Amino acid dipepetide frequency for Natronolimnobius baerhuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.63AlaAla: 11.63 ± 0.168	0.74AlaCys: 0.74 ± 0.027	9.948AlaAsp: 9.948 ± 0.117	7.942AlaGlu: 7.942 ± 0.1	3.506AlaPhe: 3.506 ± 0.063	8.614AlaGly: 8.614 ± 0.107	1.889AlaHis: 1.889 ± 0.04	5.365AlaIle: 5.365 ± 0.078	1.709AlaLys: 1.709 ± 0.051	10.26AlaLeu: 10.26 ± 0.133	2.061AlaMet: 2.061 ± 0.046	2.385AlaAsn: 2.385 ± 0.047	3.492AlaPro: 3.492 ± 0.056	2.433AlaGln: 2.433 ± 0.049	5.353AlaArg: 5.353 ± 0.091	5.324AlaSer: 5.324 ± 0.077	7.362AlaThr: 7.362 ± 0.103	9.478AlaVal: 9.478 ± 0.107	1.04AlaTrp: 1.04 ± 0.032	2.649AlaTyr: 2.649 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.631CysAla: 0.631 ± 0.026	0.107CysCys: 0.107 ± 0.01	0.626CysAsp: 0.626 ± 0.026	0.661CysGlu: 0.661 ± 0.025	0.197CysPhe: 0.197 ± 0.013	0.818CysGly: 0.818 ± 0.032	0.216CysHis: 0.216 ± 0.013	0.246CysIle: 0.246 ± 0.015	0.14CysLys: 0.14 ± 0.011	0.653CysLeu: 0.653 ± 0.023	0.106CysMet: 0.106 ± 0.012	0.207CysAsn: 0.207 ± 0.014	0.518CysPro: 0.518 ± 0.023	0.229CysGln: 0.229 ± 0.014	0.479CysArg: 0.479 ± 0.024	0.491CysSer: 0.491 ± 0.023	0.473CysThr: 0.473 ± 0.02	0.501CysVal: 0.501 ± 0.024	0.116CysTrp: 0.116 ± 0.01	0.241CysTyr: 0.241 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.713AspAla: 9.713 ± 0.123	0.692AspCys: 0.692 ± 0.03	9.555AspAsp: 9.555 ± 0.168	9.24AspGlu: 9.24 ± 0.13	1.885AspPhe: 1.885 ± 0.045	8.011AspGly: 8.011 ± 0.116	2.179AspHis: 2.179 ± 0.055	3.783AspIle: 3.783 ± 0.069	1.017AspLys: 1.017 ± 0.04	7.585AspLeu: 7.585 ± 0.093	1.165AspMet: 1.165 ± 0.036	1.748AspAsn: 1.748 ± 0.046	4.435AspPro: 4.435 ± 0.07	2.08AspGln: 2.08 ± 0.048	5.63AspArg: 5.63 ± 0.075	4.592AspSer: 4.592 ± 0.087	4.575AspThr: 4.575 ± 0.074	7.277AspVal: 7.277 ± 0.095	1.022AspTrp: 1.022 ± 0.033	1.947AspTyr: 1.947 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.693GluAla: 8.693 ± 0.1	0.637GluCys: 0.637 ± 0.027	6.813GluAsp: 6.813 ± 0.115	6.802GluGlu: 6.802 ± 0.121	3.247GluPhe: 3.247 ± 0.058	5.268GluGly: 5.268 ± 0.079	2.303GluHis: 2.303 ± 0.048	4.65GluIle: 4.65 ± 0.081	1.717GluLys: 1.717 ± 0.053	7.687GluLeu: 7.687 ± 0.105	2.041GluMet: 2.041 ± 0.044	2.6GluAsn: 2.6 ± 0.059	4.476GluPro: 4.476 ± 0.077	3.5GluGln: 3.5 ± 0.068	7.387GluArg: 7.387 ± 0.103	6.054GluSer: 6.054 ± 0.087	8.12GluThr: 8.12 ± 0.097	5.292GluVal: 5.292 ± 0.078	1.274GluTrp: 1.274 ± 0.036	3.097GluTyr: 3.097 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.481PheAla: 3.481 ± 0.066	0.303PheCys: 0.303 ± 0.018	3.46PheAsp: 3.46 ± 0.065	3.18PheGlu: 3.18 ± 0.061	0.997PhePhe: 0.997 ± 0.033	2.976PheGly: 2.976 ± 0.067	0.663PheHis: 0.663 ± 0.028	1.248PheIle: 1.248 ± 0.041	0.422PheLys: 0.422 ± 0.02	2.665PheLeu: 2.665 ± 0.055	0.511PheMet: 0.511 ± 0.024	0.759PheAsn: 0.759 ± 0.026	1.226PhePro: 1.226 ± 0.033	0.846PheGln: 0.846 ± 0.029	1.613PheArg: 1.613 ± 0.043	1.661PheSer: 1.661 ± 0.039	1.853PheThr: 1.853 ± 0.039	3.13PheVal: 3.13 ± 0.055	0.397PheTrp: 0.397 ± 0.017	0.832PheTyr: 0.832 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	7.086GlyAla: 7.086 ± 0.093	0.722GlyCys: 0.722 ± 0.025	6.778GlyAsp: 6.778 ± 0.097	6.865GlyGlu: 6.865 ± 0.098	2.898GlyPhe: 2.898 ± 0.057	6.366GlyGly: 6.366 ± 0.104	1.745GlyHis: 1.745 ± 0.04	4.374GlyIle: 4.374 ± 0.071	1.699GlyLys: 1.699 ± 0.048	7.215GlyLeu: 7.215 ± 0.089	1.574GlyMet: 1.574 ± 0.039	2.011GlyAsn: 2.011 ± 0.05	3.11GlyPro: 3.11 ± 0.06	2.142GlyGln: 2.142 ± 0.049	4.021GlyArg: 4.021 ± 0.069	4.944GlySer: 4.944 ± 0.077	5.815GlyThr: 5.815 ± 0.083	6.652GlyVal: 6.652 ± 0.085	1.063GlyTrp: 1.063 ± 0.032	2.635GlyTyr: 2.635 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.106HisAla: 2.106 ± 0.045	0.231HisCys: 0.231 ± 0.015	2.113HisAsp: 2.113 ± 0.056	1.877HisGlu: 1.877 ± 0.043	0.575HisPhe: 0.575 ± 0.022	1.964HisGly: 1.964 ± 0.05	0.602HisHis: 0.602 ± 0.022	0.852HisIle: 0.852 ± 0.028	0.318HisLys: 0.318 ± 0.021	1.883HisLeu: 1.883 ± 0.044	0.318HisMet: 0.318 ± 0.017	0.534HisAsn: 0.534 ± 0.023	1.248HisPro: 1.248 ± 0.036	0.579HisGln: 0.579 ± 0.028	1.302HisArg: 1.302 ± 0.04	1.084HisSer: 1.084 ± 0.03	1.146HisThr: 1.146 ± 0.031	1.837HisVal: 1.837 ± 0.044	0.279HisTrp: 0.279 ± 0.018	0.6HisTyr: 0.6 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.364IleAla: 5.364 ± 0.089	0.352IleCys: 0.352 ± 0.019	4.949IleAsp: 4.949 ± 0.076	4.437IleGlu: 4.437 ± 0.066	1.177IlePhe: 1.177 ± 0.036	4.394IleGly: 4.394 ± 0.071	0.958IleHis: 0.958 ± 0.029	1.872IleIle: 1.872 ± 0.042	0.815IleLys: 0.815 ± 0.03	3.396IleLeu: 3.396 ± 0.068	0.604IleMet: 0.604 ± 0.024	1.137IleAsn: 1.137 ± 0.033	2.29IlePro: 2.29 ± 0.048	1.33IleGln: 1.33 ± 0.034	2.633IleArg: 2.633 ± 0.049	2.637IleSer: 2.637 ± 0.052	2.999IleThr: 2.999 ± 0.06	4.007IleVal: 4.007 ± 0.064	0.391IleTrp: 0.391 ± 0.018	1.087IleTyr: 1.087 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	1.652LysAla: 1.652 ± 0.043	0.11LysCys: 0.11 ± 0.01	1.091LysAsp: 1.091 ± 0.042	1.179LysGlu: 1.179 ± 0.043	0.468LysPhe: 0.468 ± 0.022	1.153LysGly: 1.153 ± 0.04	0.522LysHis: 0.522 ± 0.024	0.808LysIle: 0.808 ± 0.03	0.5LysLys: 0.5 ± 0.026	1.595LysLeu: 1.595 ± 0.039	0.35LysMet: 0.35 ± 0.02	0.572LysAsn: 0.572 ± 0.025	0.922LysPro: 0.922 ± 0.033	0.745LysGln: 0.745 ± 0.028	1.549LysArg: 1.549 ± 0.043	1.115LysSer: 1.115 ± 0.034	1.328LysThr: 1.328 ± 0.04	1.002LysVal: 1.002 ± 0.032	0.211LysTrp: 0.211 ± 0.015	0.542LysTyr: 0.542 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	10.352LeuAla: 10.352 ± 0.136	0.706LeuCys: 0.706 ± 0.023	5.254LeuAsp: 5.254 ± 0.073	13.961LeuGlu: 13.961 ± 0.148	3.144LeuPhe: 3.144 ± 0.063	6.865LeuGly: 6.865 ± 0.091	1.472LeuHis: 1.472 ± 0.04	3.565LeuIle: 3.565 ± 0.07	1.444LeuLys: 1.444 ± 0.04	8.27LeuLeu: 8.27 ± 0.131	1.211LeuMet: 1.211 ± 0.041	1.751LeuAsn: 1.751 ± 0.046	3.806LeuPro: 3.806 ± 0.06	2.18LeuGln: 2.18 ± 0.049	4.568LeuArg: 4.568 ± 0.078	5.488LeuSer: 5.488 ± 0.075	5.249LeuThr: 5.249 ± 0.071	7.647LeuVal: 7.647 ± 0.097	0.869LeuTrp: 0.869 ± 0.031	2.159LeuTyr: 2.159 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.797MetAla: 1.797 ± 0.039	0.111MetCys: 0.111 ± 0.011	1.33MetAsp: 1.33 ± 0.032	1.081MetGlu: 1.081 ± 0.035	0.531MetPhe: 0.531 ± 0.025	1.448MetGly: 1.448 ± 0.038	0.368MetHis: 0.368 ± 0.018	0.759MetIle: 0.759 ± 0.027	0.392MetLys: 0.392 ± 0.02	1.526MetLeu: 1.526 ± 0.036	0.342MetMet: 0.342 ± 0.021	0.616MetAsn: 0.616 ± 0.023	0.789MetPro: 0.789 ± 0.026	0.545MetGln: 0.545 ± 0.025	0.963MetArg: 0.963 ± 0.033	1.474MetSer: 1.474 ± 0.039	1.615MetThr: 1.615 ± 0.037	1.246MetVal: 1.246 ± 0.041	0.179MetTrp: 0.179 ± 0.012	0.412MetTyr: 0.412 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.74AsnAla: 2.74 ± 0.051	0.207AsnCys: 0.207 ± 0.015	1.943AsnAsp: 1.943 ± 0.05	1.987AsnGlu: 1.987 ± 0.05	0.692AsnPhe: 0.692 ± 0.025	2.225AsnGly: 2.225 ± 0.046	0.572AsnHis: 0.572 ± 0.027	1.049AsnIle: 1.049 ± 0.034	0.462AsnLys: 0.462 ± 0.022	1.909AsnLeu: 1.909 ± 0.042	0.432AsnMet: 0.432 ± 0.018	0.605AsnAsn: 0.605 ± 0.024	1.56AsnPro: 1.56 ± 0.038	0.729AsnGln: 0.729 ± 0.029	1.677AsnArg: 1.677 ± 0.041	1.185AsnSer: 1.185 ± 0.038	1.415AsnThr: 1.415 ± 0.041	2.185AsnVal: 2.185 ± 0.053	0.377AsnTrp: 0.377 ± 0.021	0.68AsnTyr: 0.68 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.582ProAla: 4.582 ± 0.078	0.231ProCys: 0.231 ± 0.017	4.878ProAsp: 4.878 ± 0.073	4.319ProGlu: 4.319 ± 0.066	1.492ProPhe: 1.492 ± 0.038	3.405ProGly: 3.405 ± 0.061	0.874ProHis: 0.874 ± 0.029	2.146ProIle: 2.146 ± 0.046	0.807ProLys: 0.807 ± 0.027	3.757ProLeu: 3.757 ± 0.063	0.802ProMet: 0.802 ± 0.027	1.171ProAsn: 1.171 ± 0.031	1.968ProPro: 1.968 ± 0.04	1.1ProGln: 1.1 ± 0.03	2.02ProArg: 2.02 ± 0.045	2.505ProSer: 2.505 ± 0.046	3.346ProThr: 3.346 ± 0.06	3.802ProVal: 3.802 ± 0.059	0.534ProTrp: 0.534 ± 0.021	1.07ProTyr: 1.07 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.684GlnAla: 2.684 ± 0.05	0.193GlnCys: 0.193 ± 0.014	1.659GlnAsp: 1.659 ± 0.045	2.008GlnGlu: 2.008 ± 0.049	1.176GlnPhe: 1.176 ± 0.034	1.702GlnGly: 1.702 ± 0.038	0.621GlnHis: 0.621 ± 0.025	1.436GlnIle: 1.436 ± 0.038	0.565GlnLys: 0.565 ± 0.026	2.738GlnLeu: 2.738 ± 0.047	0.61GlnMet: 0.61 ± 0.023	0.827GlnAsn: 0.827 ± 0.026	1.389GlnPro: 1.389 ± 0.037	1.261GlnGln: 1.261 ± 0.04	2.105GlnArg: 2.105 ± 0.046	1.878GlnSer: 1.878 ± 0.052	2.076GlnThr: 2.076 ± 0.051	1.909GlnVal: 1.909 ± 0.039	0.413GlnTrp: 0.413 ± 0.022	1.031GlnTyr: 1.031 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	5.545ArgAla: 5.545 ± 0.082	0.478ArgCys: 0.478 ± 0.023	4.577ArgAsp: 4.577 ± 0.072	5.954ArgGlu: 5.954 ± 0.096	2.057ArgPhe: 2.057 ± 0.05	3.91ArgGly: 3.91 ± 0.064	1.214ArgHis: 1.214 ± 0.036	2.908ArgIle: 2.908 ± 0.057	1.325ArgLys: 1.325 ± 0.036	5.717ArgLeu: 5.717 ± 0.081	1.194ArgMet: 1.194 ± 0.032	1.591ArgAsn: 1.591 ± 0.037	2.252ArgPro: 2.252 ± 0.046	1.922ArgGln: 1.922 ± 0.048	4.108ArgArg: 4.108 ± 0.079	3.334ArgSer: 3.334 ± 0.064	3.953ArgThr: 3.953 ± 0.07	4.475ArgVal: 4.475 ± 0.073	0.746ArgTrp: 0.746 ± 0.029	1.813ArgTyr: 1.813 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.375SerAla: 5.375 ± 0.08	0.33SerCys: 0.33 ± 0.021	5.161SerAsp: 5.161 ± 0.091	4.743SerGlu: 4.743 ± 0.072	1.883SerPhe: 1.883 ± 0.041	5.075SerGly: 5.075 ± 0.072	1.194SerHis: 1.194 ± 0.034	2.754SerIle: 2.754 ± 0.057	1.123SerLys: 1.123 ± 0.037	5.216SerLeu: 5.216 ± 0.08	1.191SerMet: 1.191 ± 0.033	1.514SerAsn: 1.514 ± 0.045	2.607SerPro: 2.607 ± 0.049	1.714SerGln: 1.714 ± 0.045	3.181SerArg: 3.181 ± 0.066	3.803SerSer: 3.803 ± 0.078	3.725SerThr: 3.725 ± 0.062	4.965SerVal: 4.965 ± 0.069	0.621SerTrp: 0.621 ± 0.023	1.445SerTyr: 1.445 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	7.423ThrAla: 7.423 ± 0.092	0.425ThrCys: 0.425 ± 0.021	6.739ThrAsp: 6.739 ± 0.086	5.18ThrGlu: 5.18 ± 0.082	2.113ThrPhe: 2.113 ± 0.044	5.576ThrGly: 5.576 ± 0.072	1.418ThrHis: 1.418 ± 0.041	3.632ThrIle: 3.632 ± 0.071	1.108ThrLys: 1.108 ± 0.032	6.317ThrLeu: 6.317 ± 0.08	1.13ThrMet: 1.13 ± 0.034	1.717ThrAsn: 1.717 ± 0.045	3.176ThrPro: 3.176 ± 0.054	1.723ThrGln: 1.723 ± 0.043	3.3ThrArg: 3.3 ± 0.064	3.148ThrSer: 3.148 ± 0.055	4.739ThrThr: 4.739 ± 0.078	6.872ThrVal: 6.872 ± 0.103	0.696ThrTrp: 0.696 ± 0.028	1.796ThrTyr: 1.796 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	8.751ValAla: 8.751 ± 0.121	0.698ValCys: 0.698 ± 0.024	7.453ValAsp: 7.453 ± 0.095	6.697ValGlu: 6.697 ± 0.091	2.839ValPhe: 2.839 ± 0.056	6.801ValGly: 6.801 ± 0.105	1.657ValHis: 1.657 ± 0.041	3.897ValIle: 3.897 ± 0.067	1.182ValLys: 1.182 ± 0.037	7.826ValLeu: 7.826 ± 0.118	1.254ValMet: 1.254 ± 0.038	1.831ValAsn: 1.831 ± 0.044	3.897ValPro: 3.897 ± 0.058	1.981ValGln: 1.981 ± 0.046	4.578ValArg: 4.578 ± 0.076	5.072ValSer: 5.072 ± 0.067	6.015ValThr: 6.015 ± 0.096	7.451ValVal: 7.451 ± 0.1	0.78ValTrp: 0.78 ± 0.025	2.023ValTyr: 2.023 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.919TrpAla: 0.919 ± 0.033	0.097TrpCys: 0.097 ± 0.01	0.9TrpAsp: 0.9 ± 0.032	0.946TrpGlu: 0.946 ± 0.034	0.472TrpPhe: 0.472 ± 0.021	0.828TrpGly: 0.828 ± 0.029	0.296TrpHis: 0.296 ± 0.017	0.559TrpIle: 0.559 ± 0.021	0.25TrpLys: 0.25 ± 0.016	1.287TrpLeu: 1.287 ± 0.041	0.227TrpMet: 0.227 ± 0.016	0.375TrpAsn: 0.375 ± 0.02	0.438TrpPro: 0.438 ± 0.02	0.414TrpGln: 0.414 ± 0.021	0.742TrpArg: 0.742 ± 0.029	0.611TrpSer: 0.611 ± 0.023	0.851TrpThr: 0.851 ± 0.028	0.789TrpVal: 0.789 ± 0.028	0.208TrpTrp: 0.208 ± 0.016	0.394TrpTyr: 0.394 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.658TyrAla: 2.658 ± 0.048	0.285TyrCys: 0.285 ± 0.018	2.906TyrAsp: 2.906 ± 0.059	2.601TyrGlu: 2.601 ± 0.058	0.874TyrPhe: 0.874 ± 0.031	2.315TyrGly: 2.315 ± 0.042	0.686TyrHis: 0.686 ± 0.025	0.925TyrIle: 0.925 ± 0.031	0.419TyrLys: 0.419 ± 0.022	2.46TyrLeu: 2.46 ± 0.049	0.401TyrMet: 0.401 ± 0.021	0.681TyrAsn: 0.681 ± 0.027	1.21TyrPro: 1.21 ± 0.035	0.825TyrGln: 0.825 ± 0.029	1.863TyrArg: 1.863 ± 0.042	1.218TyrSer: 1.218 ± 0.032	1.573TyrThr: 1.573 ± 0.041	2.169TyrVal: 2.169 ± 0.052	0.384TyrTrp: 0.384 ± 0.02	0.884TyrTyr: 0.884 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3662 proteins (1089211 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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