Human papillomavirus 165

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 12

Average proteome isoelectric point is 6.03

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 6 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|K4MZ15|K4MZ15_9PAPI Minor capsid protein L2 OS=Human papillomavirus 165 OX=1315266 GN=L2 PE=3 SV=1
MM1 pKa = 8.1PDD3 pKa = 3.1VQNKK7 pKa = 9.25FEE9 pKa = 4.23QKK11 pKa = 7.68TWADD15 pKa = 3.5TLLKK19 pKa = 10.44IFGSLLYY26 pKa = 10.37FGNLGIGTGRR36 pKa = 11.84GSGGTLGYY44 pKa = 10.16RR45 pKa = 11.84PLGTPSAPRR54 pKa = 11.84ATEE57 pKa = 3.74VTPIRR62 pKa = 11.84PNLTIDD68 pKa = 3.46PVGPTDD74 pKa = 3.41ITVVDD79 pKa = 4.5AAAPSIVPLSEE90 pKa = 3.76GVPDD94 pKa = 3.92ISYY97 pKa = 9.92IAPDD101 pKa = 3.97AGPGAGAEE109 pKa = 4.23DD110 pKa = 3.78IEE112 pKa = 5.46LFTITNPSTDD122 pKa = 3.02VGGAAVTPTVISTEE136 pKa = 3.97EE137 pKa = 3.94GAVAILDD144 pKa = 3.78TQTIPEE150 pKa = 4.16RR151 pKa = 11.84PVQVFYY157 pKa = 11.39DD158 pKa = 4.32PAATTTHH165 pKa = 7.22EE166 pKa = 4.52INVFAAPIEE175 pKa = 4.23TSSNVNVFVDD185 pKa = 4.12SNVSGTIIGGEE196 pKa = 4.24DD197 pKa = 3.11IPLEE201 pKa = 3.97RR202 pKa = 11.84LNYY205 pKa = 9.95SEE207 pKa = 5.68FEE209 pKa = 4.05IEE211 pKa = 4.17EE212 pKa = 4.48TPLTSTPTRR221 pKa = 11.84RR222 pKa = 11.84LEE224 pKa = 3.95SAINRR229 pKa = 11.84TKK231 pKa = 10.5GFYY234 pKa = 10.08RR235 pKa = 11.84RR236 pKa = 11.84FIKK239 pKa = 9.93QVPVRR244 pKa = 11.84SFEE247 pKa = 4.52FVTQPSRR254 pKa = 11.84LVEE257 pKa = 4.26FQFEE261 pKa = 4.27NPAFDD266 pKa = 4.81ADD268 pKa = 3.69VTLEE272 pKa = 3.87FEE274 pKa = 4.95RR275 pKa = 11.84DD276 pKa = 3.35LADD279 pKa = 3.24ITAAPADD286 pKa = 3.88EE287 pKa = 4.58FQDD290 pKa = 3.54VIRR293 pKa = 11.84LHH295 pKa = 6.84RR296 pKa = 11.84PLFSSVEE303 pKa = 3.9GAVRR307 pKa = 11.84VSRR310 pKa = 11.84LGDD313 pKa = 3.03TGTIRR318 pKa = 11.84TRR320 pKa = 11.84SGTIIGQQVHH330 pKa = 7.1FYY332 pKa = 10.77HH333 pKa = 7.55DD334 pKa = 3.09ISDD337 pKa = 3.52IVTEE341 pKa = 4.46EE342 pKa = 4.32IEE344 pKa = 4.62LEE346 pKa = 4.37TIPTEE351 pKa = 4.26PEE353 pKa = 3.52TSIVDD358 pKa = 4.27DD359 pKa = 4.15IMDD362 pKa = 4.02SVIVDD367 pKa = 4.91PINTADD373 pKa = 3.51VAIAEE378 pKa = 4.15EE379 pKa = 4.76DD380 pKa = 3.73LLDD383 pKa = 4.21SYY385 pKa = 11.91GEE387 pKa = 4.24NFAQTHH393 pKa = 6.93LILGDD398 pKa = 3.58VEE400 pKa = 4.71LAGEE404 pKa = 4.29PEE406 pKa = 4.03ILIIPITAEE415 pKa = 3.91TASLNTFIPALVDD428 pKa = 3.4ASIIDD433 pKa = 3.99ASSTAYY439 pKa = 9.71PIAPILPVPEE449 pKa = 4.54PAPHH453 pKa = 5.9TVSDD457 pKa = 4.04INDD460 pKa = 3.74DD461 pKa = 3.97YY462 pKa = 11.89YY463 pKa = 11.32LYY465 pKa = 10.32PSLYY469 pKa = 9.01PKK471 pKa = 10.27RR472 pKa = 11.84KK473 pKa = 9.26RR474 pKa = 11.84RR475 pKa = 11.84RR476 pKa = 11.84LDD478 pKa = 3.22FFF480 pKa = 5.54

Molecular weight: 52.15 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|K4MNC5|K4MNC5_9PAPI Protein E6 OS=Human papillomavirus 165 OX=1315266 GN=E6 PE=3 SV=1
MM1 pKa = 7.37EE2 pKa = 4.95TPQTLADD9 pKa = 3.92RR10 pKa = 11.84FAAQQEE16 pKa = 4.34KK17 pKa = 10.7QMTLIEE23 pKa = 4.37NEE25 pKa = 4.21STQLTDD31 pKa = 5.35HH32 pKa = 6.55IEE34 pKa = 4.01YY35 pKa = 9.22WNSVRR40 pKa = 11.84LEE42 pKa = 4.11NVLGYY47 pKa = 8.03YY48 pKa = 9.63ARR50 pKa = 11.84KK51 pKa = 9.82EE52 pKa = 4.03GLTQLGMQPLPVLQVLEE69 pKa = 4.54YY70 pKa = 9.82KK71 pKa = 10.67AKK73 pKa = 10.21EE74 pKa = 4.08AIKK77 pKa = 10.21MSLLLNSLNKK87 pKa = 9.85SEE89 pKa = 4.33YY90 pKa = 10.57GKK92 pKa = 10.58EE93 pKa = 3.68PWTLAEE99 pKa = 4.12VSAEE103 pKa = 3.75IVNTNPKK110 pKa = 10.1NCFKK114 pKa = 10.75KK115 pKa = 10.65KK116 pKa = 9.44PFTVTVYY123 pKa = 10.64FDD125 pKa = 4.16NDD127 pKa = 3.42EE128 pKa = 4.38QNSFPYY134 pKa = 10.01TNWDD138 pKa = 3.44SIYY141 pKa = 10.25YY142 pKa = 9.94QDD144 pKa = 5.91DD145 pKa = 3.35NSVWHH150 pKa = 6.36KK151 pKa = 10.68VHH153 pKa = 6.8GKK155 pKa = 9.85VDD157 pKa = 3.61TNGLYY162 pKa = 10.22FQEE165 pKa = 4.02ITGDD169 pKa = 3.06IVYY172 pKa = 9.6FALFQPDD179 pKa = 3.46AEE181 pKa = 4.65RR182 pKa = 11.84YY183 pKa = 7.77GHH185 pKa = 6.04SGQWSVKK192 pKa = 9.72YY193 pKa = 10.76KK194 pKa = 9.61NTTLFTSVTSSTPGPSSTEE213 pKa = 3.61PASQRR218 pKa = 11.84RR219 pKa = 11.84ATTHH223 pKa = 5.13TVSKK227 pKa = 10.64QKK229 pKa = 9.52TPRR232 pKa = 11.84KK233 pKa = 9.14RR234 pKa = 11.84KK235 pKa = 9.82HH236 pKa = 5.37EE237 pKa = 4.17TDD239 pKa = 3.14EE240 pKa = 4.46DD241 pKa = 4.32TDD243 pKa = 4.36GEE245 pKa = 4.85SPSSTSSGFRR255 pKa = 11.84LRR257 pKa = 11.84RR258 pKa = 11.84RR259 pKa = 11.84RR260 pKa = 11.84GEE262 pKa = 3.9QGEE265 pKa = 4.56STSRR269 pKa = 11.84ASSSRR274 pKa = 11.84RR275 pKa = 11.84RR276 pKa = 11.84GGNGGAVSPEE286 pKa = 3.94EE287 pKa = 3.97VGSRR291 pKa = 11.84TRR293 pKa = 11.84TVPTQGLTRR302 pKa = 11.84LRR304 pKa = 11.84RR305 pKa = 11.84LQEE308 pKa = 3.82EE309 pKa = 4.16ARR311 pKa = 11.84DD312 pKa = 3.71PPIIILQGCPNTLKK326 pKa = 10.66CFRR329 pKa = 11.84NRR331 pKa = 11.84VSHH334 pKa = 5.99KK335 pKa = 9.99HH336 pKa = 5.26HH337 pKa = 6.69SLYY340 pKa = 10.67TDD342 pKa = 3.33ATTVFHH348 pKa = 6.83WVLANCQDD356 pKa = 3.55KK357 pKa = 11.2KK358 pKa = 10.87EE359 pKa = 4.2SARR362 pKa = 11.84MLIAFTDD369 pKa = 3.23NRR371 pKa = 11.84QRR373 pKa = 11.84DD374 pKa = 3.61AFLAHH379 pKa = 5.32VTLPKK384 pKa = 9.69GTNHH388 pKa = 6.48WFGSLDD394 pKa = 3.56TLL396 pKa = 4.76

Molecular weight: 45.11 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

6

0

6

2222

93

608

370.3

41.77

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.986 ± 0.468

2.295 ± 0.813

6.391 ± 0.467

6.391 ± 0.476

5.041 ± 0.385

5.221 ± 0.766

1.935 ± 0.291

5.401 ± 0.894

4.995 ± 0.754

8.506 ± 0.624

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.26 ± 0.274

5.491 ± 0.782

5.896 ± 0.868

3.735 ± 0.381

5.311 ± 0.579

7.111 ± 0.765

7.381 ± 0.711

6.841 ± 0.438

1.305 ± 0.245

3.51 ± 0.19
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski