 ± 0.083
1.649PheLys: 1.649 ± 0.067
3.077PheLeu: 3.077 ± 0.094
1.304PheMet: 1.304 ± 0.05
1.263PheAsn: 1.263 ± 0.054
1.466PhePro: 1.466 ± 0.057
0.85PheGln: 0.85 ± 0.047
2.242PheArg: 2.242 ± 0.078
2.63PheSer: 2.63 ± 0.081
2.285PheThr: 2.285 ± 0.086
3.077PheVal: 3.077 ± 0.094
0.372PheTrp: 0.372 ± 0.033
1.29PheTyr: 1.29 ± 0.053
0.0PheXaa: 0.0 ± 0.0
Gly
6.131GlyAla: 6.131 ± 0.132
1.624GlyCys: 1.624 ± 0.079
4.814GlyAsp: 4.814 ± 0.11
4.852GlyGlu: 4.852 ± 0.115
3.262GlyPhe: 3.262 ± 0.081
5.861GlyGly: 5.861 ± 0.141
1.423GlyHis: 1.423 ± 0.067
6.104GlyIle: 6.104 ± 0.127
5.764GlyLys: 5.764 ± 0.142
6.161GlyLeu: 6.161 ± 0.129
3.018GlyMet: 3.018 ± 0.087
3.129GlyAsn: 3.129 ± 0.101
2.348GlyPro: 2.348 ± 0.079
1.755GlyGln: 1.755 ± 0.064
4.275GlyArg: 4.275 ± 0.108
5.046GlySer: 5.046 ± 0.148
5.225GlyThr: 5.225 ± 0.129
5.818GlyVal: 5.818 ± 0.129
0.873GlyTrp: 0.873 ± 0.052
3.027GlyTyr: 3.027 ± 0.088
0.0GlyXaa: 0.0 ± 0.0
His
1.175HisAla: 1.175 ± 0.056
0.298HisCys: 0.298 ± 0.022
1.067HisAsp: 1.067 ± 0.056
0.855HisGlu: 0.855 ± 0.052
0.609HisPhe: 0.609 ± 0.04
1.419HisGly: 1.419 ± 0.059
0.399HisHis: 0.399 ± 0.054
1.117HisIle: 1.117 ± 0.049
0.715HisLys: 0.715 ± 0.038
1.462HisLeu: 1.462 ± 0.055
0.598HisMet: 0.598 ± 0.039
0.544HisAsn: 0.544 ± 0.036
0.95HisPro: 0.95 ± 0.052
0.379HisGln: 0.379 ± 0.03
0.882HisArg: 0.882 ± 0.041
0.927HisSer: 0.927 ± 0.052
0.844HisThr: 0.844 ± 0.044
1.256HisVal: 1.256 ± 0.064
0.174HisTrp: 0.174 ± 0.021
0.587HisTyr: 0.587 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.26IleAla: 6.26 ± 0.139
1.051IleCys: 1.051 ± 0.049
4.888IleAsp: 4.888 ± 0.117
4.304IleGlu: 4.304 ± 0.093
2.204IlePhe: 2.204 ± 0.075
5.933IleGly: 5.933 ± 0.141
1.065IleHis: 1.065 ± 0.049
4.496IleIle: 4.496 ± 0.109
2.887IleLys: 2.887 ± 0.085
5.664IleLeu: 5.664 ± 0.116
2.053IleMet: 2.053 ± 0.073
2.139IleAsn: 2.139 ± 0.077
3.307IlePro: 3.307 ± 0.089
1.385IleGln: 1.385 ± 0.058
3.968IleArg: 3.968 ± 0.102
4.539IleSer: 4.539 ± 0.096
3.792IleThr: 3.792 ± 0.109
5.669IleVal: 5.669 ± 0.109
0.544IleTrp: 0.544 ± 0.04
1.958IleTyr: 1.958 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
5.428LysAla: 5.428 ± 0.14
0.916LysCys: 0.916 ± 0.05
4.18LysAsp: 4.18 ± 0.086
4.394LysGlu: 4.394 ± 0.124
1.805LysPhe: 1.805 ± 0.065
4.137LysGly: 4.137 ± 0.123
0.882LysHis: 0.882 ± 0.044
3.569LysIle: 3.569 ± 0.102
4.379LysLys: 4.379 ± 0.135
4.135LysLeu: 4.135 ± 0.095
1.852LysMet: 1.852 ± 0.078
2.148LysAsn: 2.148 ± 0.076
1.888LysPro: 1.888 ± 0.069
1.509LysGln: 1.509 ± 0.063
2.736LysArg: 2.736 ± 0.083
2.984LysSer: 2.984 ± 0.084
3.068LysThr: 3.068 ± 0.09
4.286LysVal: 4.286 ± 0.097
0.55LysTrp: 0.55 ± 0.038
2.042LysTyr: 2.042 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
7.088LeuAla: 7.088 ± 0.131
1.403LeuCys: 1.403 ± 0.064
5.455LeuAsp: 5.455 ± 0.1
4.999LeuGlu: 4.999 ± 0.114
3.174LeuPhe: 3.174 ± 0.112
6.429LeuGly: 6.429 ± 0.127
1.182LeuHis: 1.182 ± 0.051
5.279LeuIle: 5.279 ± 0.145
4.351LeuLys: 4.351 ± 0.096
6.021LeuLeu: 6.021 ± 0.15
2.799LeuMet: 2.799 ± 0.097
2.93LeuAsn: 2.93 ± 0.078
3.273LeuPro: 3.273 ± 0.088
1.884LeuGln: 1.884 ± 0.064
4.527LeuArg: 4.527 ± 0.108
5.865LeuSer: 5.865 ± 0.119
4.225LeuThr: 4.225 ± 0.114
5.703LeuVal: 5.703 ± 0.118
0.627LeuTrp: 0.627 ± 0.036
2.346LeuTyr: 2.346 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
3.016MetAla: 3.016 ± 0.091
0.562MetCys: 0.562 ± 0.038
2.445MetAsp: 2.445 ± 0.081
2.181MetGlu: 2.181 ± 0.082
1.311MetPhe: 1.311 ± 0.059
2.651MetGly: 2.651 ± 0.09
0.555MetHis: 0.555 ± 0.033
2.057MetIle: 2.057 ± 0.074
2.145MetLys: 2.145 ± 0.069
2.581MetLeu: 2.581 ± 0.092
1.22MetMet: 1.22 ± 0.052
1.263MetAsn: 1.263 ± 0.056
1.284MetPro: 1.284 ± 0.052
0.799MetGln: 0.799 ± 0.044
1.757MetArg: 1.757 ± 0.062
2.344MetSer: 2.344 ± 0.068
2.033MetThr: 2.033 ± 0.069
2.596MetVal: 2.596 ± 0.078
0.268MetTrp: 0.268 ± 0.025
0.993MetTyr: 0.993 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
2.939AsnAla: 2.939 ± 0.085
0.541AsnCys: 0.541 ± 0.044
1.987AsnAsp: 1.987 ± 0.069
1.958AsnGlu: 1.958 ± 0.067
1.006AsnPhe: 1.006 ± 0.047
3.246AsnGly: 3.246 ± 0.101
0.526AsnHis: 0.526 ± 0.032
2.752AsnIle: 2.752 ± 0.082
1.631AsnLys: 1.631 ± 0.065
2.962AsnLeu: 2.962 ± 0.088
1.162AsnMet: 1.162 ± 0.058
1.263AsnAsn: 1.263 ± 0.056
2.01AsnPro: 2.01 ± 0.07
0.69AsnGln: 0.69 ± 0.041
1.814AsnArg: 1.814 ± 0.069
1.974AsnSer: 1.974 ± 0.073
1.737AsnThr: 1.737 ± 0.069
2.915AsnVal: 2.915 ± 0.097
0.316AsnTrp: 0.316 ± 0.025
1.175AsnTyr: 1.175 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
3.233ProAla: 3.233 ± 0.119
0.582ProCys: 0.582 ± 0.038
3.163ProAsp: 3.163 ± 0.087
3.72ProGlu: 3.72 ± 0.094
1.606ProPhe: 1.606 ± 0.053
3.26ProGly: 3.26 ± 0.095
0.663ProHis: 0.663 ± 0.045
2.348ProIle: 2.348 ± 0.069
2.283ProLys: 2.283 ± 0.085
2.978ProLeu: 2.978 ± 0.091
1.311ProMet: 1.311 ± 0.052
1.261ProAsn: 1.261 ± 0.057
1.286ProPro: 1.286 ± 0.063
0.932ProGln: 0.932 ± 0.055
1.742ProArg: 1.742 ± 0.072
2.626ProSer: 2.626 ± 0.079
1.861ProThr: 1.861 ± 0.072
3.515ProVal: 3.515 ± 0.102
0.352ProTrp: 0.352 ± 0.027
1.426ProTyr: 1.426 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
1.992GlnAla: 1.992 ± 0.071
0.374GlnCys: 0.374 ± 0.028
1.245GlnAsp: 1.245 ± 0.052
1.502GlnGlu: 1.502 ± 0.063
0.968GlnPhe: 0.968 ± 0.047
1.511GlnGly: 1.511 ± 0.058
0.411GlnHis: 0.411 ± 0.033
1.669GlnIle: 1.669 ± 0.064
1.631GlnLys: 1.631 ± 0.06
1.825GlnLeu: 1.825 ± 0.066
1.04GlnMet: 1.04 ± 0.044
0.868GlnAsn: 0.868 ± 0.04
0.758GlnPro: 0.758 ± 0.041
0.753GlnGln: 0.753 ± 0.055
1.311GlnArg: 1.311 ± 0.064
1.313GlnSer: 1.313 ± 0.061
1.135GlnThr: 1.135 ± 0.057
1.604GlnVal: 1.604 ± 0.056
0.235GlnTrp: 0.235 ± 0.02
1.015GlnTyr: 1.015 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.943ArgAla: 3.943 ± 0.103
0.932ArgCys: 0.932 ± 0.048
3.729ArgAsp: 3.729 ± 0.097
3.997ArgGlu: 3.997 ± 0.116
2.296ArgPhe: 2.296 ± 0.074
3.639ArgGly: 3.639 ± 0.113
0.85ArgHis: 0.85 ± 0.046
4.02ArgIle: 4.02 ± 0.113
3.366ArgLys: 3.366 ± 0.095
4.094ArgLeu: 4.094 ± 0.099
2.037ArgMet: 2.037 ± 0.064
2.227ArgAsn: 2.227 ± 0.081
2.021ArgPro: 2.021 ± 0.073
1.396ArgGln: 1.396 ± 0.057
3.206ArgArg: 3.206 ± 0.105
3.201ArgSer: 3.201 ± 0.097
2.689ArgThr: 2.689 ± 0.077
3.481ArgVal: 3.481 ± 0.095
0.505ArgTrp: 0.505 ± 0.034
1.99ArgTyr: 1.99 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
5.01SerAla: 5.01 ± 0.132
0.916SerCys: 0.916 ± 0.053
4.448SerAsp: 4.448 ± 0.109
4.361SerGlu: 4.361 ± 0.11
2.644SerPhe: 2.644 ± 0.074
5.743SerGly: 5.743 ± 0.132
0.999SerHis: 0.999 ± 0.043
4.047SerIle: 4.047 ± 0.112
3.524SerLys: 3.524 ± 0.096
4.958SerLeu: 4.958 ± 0.109
2.073SerMet: 2.073 ± 0.06
1.886SerAsn: 1.886 ± 0.064
2.272SerPro: 2.272 ± 0.074
1.5SerGln: 1.5 ± 0.057
3.3SerArg: 3.3 ± 0.082
4.257SerSer: 4.257 ± 0.134
2.957SerThr: 2.957 ± 0.093
5.342SerVal: 5.342 ± 0.129
0.638SerTrp: 0.638 ± 0.037
1.994SerTyr: 1.994 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
4.478ThrAla: 4.478 ± 0.124
0.771ThrCys: 0.771 ± 0.042
3.56ThrAsp: 3.56 ± 0.087
3.372ThrGlu: 3.372 ± 0.087
2.181ThrPhe: 2.181 ± 0.089
4.832ThrGly: 4.832 ± 0.106
0.826ThrHis: 0.826 ± 0.048
3.562ThrIle: 3.562 ± 0.101
2.407ThrLys: 2.407 ± 0.063
4.415ThrLeu: 4.415 ± 0.108
1.561ThrMet: 1.561 ± 0.054
1.672ThrAsn: 1.672 ± 0.067
2.409ThrPro: 2.409 ± 0.075
1.094ThrGln: 1.094 ± 0.05
2.195ThrArg: 2.195 ± 0.067
3.169ThrSer: 3.169 ± 0.1
2.736ThrThr: 2.736 ± 0.099
5.622ThrVal: 5.622 ± 0.158
0.395ThrTrp: 0.395 ± 0.029
1.994ThrTyr: 1.994 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
6.316ValAla: 6.316 ± 0.15
1.493ValCys: 1.493 ± 0.056
5.01ValAsp: 5.01 ± 0.108
4.439ValGlu: 4.439 ± 0.123
3.307ValPhe: 3.307 ± 0.092
5.497ValGly: 5.497 ± 0.119
1.288ValHis: 1.288 ± 0.059
5.227ValIle: 5.227 ± 0.112
4.448ValLys: 4.448 ± 0.098
6.603ValLeu: 6.603 ± 0.139
2.405ValMet: 2.405 ± 0.089
2.639ValAsn: 2.639 ± 0.098
3.788ValPro: 3.788 ± 0.099
1.712ValGln: 1.712 ± 0.066
4.624ValArg: 4.624 ± 0.106
5.737ValSer: 5.737 ± 0.119
4.904ValThr: 4.904 ± 0.119
5.739ValVal: 5.739 ± 0.117
0.706ValTrp: 0.706 ± 0.038
2.644ValTyr: 2.644 ± 0.08
0.0ValXaa: 0.0 ± 0.0
Trp
0.697TrpAla: 0.697 ± 0.042
0.176TrpCys: 0.176 ± 0.02
0.641TrpAsp: 0.641 ± 0.04
0.659TrpGlu: 0.659 ± 0.037
0.433TrpPhe: 0.433 ± 0.035
0.659TrpGly: 0.659 ± 0.043
0.171TrpHis: 0.171 ± 0.019
0.611TrpIle: 0.611 ± 0.034
0.632TrpLys: 0.632 ± 0.033
0.69TrpLeu: 0.69 ± 0.042
0.354TrpMet: 0.354 ± 0.027
0.449TrpAsn: 0.449 ± 0.029
0.282TrpPro: 0.282 ± 0.032
0.259TrpGln: 0.259 ± 0.023
0.438TrpArg: 0.438 ± 0.031
0.494TrpSer: 0.494 ± 0.032
0.496TrpThr: 0.496 ± 0.039
0.575TrpVal: 0.575 ± 0.036
0.113TrpTrp: 0.113 ± 0.017
0.359TrpTyr: 0.359 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.779TyrAla: 2.779 ± 0.1
0.654TyrCys: 0.654 ± 0.038
2.481TyrAsp: 2.481 ± 0.078
2.033TyrGlu: 2.033 ± 0.064
1.322TyrPhe: 1.322 ± 0.053
3.012TyrGly: 3.012 ± 0.101
0.645TyrHis: 0.645 ± 0.041
1.929TyrIle: 1.929 ± 0.073
1.469TyrLys: 1.469 ± 0.063
2.845TyrLeu: 2.845 ± 0.075
1.029TyrMet: 1.029 ± 0.048
1.302TyrAsn: 1.302 ± 0.06
1.396TyrPro: 1.396 ± 0.058
0.738TyrGln: 0.738 ± 0.036
2.023TyrArg: 2.023 ± 0.078
2.396TyrSer: 2.396 ± 0.075
1.936TyrThr: 1.936 ± 0.08
2.653TyrVal: 2.653 ± 0.081
0.332TyrTrp: 0.332 ± 0.026
1.25TyrTyr: 1.25 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1528 proteins (443297 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski