Human papillomavirus

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; unclassified Papillomaviridae; Human papillomavirus types

Average proteome isoelectric point is 5.71

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A0A0K1YWK4|A0A0K1YWK4_9PAPI Protein E6 OS=Human papillomavirus OX=10566 GN=E6 PE=3 SV=1
MM1 pKa = 7.67IGAQPDD7 pKa = 3.48IKK9 pKa = 11.1DD10 pKa = 3.28IDD12 pKa = 4.57LDD14 pKa = 3.88LQEE17 pKa = 5.75LVLPQNLLAEE27 pKa = 4.75EE28 pKa = 4.44SLSPDD33 pKa = 3.38ADD35 pKa = 3.72PEE37 pKa = 4.18EE38 pKa = 5.06EE39 pKa = 4.1EE40 pKa = 4.17QQLYY44 pKa = 8.01WVDD47 pKa = 3.93TCCGTCKK54 pKa = 10.06ATVRR58 pKa = 11.84VCVFATSTAVCTLQFLLQGQLSFVCILCSKK88 pKa = 9.62GRR90 pKa = 11.84RR91 pKa = 11.84HH92 pKa = 6.19GRR94 pKa = 11.84PNN96 pKa = 3.03

Molecular weight: 10.63 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A0A0K1YX24|A0A0K1YX24_9PAPI Replication protein E1 OS=Human papillomavirus OX=10566 GN=E1 PE=3 SV=1
MM1 pKa = 7.04MRR3 pKa = 11.84MEE5 pKa = 4.21TQEE8 pKa = 4.05TLTDD12 pKa = 3.82RR13 pKa = 11.84FNALQDD19 pKa = 4.39AILNLIEE26 pKa = 4.98EE27 pKa = 4.66NPSDD31 pKa = 3.73LKK33 pKa = 11.31SIIRR37 pKa = 11.84YY38 pKa = 8.38WEE40 pKa = 3.99LNRR43 pKa = 11.84KK44 pKa = 7.44EE45 pKa = 4.97HH46 pKa = 5.0VTLYY50 pKa = 9.7YY51 pKa = 10.48ARR53 pKa = 11.84KK54 pKa = 9.74EE55 pKa = 3.98GFTRR59 pKa = 11.84LGLQPVPTPAVSEE72 pKa = 4.42YY73 pKa = 10.23NAKK76 pKa = 9.92QAIQMQLLVNSLSKK90 pKa = 10.88SVFAKK95 pKa = 7.6EE96 pKa = 3.57TWTLSDD102 pKa = 4.75CSAEE106 pKa = 5.05LINTLPKK113 pKa = 10.79DD114 pKa = 3.68CFKK117 pKa = 11.05KK118 pKa = 10.04QGYY121 pKa = 6.22TVEE124 pKa = 3.65VWYY127 pKa = 10.46DD128 pKa = 3.13NDD130 pKa = 3.65RR131 pKa = 11.84NKK133 pKa = 10.83AYY135 pKa = 9.57PYY137 pKa = 9.16TNWKK141 pKa = 9.36RR142 pKa = 11.84IYY144 pKa = 9.93YY145 pKa = 9.43QDD147 pKa = 4.75SHH149 pKa = 8.38DD150 pKa = 3.66EE151 pKa = 3.99WQLTEE156 pKa = 4.31GKK158 pKa = 10.12VDD160 pKa = 3.8EE161 pKa = 4.8NGLYY165 pKa = 10.31YY166 pKa = 10.31DD167 pKa = 4.39EE168 pKa = 5.56KK169 pKa = 11.35NGDD172 pKa = 3.08RR173 pKa = 11.84VYY175 pKa = 11.47FMLFGADD182 pKa = 3.1ADD184 pKa = 4.11KK185 pKa = 11.67YY186 pKa = 11.0GVTKK190 pKa = 10.09EE191 pKa = 4.03WTVHH195 pKa = 5.38YY196 pKa = 10.02RR197 pKa = 11.84DD198 pKa = 3.59TTIVSSSSSSRR209 pKa = 11.84RR210 pKa = 11.84VADD213 pKa = 3.2SSQAFTQPSTSGYY226 pKa = 10.69SKK228 pKa = 9.69TPSPKK233 pKa = 9.02RR234 pKa = 11.84RR235 pKa = 11.84RR236 pKa = 11.84AAEE239 pKa = 3.96EE240 pKa = 4.21ADD242 pKa = 3.59SSTSSSSSSAPSGSPASNLRR262 pKa = 11.84DD263 pKa = 3.28RR264 pKa = 11.84GGGQGEE270 pKa = 4.06RR271 pKa = 11.84SVPLSKK277 pKa = 10.27RR278 pKa = 11.84RR279 pKa = 11.84RR280 pKa = 11.84HH281 pKa = 4.92TSEE284 pKa = 3.82SAGEE288 pKa = 4.2SAVPSPSEE296 pKa = 3.75VGTGHH301 pKa = 7.75RR302 pKa = 11.84LLARR306 pKa = 11.84QALGRR311 pKa = 11.84VQRR314 pKa = 11.84LQAEE318 pKa = 4.1AWDD321 pKa = 4.03PFILILKK328 pKa = 9.29GPSNNLKK335 pKa = 10.14CWRR338 pKa = 11.84NRR340 pKa = 11.84NKK342 pKa = 10.29HH343 pKa = 4.34NHH345 pKa = 4.08VHH347 pKa = 5.89VKK349 pKa = 10.45ASSNVWRR356 pKa = 11.84WLGEE360 pKa = 3.88GYY362 pKa = 9.2TYY364 pKa = 11.52SRR366 pKa = 11.84MLLAFDD372 pKa = 4.55SEE374 pKa = 4.81TEE376 pKa = 3.9RR377 pKa = 11.84EE378 pKa = 4.0RR379 pKa = 11.84FVQFTRR385 pKa = 11.84FPKK388 pKa = 9.88DD389 pKa = 2.81TTYY392 pKa = 11.19AYY394 pKa = 10.76GNLEE398 pKa = 4.04SLL400 pKa = 4.22

Molecular weight: 45.72 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2309

96

600

384.8

43.5

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.933 ± 0.319

2.252 ± 0.92

6.063 ± 0.315

6.54 ± 0.563

4.807 ± 0.471

5.024 ± 0.562

1.689 ± 0.169

4.894 ± 1.072

4.981 ± 0.811

9.181 ± 0.61

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.602 ± 0.382

5.24 ± 0.372

5.673 ± 1.148

4.721 ± 0.365

5.37 ± 0.69

8.922 ± 0.651

5.544 ± 0.699

6.453 ± 0.33

1.343 ± 0.404

3.768 ± 0.408
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski