Amino acid dipepetide frequency for Camellia sinensis var. sinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.792AlaAla: 5.792 ± 0.027
1.271AlaCys: 1.271 ± 0.011
2.853AlaAsp: 2.853 ± 0.015
3.89AlaGlu: 3.89 ± 0.02
2.745AlaPhe: 2.745 ± 0.016
3.772AlaGly: 3.772 ± 0.02
1.285AlaHis: 1.285 ± 0.011
3.855AlaIle: 3.855 ± 0.02
3.683AlaLys: 3.683 ± 0.018
6.488AlaLeu: 6.488 ± 0.027
1.865AlaMet: 1.865 ± 0.014
2.618AlaAsn: 2.618 ± 0.014
2.574AlaPro: 2.574 ± 0.017
2.056AlaGln: 2.056 ± 0.013
3.2AlaArg: 3.2 ± 0.022
5.713AlaSer: 5.713 ± 0.023
3.604AlaThr: 3.604 ± 0.018
4.634AlaVal: 4.634 ± 0.024
0.762AlaTrp: 0.762 ± 0.008
1.72AlaTyr: 1.72 ± 0.013
0.0AlaXaa: 0.0 ± 0.0
Cys
1.022CysAla: 1.022 ± 0.012
0.595CysCys: 0.595 ± 0.007
0.92CysAsp: 0.92 ± 0.008
0.954CysGlu: 0.954 ± 0.01
0.994CysPhe: 0.994 ± 0.01
1.463CysGly: 1.463 ± 0.012
0.495CysHis: 0.495 ± 0.007
1.061CysIle: 1.061 ± 0.01
1.133CysLys: 1.133 ± 0.012
2.017CysLeu: 2.017 ± 0.012
0.449CysMet: 0.449 ± 0.007
0.942CysAsn: 0.942 ± 0.011
1.005CysPro: 1.005 ± 0.01
0.624CysGln: 0.624 ± 0.007
1.057CysArg: 1.057 ± 0.012
1.909CysSer: 1.909 ± 0.014
0.884CysThr: 0.884 ± 0.009
1.14CysVal: 1.14 ± 0.009
0.273CysTrp: 0.273 ± 0.005
0.573CysTyr: 0.573 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
3.147AspAla: 3.147 ± 0.018
1.0AspCys: 1.0 ± 0.009
3.594AspAsp: 3.594 ± 0.022
3.833AspGlu: 3.833 ± 0.023
2.359AspPhe: 2.359 ± 0.015
3.792AspGly: 3.792 ± 0.018
1.256AspHis: 1.256 ± 0.011
2.901AspIle: 2.901 ± 0.016
2.53AspLys: 2.53 ± 0.016
5.284AspLeu: 5.284 ± 0.027
1.325AspMet: 1.325 ± 0.01
2.124AspAsn: 2.124 ± 0.014
2.532AspPro: 2.532 ± 0.014
1.769AspGln: 1.769 ± 0.014
2.356AspArg: 2.356 ± 0.02
4.138AspSer: 4.138 ± 0.024
2.154AspThr: 2.154 ± 0.012
3.53AspVal: 3.53 ± 0.016
0.743AspTrp: 0.743 ± 0.009
1.489AspTyr: 1.489 ± 0.012
0.0AspXaa: 0.0 ± 0.0
Glu
4.57GluAla: 4.57 ± 0.021
0.945GluCys: 0.945 ± 0.009
3.76GluAsp: 3.76 ± 0.025
6.2GluGlu: 6.2 ± 0.051
2.419GluPhe: 2.419 ± 0.014
3.788GluGly: 3.788 ± 0.022
1.212GluHis: 1.212 ± 0.011
3.874GluIle: 3.874 ± 0.023
4.501GluLys: 4.501 ± 0.028
6.039GluLeu: 6.039 ± 0.029
1.846GluMet: 1.846 ± 0.012
3.027GluAsn: 3.027 ± 0.02
1.989GluPro: 1.989 ± 0.015
2.103GluGln: 2.103 ± 0.017
3.268GluArg: 3.268 ± 0.021
4.448GluSer: 4.448 ± 0.024
2.979GluThr: 2.979 ± 0.017
4.206GluVal: 4.206 ± 0.023
0.739GluTrp: 0.739 ± 0.009
1.578GluTyr: 1.578 ± 0.011
0.0GluXaa: 0.0 ± 0.0
Phe
2.487PheAla: 2.487 ± 0.016
0.979PheCys: 0.979 ± 0.008
2.431PheAsp: 2.431 ± 0.015
2.373PheGlu: 2.373 ± 0.019
2.064PhePhe: 2.064 ± 0.014
3.335PheGly: 3.335 ± 0.024
1.153PheHis: 1.153 ± 0.011
2.113PheIle: 2.113 ± 0.013
2.09PheLys: 2.09 ± 0.013
4.394PheLeu: 4.394 ± 0.022
1.016PheMet: 1.016 ± 0.01
1.913PheAsn: 1.913 ± 0.013
2.119PhePro: 2.119 ± 0.014
1.58PheGln: 1.58 ± 0.012
2.028PheArg: 2.028 ± 0.015
4.158PheSer: 4.158 ± 0.021
2.055PheThr: 2.055 ± 0.013
2.851PheVal: 2.851 ± 0.015
0.574PheTrp: 0.574 ± 0.007
1.272PheTyr: 1.272 ± 0.011
0.0PheXaa: 0.0 ± 0.0
Gly
3.612GlyAla: 3.612 ± 0.019
1.409GlyCys: 1.409 ± 0.013
3.417GlyAsp: 3.417 ± 0.019
3.675GlyGlu: 3.675 ± 0.023
3.353GlyPhe: 3.353 ± 0.018
6.058GlyGly: 6.058 ± 0.235
1.574GlyHis: 1.574 ± 0.013
3.713GlyIle: 3.713 ± 0.019
4.027GlyLys: 4.027 ± 0.025
6.265GlyLeu: 6.265 ± 0.025
1.633GlyMet: 1.633 ± 0.012
3.275GlyAsn: 3.275 ± 0.02
2.426GlyPro: 2.426 ± 0.019
2.077GlyGln: 2.077 ± 0.018
3.548GlyArg: 3.548 ± 0.018
5.948GlySer: 5.948 ± 0.034
3.279GlyThr: 3.279 ± 0.017
4.343GlyVal: 4.343 ± 0.023
0.946GlyTrp: 0.946 ± 0.008
2.084GlyTyr: 2.084 ± 0.014
0.0GlyXaa: 0.0 ± 0.0
His
1.316HisAla: 1.316 ± 0.013
0.596HisCys: 0.596 ± 0.008
1.168HisAsp: 1.168 ± 0.01
1.292HisGlu: 1.292 ± 0.01
1.108HisPhe: 1.108 ± 0.01
1.766HisGly: 1.766 ± 0.013
1.099HisHis: 1.099 ± 0.015
1.229HisIle: 1.229 ± 0.01
1.161HisLys: 1.161 ± 0.01
2.631HisLeu: 2.631 ± 0.02
0.534HisMet: 0.534 ± 0.007
1.066HisAsn: 1.066 ± 0.009
1.371HisPro: 1.371 ± 0.012
1.026HisGln: 1.026 ± 0.01
1.467HisArg: 1.467 ± 0.012
1.981HisSer: 1.981 ± 0.014
0.993HisThr: 0.993 ± 0.009
1.558HisVal: 1.558 ± 0.011
0.321HisTrp: 0.321 ± 0.005
0.703HisTyr: 0.703 ± 0.007
0.0HisXaa: 0.0 ± 0.0
Ile
3.729IleAla: 3.729 ± 0.018
1.144IleCys: 1.144 ± 0.01
3.028IleAsp: 3.028 ± 0.018
3.318IleGlu: 3.318 ± 0.019
2.292IlePhe: 2.292 ± 0.015
3.708IleGly: 3.708 ± 0.025
1.407IleHis: 1.407 ± 0.013
2.857IleIle: 2.857 ± 0.018
2.827IleLys: 2.827 ± 0.018
5.345IleLeu: 5.345 ± 0.024
1.172IleMet: 1.172 ± 0.01
2.236IleAsn: 2.236 ± 0.015
3.175IlePro: 3.175 ± 0.029
2.016IleGln: 2.016 ± 0.013
2.592IleArg: 2.592 ± 0.017
4.964IleSer: 4.964 ± 0.022
2.658IleThr: 2.658 ± 0.015
3.677IleVal: 3.677 ± 0.02
0.734IleTrp: 0.734 ± 0.009
1.507IleTyr: 1.507 ± 0.012
0.0IleXaa: 0.0 ± 0.0
Lys
3.833LysAla: 3.833 ± 0.022
0.954LysCys: 0.954 ± 0.009
3.012LysAsp: 3.012 ± 0.018
4.363LysGlu: 4.363 ± 0.027
2.17LysPhe: 2.17 ± 0.016
3.527LysGly: 3.527 ± 0.022
1.308LysHis: 1.308 ± 0.012
3.204LysIle: 3.204 ± 0.018
4.593LysLys: 4.593 ± 0.043
6.026LysLeu: 6.026 ± 0.03
1.543LysMet: 1.543 ± 0.012
2.695LysAsn: 2.695 ± 0.017
2.634LysPro: 2.634 ± 0.02
2.203LysGln: 2.203 ± 0.016
3.381LysArg: 3.381 ± 0.021
4.48LysSer: 4.48 ± 0.027
2.81LysThr: 2.81 ± 0.018
3.705LysVal: 3.705 ± 0.019
0.791LysTrp: 0.791 ± 0.008
1.492LysTyr: 1.492 ± 0.012
0.0LysXaa: 0.0 ± 0.0
Leu
6.389LeuAla: 6.389 ± 0.027
2.033LeuCys: 2.033 ± 0.014
5.219LeuAsp: 5.219 ± 0.027
6.414LeuGlu: 6.414 ± 0.028
4.108LeuPhe: 4.108 ± 0.021
6.106LeuGly: 6.106 ± 0.028
2.779LeuHis: 2.779 ± 0.018
4.934LeuIle: 4.934 ± 0.024
6.067LeuLys: 6.067 ± 0.029
10.286LeuLeu: 10.286 ± 0.041
2.214LeuMet: 2.214 ± 0.013
4.213LeuAsn: 4.213 ± 0.021
5.32LeuPro: 5.32 ± 0.024
4.4LeuGln: 4.4 ± 0.028
5.394LeuArg: 5.394 ± 0.022
9.197LeuSer: 9.197 ± 0.048
4.711LeuThr: 4.711 ± 0.032
6.603LeuVal: 6.603 ± 0.026
1.21LeuTrp: 1.21 ± 0.01
2.593LeuTyr: 2.593 ± 0.018
0.0LeuXaa: 0.0 ± 0.0
Met
2.101MetAla: 2.101 ± 0.021
0.338MetCys: 0.338 ± 0.005
1.424MetAsp: 1.424 ± 0.011
2.039MetGlu: 2.039 ± 0.015
0.867MetPhe: 0.867 ± 0.009
1.717MetGly: 1.717 ± 0.013
0.536MetHis: 0.536 ± 0.006
1.261MetIle: 1.261 ± 0.011
1.668MetLys: 1.668 ± 0.014
2.305MetLeu: 2.305 ± 0.012
0.736MetMet: 0.736 ± 0.008
1.068MetAsn: 1.068 ± 0.01
1.103MetPro: 1.103 ± 0.01
0.885MetGln: 0.885 ± 0.009
1.204MetArg: 1.204 ± 0.011
1.791MetSer: 1.791 ± 0.016
1.086MetThr: 1.086 ± 0.009
1.829MetVal: 1.829 ± 0.013
0.271MetTrp: 0.271 ± 0.005
0.604MetTyr: 0.604 ± 0.007
0.0MetXaa: 0.0 ± 0.0
Asn
2.584AsnAla: 2.584 ± 0.016
0.963AsnCys: 0.963 ± 0.011
2.086AsnAsp: 2.086 ± 0.016
2.525AsnGlu: 2.525 ± 0.017
2.085AsnPhe: 2.085 ± 0.016
3.411AsnGly: 3.411 ± 0.021
1.203AsnHis: 1.203 ± 0.011
2.485AsnIle: 2.485 ± 0.015
2.411AsnLys: 2.411 ± 0.016
5.207AsnLeu: 5.207 ± 0.039
1.109AsnMet: 1.109 ± 0.011
2.58AsnAsn: 2.58 ± 0.02
2.466AsnPro: 2.466 ± 0.015
1.819AsnGln: 1.819 ± 0.014
2.047AsnArg: 2.047 ± 0.019
4.119AsnSer: 4.119 ± 0.028
2.051AsnThr: 2.051 ± 0.016
2.801AsnVal: 2.801 ± 0.016
0.603AsnTrp: 0.603 ± 0.009
1.333AsnTyr: 1.333 ± 0.011
0.0AsnXaa: 0.0 ± 0.0
Pro
2.676ProAla: 2.676 ± 0.019
0.806ProCys: 0.806 ± 0.009
2.352ProAsp: 2.352 ± 0.015
2.952ProGlu: 2.952 ± 0.015
2.051ProPhe: 2.051 ± 0.015
2.458ProGly: 2.458 ± 0.016
1.174ProHis: 1.174 ± 0.01
2.558ProIle: 2.558 ± 0.021
2.719ProLys: 2.719 ± 0.017
4.466ProLeu: 4.466 ± 0.026
1.018ProMet: 1.018 ± 0.009
2.566ProAsn: 2.566 ± 0.017
4.216ProPro: 4.216 ± 0.058
1.849ProGln: 1.849 ± 0.012
2.264ProArg: 2.264 ± 0.016
5.257ProSer: 5.257 ± 0.026
2.741ProThr: 2.741 ± 0.018
2.925ProVal: 2.925 ± 0.016
0.594ProTrp: 0.594 ± 0.008
1.297ProTyr: 1.297 ± 0.013
0.0ProXaa: 0.0 ± 0.0
Gln
2.233GlnAla: 2.233 ± 0.016
0.606GlnCys: 0.606 ± 0.007
1.565GlnAsp: 1.565 ± 0.011
2.268GlnGlu: 2.268 ± 0.018
1.494GlnPhe: 1.494 ± 0.015
2.081GlnGly: 2.081 ± 0.014
0.924GlnHis: 0.924 ± 0.009
2.106GlnIle: 2.106 ± 0.014
2.179GlnLys: 2.179 ± 0.015
3.809GlnLeu: 3.809 ± 0.022
0.943GlnMet: 0.943 ± 0.01
1.848GlnAsn: 1.848 ± 0.015
1.756GlnPro: 1.756 ± 0.015
2.014GlnGln: 2.014 ± 0.022
2.038GlnArg: 2.038 ± 0.013
2.991GlnSer: 2.991 ± 0.021
1.776GlnThr: 1.776 ± 0.013
2.325GlnVal: 2.325 ± 0.016
0.482GlnTrp: 0.482 ± 0.006
0.924GlnTyr: 0.924 ± 0.008
0.0GlnXaa: 0.0 ± 0.0
Arg
3.083ArgAla: 3.083 ± 0.018
0.974ArgCys: 0.974 ± 0.013
2.56ArgAsp: 2.56 ± 0.017
3.31ArgGlu: 3.31 ± 0.021
2.163ArgPhe: 2.163 ± 0.017
3.265ArgGly: 3.265 ± 0.02
1.287ArgHis: 1.287 ± 0.01
2.75ArgIle: 2.75 ± 0.015
3.522ArgLys: 3.522 ± 0.022
5.061ArgLeu: 5.061 ± 0.024
1.274ArgMet: 1.274 ± 0.01
2.428ArgAsn: 2.428 ± 0.016
2.245ArgPro: 2.245 ± 0.024
1.742ArgGln: 1.742 ± 0.013
3.786ArgArg: 3.786 ± 0.024
4.21ArgSer: 4.21 ± 0.022
2.357ArgThr: 2.357 ± 0.015
3.318ArgVal: 3.318 ± 0.019
0.747ArgTrp: 0.747 ± 0.009
1.373ArgTyr: 1.373 ± 0.01
0.0ArgXaa: 0.0 ± 0.0
Ser
5.088SerAla: 5.088 ± 0.022
1.783SerCys: 1.783 ± 0.012
4.381SerAsp: 4.381 ± 0.027
4.693SerGlu: 4.693 ± 0.026
4.081SerPhe: 4.081 ± 0.022
5.905SerGly: 5.905 ± 0.03
2.05SerHis: 2.05 ± 0.014
4.908SerIle: 4.908 ± 0.023
4.809SerLys: 4.809 ± 0.026
9.171SerLeu: 9.171 ± 0.036
2.154SerMet: 2.154 ± 0.013
4.298SerAsn: 4.298 ± 0.031
4.605SerPro: 4.605 ± 0.031
2.987SerGln: 2.987 ± 0.02
4.24SerArg: 4.24 ± 0.025
11.179SerSer: 11.179 ± 0.065
4.806SerThr: 4.806 ± 0.025
5.227SerVal: 5.227 ± 0.021
1.172SerTrp: 1.172 ± 0.009
2.261SerTyr: 2.261 ± 0.014
0.0SerXaa: 0.0 ± 0.0
Thr
3.326ThrAla: 3.326 ± 0.018
0.95ThrCys: 0.95 ± 0.01
2.226ThrAsp: 2.226 ± 0.012
2.705ThrGlu: 2.705 ± 0.017
2.051ThrPhe: 2.051 ± 0.013
3.242ThrGly: 3.242 ± 0.019
1.147ThrHis: 1.147 ± 0.011
2.978ThrIle: 2.978 ± 0.016
2.639ThrLys: 2.639 ± 0.015
4.767ThrLeu: 4.767 ± 0.019
1.289ThrMet: 1.289 ± 0.019
2.27ThrAsn: 2.27 ± 0.019
2.534ThrPro: 2.534 ± 0.018
1.625ThrGln: 1.625 ± 0.012
2.3ThrArg: 2.3 ± 0.014
4.622ThrSer: 4.622 ± 0.021
3.445ThrThr: 3.445 ± 0.024
3.375ThrVal: 3.375 ± 0.02
0.647ThrTrp: 0.647 ± 0.01
1.359ThrTyr: 1.359 ± 0.011
0.0ThrXaa: 0.0 ± 0.0
Val
4.874ValAla: 4.874 ± 0.023
1.234ValCys: 1.234 ± 0.011
3.74ValAsp: 3.74 ± 0.018
4.411ValGlu: 4.411 ± 0.021
2.764ValPhe: 2.764 ± 0.017
4.398ValGly: 4.398 ± 0.019
1.501ValHis: 1.501 ± 0.012
3.419ValIle: 3.419 ± 0.02
3.754ValLys: 3.754 ± 0.02
6.502ValLeu: 6.502 ± 0.026
1.633ValMet: 1.633 ± 0.015
2.656ValAsn: 2.656 ± 0.014
3.1ValPro: 3.1 ± 0.019
2.251ValGln: 2.251 ± 0.016
3.071ValArg: 3.071 ± 0.016
5.432ValSer: 5.432 ± 0.021
3.174ValThr: 3.174 ± 0.017
5.381ValVal: 5.381 ± 0.028
0.853ValTrp: 0.853 ± 0.009
1.949ValTyr: 1.949 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
0.796TrpAla: 0.796 ± 0.01
0.272TrpCys: 0.272 ± 0.005
0.662TrpAsp: 0.662 ± 0.007
0.751TrpGlu: 0.751 ± 0.008
0.556TrpPhe: 0.556 ± 0.007
0.754TrpGly: 0.754 ± 0.009
0.298TrpHis: 0.298 ± 0.005
0.737TrpIle: 0.737 ± 0.008
0.942TrpLys: 0.942 ± 0.009
1.309TrpLeu: 1.309 ± 0.012
0.344TrpMet: 0.344 ± 0.005
0.731TrpAsn: 0.731 ± 0.009
0.533TrpPro: 0.533 ± 0.007
0.444TrpGln: 0.444 ± 0.006
0.819TrpArg: 0.819 ± 0.009
0.992TrpSer: 0.992 ± 0.01
0.656TrpThr: 0.656 ± 0.007
0.932TrpVal: 0.932 ± 0.009
0.268TrpTrp: 0.268 ± 0.005
0.345TrpTyr: 0.345 ± 0.005
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.724TyrAla: 1.724 ± 0.014
0.66TyrCys: 0.66 ± 0.007
1.458TyrAsp: 1.458 ± 0.011
1.527TyrGlu: 1.527 ± 0.011
1.261TyrPhe: 1.261 ± 0.011
2.116TyrGly: 2.116 ± 0.017
0.697TyrHis: 0.697 ± 0.008
1.444TyrIle: 1.444 ± 0.012
1.464TyrLys: 1.464 ± 0.013
2.818TyrLeu: 2.818 ± 0.016
0.738TyrMet: 0.738 ± 0.008
1.332TyrAsn: 1.332 ± 0.011
1.236TyrPro: 1.236 ± 0.011
0.891TyrGln: 0.891 ± 0.008
1.392TyrArg: 1.392 ± 0.013
2.266TyrSer: 2.266 ± 0.016
1.279TyrThr: 1.279 ± 0.011
1.738TyrVal: 1.738 ± 0.013
0.414TyrTrp: 0.414 ± 0.006
0.962TyrTyr: 0.962 ± 0.014
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.005XaaXaa: 0.005 ± 0.002
Statistics based on 30052 proteins (13452360 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski