Amino acid dipepetide frequency for Thermogutta terrifontis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.406AlaAla: 10.406 ± 0.129	1.279AlaCys: 1.279 ± 0.037	4.66AlaAsp: 4.66 ± 0.062	6.996AlaGlu: 6.996 ± 0.09	3.238AlaPhe: 3.238 ± 0.057	7.763AlaGly: 7.763 ± 0.077	1.66AlaHis: 1.66 ± 0.041	5.119AlaIle: 5.119 ± 0.06	3.289AlaLys: 3.289 ± 0.063	9.106AlaLeu: 9.106 ± 0.101	2.074AlaMet: 2.074 ± 0.047	2.406AlaAsn: 2.406 ± 0.049	4.406AlaPro: 4.406 ± 0.075	3.838AlaGln: 3.838 ± 0.069	6.979AlaArg: 6.979 ± 0.072	4.914AlaSer: 4.914 ± 0.079	4.674AlaThr: 4.674 ± 0.075	7.753AlaVal: 7.753 ± 0.085	1.603AlaTrp: 1.603 ± 0.036	2.193AlaTyr: 2.193 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.887CysAla: 0.887 ± 0.029	0.264CysCys: 0.264 ± 0.016	0.726CysAsp: 0.726 ± 0.025	0.828CysGlu: 0.828 ± 0.028	0.455CysPhe: 0.455 ± 0.021	1.26CysGly: 1.26 ± 0.039	0.463CysHis: 0.463 ± 0.022	0.486CysIle: 0.486 ± 0.017	0.286CysLys: 0.286 ± 0.018	1.37CysLeu: 1.37 ± 0.035	0.212CysMet: 0.212 ± 0.012	0.326CysAsn: 0.326 ± 0.016	0.943CysPro: 0.943 ± 0.032	0.603CysGln: 0.603 ± 0.021	1.252CysArg: 1.252 ± 0.032	0.675CysSer: 0.675 ± 0.025	0.581CysThr: 0.581 ± 0.024	0.938CysVal: 0.938 ± 0.029	0.261CysTrp: 0.261 ± 0.016	0.373CysTyr: 0.373 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.27AspAla: 4.27 ± 0.066	0.632AspCys: 0.632 ± 0.023	2.408AspAsp: 2.408 ± 0.05	3.183AspGlu: 3.183 ± 0.062	2.14AspPhe: 2.14 ± 0.043	4.265AspGly: 4.265 ± 0.089	1.125AspHis: 1.125 ± 0.028	2.401AspIle: 2.401 ± 0.044	1.46AspLys: 1.46 ± 0.037	5.32AspLeu: 5.32 ± 0.067	0.853AspMet: 0.853 ± 0.027	1.245AspAsn: 1.245 ± 0.039	3.847AspPro: 3.847 ± 0.062	1.88AspGln: 1.88 ± 0.038	3.983AspArg: 3.983 ± 0.052	2.437AspSer: 2.437 ± 0.047	2.105AspThr: 2.105 ± 0.05	3.885AspVal: 3.885 ± 0.052	1.112AspTrp: 1.112 ± 0.034	1.573AspTyr: 1.573 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.416GluAla: 6.416 ± 0.096	0.699GluCys: 0.699 ± 0.021	2.985GluAsp: 2.985 ± 0.064	5.046GluGlu: 5.046 ± 0.097	2.319GluPhe: 2.319 ± 0.04	4.344GluGly: 4.344 ± 0.06	1.323GluHis: 1.323 ± 0.032	3.912GluIle: 3.912 ± 0.065	3.54GluLys: 3.54 ± 0.063	6.897GluLeu: 6.897 ± 0.095	1.499GluMet: 1.499 ± 0.038	2.154GluAsn: 2.154 ± 0.044	3.092GluPro: 3.092 ± 0.051	2.716GluGln: 2.716 ± 0.055	4.88GluArg: 4.88 ± 0.086	3.39GluSer: 3.39 ± 0.057	3.371GluThr: 3.371 ± 0.051	4.751GluVal: 4.751 ± 0.062	1.114GluTrp: 1.114 ± 0.028	1.678GluTyr: 1.678 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.431PheAla: 3.431 ± 0.052	0.631PheCys: 0.631 ± 0.021	2.293PheAsp: 2.293 ± 0.045	2.164PheGlu: 2.164 ± 0.044	1.593PhePhe: 1.593 ± 0.04	3.046PheGly: 3.046 ± 0.055	0.983PheHis: 0.983 ± 0.03	1.52PheIle: 1.52 ± 0.042	0.787PheLys: 0.787 ± 0.025	4.076PheLeu: 4.076 ± 0.06	0.627PheMet: 0.627 ± 0.021	0.977PheAsn: 0.977 ± 0.031	2.209PhePro: 2.209 ± 0.042	1.459PheGln: 1.459 ± 0.034	2.983PheArg: 2.983 ± 0.046	2.29PheSer: 2.29 ± 0.043	1.917PheThr: 1.917 ± 0.04	2.881PheVal: 2.881 ± 0.051	0.762PheTrp: 0.762 ± 0.024	1.108PheTyr: 1.108 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.882GlyAla: 5.882 ± 0.08	1.203GlyCys: 1.203 ± 0.033	4.036GlyAsp: 4.036 ± 0.085	4.821GlyGlu: 4.821 ± 0.062	3.073GlyPhe: 3.073 ± 0.055	6.027GlyGly: 6.027 ± 0.09	1.731GlyHis: 1.731 ± 0.045	4.008GlyIle: 4.008 ± 0.064	3.49GlyLys: 3.49 ± 0.059	7.414GlyLeu: 7.414 ± 0.091	1.902GlyMet: 1.902 ± 0.038	2.376GlyAsn: 2.376 ± 0.06	4.062GlyPro: 4.062 ± 0.06	3.462GlyGln: 3.462 ± 0.062	5.91GlyArg: 5.91 ± 0.072	4.374GlySer: 4.374 ± 0.097	4.588GlyThr: 4.588 ± 0.082	5.564GlyVal: 5.564 ± 0.072	1.694GlyTrp: 1.694 ± 0.038	2.301GlyTyr: 2.301 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.748HisAla: 1.748 ± 0.041	0.372HisCys: 0.372 ± 0.018	0.989HisAsp: 0.989 ± 0.031	1.238HisGlu: 1.238 ± 0.034	0.952HisPhe: 0.952 ± 0.029	1.685HisGly: 1.685 ± 0.038	0.603HisHis: 0.603 ± 0.022	0.963HisIle: 0.963 ± 0.029	0.507HisLys: 0.507 ± 0.021	2.269HisLeu: 2.269 ± 0.039	0.347HisMet: 0.347 ± 0.017	0.665HisAsn: 0.665 ± 0.025	1.738HisPro: 1.738 ± 0.037	0.796HisGln: 0.796 ± 0.02	1.792HisArg: 1.792 ± 0.037	1.125HisSer: 1.125 ± 0.03	0.984HisThr: 0.984 ± 0.026	1.582HisVal: 1.582 ± 0.035	0.454HisTrp: 0.454 ± 0.02	0.624HisTyr: 0.624 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.858IleAla: 4.858 ± 0.066	0.687IleCys: 0.687 ± 0.023	2.82IleAsp: 2.82 ± 0.053	3.195IleGlu: 3.195 ± 0.06	1.808IlePhe: 1.808 ± 0.041	3.614IleGly: 3.614 ± 0.058	1.225IleHis: 1.225 ± 0.028	2.319IleIle: 2.319 ± 0.044	1.44IleLys: 1.44 ± 0.033	5.18IleLeu: 5.18 ± 0.074	0.711IleMet: 0.711 ± 0.024	1.375IleAsn: 1.375 ± 0.029	3.273IlePro: 3.273 ± 0.044	1.73IleGln: 1.73 ± 0.038	4.058IleArg: 4.058 ± 0.057	2.644IleSer: 2.644 ± 0.05	2.801IleThr: 2.801 ± 0.059	3.986IleVal: 3.986 ± 0.06	0.766IleTrp: 0.766 ± 0.027	1.281IleTyr: 1.281 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.243LysAla: 3.243 ± 0.061	0.326LysCys: 0.326 ± 0.017	1.64LysAsp: 1.64 ± 0.035	2.325LysGlu: 2.325 ± 0.049	1.056LysPhe: 1.056 ± 0.027	2.288LysGly: 2.288 ± 0.038	0.696LysHis: 0.696 ± 0.021	1.982LysIle: 1.982 ± 0.045	1.751LysLys: 1.751 ± 0.048	3.544LysLeu: 3.544 ± 0.061	0.762LysMet: 0.762 ± 0.024	1.158LysAsn: 1.158 ± 0.032	2.24LysPro: 2.24 ± 0.047	1.311LysGln: 1.311 ± 0.035	2.559LysArg: 2.559 ± 0.048	1.826LysSer: 1.826 ± 0.04	2.114LysThr: 2.114 ± 0.047	2.484LysVal: 2.484 ± 0.044	0.551LysTrp: 0.551 ± 0.02	0.985LysTyr: 0.985 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.669LeuAla: 11.669 ± 0.12	1.31LeuCys: 1.31 ± 0.033	4.915LeuAsp: 4.915 ± 0.062	6.596LeuGlu: 6.596 ± 0.086	3.592LeuPhe: 3.592 ± 0.056	7.975LeuGly: 7.975 ± 0.09	1.928LeuHis: 1.928 ± 0.042	4.494LeuIle: 4.494 ± 0.066	3.544LeuLys: 3.544 ± 0.06	9.778LeuLeu: 9.778 ± 0.109	1.77LeuMet: 1.77 ± 0.044	2.547LeuAsn: 2.547 ± 0.044	6.287LeuPro: 6.287 ± 0.08	3.64LeuGln: 3.64 ± 0.061	8.092LeuArg: 8.092 ± 0.099	5.639LeuSer: 5.639 ± 0.071	5.229LeuThr: 5.229 ± 0.062	7.913LeuVal: 7.913 ± 0.079	1.708LeuTrp: 1.708 ± 0.039	2.242LeuTyr: 2.242 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.189MetAla: 2.189 ± 0.047	0.213MetCys: 0.213 ± 0.014	0.925MetAsp: 0.925 ± 0.028	1.271MetGlu: 1.271 ± 0.034	0.632MetPhe: 0.632 ± 0.022	1.495MetGly: 1.495 ± 0.034	0.341MetHis: 0.341 ± 0.014	1.083MetIle: 1.083 ± 0.029	0.831MetLys: 0.831 ± 0.024	1.854MetLeu: 1.854 ± 0.039	0.444MetMet: 0.444 ± 0.02	0.621MetAsn: 0.621 ± 0.023	1.18MetPro: 1.18 ± 0.03	0.622MetGln: 0.622 ± 0.024	1.342MetArg: 1.342 ± 0.029	1.161MetSer: 1.161 ± 0.028	1.237MetThr: 1.237 ± 0.032	1.394MetVal: 1.394 ± 0.032	0.236MetTrp: 0.236 ± 0.014	0.376MetTyr: 0.376 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.323AsnAla: 2.323 ± 0.048	0.393AsnCys: 0.393 ± 0.017	1.369AsnAsp: 1.369 ± 0.046	1.467AsnGlu: 1.467 ± 0.038	1.02AsnPhe: 1.02 ± 0.033	2.278AsnGly: 2.278 ± 0.058	0.648AsnHis: 0.648 ± 0.023	1.344AsnIle: 1.344 ± 0.035	0.739AsnLys: 0.739 ± 0.026	2.956AsnLeu: 2.956 ± 0.042	0.494AsnMet: 0.494 ± 0.019	0.91AsnAsn: 0.91 ± 0.042	2.19AsnPro: 2.19 ± 0.052	1.094AsnGln: 1.094 ± 0.031	2.275AsnArg: 2.275 ± 0.045	1.571AsnSer: 1.571 ± 0.047	1.424AsnThr: 1.424 ± 0.035	2.033AsnVal: 2.033 ± 0.046	0.59AsnTrp: 0.59 ± 0.022	0.809AsnTyr: 0.809 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.785ProAla: 5.785 ± 0.089	0.584ProCys: 0.584 ± 0.022	3.737ProAsp: 3.737 ± 0.063	5.084ProGlu: 5.084 ± 0.07	2.143ProPhe: 2.143 ± 0.036	5.487ProGly: 5.487 ± 0.082	1.362ProHis: 1.362 ± 0.035	2.582ProIle: 2.582 ± 0.043	1.853ProLys: 1.853 ± 0.034	5.331ProLeu: 5.331 ± 0.064	1.112ProMet: 1.112 ± 0.03	1.795ProAsn: 1.795 ± 0.043	4.564ProPro: 4.564 ± 0.082	2.695ProGln: 2.695 ± 0.055	3.993ProArg: 3.993 ± 0.061	3.61ProSer: 3.61 ± 0.064	3.055ProThr: 3.055 ± 0.053	4.848ProVal: 4.848 ± 0.063	1.092ProTrp: 1.092 ± 0.027	1.524ProTyr: 1.524 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.116GlnAla: 4.116 ± 0.068	0.432GlnCys: 0.432 ± 0.018	1.543GlnAsp: 1.543 ± 0.031	2.528GlnGlu: 2.528 ± 0.051	1.488GlnPhe: 1.488 ± 0.033	2.672GlnGly: 2.672 ± 0.048	0.771GlnHis: 0.771 ± 0.025	2.261GlnIle: 2.261 ± 0.04	1.821GlnLys: 1.821 ± 0.045	4.065GlnLeu: 4.065 ± 0.066	0.864GlnMet: 0.864 ± 0.027	1.209GlnAsn: 1.209 ± 0.028	2.748GlnPro: 2.748 ± 0.061	1.854GlnGln: 1.854 ± 0.051	3.112GlnArg: 3.112 ± 0.056	2.189GlnSer: 2.189 ± 0.048	2.119GlnThr: 2.119 ± 0.045	2.814GlnVal: 2.814 ± 0.044	0.786GlnTrp: 0.786 ± 0.026	0.981GlnTyr: 0.981 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.102ArgAla: 6.102 ± 0.069	0.999ArgCys: 0.999 ± 0.033	3.639ArgAsp: 3.639 ± 0.057	5.557ArgGlu: 5.557 ± 0.087	3.386ArgPhe: 3.386 ± 0.049	4.948ArgGly: 4.948 ± 0.07	1.666ArgHis: 1.666 ± 0.035	4.189ArgIle: 4.189 ± 0.055	2.774ArgLys: 2.774 ± 0.049	8.424ArgLeu: 8.424 ± 0.082	1.708ArgMet: 1.708 ± 0.035	2.055ArgAsn: 2.055 ± 0.043	4.521ArgPro: 4.521 ± 0.064	3.658ArgGln: 3.658 ± 0.065	6.65ArgArg: 6.65 ± 0.087	3.845ArgSer: 3.845 ± 0.057	3.395ArgThr: 3.395 ± 0.046	5.498ArgVal: 5.498 ± 0.071	1.783ArgTrp: 1.783 ± 0.042	2.248ArgTyr: 2.248 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.063SerAla: 5.063 ± 0.078	0.637SerCys: 0.637 ± 0.021	2.677SerAsp: 2.677 ± 0.058	3.225SerGlu: 3.225 ± 0.047	1.96SerPhe: 1.96 ± 0.043	5.141SerGly: 5.141 ± 0.106	1.201SerHis: 1.201 ± 0.029	2.226SerIle: 2.226 ± 0.048	1.402SerLys: 1.402 ± 0.031	5.363SerLeu: 5.363 ± 0.067	0.976SerMet: 0.976 ± 0.031	1.347SerAsn: 1.347 ± 0.04	4.333SerPro: 4.333 ± 0.082	2.454SerGln: 2.454 ± 0.05	4.115SerArg: 4.115 ± 0.065	3.408SerSer: 3.408 ± 0.081	2.666SerThr: 2.666 ± 0.049	3.952SerVal: 3.952 ± 0.055	0.943SerTrp: 0.943 ± 0.025	1.241SerTyr: 1.241 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.031ThrAla: 5.031 ± 0.076	0.703ThrCys: 0.703 ± 0.028	2.383ThrAsp: 2.383 ± 0.057	2.784ThrGlu: 2.784 ± 0.042	1.928ThrPhe: 1.928 ± 0.04	4.706ThrGly: 4.706 ± 0.076	1.013ThrHis: 1.013 ± 0.03	2.684ThrIle: 2.684 ± 0.046	1.455ThrLys: 1.455 ± 0.035	5.431ThrLeu: 5.431 ± 0.067	0.903ThrMet: 0.903 ± 0.03	1.33ThrAsn: 1.33 ± 0.034	3.641ThrPro: 3.641 ± 0.057	1.856ThrGln: 1.856 ± 0.043	3.37ThrArg: 3.37 ± 0.052	2.908ThrSer: 2.908 ± 0.063	2.784ThrThr: 2.784 ± 0.058	4.309ThrVal: 4.309 ± 0.064	0.941ThrTrp: 0.941 ± 0.028	1.283ThrTyr: 1.283 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.423ValAla: 7.423 ± 0.077	1.096ValCys: 1.096 ± 0.04	3.879ValAsp: 3.879 ± 0.062	4.975ValGlu: 4.975 ± 0.063	3.114ValPhe: 3.114 ± 0.053	5.611ValGly: 5.611 ± 0.079	1.512ValHis: 1.512 ± 0.03	4.177ValIle: 4.177 ± 0.059	2.522ValLys: 2.522 ± 0.049	7.616ValLeu: 7.616 ± 0.091	1.372ValMet: 1.372 ± 0.036	2.076ValAsn: 2.076 ± 0.045	4.478ValPro: 4.478 ± 0.063	2.586ValGln: 2.586 ± 0.046	5.684ValArg: 5.684 ± 0.081	4.039ValSer: 4.039 ± 0.062	4.297ValThr: 4.297 ± 0.074	6.421ValVal: 6.421 ± 0.085	1.208ValTrp: 1.208 ± 0.034	1.992ValTyr: 1.992 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.465TrpAla: 1.465 ± 0.038	0.318TrpCys: 0.318 ± 0.016	0.927TrpAsp: 0.927 ± 0.026	1.197TrpGlu: 1.197 ± 0.031	0.665TrpPhe: 0.665 ± 0.024	1.332TrpGly: 1.332 ± 0.038	0.467TrpHis: 0.467 ± 0.019	0.982TrpIle: 0.982 ± 0.027	0.723TrpLys: 0.723 ± 0.028	1.997TrpLeu: 1.997 ± 0.042	0.447TrpMet: 0.447 ± 0.018	0.644TrpAsn: 0.644 ± 0.023	0.976TrpPro: 0.976 ± 0.028	0.936TrpGln: 0.936 ± 0.029	1.426TrpArg: 1.426 ± 0.037	0.978TrpSer: 0.978 ± 0.031	0.959TrpThr: 0.959 ± 0.027	1.207TrpVal: 1.207 ± 0.031	0.41TrpTrp: 0.41 ± 0.022	0.511TrpTyr: 0.511 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.046TyrAla: 2.046 ± 0.04	0.41TyrCys: 0.41 ± 0.018	1.571TyrAsp: 1.571 ± 0.053	1.644TyrGlu: 1.644 ± 0.041	1.175TyrPhe: 1.175 ± 0.032	1.984TyrGly: 1.984 ± 0.043	0.713TyrHis: 0.713 ± 0.027	1.037TyrIle: 1.037 ± 0.03	0.627TyrLys: 0.627 ± 0.022	2.877TyrLeu: 2.877 ± 0.046	0.37TyrMet: 0.37 ± 0.016	0.71TyrAsn: 0.71 ± 0.024	1.512TyrPro: 1.512 ± 0.043	1.183TyrGln: 1.183 ± 0.03	2.587TyrArg: 2.587 ± 0.043	1.306TyrSer: 1.306 ± 0.034	1.143TyrThr: 1.143 ± 0.039	1.868TyrVal: 1.868 ± 0.043	0.556TyrTrp: 0.556 ± 0.022	0.874TyrTyr: 0.874 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4494 proteins (1372611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---