Amino acid dipepetide frequency for Bos mutus (wild yak)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.301AlaAla: 6.301 ± 0.049	1.482AlaCys: 1.482 ± 0.017	2.834AlaAsp: 2.834 ± 0.019	4.582AlaGlu: 4.582 ± 0.035	2.811AlaPhe: 2.811 ± 0.023	4.602AlaGly: 4.602 ± 0.032	1.604AlaHis: 1.604 ± 0.014	2.927AlaIle: 2.927 ± 0.024	3.354AlaLys: 3.354 ± 0.026	7.291AlaLeu: 7.291 ± 0.036	1.507AlaMet: 1.507 ± 0.018	1.99AlaAsn: 1.99 ± 0.017	4.112AlaPro: 4.112 ± 0.037	3.115AlaGln: 3.115 ± 0.026	3.588AlaArg: 3.588 ± 0.028	5.68AlaSer: 5.68 ± 0.03	3.46AlaThr: 3.46 ± 0.022	4.852AlaVal: 4.852 ± 0.029	0.819AlaTrp: 0.819 ± 0.012	1.584AlaTyr: 1.584 ± 0.015	0.001AlaXaa: 0.001 ± 0.0
Cys	1.348CysAla: 1.348 ± 0.016	0.678CysCys: 0.678 ± 0.017	1.065CysAsp: 1.065 ± 0.017	1.259CysGlu: 1.259 ± 0.017	0.931CysPhe: 0.931 ± 0.011	1.866CysGly: 1.866 ± 0.033	0.679CysHis: 0.679 ± 0.01	1.018CysIle: 1.018 ± 0.013	1.151CysLys: 1.151 ± 0.016	2.281CysLeu: 2.281 ± 0.019	0.425CysMet: 0.425 ± 0.008	0.803CysAsn: 0.803 ± 0.013	1.433CysPro: 1.433 ± 0.024	1.066CysGln: 1.066 ± 0.016	1.311CysArg: 1.311 ± 0.018	2.102CysSer: 2.102 ± 0.022	1.153CysThr: 1.153 ± 0.015	1.405CysVal: 1.405 ± 0.017	0.33CysTrp: 0.33 ± 0.007	0.629CysTyr: 0.629 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	2.772AspAla: 2.772 ± 0.019	1.036AspCys: 1.036 ± 0.013	2.468AspAsp: 2.468 ± 0.024	3.248AspGlu: 3.248 ± 0.028	2.139AspPhe: 2.139 ± 0.016	3.131AspGly: 3.131 ± 0.025	1.151AspHis: 1.151 ± 0.011	2.526AspIle: 2.526 ± 0.02	2.469AspLys: 2.469 ± 0.022	4.929AspLeu: 4.929 ± 0.029	1.056AspMet: 1.056 ± 0.012	1.591AspAsn: 1.591 ± 0.017	2.909AspPro: 2.909 ± 0.019	1.795AspGln: 1.795 ± 0.016	2.46AspArg: 2.46 ± 0.02	4.036AspSer: 4.036 ± 0.032	2.454AspThr: 2.454 ± 0.017	3.012AspVal: 3.012 ± 0.018	0.631AspTrp: 0.631 ± 0.009	1.418AspTyr: 1.418 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.15GluAla: 5.15 ± 0.034	1.416GluCys: 1.416 ± 0.031	4.234GluAsp: 4.234 ± 0.028	7.577GluGlu: 7.577 ± 0.073	2.052GluPhe: 2.052 ± 0.018	4.104GluGly: 4.104 ± 0.026	1.44GluHis: 1.44 ± 0.014	3.126GluIle: 3.126 ± 0.025	5.257GluLys: 5.257 ± 0.044	6.234GluLeu: 6.234 ± 0.037	1.582GluMet: 1.582 ± 0.016	2.994GluAsn: 2.994 ± 0.026	3.158GluPro: 3.158 ± 0.024	2.959GluGln: 2.959 ± 0.026	3.832GluArg: 3.832 ± 0.035	4.206GluSer: 4.206 ± 0.029	3.356GluThr: 3.356 ± 0.025	4.102GluVal: 4.102 ± 0.028	0.714GluTrp: 0.714 ± 0.012	1.512GluTyr: 1.512 ± 0.014	0.0GluXaa: 0.0 ± 0.0
Phe	2.017PheAla: 2.017 ± 0.015	1.12PheCys: 1.12 ± 0.011	1.664PheAsp: 1.664 ± 0.014	1.944PheGlu: 1.944 ± 0.015	1.941PhePhe: 1.941 ± 0.021	2.273PheGly: 2.273 ± 0.023	1.063PheHis: 1.063 ± 0.012	2.083PheIle: 2.083 ± 0.019	1.765PheLys: 1.765 ± 0.02	4.655PheLeu: 4.655 ± 0.029	0.784PheMet: 0.784 ± 0.011	1.368PheAsn: 1.368 ± 0.013	2.086PhePro: 2.086 ± 0.019	1.818PheGln: 1.818 ± 0.013	2.004PheArg: 2.004 ± 0.017	3.651PheSer: 3.651 ± 0.026	2.155PheThr: 2.155 ± 0.02	2.307PheVal: 2.307 ± 0.019	0.525PheTrp: 0.525 ± 0.008	1.357PheTyr: 1.357 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.432GlyAla: 4.432 ± 0.033	1.374GlyCys: 1.374 ± 0.017	3.025GlyAsp: 3.025 ± 0.027	4.041GlyGlu: 4.041 ± 0.037	2.506GlyPhe: 2.506 ± 0.026	4.758GlyGly: 4.758 ± 0.044	1.687GlyHis: 1.687 ± 0.016	2.814GlyIle: 2.814 ± 0.021	3.775GlyLys: 3.775 ± 0.031	6.071GlyLeu: 6.071 ± 0.039	1.251GlyMet: 1.251 ± 0.016	2.367GlyAsn: 2.367 ± 0.018	4.213GlyPro: 4.213 ± 0.062	2.708GlyGln: 2.708 ± 0.029	3.731GlyArg: 3.731 ± 0.029	5.66GlySer: 5.66 ± 0.043	3.529GlyThr: 3.529 ± 0.022	3.61GlyVal: 3.61 ± 0.029	0.799GlyTrp: 0.799 ± 0.014	1.697GlyTyr: 1.697 ± 0.018	0.0GlyXaa: 0.0 ± 0.0
His	1.32HisAla: 1.32 ± 0.013	0.719HisCys: 0.719 ± 0.011	0.859HisAsp: 0.859 ± 0.01	1.244HisGlu: 1.244 ± 0.014	1.18HisPhe: 1.18 ± 0.013	1.524HisGly: 1.524 ± 0.023	0.891HisHis: 0.891 ± 0.013	1.26HisIle: 1.26 ± 0.013	1.237HisLys: 1.237 ± 0.015	3.025HisLeu: 3.025 ± 0.02	0.581HisMet: 0.581 ± 0.01	0.815HisAsn: 0.815 ± 0.008	1.733HisPro: 1.733 ± 0.028	1.365HisGln: 1.365 ± 0.021	1.613HisArg: 1.613 ± 0.017	2.296HisSer: 2.296 ± 0.02	1.678HisThr: 1.678 ± 0.027	1.522HisVal: 1.522 ± 0.014	0.354HisTrp: 0.354 ± 0.007	0.853HisTyr: 0.853 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	2.566IleAla: 2.566 ± 0.019	1.215IleCys: 1.215 ± 0.015	1.953IleAsp: 1.953 ± 0.018	2.452IleGlu: 2.452 ± 0.02	2.101IlePhe: 2.101 ± 0.023	2.19IleGly: 2.19 ± 0.021	1.489IleHis: 1.489 ± 0.02	2.573IleIle: 2.573 ± 0.024	2.663IleLys: 2.663 ± 0.026	4.98IleLeu: 4.98 ± 0.034	1.041IleMet: 1.041 ± 0.013	1.901IleAsn: 1.901 ± 0.023	2.653IlePro: 2.653 ± 0.021	2.313IleGln: 2.313 ± 0.018	2.395IleArg: 2.395 ± 0.015	3.843IleSer: 3.843 ± 0.025	2.607IleThr: 2.607 ± 0.021	2.57IleVal: 2.57 ± 0.022	0.558IleTrp: 0.558 ± 0.008	1.603IleTyr: 1.603 ± 0.021	0.001IleXaa: 0.001 ± 0.0
Lys	4.155LysAla: 4.155 ± 0.032	1.148LysCys: 1.148 ± 0.019	3.056LysAsp: 3.056 ± 0.024	4.99LysGlu: 4.99 ± 0.039	1.713LysPhe: 1.713 ± 0.016	3.229LysGly: 3.229 ± 0.035	1.401LysHis: 1.401 ± 0.015	2.827LysIle: 2.827 ± 0.027	4.696LysLys: 4.696 ± 0.04	5.136LysLeu: 5.136 ± 0.032	1.46LysMet: 1.46 ± 0.014	2.357LysAsn: 2.357 ± 0.021	3.112LysPro: 3.112 ± 0.029	2.527LysGln: 2.527 ± 0.022	3.277LysArg: 3.277 ± 0.025	3.799LysSer: 3.799 ± 0.029	3.113LysThr: 3.113 ± 0.022	3.414LysVal: 3.414 ± 0.025	0.624LysTrp: 0.624 ± 0.009	1.558LysTyr: 1.558 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.077LeuAla: 7.077 ± 0.035	2.322LeuCys: 2.322 ± 0.022	4.669LeuAsp: 4.669 ± 0.028	6.99LeuGlu: 6.99 ± 0.044	3.75LeuPhe: 3.75 ± 0.028	6.178LeuGly: 6.178 ± 0.031	2.833LeuHis: 2.833 ± 0.021	4.23LeuIle: 4.23 ± 0.028	5.751LeuLys: 5.751 ± 0.036	11.362LeuLeu: 11.362 ± 0.059	2.028LeuMet: 2.028 ± 0.016	3.586LeuAsn: 3.586 ± 0.027	6.021LeuPro: 6.021 ± 0.043	5.682LeuGln: 5.682 ± 0.039	6.034LeuArg: 6.034 ± 0.038	8.305LeuSer: 8.305 ± 0.039	5.327LeuThr: 5.327 ± 0.029	5.895LeuVal: 5.895 ± 0.033	1.215LeuTrp: 1.215 ± 0.014	2.665LeuTyr: 2.665 ± 0.021	0.001LeuXaa: 0.001 ± 0.0
Met	1.944MetAla: 1.944 ± 0.018	0.404MetCys: 0.404 ± 0.008	1.206MetAsp: 1.206 ± 0.013	1.727MetGlu: 1.727 ± 0.016	0.751MetPhe: 0.751 ± 0.009	1.278MetGly: 1.278 ± 0.016	0.438MetHis: 0.438 ± 0.007	0.892MetIle: 0.892 ± 0.01	1.456MetLys: 1.456 ± 0.014	2.049MetLeu: 2.049 ± 0.019	0.543MetMet: 0.543 ± 0.01	0.892MetAsn: 0.892 ± 0.012	1.01MetPro: 1.01 ± 0.013	0.87MetGln: 0.87 ± 0.011	1.001MetArg: 1.001 ± 0.011	1.547MetSer: 1.547 ± 0.014	1.101MetThr: 1.101 ± 0.013	1.403MetVal: 1.403 ± 0.016	0.23MetTrp: 0.23 ± 0.006	0.72MetTyr: 0.72 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	1.997AsnAla: 1.997 ± 0.015	0.835AsnCys: 0.835 ± 0.012	1.438AsnAsp: 1.438 ± 0.019	2.123AsnGlu: 2.123 ± 0.021	1.495AsnPhe: 1.495 ± 0.016	2.3AsnGly: 2.3 ± 0.021	0.953AsnHis: 0.953 ± 0.012	2.144AsnIle: 2.144 ± 0.021	2.252AsnLys: 2.252 ± 0.02	3.758AsnLeu: 3.758 ± 0.025	0.849AsnMet: 0.849 ± 0.011	1.465AsnAsn: 1.465 ± 0.016	2.25AsnPro: 2.25 ± 0.017	1.602AsnGln: 1.602 ± 0.017	1.777AsnArg: 1.777 ± 0.014	3.023AsnSer: 3.023 ± 0.021	1.922AsnThr: 1.922 ± 0.018	2.159AsnVal: 2.159 ± 0.017	0.444AsnTrp: 0.444 ± 0.009	1.094AsnTyr: 1.094 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	4.644ProAla: 4.644 ± 0.039	1.181ProCys: 1.181 ± 0.02	2.738ProAsp: 2.738 ± 0.021	4.45ProGlu: 4.45 ± 0.028	2.03ProPhe: 2.03 ± 0.014	5.144ProGly: 5.144 ± 0.087	1.424ProHis: 1.424 ± 0.014	1.832ProIle: 1.832 ± 0.015	2.834ProLys: 2.834 ± 0.026	5.481ProLeu: 5.481 ± 0.036	1.126ProMet: 1.126 ± 0.012	1.764ProAsn: 1.764 ± 0.016	5.632ProPro: 5.632 ± 0.068	2.787ProGln: 2.787 ± 0.025	3.376ProArg: 3.376 ± 0.026	5.618ProSer: 5.618 ± 0.049	2.992ProThr: 2.992 ± 0.025	3.79ProVal: 3.79 ± 0.032	0.723ProTrp: 0.723 ± 0.011	1.553ProTyr: 1.553 ± 0.02	0.001ProXaa: 0.001 ± 0.0
Gln	3.422GlnAla: 3.422 ± 0.028	0.913GlnCys: 0.913 ± 0.014	2.254GlnAsp: 2.254 ± 0.017	3.794GlnGlu: 3.794 ± 0.036	1.35GlnPhe: 1.35 ± 0.015	2.83GlnGly: 2.83 ± 0.026	1.246GlnHis: 1.246 ± 0.015	1.972GlnIle: 1.972 ± 0.014	2.942GlnLys: 2.942 ± 0.023	4.681GlnLeu: 4.681 ± 0.033	1.086GlnMet: 1.086 ± 0.012	1.759GlnAsn: 1.759 ± 0.015	2.69GlnPro: 2.69 ± 0.024	2.705GlnGln: 2.705 ± 0.034	2.956GlnArg: 2.956 ± 0.024	3.016GlnSer: 3.016 ± 0.026	2.288GlnThr: 2.288 ± 0.019	2.837GlnVal: 2.837 ± 0.021	0.534GlnTrp: 0.534 ± 0.01	1.099GlnTyr: 1.099 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	3.82ArgAla: 3.82 ± 0.025	1.227ArgCys: 1.227 ± 0.019	2.689ArgAsp: 2.689 ± 0.024	3.907ArgGlu: 3.907 ± 0.034	1.901ArgPhe: 1.901 ± 0.015	3.566ArgGly: 3.566 ± 0.035	1.545ArgHis: 1.545 ± 0.018	2.474ArgIle: 2.474 ± 0.02	3.699ArgLys: 3.699 ± 0.024	5.466ArgLeu: 5.466 ± 0.033	1.168ArgMet: 1.168 ± 0.012	2.153ArgAsn: 2.153 ± 0.015	3.208ArgPro: 3.208 ± 0.03	2.55ArgGln: 2.55 ± 0.022	4.177ArgArg: 4.177 ± 0.035	4.093ArgSer: 4.093 ± 0.038	2.757ArgThr: 2.757 ± 0.02	3.207ArgVal: 3.207 ± 0.022	0.699ArgTrp: 0.699 ± 0.01	1.544ArgTyr: 1.544 ± 0.014	0.001ArgXaa: 0.001 ± 0.0
Ser	5.214SerAla: 5.214 ± 0.032	1.917SerCys: 1.917 ± 0.017	3.749SerAsp: 3.749 ± 0.025	5.045SerGlu: 5.045 ± 0.035	3.227SerPhe: 3.227 ± 0.022	5.511SerGly: 5.511 ± 0.042	2.185SerHis: 2.185 ± 0.019	3.298SerIle: 3.298 ± 0.027	3.997SerLys: 3.997 ± 0.028	8.372SerLeu: 8.372 ± 0.037	1.559SerMet: 1.559 ± 0.013	2.559SerAsn: 2.559 ± 0.018	5.835SerPro: 5.835 ± 0.046	3.819SerGln: 3.819 ± 0.029	4.47SerArg: 4.47 ± 0.039	9.058SerSer: 9.058 ± 0.07	4.431SerThr: 4.431 ± 0.029	5.043SerVal: 5.043 ± 0.032	1.108SerTrp: 1.108 ± 0.012	2.194SerTyr: 2.194 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	3.706ThrAla: 3.706 ± 0.024	1.405ThrCys: 1.405 ± 0.018	2.433ThrAsp: 2.433 ± 0.016	3.45ThrGlu: 3.45 ± 0.025	2.206ThrPhe: 2.206 ± 0.017	3.603ThrGly: 3.603 ± 0.036	1.4ThrHis: 1.4 ± 0.022	2.491ThrIle: 2.491 ± 0.022	2.588ThrLys: 2.588 ± 0.021	5.436ThrLeu: 5.436 ± 0.028	1.107ThrMet: 1.107 ± 0.013	1.664ThrAsn: 1.664 ± 0.014	3.562ThrPro: 3.562 ± 0.031	2.278ThrGln: 2.278 ± 0.018	2.426ThrArg: 2.426 ± 0.02	4.498ThrSer: 4.498 ± 0.032	2.911ThrThr: 2.911 ± 0.034	4.042ThrVal: 4.042 ± 0.026	0.693ThrTrp: 0.693 ± 0.011	1.488ThrTyr: 1.488 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	4.331ValAla: 4.331 ± 0.026	1.563ValCys: 1.563 ± 0.019	2.902ValAsp: 2.902 ± 0.02	3.702ValGlu: 3.702 ± 0.024	2.616ValPhe: 2.616 ± 0.021	3.48ValGly: 3.48 ± 0.028	1.591ValHis: 1.591 ± 0.016	3.092ValIle: 3.092 ± 0.024	3.381ValLys: 3.381 ± 0.024	6.625ValLeu: 6.625 ± 0.04	1.374ValMet: 1.374 ± 0.015	2.234ValAsn: 2.234 ± 0.018	3.645ValPro: 3.645 ± 0.026	2.683ValGln: 2.683 ± 0.023	3.044ValArg: 3.044 ± 0.021	4.989ValSer: 4.989 ± 0.032	3.884ValThr: 3.884 ± 0.028	4.155ValVal: 4.155 ± 0.027	0.768ValTrp: 0.768 ± 0.012	1.713ValTyr: 1.713 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.831TrpAla: 0.831 ± 0.011	0.262TrpCys: 0.262 ± 0.007	0.673TrpAsp: 0.673 ± 0.009	0.825TrpGlu: 0.825 ± 0.01	0.482TrpPhe: 0.482 ± 0.008	0.771TrpGly: 0.771 ± 0.012	0.305TrpHis: 0.305 ± 0.007	0.612TrpIle: 0.612 ± 0.01	0.818TrpLys: 0.818 ± 0.011	1.228TrpLeu: 1.228 ± 0.013	0.317TrpMet: 0.317 ± 0.006	0.544TrpAsn: 0.544 ± 0.008	0.526TrpPro: 0.526 ± 0.009	0.517TrpGln: 0.517 ± 0.009	0.78TrpArg: 0.78 ± 0.011	0.875TrpSer: 0.875 ± 0.014	0.664TrpThr: 0.664 ± 0.011	0.746TrpVal: 0.746 ± 0.011	0.201TrpTrp: 0.201 ± 0.006	0.368TrpTyr: 0.368 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.45TyrAla: 1.45 ± 0.015	0.719TyrCys: 0.719 ± 0.009	1.32TyrAsp: 1.32 ± 0.016	1.653TyrGlu: 1.653 ± 0.018	1.4TyrPhe: 1.4 ± 0.014	1.709TyrGly: 1.709 ± 0.02	0.744TyrHis: 0.744 ± 0.009	1.475TyrIle: 1.475 ± 0.016	1.507TyrLys: 1.507 ± 0.018	2.857TyrLeu: 2.857 ± 0.022	0.619TyrMet: 0.619 ± 0.009	1.076TyrAsn: 1.076 ± 0.013	1.332TyrPro: 1.332 ± 0.015	1.216TyrGln: 1.216 ± 0.012	1.596TyrArg: 1.596 ± 0.015	2.297TyrSer: 2.297 ± 0.021	1.607TyrThr: 1.607 ± 0.016	1.699TyrVal: 1.699 ± 0.016	0.374TyrTrp: 0.374 ± 0.008	0.977TyrTyr: 0.977 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.031XaaXaa: 0.031 ± 0.004

Statistics based on 18553 proteins (8861750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---