Amino acid dipepetide frequency for Takifugu flavidus (sansaifugu)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.965AlaAla: 6.965 ± 0.045	1.374AlaCys: 1.374 ± 0.016	3.239AlaAsp: 3.239 ± 0.015	4.748AlaGlu: 4.748 ± 0.031	2.291AlaPhe: 2.291 ± 0.015	4.671AlaGly: 4.671 ± 0.028	1.543AlaHis: 1.543 ± 0.012	2.523AlaIle: 2.523 ± 0.015	3.132AlaLys: 3.132 ± 0.024	6.526AlaLeu: 6.526 ± 0.03	1.527AlaMet: 1.527 ± 0.012	2.035AlaAsn: 2.035 ± 0.015	3.846AlaPro: 3.846 ± 0.032	2.865AlaGln: 2.865 ± 0.018	3.263AlaArg: 3.263 ± 0.018	5.628AlaSer: 5.628 ± 0.028	3.507AlaThr: 3.507 ± 0.028	5.021AlaVal: 5.021 ± 0.025	0.724AlaTrp: 0.724 ± 0.011	1.415AlaTyr: 1.415 ± 0.012	0.0AlaXaa: 0.0 ± 0.0
Cys	1.207CysAla: 1.207 ± 0.012	0.728CysCys: 0.728 ± 0.013	1.093CysAsp: 1.093 ± 0.016	1.201CysGlu: 1.201 ± 0.013	0.886CysPhe: 0.886 ± 0.01	1.673CysGly: 1.673 ± 0.019	0.659CysHis: 0.659 ± 0.009	0.863CysIle: 0.863 ± 0.01	1.046CysLys: 1.046 ± 0.011	2.261CysLeu: 2.261 ± 0.024	0.431CysMet: 0.431 ± 0.007	0.808CysAsn: 0.808 ± 0.016	1.462CysPro: 1.462 ± 0.019	1.024CysGln: 1.024 ± 0.012	1.463CysArg: 1.463 ± 0.014	2.32CysSer: 2.32 ± 0.021	1.149CysThr: 1.149 ± 0.012	1.503CysVal: 1.503 ± 0.014	0.376CysTrp: 0.376 ± 0.007	0.573CysTyr: 0.573 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	2.982AspAla: 2.982 ± 0.02	1.095AspCys: 1.095 ± 0.014	2.875AspAsp: 2.875 ± 0.023	3.587AspGlu: 3.587 ± 0.024	2.009AspPhe: 2.009 ± 0.014	3.621AspGly: 3.621 ± 0.022	1.23AspHis: 1.23 ± 0.011	2.429AspIle: 2.429 ± 0.015	2.438AspLys: 2.438 ± 0.016	4.994AspLeu: 4.994 ± 0.026	1.189AspMet: 1.189 ± 0.011	1.748AspAsn: 1.748 ± 0.016	2.9AspPro: 2.9 ± 0.022	2.013AspGln: 2.013 ± 0.014	3.068AspArg: 3.068 ± 0.023	4.306AspSer: 4.306 ± 0.023	2.542AspThr: 2.542 ± 0.014	3.293AspVal: 3.293 ± 0.019	0.709AspTrp: 0.709 ± 0.007	1.413AspTyr: 1.413 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.762GluAla: 4.762 ± 0.029	1.17GluCys: 1.17 ± 0.015	4.265GluAsp: 4.265 ± 0.03	8.208GluGlu: 8.208 ± 0.062	1.884GluPhe: 1.884 ± 0.012	4.362GluGly: 4.362 ± 0.029	1.454GluHis: 1.454 ± 0.012	2.702GluIle: 2.702 ± 0.016	4.321GluLys: 4.321 ± 0.033	6.207GluLeu: 6.207 ± 0.038	1.742GluMet: 1.742 ± 0.013	2.536GluAsn: 2.536 ± 0.019	2.825GluPro: 2.825 ± 0.024	3.082GluGln: 3.082 ± 0.026	4.928GluArg: 4.928 ± 0.039	4.255GluSer: 4.255 ± 0.019	3.357GluThr: 3.357 ± 0.021	4.363GluVal: 4.363 ± 0.025	0.672GluTrp: 0.672 ± 0.008	1.434GluTyr: 1.434 ± 0.012	0.0GluXaa: 0.0 ± 0.0
Phe	1.843PheAla: 1.843 ± 0.013	0.955PheCys: 0.955 ± 0.016	1.639PheAsp: 1.639 ± 0.011	1.688PheGlu: 1.688 ± 0.013	1.487PhePhe: 1.487 ± 0.013	2.074PheGly: 2.074 ± 0.018	1.01PheHis: 1.01 ± 0.009	1.736PheIle: 1.736 ± 0.014	1.672PheLys: 1.672 ± 0.011	3.837PheLeu: 3.837 ± 0.023	0.778PheMet: 0.778 ± 0.008	1.439PheAsn: 1.439 ± 0.018	1.773PhePro: 1.773 ± 0.014	1.568PheGln: 1.568 ± 0.012	1.986PheArg: 1.986 ± 0.015	3.326PheSer: 3.326 ± 0.022	2.148PheThr: 2.148 ± 0.016	2.151PheVal: 2.151 ± 0.016	0.474PheTrp: 0.474 ± 0.006	1.152PheTyr: 1.152 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	4.311GlyAla: 4.311 ± 0.026	1.371GlyCys: 1.371 ± 0.015	3.269GlyAsp: 3.269 ± 0.019	4.547GlyGlu: 4.547 ± 0.032	2.317GlyPhe: 2.317 ± 0.018	5.747GlyGly: 5.747 ± 0.045	1.763GlyHis: 1.763 ± 0.014	2.463GlyIle: 2.463 ± 0.015	3.317GlyLys: 3.317 ± 0.019	5.62GlyLeu: 5.62 ± 0.025	1.363GlyMet: 1.363 ± 0.012	2.328GlyAsn: 2.328 ± 0.019	3.443GlyPro: 3.443 ± 0.031	2.775GlyGln: 2.775 ± 0.025	4.297GlyArg: 4.297 ± 0.032	5.809GlySer: 5.809 ± 0.029	3.472GlyThr: 3.472 ± 0.021	4.359GlyVal: 4.359 ± 0.024	0.831GlyTrp: 0.831 ± 0.01	1.656GlyTyr: 1.656 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.34HisAla: 1.34 ± 0.012	0.773HisCys: 0.773 ± 0.009	0.902HisAsp: 0.902 ± 0.009	1.135HisGlu: 1.135 ± 0.01	1.033HisPhe: 1.033 ± 0.009	1.614HisGly: 1.614 ± 0.012	1.27HisHis: 1.27 ± 0.031	1.3HisIle: 1.3 ± 0.016	1.208HisLys: 1.208 ± 0.011	3.107HisLeu: 3.107 ± 0.025	0.674HisMet: 0.674 ± 0.007	0.994HisAsn: 0.994 ± 0.015	2.238HisPro: 2.238 ± 0.044	1.467HisGln: 1.467 ± 0.017	1.736HisArg: 1.736 ± 0.015	2.392HisSer: 2.392 ± 0.021	1.454HisThr: 1.454 ± 0.014	1.534HisVal: 1.534 ± 0.012	0.358HisTrp: 0.358 ± 0.006	0.77HisTyr: 0.77 ± 0.009	0.0HisXaa: 0.0 ± 0.0
Ile	2.209IleAla: 2.209 ± 0.015	0.954IleCys: 0.954 ± 0.01	1.847IleAsp: 1.847 ± 0.014	2.113IleGlu: 2.113 ± 0.014	1.732IlePhe: 1.732 ± 0.015	2.164IleGly: 2.164 ± 0.015	1.559IleHis: 1.559 ± 0.034	2.287IleIle: 2.287 ± 0.031	2.333IleLys: 2.333 ± 0.019	4.021IleLeu: 4.021 ± 0.021	1.009IleMet: 1.009 ± 0.009	1.765IleAsn: 1.765 ± 0.015	2.38IlePro: 2.38 ± 0.017	2.121IleGln: 2.121 ± 0.014	2.489IleArg: 2.489 ± 0.014	3.752IleSer: 3.752 ± 0.023	2.708IleThr: 2.708 ± 0.02	2.39IleVal: 2.39 ± 0.017	0.478IleTrp: 0.478 ± 0.005	1.259IleTyr: 1.259 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	3.59LysAla: 3.59 ± 0.022	0.949LysCys: 0.949 ± 0.01	2.976LysAsp: 2.976 ± 0.021	4.449LysGlu: 4.449 ± 0.034	1.462LysPhe: 1.462 ± 0.017	2.975LysGly: 2.975 ± 0.019	1.31LysHis: 1.31 ± 0.013	2.215LysIle: 2.215 ± 0.014	4.099LysLys: 4.099 ± 0.035	4.788LysLeu: 4.788 ± 0.027	1.435LysMet: 1.435 ± 0.012	2.029LysAsn: 2.029 ± 0.013	2.634LysPro: 2.634 ± 0.02	2.322LysGln: 2.322 ± 0.016	3.476LysArg: 3.476 ± 0.022	3.669LysSer: 3.669 ± 0.023	2.946LysThr: 2.946 ± 0.017	3.383LysVal: 3.383 ± 0.021	0.565LysTrp: 0.565 ± 0.007	1.349LysTyr: 1.349 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	6.047LeuAla: 6.047 ± 0.03	2.29LeuCys: 2.29 ± 0.018	4.922LeuAsp: 4.922 ± 0.025	6.463LeuGlu: 6.463 ± 0.04	3.359LeuPhe: 3.359 ± 0.022	5.338LeuGly: 5.338 ± 0.024	2.871LeuHis: 2.871 ± 0.022	3.637LeuIle: 3.637 ± 0.02	5.368LeuLys: 5.368 ± 0.028	10.835LeuLeu: 10.835 ± 0.054	2.135LeuMet: 2.135 ± 0.013	3.545LeuAsn: 3.545 ± 0.019	5.627LeuPro: 5.627 ± 0.033	5.631LeuGln: 5.631 ± 0.037	6.297LeuArg: 6.297 ± 0.031	8.811LeuSer: 8.811 ± 0.032	5.298LeuThr: 5.298 ± 0.032	5.629LeuVal: 5.629 ± 0.031	1.191LeuTrp: 1.191 ± 0.012	2.423LeuTyr: 2.423 ± 0.017	0.0LeuXaa: 0.0 ± 0.0
Met	1.821MetAla: 1.821 ± 0.012	0.499MetCys: 0.499 ± 0.007	1.405MetAsp: 1.405 ± 0.01	2.013MetGlu: 2.013 ± 0.013	0.895MetPhe: 0.895 ± 0.01	1.356MetGly: 1.356 ± 0.014	0.453MetHis: 0.453 ± 0.006	0.833MetIle: 0.833 ± 0.009	1.485MetLys: 1.485 ± 0.01	1.993MetLeu: 1.993 ± 0.015	0.708MetMet: 0.708 ± 0.01	0.822MetAsn: 0.822 ± 0.008	1.004MetPro: 1.004 ± 0.01	0.895MetGln: 0.895 ± 0.009	1.247MetArg: 1.247 ± 0.011	1.896MetSer: 1.896 ± 0.014	1.234MetThr: 1.234 ± 0.01	1.565MetVal: 1.565 ± 0.012	0.27MetTrp: 0.27 ± 0.004	0.538MetTyr: 0.538 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.035AsnAla: 2.035 ± 0.014	0.877AsnCys: 0.877 ± 0.011	1.533AsnAsp: 1.533 ± 0.011	1.857AsnGlu: 1.857 ± 0.014	1.263AsnPhe: 1.263 ± 0.016	2.516AsnGly: 2.516 ± 0.021	0.986AsnHis: 0.986 ± 0.016	2.004AsnIle: 2.004 ± 0.02	2.029AsnLys: 2.029 ± 0.02	3.455AsnLeu: 3.455 ± 0.027	0.957AsnMet: 0.957 ± 0.009	1.69AsnAsn: 1.69 ± 0.026	2.185AsnPro: 2.185 ± 0.017	1.768AsnGln: 1.768 ± 0.016	1.974AsnArg: 1.974 ± 0.015	3.037AsnSer: 3.037 ± 0.017	2.181AsnThr: 2.181 ± 0.015	2.14AsnVal: 2.14 ± 0.014	0.437AsnTrp: 0.437 ± 0.006	1.054AsnTyr: 1.054 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	4.503ProAla: 4.503 ± 0.034	1.117ProCys: 1.117 ± 0.018	2.897ProAsp: 2.897 ± 0.017	3.713ProGlu: 3.713 ± 0.021	1.731ProPhe: 1.731 ± 0.014	4.302ProGly: 4.302 ± 0.035	1.596ProHis: 1.596 ± 0.018	1.795ProIle: 1.795 ± 0.014	2.343ProLys: 2.343 ± 0.017	5.197ProLeu: 5.197 ± 0.034	0.941ProMet: 0.941 ± 0.01	1.854ProAsn: 1.854 ± 0.018	6.085ProPro: 6.085 ± 0.058	2.707ProGln: 2.707 ± 0.021	3.04ProArg: 3.04 ± 0.02	6.307ProSer: 6.307 ± 0.056	3.14ProThr: 3.14 ± 0.022	3.979ProVal: 3.979 ± 0.025	0.593ProTrp: 0.593 ± 0.008	1.264ProTyr: 1.264 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.076GlnAla: 3.076 ± 0.022	0.933GlnCys: 0.933 ± 0.013	2.372GlnAsp: 2.372 ± 0.019	3.582GlnGlu: 3.582 ± 0.026	1.288GlnPhe: 1.288 ± 0.009	2.715GlnGly: 2.715 ± 0.023	1.449GlnHis: 1.449 ± 0.014	1.766GlnIle: 1.766 ± 0.011	2.564GlnLys: 2.564 ± 0.02	4.563GlnLeu: 4.563 ± 0.029	1.177GlnMet: 1.177 ± 0.011	1.738GlnAsn: 1.738 ± 0.023	2.631GlnPro: 2.631 ± 0.023	3.321GlnGln: 3.321 ± 0.04	3.266GlnArg: 3.266 ± 0.02	3.414GlnSer: 3.414 ± 0.024	2.548GlnThr: 2.548 ± 0.027	2.851GlnVal: 2.851 ± 0.018	0.553GlnTrp: 0.553 ± 0.006	1.09GlnTyr: 1.09 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	3.857ArgAla: 3.857 ± 0.021	1.448ArgCys: 1.448 ± 0.014	3.098ArgAsp: 3.098 ± 0.022	4.314ArgGlu: 4.314 ± 0.034	1.979ArgPhe: 1.979 ± 0.013	4.411ArgGly: 4.411 ± 0.037	1.638ArgHis: 1.638 ± 0.011	2.384ArgIle: 2.384 ± 0.015	3.58ArgLys: 3.58 ± 0.021	5.848ArgLeu: 5.848 ± 0.029	1.436ArgMet: 1.436 ± 0.011	2.055ArgAsn: 2.055 ± 0.014	3.311ArgPro: 3.311 ± 0.022	2.737ArgGln: 2.737 ± 0.02	5.609ArgArg: 5.609 ± 0.04	5.121ArgSer: 5.121 ± 0.029	3.169ArgThr: 3.169 ± 0.019	3.748ArgVal: 3.748 ± 0.021	0.9ArgTrp: 0.9 ± 0.01	1.464ArgTyr: 1.464 ± 0.011	0.0ArgXaa: 0.0 ± 0.0
Ser	5.87SerAla: 5.87 ± 0.03	2.188SerCys: 2.188 ± 0.019	4.229SerAsp: 4.229 ± 0.022	5.012SerGlu: 5.012 ± 0.026	3.043SerPhe: 3.043 ± 0.015	5.869SerGly: 5.869 ± 0.027	2.447SerHis: 2.447 ± 0.02	3.646SerIle: 3.646 ± 0.034	3.739SerLys: 3.739 ± 0.02	8.691SerLeu: 8.691 ± 0.037	1.733SerMet: 1.733 ± 0.011	2.931SerAsn: 2.931 ± 0.033	6.055SerPro: 6.055 ± 0.048	3.819SerGln: 3.819 ± 0.027	4.994SerArg: 4.994 ± 0.027	10.453SerSer: 10.453 ± 0.069	4.86SerThr: 4.86 ± 0.029	5.493SerVal: 5.493 ± 0.023	1.139SerTrp: 1.139 ± 0.011	2.029SerTyr: 2.029 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	4.054ThrAla: 4.054 ± 0.026	1.378ThrCys: 1.378 ± 0.019	2.794ThrAsp: 2.794 ± 0.017	3.61ThrGlu: 3.61 ± 0.021	1.996ThrPhe: 1.996 ± 0.013	3.745ThrGly: 3.745 ± 0.022	1.4ThrHis: 1.4 ± 0.013	2.325ThrIle: 2.325 ± 0.019	2.457ThrLys: 2.457 ± 0.016	5.434ThrLeu: 5.434 ± 0.034	1.151ThrMet: 1.151 ± 0.01	1.85ThrAsn: 1.85 ± 0.019	3.542ThrPro: 3.542 ± 0.025	2.279ThrGln: 2.279 ± 0.016	2.731ThrArg: 2.731 ± 0.017	5.061ThrSer: 5.061 ± 0.029	3.308ThrThr: 3.308 ± 0.039	4.148ThrVal: 4.148 ± 0.025	0.703ThrTrp: 0.703 ± 0.01	1.33ThrTyr: 1.33 ± 0.012	0.0ThrXaa: 0.0 ± 0.0
Val	4.338ValAla: 4.338 ± 0.025	1.672ValCys: 1.672 ± 0.015	3.237ValAsp: 3.237 ± 0.016	4.113ValGlu: 4.113 ± 0.027	2.542ValPhe: 2.542 ± 0.016	3.647ValGly: 3.647 ± 0.021	1.647ValHis: 1.647 ± 0.012	2.783ValIle: 2.783 ± 0.018	3.469ValLys: 3.469 ± 0.022	6.652ValLeu: 6.652 ± 0.028	1.569ValMet: 1.569 ± 0.011	2.237ValAsn: 2.237 ± 0.017	3.502ValPro: 3.502 ± 0.025	2.814ValGln: 2.814 ± 0.022	3.609ValArg: 3.609 ± 0.02	5.434ValSer: 5.434 ± 0.023	3.947ValThr: 3.947 ± 0.03	4.643ValVal: 4.643 ± 0.026	0.843ValTrp: 0.843 ± 0.009	1.697ValTyr: 1.697 ± 0.012	0.0ValXaa: 0.0 ± 0.0
Trp	0.726TrpAla: 0.726 ± 0.008	0.272TrpCys: 0.272 ± 0.005	0.641TrpAsp: 0.641 ± 0.009	0.827TrpGlu: 0.827 ± 0.009	0.466TrpPhe: 0.466 ± 0.007	0.698TrpGly: 0.698 ± 0.01	0.268TrpHis: 0.268 ± 0.005	0.588TrpIle: 0.588 ± 0.007	0.753TrpLys: 0.753 ± 0.008	1.227TrpLeu: 1.227 ± 0.012	0.355TrpMet: 0.355 ± 0.006	0.516TrpAsn: 0.516 ± 0.007	0.461TrpPro: 0.461 ± 0.008	0.485TrpGln: 0.485 ± 0.006	0.912TrpArg: 0.912 ± 0.009	1.058TrpSer: 1.058 ± 0.012	0.833TrpThr: 0.833 ± 0.01	0.766TrpVal: 0.766 ± 0.008	0.238TrpTrp: 0.238 ± 0.005	0.325TrpTyr: 0.325 ± 0.005	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.307TyrAla: 1.307 ± 0.011	0.682TyrCys: 0.682 ± 0.009	1.21TyrAsp: 1.21 ± 0.01	1.348TyrGlu: 1.348 ± 0.011	1.071TyrPhe: 1.071 ± 0.01	1.561TyrGly: 1.561 ± 0.012	0.748TyrHis: 0.748 ± 0.008	1.29TyrIle: 1.29 ± 0.016	1.265TyrLys: 1.265 ± 0.012	2.464TyrLeu: 2.464 ± 0.017	0.622TyrMet: 0.622 ± 0.007	1.057TyrAsn: 1.057 ± 0.01	1.199TyrPro: 1.199 ± 0.012	1.203TyrGln: 1.203 ± 0.019	1.725TyrArg: 1.725 ± 0.017	2.191TyrSer: 2.191 ± 0.017	1.494TyrThr: 1.494 ± 0.013	1.435TyrVal: 1.435 ± 0.012	0.36TyrTrp: 0.36 ± 0.01	0.864TyrTyr: 0.864 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 29076 proteins (14023189 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---