Amino acid dipepetide frequency for Tenacibaculum sp. KUL118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.861AlaAla: 5.861 ± 0.06
0.766AlaCys: 0.766 ± 0.021
3.987AlaAsp: 3.987 ± 0.051
4.705AlaGlu: 4.705 ± 0.05
3.538AlaPhe: 3.538 ± 0.039
4.922AlaGly: 4.922 ± 0.06
1.485AlaHis: 1.485 ± 0.028
5.589AlaIle: 5.589 ± 0.056
5.121AlaLys: 5.121 ± 0.055
8.398AlaLeu: 8.398 ± 0.082
2.14AlaMet: 2.14 ± 0.036
3.688AlaAsn: 3.688 ± 0.041
2.554AlaPro: 2.554 ± 0.034
3.14AlaGln: 3.14 ± 0.043
2.975AlaArg: 2.975 ± 0.043
5.235AlaSer: 5.235 ± 0.059
4.205AlaThr: 4.205 ± 0.051
5.001AlaVal: 5.001 ± 0.054
0.75AlaTrp: 0.75 ± 0.018
2.48AlaTyr: 2.48 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.621CysAla: 0.621 ± 0.018
0.117CysCys: 0.117 ± 0.008
0.492CysAsp: 0.492 ± 0.016
0.571CysGlu: 0.571 ± 0.018
0.419CysPhe: 0.419 ± 0.012
0.654CysGly: 0.654 ± 0.017
0.225CysHis: 0.225 ± 0.011
0.55CysIle: 0.55 ± 0.016
0.502CysLys: 0.502 ± 0.015
0.744CysLeu: 0.744 ± 0.019
0.18CysMet: 0.18 ± 0.009
0.391CysAsn: 0.391 ± 0.013
0.346CysPro: 0.346 ± 0.014
0.295CysGln: 0.295 ± 0.013
0.319CysArg: 0.319 ± 0.013
0.588CysSer: 0.588 ± 0.016
0.404CysThr: 0.404 ± 0.013
0.533CysVal: 0.533 ± 0.017
0.088CysTrp: 0.088 ± 0.006
0.277CysTyr: 0.277 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.56AspAla: 4.56 ± 0.053
0.453AspCys: 0.453 ± 0.013
3.186AspAsp: 3.186 ± 0.041
4.116AspGlu: 4.116 ± 0.039
2.993AspPhe: 2.993 ± 0.043
3.722AspGly: 3.722 ± 0.048
0.865AspHis: 0.865 ± 0.019
4.385AspIle: 4.385 ± 0.039
3.896AspLys: 3.896 ± 0.039
4.806AspLeu: 4.806 ± 0.051
1.299AspMet: 1.299 ± 0.025
3.045AspAsn: 3.045 ± 0.042
1.71AspPro: 1.71 ± 0.032
1.322AspGln: 1.322 ± 0.024
1.956AspArg: 1.956 ± 0.03
3.252AspSer: 3.252 ± 0.042
3.125AspThr: 3.125 ± 0.039
4.171AspVal: 4.171 ± 0.046
0.774AspTrp: 0.774 ± 0.018
2.295AspTyr: 2.295 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.158GluAla: 5.158 ± 0.049
0.39GluCys: 0.39 ± 0.013
3.45GluAsp: 3.45 ± 0.038
4.894GluGlu: 4.894 ± 0.051
2.747GluPhe: 2.747 ± 0.036
4.03GluGly: 4.03 ± 0.048
1.405GluHis: 1.405 ± 0.029
4.544GluIle: 4.544 ± 0.054
5.305GluLys: 5.305 ± 0.054
6.485GluLeu: 6.485 ± 0.059
1.576GluMet: 1.576 ± 0.027
4.007GluAsn: 4.007 ± 0.05
1.798GluPro: 1.798 ± 0.028
2.994GluGln: 2.994 ± 0.04
3.026GluArg: 3.026 ± 0.04
3.774GluSer: 3.774 ± 0.038
3.608GluThr: 3.608 ± 0.037
4.525GluVal: 4.525 ± 0.048
0.703GluTrp: 0.703 ± 0.019
2.274GluTyr: 2.274 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.255PheAla: 3.255 ± 0.044
0.452PheCys: 0.452 ± 0.014
3.113PheAsp: 3.113 ± 0.046
3.025PheGlu: 3.025 ± 0.037
2.227PhePhe: 2.227 ± 0.037
3.301PheGly: 3.301 ± 0.04
0.795PheHis: 0.795 ± 0.018
3.33PheIle: 3.33 ± 0.042
2.971PheLys: 2.971 ± 0.045
3.97PheLeu: 3.97 ± 0.046
1.037PheMet: 1.037 ± 0.023
2.747PheAsn: 2.747 ± 0.035
1.492PhePro: 1.492 ± 0.027
1.266PheGln: 1.266 ± 0.023
1.544PheArg: 1.544 ± 0.027
3.801PheSer: 3.801 ± 0.042
2.88PheThr: 2.88 ± 0.035
2.921PheVal: 2.921 ± 0.032
0.553PheTrp: 0.553 ± 0.015
1.778PheTyr: 1.778 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
4.853GlyAla: 4.853 ± 0.057
0.648GlyCys: 0.648 ± 0.018
3.527GlyAsp: 3.527 ± 0.045
4.157GlyGlu: 4.157 ± 0.045
3.467GlyPhe: 3.467 ± 0.04
4.572GlyGly: 4.572 ± 0.06
1.294GlyHis: 1.294 ± 0.023
4.824GlyIle: 4.824 ± 0.052
4.577GlyLys: 4.577 ± 0.054
6.054GlyLeu: 6.054 ± 0.059
1.745GlyMet: 1.745 ± 0.031
3.238GlyAsn: 3.238 ± 0.046
1.427GlyPro: 1.427 ± 0.03
2.109GlyGln: 2.109 ± 0.032
2.534GlyArg: 2.534 ± 0.038
3.864GlySer: 3.864 ± 0.047
3.675GlyThr: 3.675 ± 0.05
4.89GlyVal: 4.89 ± 0.05
0.81GlyTrp: 0.81 ± 0.018
2.607GlyTyr: 2.607 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
1.423HisAla: 1.423 ± 0.029
0.24HisCys: 0.24 ± 0.01
0.988HisAsp: 0.988 ± 0.02
1.16HisGlu: 1.16 ± 0.026
1.094HisPhe: 1.094 ± 0.022
1.263HisGly: 1.263 ± 0.024
0.569HisHis: 0.569 ± 0.017
1.448HisIle: 1.448 ± 0.025
1.219HisLys: 1.219 ± 0.023
1.905HisLeu: 1.905 ± 0.029
0.409HisMet: 0.409 ± 0.014
0.986HisAsn: 0.986 ± 0.022
1.003HisPro: 1.003 ± 0.021
0.825HisGln: 0.825 ± 0.021
0.847HisArg: 0.847 ± 0.022
1.21HisSer: 1.21 ± 0.026
1.076HisThr: 1.076 ± 0.022
1.211HisVal: 1.211 ± 0.026
0.284HisTrp: 0.284 ± 0.011
0.833HisTyr: 0.833 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
5.954IleAla: 5.954 ± 0.057
0.557IleCys: 0.557 ± 0.018
4.629IleAsp: 4.629 ± 0.046
5.13IleGlu: 5.13 ± 0.055
2.639IlePhe: 2.639 ± 0.038
4.627IleGly: 4.627 ± 0.056
1.273IleHis: 1.273 ± 0.025
4.583IleIle: 4.583 ± 0.052
4.697IleLys: 4.697 ± 0.057
5.517IleLeu: 5.517 ± 0.065
1.231IleMet: 1.231 ± 0.026
4.072IleAsn: 4.072 ± 0.047
2.783IlePro: 2.783 ± 0.033
2.387IleGln: 2.387 ± 0.036
2.588IleArg: 2.588 ± 0.033
4.903IleSer: 4.903 ± 0.049
4.295IleThr: 4.295 ± 0.049
4.478IleVal: 4.478 ± 0.051
0.588IleTrp: 0.588 ± 0.016
2.119IleTyr: 2.119 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
5.243LysAla: 5.243 ± 0.063
0.35LysCys: 0.35 ± 0.014
3.647LysAsp: 3.647 ± 0.044
5.37LysGlu: 5.37 ± 0.054
2.242LysPhe: 2.242 ± 0.035
4.192LysGly: 4.192 ± 0.047
1.461LysHis: 1.461 ± 0.028
4.465LysIle: 4.465 ± 0.056
5.412LysLys: 5.412 ± 0.077
6.085LysLeu: 6.085 ± 0.058
1.649LysMet: 1.649 ± 0.031
3.982LysAsn: 3.982 ± 0.053
2.433LysPro: 2.433 ± 0.03
2.956LysGln: 2.956 ± 0.039
3.187LysArg: 3.187 ± 0.043
4.012LysSer: 4.012 ± 0.045
4.019LysThr: 4.019 ± 0.048
4.469LysVal: 4.469 ± 0.048
0.737LysTrp: 0.737 ± 0.018
2.285LysTyr: 2.285 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
7.721LeuAla: 7.721 ± 0.07
0.799LeuCys: 0.799 ± 0.019
5.208LeuAsp: 5.208 ± 0.045
5.997LeuGlu: 5.997 ± 0.061
4.477LeuPhe: 4.477 ± 0.057
6.085LeuGly: 6.085 ± 0.051
1.875LeuHis: 1.875 ± 0.029
6.131LeuIle: 6.131 ± 0.07
6.458LeuLys: 6.458 ± 0.073
9.15LeuLeu: 9.15 ± 0.088
2.132LeuMet: 2.132 ± 0.038
5.198LeuAsn: 5.198 ± 0.052
4.08LeuPro: 4.08 ± 0.041
3.531LeuGln: 3.531 ± 0.046
3.743LeuArg: 3.743 ± 0.037
7.454LeuSer: 7.454 ± 0.063
5.588LeuThr: 5.588 ± 0.049
6.002LeuVal: 6.002 ± 0.059
0.887LeuTrp: 0.887 ± 0.021
2.846LeuTyr: 2.846 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
1.937MetAla: 1.937 ± 0.031
0.18MetCys: 0.18 ± 0.008
1.131MetAsp: 1.131 ± 0.024
1.231MetGlu: 1.231 ± 0.025
0.883MetPhe: 0.883 ± 0.02
1.479MetGly: 1.479 ± 0.025
0.449MetHis: 0.449 ± 0.013
1.296MetIle: 1.296 ± 0.023
1.74MetLys: 1.74 ± 0.032
2.375MetLeu: 2.375 ± 0.036
0.632MetMet: 0.632 ± 0.017
1.13MetAsn: 1.13 ± 0.02
1.052MetPro: 1.052 ± 0.02
1.025MetGln: 1.025 ± 0.02
1.077MetArg: 1.077 ± 0.024
1.623MetSer: 1.623 ± 0.029
1.331MetThr: 1.331 ± 0.027
1.478MetVal: 1.478 ± 0.027
0.204MetTrp: 0.204 ± 0.008
0.643MetTyr: 0.643 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
4.077AsnAla: 4.077 ± 0.048
0.426AsnCys: 0.426 ± 0.013
3.01AsnAsp: 3.01 ± 0.037
3.424AsnGlu: 3.424 ± 0.042
2.362AsnPhe: 2.362 ± 0.04
3.615AsnGly: 3.615 ± 0.048
1.011AsnHis: 1.011 ± 0.021
3.926AsnIle: 3.926 ± 0.047
3.696AsnLys: 3.696 ± 0.052
4.617AsnLeu: 4.617 ± 0.048
1.109AsnMet: 1.109 ± 0.021
3.225AsnAsn: 3.225 ± 0.055
2.344AsnPro: 2.344 ± 0.035
1.988AsnGln: 1.988 ± 0.032
2.073AsnArg: 2.073 ± 0.031
3.345AsnSer: 3.345 ± 0.045
3.347AsnThr: 3.347 ± 0.046
3.498AsnVal: 3.498 ± 0.039
0.685AsnTrp: 0.685 ± 0.018
2.167AsnTyr: 2.167 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
2.422ProAla: 2.422 ± 0.034
0.26ProCys: 0.26 ± 0.011
2.137ProAsp: 2.137 ± 0.033
2.802ProGlu: 2.802 ± 0.041
1.807ProPhe: 1.807 ± 0.027
2.031ProGly: 2.031 ± 0.033
0.775ProHis: 0.775 ± 0.019
2.548ProIle: 2.548 ± 0.034
2.32ProLys: 2.32 ± 0.031
3.414ProLeu: 3.414 ± 0.038
0.786ProMet: 0.786 ± 0.019
2.009ProAsn: 2.009 ± 0.032
1.003ProPro: 1.003 ± 0.024
1.31ProGln: 1.31 ± 0.024
1.148ProArg: 1.148 ± 0.024
2.512ProSer: 2.512 ± 0.033
2.179ProThr: 2.179 ± 0.032
2.729ProVal: 2.729 ± 0.036
0.412ProTrp: 0.412 ± 0.013
1.275ProTyr: 1.275 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
2.989GlnAla: 2.989 ± 0.042
0.274GlnCys: 0.274 ± 0.012
1.663GlnAsp: 1.663 ± 0.03
2.408GlnGlu: 2.408 ± 0.034
1.732GlnPhe: 1.732 ± 0.033
2.214GlnGly: 2.214 ± 0.031
0.898GlnHis: 0.898 ± 0.019
2.358GlnIle: 2.358 ± 0.035
2.597GlnLys: 2.597 ± 0.035
4.008GlnLeu: 4.008 ± 0.045
0.877GlnMet: 0.877 ± 0.02
1.926GlnAsn: 1.926 ± 0.035
1.31GlnPro: 1.31 ± 0.021
2.125GlnGln: 2.125 ± 0.041
1.775GlnArg: 1.775 ± 0.03
2.351GlnSer: 2.351 ± 0.035
2.083GlnThr: 2.083 ± 0.031
2.381GlnVal: 2.381 ± 0.036
0.471GlnTrp: 0.471 ± 0.017
1.333GlnTyr: 1.333 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
2.923ArgAla: 2.923 ± 0.042
0.3ArgCys: 0.3 ± 0.012
2.177ArgAsp: 2.177 ± 0.034
2.804ArgGlu: 2.804 ± 0.033
2.121ArgPhe: 2.121 ± 0.03
2.328ArgGly: 2.328 ± 0.035
0.864ArgHis: 0.864 ± 0.021
2.836ArgIle: 2.836 ± 0.037
2.672ArgLys: 2.672 ± 0.038
4.05ArgLeu: 4.05 ± 0.042
1.003ArgMet: 1.003 ± 0.02
2.031ArgAsn: 2.031 ± 0.034
1.331ArgPro: 1.331 ± 0.029
1.548ArgGln: 1.548 ± 0.025
1.77ArgArg: 1.77 ± 0.031
2.179ArgSer: 2.179 ± 0.031
2.034ArgThr: 2.034 ± 0.027
2.833ArgVal: 2.833 ± 0.042
0.499ArgTrp: 0.499 ± 0.014
1.662ArgTyr: 1.662 ± 0.026
0.0ArgXaa: 0.0 ± 0.0
Ser
4.926SerAla: 4.926 ± 0.051
0.588SerCys: 0.588 ± 0.015
3.81SerAsp: 3.81 ± 0.049
4.393SerGlu: 4.393 ± 0.048
3.422SerPhe: 3.422 ± 0.046
4.513SerGly: 4.513 ± 0.058
1.303SerHis: 1.303 ± 0.025
4.591SerIle: 4.591 ± 0.047
4.251SerLys: 4.251 ± 0.051
6.657SerLeu: 6.657 ± 0.06
1.491SerMet: 1.491 ± 0.027
3.3SerAsn: 3.3 ± 0.04
2.338SerPro: 2.338 ± 0.034
2.493SerGln: 2.493 ± 0.036
2.577SerArg: 2.577 ± 0.038
4.583SerSer: 4.583 ± 0.051
3.628SerThr: 3.628 ± 0.048
4.628SerVal: 4.628 ± 0.052
0.747SerTrp: 0.747 ± 0.02
2.426SerTyr: 2.426 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.136ThrAla: 4.136 ± 0.045
0.44ThrCys: 0.44 ± 0.014
3.128ThrAsp: 3.128 ± 0.046
3.341ThrGlu: 3.341 ± 0.036
2.686ThrPhe: 2.686 ± 0.037
4.058ThrGly: 4.058 ± 0.051
1.203ThrHis: 1.203 ± 0.024
4.192ThrIle: 4.192 ± 0.047
3.378ThrLys: 3.378 ± 0.043
6.016ThrLeu: 6.016 ± 0.052
1.064ThrMet: 1.064 ± 0.023
2.852ThrAsn: 2.852 ± 0.044
2.769ThrPro: 2.769 ± 0.04
2.268ThrGln: 2.268 ± 0.039
2.064ThrArg: 2.064 ± 0.031
3.91ThrSer: 3.91 ± 0.045
3.408ThrThr: 3.408 ± 0.05
3.989ThrVal: 3.989 ± 0.049
0.609ThrTrp: 0.609 ± 0.016
2.044ThrTyr: 2.044 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
5.346ValAla: 5.346 ± 0.062
0.628ValCys: 0.628 ± 0.018
4.032ValAsp: 4.032 ± 0.042
4.449ValGlu: 4.449 ± 0.043
3.137ValPhe: 3.137 ± 0.039
4.25ValGly: 4.25 ± 0.039
1.181ValHis: 1.181 ± 0.025
4.654ValIle: 4.654 ± 0.052
4.279ValLys: 4.279 ± 0.048
6.393ValLeu: 6.393 ± 0.062
1.569ValMet: 1.569 ± 0.027
3.604ValAsn: 3.604 ± 0.041
2.445ValPro: 2.445 ± 0.032
2.026ValGln: 2.026 ± 0.035
2.548ValArg: 2.548 ± 0.034
5.097ValSer: 5.097 ± 0.047
4.109ValThr: 4.109 ± 0.053
4.961ValVal: 4.961 ± 0.056
0.679ValTrp: 0.679 ± 0.019
2.127ValTyr: 2.127 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
0.713TrpAla: 0.713 ± 0.017
0.111TrpCys: 0.111 ± 0.007
0.592TrpAsp: 0.592 ± 0.018
0.622TrpGlu: 0.622 ± 0.016
0.586TrpPhe: 0.586 ± 0.015
0.694TrpGly: 0.694 ± 0.018
0.287TrpHis: 0.287 ± 0.01
0.673TrpIle: 0.673 ± 0.018
0.68TrpLys: 0.68 ± 0.018
1.308TrpLeu: 1.308 ± 0.024
0.314TrpMet: 0.314 ± 0.011
0.563TrpAsn: 0.563 ± 0.017
0.321TrpPro: 0.321 ± 0.013
0.603TrpGln: 0.603 ± 0.019
0.569TrpArg: 0.569 ± 0.015
0.661TrpSer: 0.661 ± 0.018
0.502TrpThr: 0.502 ± 0.017
0.748TrpVal: 0.748 ± 0.019
0.162TrpTrp: 0.162 ± 0.009
0.411TrpTyr: 0.411 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.42TyrAla: 2.42 ± 0.033
0.336TyrCys: 0.336 ± 0.013
2.025TyrAsp: 2.025 ± 0.034
2.093TyrGlu: 2.093 ± 0.03
1.878TyrPhe: 1.878 ± 0.033
2.324TyrGly: 2.324 ± 0.034
0.776TyrHis: 0.776 ± 0.02
2.129TyrIle: 2.129 ± 0.035
2.423TyrLys: 2.423 ± 0.037
3.412TyrLeu: 3.412 ± 0.041
0.648TyrMet: 0.648 ± 0.016
1.955TyrAsn: 1.955 ± 0.039
1.338TyrPro: 1.338 ± 0.021
1.564TyrGln: 1.564 ± 0.026
1.644TyrArg: 1.644 ± 0.026
2.309TyrSer: 2.309 ± 0.033
2.061TyrThr: 2.061 ± 0.036
2.069TyrVal: 2.069 ± 0.035
0.479TyrTrp: 0.479 ± 0.014
1.39TyrTyr: 1.39 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6803 proteins (2271612 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski