Amino acid dipepetide frequency for Torque teno midi virus 9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.897AlaAla: 15.897 ± 7.048
0.757AlaCys: 0.757 ± 0.466
5.299AlaAsp: 5.299 ± 2.647
0.0AlaGlu: 0.0 ± 0.0
5.299AlaPhe: 5.299 ± 0.891
1.514AlaGly: 1.514 ± 0.617
0.757AlaHis: 0.757 ± 0.845
0.757AlaIle: 0.757 ± 0.466
2.271AlaLys: 2.271 ± 0.82
1.514AlaLeu: 1.514 ± 0.932
0.757AlaMet: 0.757 ± 0.466
0.757AlaAsn: 0.757 ± 0.723
0.757AlaPro: 0.757 ± 0.845
3.028AlaGln: 3.028 ± 1.121
3.785AlaArg: 3.785 ± 1.634
2.271AlaSer: 2.271 ± 0.82
8.327AlaThr: 8.327 ± 2.986
1.514AlaVal: 1.514 ± 0.932
0.0AlaTrp: 0.0 ± 0.0
2.271AlaTyr: 2.271 ± 1.535
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.757CysAsp: 0.757 ± 0.466
0.757CysGlu: 0.757 ± 0.466
0.0CysPhe: 0.0 ± 0.0
2.271CysGly: 2.271 ± 1.535
0.0CysHis: 0.0 ± 0.0
0.757CysIle: 0.757 ± 0.845
2.271CysLys: 2.271 ± 0.82
3.028CysLeu: 3.028 ± 1.121
0.757CysMet: 0.757 ± 0.754
0.0CysAsn: 0.0 ± 0.0
0.757CysPro: 0.757 ± 0.723
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
1.514CysSer: 1.514 ± 0.617
4.542CysThr: 4.542 ± 3.07
0.0CysVal: 0.0 ± 0.0
0.757CysTrp: 0.757 ± 0.466
0.757CysTyr: 0.757 ± 0.466
0.0CysXaa: 0.0 ± 0.0
Asp
6.813AspAla: 6.813 ± 4.605
0.0AspCys: 0.0 ± 0.0
0.0AspAsp: 0.0 ± 0.0
3.028AspGlu: 3.028 ± 1.121
3.028AspPhe: 3.028 ± 1.865
2.271AspGly: 2.271 ± 1.535
0.0AspHis: 0.0 ± 0.0
2.271AspIle: 2.271 ± 1.535
0.0AspLys: 0.0 ± 0.0
9.841AspLeu: 9.841 ± 3.621
0.757AspMet: 0.757 ± 0.466
1.514AspAsn: 1.514 ± 0.666
4.542AspPro: 4.542 ± 1.231
1.514AspGln: 1.514 ± 0.932
0.0AspArg: 0.0 ± 0.0
3.785AspSer: 3.785 ± 0.768
6.056AspThr: 6.056 ± 2.241
2.271AspVal: 2.271 ± 1.535
0.0AspTrp: 0.0 ± 0.0
1.514AspTyr: 1.514 ± 0.932
0.0AspXaa: 0.0 ± 0.0
Glu
3.785GluAla: 3.785 ± 0.768
0.0GluCys: 0.0 ± 0.0
9.841GluAsp: 9.841 ± 4.414
6.813GluGlu: 6.813 ± 1.863
3.028GluPhe: 3.028 ± 1.916
3.028GluGly: 3.028 ± 1.121
0.0GluHis: 0.0 ± 0.0
0.757GluIle: 0.757 ± 0.466
9.841GluLys: 9.841 ± 2.098
4.542GluLeu: 4.542 ± 1.926
0.757GluMet: 0.757 ± 0.845
0.0GluAsn: 0.0 ± 0.0
1.514GluPro: 1.514 ± 0.666
2.271GluGln: 2.271 ± 1.535
3.785GluArg: 3.785 ± 1.634
2.271GluSer: 2.271 ± 1.399
4.542GluThr: 4.542 ± 1.558
0.757GluVal: 0.757 ± 0.723
0.0GluTrp: 0.0 ± 0.0
0.757GluTyr: 0.757 ± 0.466
0.0GluXaa: 0.0 ± 0.0
Phe
3.028PheAla: 3.028 ± 1.916
2.271PheCys: 2.271 ± 1.535
0.757PheAsp: 0.757 ± 0.466
0.757PheGlu: 0.757 ± 0.845
0.757PhePhe: 0.757 ± 0.466
4.542PheGly: 4.542 ± 0.598
0.0PheHis: 0.0 ± 0.0
2.271PheIle: 2.271 ± 1.399
3.028PheLys: 3.028 ± 2.275
0.757PheLeu: 0.757 ± 0.466
0.0PheMet: 0.0 ± 0.0
4.542PheAsn: 4.542 ± 1.231
3.028PhePro: 3.028 ± 1.121
2.271PheGln: 2.271 ± 1.399
1.514PheArg: 1.514 ± 0.666
2.271PheSer: 2.271 ± 0.82
3.785PheThr: 3.785 ± 0.768
3.028PheVal: 3.028 ± 1.865
0.757PheTrp: 0.757 ± 0.466
3.028PheTyr: 3.028 ± 1.865
0.0PheXaa: 0.0 ± 0.0
Gly
2.271GlyAla: 2.271 ± 1.399
3.028GlyCys: 3.028 ± 1.121
0.757GlyAsp: 0.757 ± 0.466
4.542GlyGlu: 4.542 ± 2.051
2.271GlyPhe: 2.271 ± 0.779
8.327GlyGly: 8.327 ± 1.294
2.271GlyHis: 2.271 ± 1.535
0.757GlyIle: 0.757 ± 0.466
3.028GlyLys: 3.028 ± 1.865
3.785GlyLeu: 3.785 ± 2.331
0.0GlyMet: 0.0 ± 0.0
3.028GlyAsn: 3.028 ± 1.865
1.514GlyPro: 1.514 ± 0.932
0.0GlyGln: 0.0 ± 0.0
0.0GlyArg: 0.0 ± 0.0
0.757GlySer: 0.757 ± 0.466
6.813GlyThr: 6.813 ± 2.531
0.757GlyVal: 0.757 ± 0.466
0.757GlyTrp: 0.757 ± 0.466
0.757GlyTyr: 0.757 ± 0.466
0.0GlyXaa: 0.0 ± 0.0
His
1.514HisAla: 1.514 ± 0.932
0.757HisCys: 0.757 ± 0.466
2.271HisAsp: 2.271 ± 1.535
2.271HisGlu: 2.271 ± 1.535
0.0HisPhe: 0.0 ± 0.0
0.757HisGly: 0.757 ± 0.466
0.0HisHis: 0.0 ± 0.0
0.757HisIle: 0.757 ± 0.466
3.028HisLys: 3.028 ± 1.96
1.514HisLeu: 1.514 ± 0.666
3.028HisMet: 3.028 ± 1.916
0.0HisAsn: 0.0 ± 0.0
1.514HisPro: 1.514 ± 0.666
1.514HisGln: 1.514 ± 0.617
2.271HisArg: 2.271 ± 1.535
2.271HisSer: 2.271 ± 1.577
2.271HisThr: 2.271 ± 0.82
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
0.757IleAla: 0.757 ± 0.845
3.028IleCys: 3.028 ± 1.121
3.028IleAsp: 3.028 ± 1.121
1.514IleGlu: 1.514 ± 0.932
0.0IlePhe: 0.0 ± 0.0
1.514IleGly: 1.514 ± 0.932
0.0IleHis: 0.0 ± 0.0
4.542IleIle: 4.542 ± 2.797
3.785IleLys: 3.785 ± 2.331
7.57IleLeu: 7.57 ± 1.535
0.0IleMet: 0.0 ± 0.0
1.514IleAsn: 1.514 ± 0.932
7.57IlePro: 7.57 ± 0.117
3.028IleGln: 3.028 ± 1.233
2.271IleArg: 2.271 ± 1.535
6.056IleSer: 6.056 ± 0.658
1.514IleThr: 1.514 ± 0.932
2.271IleVal: 2.271 ± 1.399
1.514IleTrp: 1.514 ± 0.932
1.514IleTyr: 1.514 ± 0.932
0.0IleXaa: 0.0 ± 0.0
Lys
2.271LysAla: 2.271 ± 1.399
1.514LysCys: 1.514 ± 0.666
3.028LysAsp: 3.028 ± 2.063
9.084LysGlu: 9.084 ± 2.975
1.514LysPhe: 1.514 ± 0.932
3.028LysGly: 3.028 ± 1.865
1.514LysHis: 1.514 ± 1.446
4.542LysIle: 4.542 ± 0.598
8.327LysLys: 8.327 ± 3.177
3.028LysLeu: 3.028 ± 1.183
0.0LysMet: 0.0 ± 0.0
3.028LysAsn: 3.028 ± 1.183
9.084LysPro: 9.084 ± 1.863
5.299LysGln: 5.299 ± 1.981
9.084LysArg: 9.084 ± 1.503
6.056LysSer: 6.056 ± 3.92
6.813LysThr: 6.813 ± 1.163
3.028LysVal: 3.028 ± 1.233
2.271LysTrp: 2.271 ± 1.399
3.785LysTyr: 3.785 ± 1.372
0.0LysXaa: 0.0 ± 0.0
Leu
4.542LeuAla: 4.542 ± 0.598
2.271LeuCys: 2.271 ± 0.668
3.028LeuAsp: 3.028 ± 1.121
0.0LeuGlu: 0.0 ± 0.0
5.299LeuPhe: 5.299 ± 2.647
2.271LeuGly: 2.271 ± 1.399
2.271LeuHis: 2.271 ± 0.82
4.542LeuIle: 4.542 ± 1.64
6.056LeuLys: 6.056 ± 2.366
7.57LeuLeu: 7.57 ± 1.127
0.757LeuMet: 0.757 ± 0.847
2.271LeuAsn: 2.271 ± 0.779
3.028LeuPro: 3.028 ± 1.331
7.57LeuGln: 7.57 ± 0.117
2.271LeuArg: 2.271 ± 1.447
5.299LeuSer: 5.299 ± 0.768
6.813LeuThr: 6.813 ± 1.373
1.514LeuVal: 1.514 ± 0.932
2.271LeuTrp: 2.271 ± 1.535
3.028LeuTyr: 3.028 ± 1.098
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
3.785MetLeu: 3.785 ± 1.486
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.271MetPro: 2.271 ± 1.399
0.757MetGln: 0.757 ± 0.466
0.0MetArg: 0.0 ± 0.0
0.757MetSer: 0.757 ± 0.845
3.028MetThr: 3.028 ± 1.121
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.514AsnAla: 1.514 ± 0.932
2.271AsnCys: 2.271 ± 1.535
2.271AsnAsp: 2.271 ± 1.535
0.757AsnGlu: 0.757 ± 0.466
4.542AsnPhe: 4.542 ± 2.347
0.757AsnGly: 0.757 ± 0.466
0.757AsnHis: 0.757 ± 0.845
2.271AsnIle: 2.271 ± 1.399
1.514AsnLys: 1.514 ± 0.666
3.028AsnLeu: 3.028 ± 0.501
0.0AsnMet: 0.0 ± 0.0
3.785AsnAsn: 3.785 ± 1.486
2.271AsnPro: 2.271 ± 0.779
3.028AsnGln: 3.028 ± 1.183
3.028AsnArg: 3.028 ± 1.098
3.028AsnSer: 3.028 ± 1.96
1.514AsnThr: 1.514 ± 0.666
0.757AsnVal: 0.757 ± 0.723
0.757AsnTrp: 0.757 ± 0.466
3.028AsnTyr: 3.028 ± 1.233
0.0AsnXaa: 0.0 ± 0.0
Pro
3.028ProAla: 3.028 ± 1.393
0.0ProCys: 0.0 ± 0.0
3.028ProAsp: 3.028 ± 1.121
4.542ProGlu: 4.542 ± 2.347
2.271ProPhe: 2.271 ± 0.779
3.785ProGly: 3.785 ± 1.634
2.271ProHis: 2.271 ± 1.399
2.271ProIle: 2.271 ± 1.399
3.028ProLys: 3.028 ± 1.183
3.028ProLeu: 3.028 ± 1.331
0.757ProMet: 0.757 ± 0.466
0.757ProAsn: 0.757 ± 0.466
2.271ProPro: 2.271 ± 1.447
2.271ProGln: 2.271 ± 1.399
4.542ProArg: 4.542 ± 3.216
3.785ProSer: 3.785 ± 1.6
6.813ProThr: 6.813 ± 1.668
4.542ProVal: 4.542 ± 1.087
1.514ProTrp: 1.514 ± 0.666
5.299ProTyr: 5.299 ± 0.748
0.0ProXaa: 0.0 ± 0.0
Gln
3.028GlnAla: 3.028 ± 0.501
1.514GlnCys: 1.514 ± 0.617
0.757GlnAsp: 0.757 ± 0.466
6.813GlnGlu: 6.813 ± 0.812
1.514GlnPhe: 1.514 ± 0.932
0.757GlnGly: 0.757 ± 0.466
0.757GlnHis: 0.757 ± 0.845
5.299GlnIle: 5.299 ± 1.679
3.028GlnLys: 3.028 ± 1.233
8.327GlnLeu: 8.327 ± 0.643
0.0GlnMet: 0.0 ± 0.0
3.028GlnAsn: 3.028 ± 0.501
3.028GlnPro: 3.028 ± 1.865
12.869GlnGln: 12.869 ± 5.136
2.271GlnArg: 2.271 ± 1.535
3.028GlnSer: 3.028 ± 1.233
3.785GlnThr: 3.785 ± 2.331
3.028GlnVal: 3.028 ± 0.501
0.757GlnTrp: 0.757 ± 0.466
2.271GlnTyr: 2.271 ± 1.399
0.0GlnXaa: 0.0 ± 0.0
Arg
2.271ArgAla: 2.271 ± 2.534
0.757ArgCys: 0.757 ± 0.466
4.542ArgAsp: 4.542 ± 3.07
3.028ArgGlu: 3.028 ± 2.063
1.514ArgPhe: 1.514 ± 0.666
1.514ArgGly: 1.514 ± 0.932
2.271ArgHis: 2.271 ± 1.399
3.028ArgIle: 3.028 ± 1.865
9.084ArgLys: 9.084 ± 2.931
0.757ArgLeu: 0.757 ± 0.466
0.757ArgMet: 0.757 ± 0.913
2.271ArgAsn: 2.271 ± 0.668
1.514ArgPro: 1.514 ± 0.932
4.542ArgGln: 4.542 ± 1.087
13.626ArgArg: 13.626 ± 6.549
0.757ArgSer: 0.757 ± 0.845
2.271ArgThr: 2.271 ± 1.447
3.785ArgVal: 3.785 ± 1.372
0.757ArgTrp: 0.757 ± 0.466
3.028ArgTyr: 3.028 ± 1.098
0.0ArgXaa: 0.0 ± 0.0
Ser
0.757SerAla: 0.757 ± 0.466
0.0SerCys: 0.0 ± 0.0
1.514SerAsp: 1.514 ± 0.932
1.514SerGlu: 1.514 ± 0.932
4.542SerPhe: 4.542 ± 0.598
0.757SerGly: 0.757 ± 0.723
5.299SerHis: 5.299 ± 1.679
5.299SerIle: 5.299 ± 0.748
5.299SerLys: 5.299 ± 2.45
1.514SerLeu: 1.514 ± 0.617
0.0SerMet: 0.0 ± 0.0
2.271SerAsn: 2.271 ± 2.169
1.514SerPro: 1.514 ± 1.038
6.056SerGln: 6.056 ± 1.547
4.542SerArg: 4.542 ± 1.85
16.654SerSer: 16.654 ± 11.382
4.542SerThr: 4.542 ± 2.183
3.028SerVal: 3.028 ± 1.865
0.0SerTrp: 0.0 ± 0.0
2.271SerTyr: 2.271 ± 0.82
0.0SerXaa: 0.0 ± 0.0
Thr
4.542ThrAla: 4.542 ± 1.861
0.757ThrCys: 0.757 ± 0.723
5.299ThrAsp: 5.299 ± 0.748
6.056ThrGlu: 6.056 ± 1.631
3.028ThrPhe: 3.028 ± 1.183
6.056ThrGly: 6.056 ± 2.942
6.056ThrHis: 6.056 ± 2.958
6.813ThrIle: 6.813 ± 2.671
14.383ThrLys: 14.383 ± 2.716
3.785ThrLeu: 3.785 ± 1.121
0.0ThrMet: 0.0 ± 0.0
3.785ThrAsn: 3.785 ± 1.121
8.327ThrPro: 8.327 ± 1.869
3.785ThrGln: 3.785 ± 1.372
3.785ThrArg: 3.785 ± 1.497
2.271ThrSer: 2.271 ± 1.447
7.57ThrThr: 7.57 ± 1.4
0.757ThrVal: 0.757 ± 0.466
1.514ThrTrp: 1.514 ± 0.932
3.785ThrTyr: 3.785 ± 2.331
0.0ThrXaa: 0.0 ± 0.0
Val
0.757ValAla: 0.757 ± 0.466
0.0ValCys: 0.0 ± 0.0
1.514ValAsp: 1.514 ± 0.932
4.542ValGlu: 4.542 ± 0.598
0.757ValPhe: 0.757 ± 0.466
0.0ValGly: 0.0 ± 0.0
0.757ValHis: 0.757 ± 0.723
1.514ValIle: 1.514 ± 0.932
3.785ValLys: 3.785 ± 1.497
3.028ValLeu: 3.028 ± 1.865
0.757ValMet: 0.757 ± 0.466
0.757ValAsn: 0.757 ± 0.845
0.757ValPro: 0.757 ± 0.723
3.028ValGln: 3.028 ± 0.501
2.271ValArg: 2.271 ± 1.399
3.028ValSer: 3.028 ± 1.96
5.299ValThr: 5.299 ± 0.748
1.514ValVal: 1.514 ± 0.932
0.757ValTrp: 0.757 ± 0.466
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.757TrpAsp: 0.757 ± 0.466
0.757TrpGlu: 0.757 ± 0.466
3.028TrpPhe: 3.028 ± 1.865
1.514TrpGly: 1.514 ± 0.932
0.0TrpHis: 0.0 ± 0.0
3.028TrpIle: 3.028 ± 1.121
0.0TrpLys: 0.0 ± 0.0
0.757TrpLeu: 0.757 ± 0.845
0.0TrpMet: 0.0 ± 0.0
0.757TrpAsn: 0.757 ± 0.466
0.0TrpPro: 0.0 ± 0.0
1.514TrpGln: 1.514 ± 0.932
0.757TrpArg: 0.757 ± 0.466
0.0TrpSer: 0.0 ± 0.0
1.514TrpThr: 1.514 ± 0.932
0.0TrpVal: 0.0 ± 0.0
1.514TrpTrp: 1.514 ± 0.932
0.757TrpTyr: 0.757 ± 0.466
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.757TyrAla: 0.757 ± 0.466
0.0TyrCys: 0.0 ± 0.0
0.757TyrAsp: 0.757 ± 0.466
1.514TyrGlu: 1.514 ± 0.932
0.0TyrPhe: 0.0 ± 0.0
0.757TyrGly: 0.757 ± 0.466
0.757TyrHis: 0.757 ± 0.723
1.514TyrIle: 1.514 ± 0.932
4.542TyrLys: 4.542 ± 1.079
2.271TyrLeu: 2.271 ± 0.779
0.757TyrMet: 0.757 ± 0.628
6.813TyrAsn: 6.813 ± 1.863
4.542TyrPro: 4.542 ± 1.558
1.514TyrGln: 1.514 ± 0.932
2.271TyrArg: 2.271 ± 1.399
1.514TyrSer: 1.514 ± 0.932
4.542TyrThr: 4.542 ± 2.797
2.271TyrVal: 2.271 ± 1.399
0.757TyrTrp: 0.757 ± 0.466
2.271TyrTyr: 2.271 ± 1.535
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1322 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski