Amino acid dipepetide frequency for Methanomassiliicoccaceae archaeon DOK

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.56AlaAla: 7.56 ± 0.153
1.152AlaCys: 1.152 ± 0.054
5.683AlaAsp: 5.683 ± 0.09
6.251AlaGlu: 6.251 ± 0.121
2.914AlaPhe: 2.914 ± 0.073
6.556AlaGly: 6.556 ± 0.118
1.228AlaHis: 1.228 ± 0.051
5.102AlaIle: 5.102 ± 0.107
3.656AlaLys: 3.656 ± 0.101
7.115AlaLeu: 7.115 ± 0.135
3.093AlaMet: 3.093 ± 0.088
2.272AlaAsn: 2.272 ± 0.068
2.518AlaPro: 2.518 ± 0.076
1.964AlaGln: 1.964 ± 0.068
4.188AlaArg: 4.188 ± 0.121
4.828AlaSer: 4.828 ± 0.107
3.995AlaThr: 3.995 ± 0.14
7.836AlaVal: 7.836 ± 0.13
0.696AlaTrp: 0.696 ± 0.035
2.514AlaTyr: 2.514 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
1.172CysAla: 1.172 ± 0.052
0.325CysCys: 0.325 ± 0.026
1.075CysAsp: 1.075 ± 0.048
0.914CysGlu: 0.914 ± 0.043
0.503CysPhe: 0.503 ± 0.027
1.87CysGly: 1.87 ± 0.08
0.332CysHis: 0.332 ± 0.031
0.986CysIle: 0.986 ± 0.048
0.624CysLys: 0.624 ± 0.034
1.143CysLeu: 1.143 ± 0.046
0.467CysMet: 0.467 ± 0.027
0.463CysAsn: 0.463 ± 0.031
1.106CysPro: 1.106 ± 0.052
0.298CysGln: 0.298 ± 0.021
1.152CysArg: 1.152 ± 0.054
0.99CysSer: 0.99 ± 0.045
0.83CysThr: 0.83 ± 0.039
1.142CysVal: 1.142 ± 0.042
0.171CysTrp: 0.171 ± 0.018
0.503CysTyr: 0.503 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
5.895AspAla: 5.895 ± 0.11
0.988AspCys: 0.988 ± 0.04
4.792AspAsp: 4.792 ± 0.1
5.037AspGlu: 5.037 ± 0.095
2.406AspPhe: 2.406 ± 0.062
6.658AspGly: 6.658 ± 0.165
1.158AspHis: 1.158 ± 0.049
4.786AspIle: 4.786 ± 0.102
2.444AspLys: 2.444 ± 0.079
6.312AspLeu: 6.312 ± 0.131
2.478AspMet: 2.478 ± 0.075
1.986AspAsn: 1.986 ± 0.079
3.533AspPro: 3.533 ± 0.086
1.324AspGln: 1.324 ± 0.05
4.536AspArg: 4.536 ± 0.101
4.245AspSer: 4.245 ± 0.109
3.338AspThr: 3.338 ± 0.092
6.04AspVal: 6.04 ± 0.11
0.727AspTrp: 0.727 ± 0.034
2.478AspTyr: 2.478 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
5.749GluAla: 5.749 ± 0.128
1.051GluCys: 1.051 ± 0.055
4.88GluAsp: 4.88 ± 0.098
4.987GluGlu: 4.987 ± 0.132
2.622GluPhe: 2.622 ± 0.073
5.241GluGly: 5.241 ± 0.126
1.212GluHis: 1.212 ± 0.048
4.485GluIle: 4.485 ± 0.094
3.322GluLys: 3.322 ± 0.091
5.313GluLeu: 5.313 ± 0.1
2.597GluMet: 2.597 ± 0.081
2.372GluAsn: 2.372 ± 0.074
2.601GluPro: 2.601 ± 0.109
1.585GluGln: 1.585 ± 0.057
4.209GluArg: 4.209 ± 0.125
4.245GluSer: 4.245 ± 0.09
3.618GluThr: 3.618 ± 0.096
4.974GluVal: 4.974 ± 0.096
0.721GluTrp: 0.721 ± 0.038
2.559GluTyr: 2.559 ± 0.068
0.0GluXaa: 0.0 ± 0.0
Phe
2.676PheAla: 2.676 ± 0.08
0.667PheCys: 0.667 ± 0.036
2.761PheAsp: 2.761 ± 0.071
2.433PheGlu: 2.433 ± 0.064
1.246PhePhe: 1.246 ± 0.053
3.226PheGly: 3.226 ± 0.081
0.573PheHis: 0.573 ± 0.034
2.079PheIle: 2.079 ± 0.07
1.335PheLys: 1.335 ± 0.05
2.895PheLeu: 2.895 ± 0.093
1.243PheMet: 1.243 ± 0.049
1.196PheAsn: 1.196 ± 0.052
1.394PhePro: 1.394 ± 0.054
0.813PheGln: 0.813 ± 0.036
2.058PheArg: 2.058 ± 0.075
2.516PheSer: 2.516 ± 0.064
2.274PheThr: 2.274 ± 0.084
2.941PheVal: 2.941 ± 0.076
0.341PheTrp: 0.341 ± 0.027
1.248PheTyr: 1.248 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
6.352GlyAla: 6.352 ± 0.148
1.616GlyCys: 1.616 ± 0.064
5.472GlyAsp: 5.472 ± 0.134
5.006GlyGlu: 5.006 ± 0.095
3.214GlyPhe: 3.214 ± 0.083
6.07GlyGly: 6.07 ± 0.151
1.407GlyHis: 1.407 ± 0.058
5.968GlyIle: 5.968 ± 0.101
4.303GlyLys: 4.303 ± 0.11
6.453GlyLeu: 6.453 ± 0.118
3.122GlyMet: 3.122 ± 0.075
2.907GlyAsn: 2.907 ± 0.068
2.509GlyPro: 2.509 ± 0.07
1.89GlyGln: 1.89 ± 0.063
5.08GlyArg: 5.08 ± 0.134
5.706GlySer: 5.706 ± 0.132
5.454GlyThr: 5.454 ± 0.209
6.372GlyVal: 6.372 ± 0.114
0.945GlyTrp: 0.945 ± 0.047
3.12GlyTyr: 3.12 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.16HisAla: 1.16 ± 0.05
0.372HisCys: 0.372 ± 0.025
1.158HisAsp: 1.158 ± 0.059
0.913HisGlu: 0.913 ± 0.041
0.512HisPhe: 0.512 ± 0.031
1.508HisGly: 1.508 ± 0.056
0.361HisHis: 0.361 ± 0.034
1.106HisIle: 1.106 ± 0.051
0.534HisLys: 0.534 ± 0.03
1.327HisLeu: 1.327 ± 0.042
0.559HisMet: 0.559 ± 0.031
0.537HisAsn: 0.537 ± 0.03
1.033HisPro: 1.033 ± 0.05
0.381HisGln: 0.381 ± 0.026
1.077HisArg: 1.077 ± 0.052
0.967HisSer: 0.967 ± 0.044
0.884HisThr: 0.884 ± 0.041
1.248HisVal: 1.248 ± 0.051
0.22HisTrp: 0.22 ± 0.021
0.505HisTyr: 0.505 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.618IleAla: 5.618 ± 0.108
0.995IleCys: 0.995 ± 0.044
4.725IleAsp: 4.725 ± 0.092
4.083IleGlu: 4.083 ± 0.101
1.807IlePhe: 1.807 ± 0.065
5.419IleGly: 5.419 ± 0.115
1.082IleHis: 1.082 ± 0.041
3.868IleIle: 3.868 ± 0.092
2.317IleLys: 2.317 ± 0.082
5.335IleLeu: 5.335 ± 0.111
1.886IleMet: 1.886 ± 0.057
2.005IleAsn: 2.005 ± 0.072
3.172IlePro: 3.172 ± 0.069
1.52IleGln: 1.52 ± 0.056
3.728IleArg: 3.728 ± 0.101
4.262IleSer: 4.262 ± 0.107
4.115IleThr: 4.115 ± 0.128
5.849IleVal: 5.849 ± 0.111
0.465IleTrp: 0.465 ± 0.03
1.771IleTyr: 1.771 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
3.901LysAla: 3.901 ± 0.107
0.662LysCys: 0.662 ± 0.038
3.107LysAsp: 3.107 ± 0.084
3.134LysGlu: 3.134 ± 0.085
1.239LysPhe: 1.239 ± 0.047
3.616LysGly: 3.616 ± 0.086
0.633LysHis: 0.633 ± 0.034
2.474LysIle: 2.474 ± 0.083
2.5LysLys: 2.5 ± 0.087
3.178LysLeu: 3.178 ± 0.07
1.284LysMet: 1.284 ± 0.052
1.533LysAsn: 1.533 ± 0.07
1.627LysPro: 1.627 ± 0.055
1.068LysGln: 1.068 ± 0.053
2.48LysArg: 2.48 ± 0.072
2.572LysSer: 2.572 ± 0.075
2.62LysThr: 2.62 ± 0.071
3.823LysVal: 3.823 ± 0.083
0.382LysTrp: 0.382 ± 0.028
1.448LysTyr: 1.448 ± 0.061
0.0LysXaa: 0.0 ± 0.0
Leu
6.703LeuAla: 6.703 ± 0.126
1.225LeuCys: 1.225 ± 0.053
6.152LeuAsp: 6.152 ± 0.13
5.596LeuGlu: 5.596 ± 0.114
3.057LeuPhe: 3.057 ± 0.094
6.534LeuGly: 6.534 ± 0.132
1.154LeuHis: 1.154 ± 0.046
4.866LeuIle: 4.866 ± 0.112
3.715LeuLys: 3.715 ± 0.089
5.939LeuLeu: 5.939 ± 0.131
2.945LeuMet: 2.945 ± 0.076
2.824LeuAsn: 2.824 ± 0.094
3.066LeuPro: 3.066 ± 0.083
1.704LeuGln: 1.704 ± 0.06
5.019LeuArg: 5.019 ± 0.138
5.793LeuSer: 5.793 ± 0.116
4.653LeuThr: 4.653 ± 0.105
6.184LeuVal: 6.184 ± 0.123
0.664LeuTrp: 0.664 ± 0.039
2.521LeuTyr: 2.521 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
3.109MetAla: 3.109 ± 0.079
0.552MetCys: 0.552 ± 0.034
2.808MetAsp: 2.808 ± 0.083
2.373MetGlu: 2.373 ± 0.065
1.288MetPhe: 1.288 ± 0.051
2.669MetGly: 2.669 ± 0.085
0.554MetHis: 0.554 ± 0.034
2.067MetIle: 2.067 ± 0.071
1.486MetLys: 1.486 ± 0.058
2.649MetLeu: 2.649 ± 0.081
1.262MetMet: 1.262 ± 0.05
1.107MetAsn: 1.107 ± 0.044
1.358MetPro: 1.358 ± 0.047
0.748MetGln: 0.748 ± 0.039
1.962MetArg: 1.962 ± 0.062
2.64MetSer: 2.64 ± 0.079
2.339MetThr: 2.339 ± 0.058
2.693MetVal: 2.693 ± 0.08
0.301MetTrp: 0.301 ± 0.022
1.014MetTyr: 1.014 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
2.693AsnAla: 2.693 ± 0.095
0.532AsnCys: 0.532 ± 0.031
1.921AsnAsp: 1.921 ± 0.068
1.74AsnGlu: 1.74 ± 0.059
0.947AsnPhe: 0.947 ± 0.044
3.484AsnGly: 3.484 ± 0.125
0.577AsnHis: 0.577 ± 0.038
2.287AsnIle: 2.287 ± 0.06
1.253AsnLys: 1.253 ± 0.056
2.709AsnLeu: 2.709 ± 0.078
1.095AsnMet: 1.095 ± 0.046
1.174AsnAsn: 1.174 ± 0.074
1.926AsnPro: 1.926 ± 0.057
0.729AsnGln: 0.729 ± 0.043
1.95AsnArg: 1.95 ± 0.071
1.986AsnSer: 1.986 ± 0.074
1.751AsnThr: 1.751 ± 0.06
2.806AsnVal: 2.806 ± 0.1
0.319AsnTrp: 0.319 ± 0.021
1.151AsnTyr: 1.151 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
2.968ProAla: 2.968 ± 0.076
0.584ProCys: 0.584 ± 0.029
3.452ProAsp: 3.452 ± 0.077
4.063ProGlu: 4.063 ± 0.104
1.511ProPhe: 1.511 ± 0.056
3.372ProGly: 3.372 ± 0.099
0.689ProHis: 0.689 ± 0.035
2.188ProIle: 2.188 ± 0.071
1.784ProLys: 1.784 ± 0.065
2.931ProLeu: 2.931 ± 0.079
1.226ProMet: 1.226 ± 0.057
1.124ProAsn: 1.124 ± 0.047
1.243ProPro: 1.243 ± 0.051
0.977ProGln: 0.977 ± 0.044
2.032ProArg: 2.032 ± 0.07
2.673ProSer: 2.673 ± 0.07
1.984ProThr: 1.984 ± 0.07
3.656ProVal: 3.656 ± 0.088
0.384ProTrp: 0.384 ± 0.028
1.45ProTyr: 1.45 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
1.903GlnAla: 1.903 ± 0.061
0.361GlnCys: 0.361 ± 0.025
1.351GlnAsp: 1.351 ± 0.048
1.551GlnGlu: 1.551 ± 0.051
0.797GlnPhe: 0.797 ± 0.034
1.618GlnGly: 1.618 ± 0.054
0.326GlnHis: 0.326 ± 0.025
1.535GlnIle: 1.535 ± 0.053
1.208GlnLys: 1.208 ± 0.05
1.782GlnLeu: 1.782 ± 0.058
0.952GlnMet: 0.952 ± 0.042
0.871GlnAsn: 0.871 ± 0.037
0.757GlnPro: 0.757 ± 0.038
0.656GlnGln: 0.656 ± 0.041
1.538GlnArg: 1.538 ± 0.055
1.418GlnSer: 1.418 ± 0.05
1.398GlnThr: 1.398 ± 0.059
1.582GlnVal: 1.582 ± 0.053
0.263GlnTrp: 0.263 ± 0.023
0.911GlnTyr: 0.911 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
4.355ArgAla: 4.355 ± 0.12
1.014ArgCys: 1.014 ± 0.053
4.276ArgAsp: 4.276 ± 0.109
4.29ArgGlu: 4.29 ± 0.113
2.491ArgPhe: 2.491 ± 0.078
4.027ArgGly: 4.027 ± 0.104
1.077ArgHis: 1.077 ± 0.046
4.164ArgIle: 4.164 ± 0.092
2.844ArgLys: 2.844 ± 0.086
4.527ArgLeu: 4.527 ± 0.124
2.489ArgMet: 2.489 ± 0.078
2.285ArgAsn: 2.285 ± 0.068
2.128ArgPro: 2.128 ± 0.076
1.461ArgGln: 1.461 ± 0.056
4.476ArgArg: 4.476 ± 0.146
3.607ArgSer: 3.607 ± 0.102
3.167ArgThr: 3.167 ± 0.094
3.996ArgVal: 3.996 ± 0.102
0.564ArgTrp: 0.564 ± 0.032
2.243ArgTyr: 2.243 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
4.886SerAla: 4.886 ± 0.106
0.911SerCys: 0.911 ± 0.045
4.75SerAsp: 4.75 ± 0.117
4.644SerGlu: 4.644 ± 0.093
2.408SerPhe: 2.408 ± 0.066
6.213SerGly: 6.213 ± 0.143
0.99SerHis: 0.99 ± 0.04
4.049SerIle: 4.049 ± 0.102
2.925SerLys: 2.925 ± 0.068
5.169SerLeu: 5.169 ± 0.115
2.397SerMet: 2.397 ± 0.072
2.036SerAsn: 2.036 ± 0.08
2.276SerPro: 2.276 ± 0.061
1.6SerGln: 1.6 ± 0.058
3.684SerArg: 3.684 ± 0.096
4.435SerSer: 4.435 ± 0.116
3.327SerThr: 3.327 ± 0.101
5.776SerVal: 5.776 ± 0.122
0.631SerTrp: 0.631 ± 0.031
2.202SerTyr: 2.202 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
4.48ThrAla: 4.48 ± 0.117
0.727ThrCys: 0.727 ± 0.037
3.946ThrAsp: 3.946 ± 0.113
3.677ThrGlu: 3.677 ± 0.094
2.168ThrPhe: 2.168 ± 0.082
5.244ThrGly: 5.244 ± 0.138
0.878ThrHis: 0.878 ± 0.042
4.207ThrIle: 4.207 ± 0.169
1.986ThrLys: 1.986 ± 0.066
4.806ThrLeu: 4.806 ± 0.137
1.686ThrMet: 1.686 ± 0.054
1.755ThrAsn: 1.755 ± 0.078
2.5ThrPro: 2.5 ± 0.08
1.098ThrGln: 1.098 ± 0.045
2.4ThrArg: 2.4 ± 0.076
3.515ThrSer: 3.515 ± 0.097
3.064ThrThr: 3.064 ± 0.128
6.509ThrVal: 6.509 ± 0.222
0.534ThrTrp: 0.534 ± 0.037
1.951ThrTyr: 1.951 ± 0.097
0.0ThrXaa: 0.0 ± 0.0
Val
6.581ValAla: 6.581 ± 0.127
1.522ValCys: 1.522 ± 0.057
5.506ValAsp: 5.506 ± 0.107
5.005ValGlu: 5.005 ± 0.094
3.151ValPhe: 3.151 ± 0.094
6.013ValGly: 6.013 ± 0.108
1.326ValHis: 1.326 ± 0.054
5.154ValIle: 5.154 ± 0.114
3.441ValLys: 3.441 ± 0.091
7.133ValLeu: 7.133 ± 0.121
2.748ValMet: 2.748 ± 0.079
2.876ValAsn: 2.876 ± 0.105
3.883ValPro: 3.883 ± 0.081
1.921ValGln: 1.921 ± 0.05
5.216ValArg: 5.216 ± 0.117
6.013ValSer: 6.013 ± 0.126
5.508ValThr: 5.508 ± 0.197
7.03ValVal: 7.03 ± 0.136
0.79ValTrp: 0.79 ± 0.04
2.839ValTyr: 2.839 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.678TrpAla: 0.678 ± 0.037
0.184TrpCys: 0.184 ± 0.021
0.703TrpAsp: 0.703 ± 0.039
0.624TrpGlu: 0.624 ± 0.033
0.424TrpPhe: 0.424 ± 0.028
0.644TrpGly: 0.644 ± 0.033
0.18TrpHis: 0.18 ± 0.019
0.646TrpIle: 0.646 ± 0.039
0.453TrpLys: 0.453 ± 0.027
0.748TrpLeu: 0.748 ± 0.036
0.37TrpMet: 0.37 ± 0.028
0.473TrpAsn: 0.473 ± 0.033
0.28TrpPro: 0.28 ± 0.022
0.249TrpGln: 0.249 ± 0.02
0.581TrpArg: 0.581 ± 0.033
0.592TrpSer: 0.592 ± 0.037
0.61TrpThr: 0.61 ± 0.039
0.644TrpVal: 0.644 ± 0.031
0.121TrpTrp: 0.121 ± 0.016
0.442TrpTyr: 0.442 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.68TyrAla: 2.68 ± 0.073
0.628TyrCys: 0.628 ± 0.031
2.644TyrAsp: 2.644 ± 0.078
2.022TyrGlu: 2.022 ± 0.064
1.212TyrPhe: 1.212 ± 0.05
2.981TyrGly: 2.981 ± 0.076
0.622TyrHis: 0.622 ± 0.03
2.007TyrIle: 2.007 ± 0.055
1.152TyrLys: 1.152 ± 0.045
2.853TyrLeu: 2.853 ± 0.077
1.078TyrMet: 1.078 ± 0.051
1.232TyrAsn: 1.232 ± 0.052
1.383TyrPro: 1.383 ± 0.048
0.792TyrGln: 0.792 ± 0.042
2.115TyrArg: 2.115 ± 0.065
2.308TyrSer: 2.308 ± 0.082
2.204TyrThr: 2.204 ± 0.113
2.554TyrVal: 2.554 ± 0.07
0.402TyrTrp: 0.402 ± 0.027
1.295TyrTyr: 1.295 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1835 proteins (554497 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski