Amino acid dipepetide frequency for Thermostaphylospora chromogena

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.927AlaAla: 20.927 ± 0.163	1.135AlaCys: 1.135 ± 0.027	8.006AlaAsp: 8.006 ± 0.078	9.593AlaGlu: 9.593 ± 0.098	3.6AlaPhe: 3.6 ± 0.053	12.37AlaGly: 12.37 ± 0.114	2.54AlaHis: 2.54 ± 0.046	4.402AlaIle: 4.402 ± 0.066	2.542AlaLys: 2.542 ± 0.047	13.852AlaLeu: 13.852 ± 0.126	2.688AlaMet: 2.688 ± 0.042	1.797AlaAsn: 1.797 ± 0.037	6.498AlaPro: 6.498 ± 0.076	3.125AlaGln: 3.125 ± 0.043	11.084AlaArg: 11.084 ± 0.097	5.616AlaSer: 5.616 ± 0.056	6.367AlaThr: 6.367 ± 0.072	12.403AlaVal: 12.403 ± 0.109	1.849AlaTrp: 1.849 ± 0.039	2.6AlaTyr: 2.6 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.006CysAla: 1.006 ± 0.026	0.096CysCys: 0.096 ± 0.008	0.517CysAsp: 0.517 ± 0.021	0.429CysGlu: 0.429 ± 0.017	0.202CysPhe: 0.202 ± 0.012	0.975CysGly: 0.975 ± 0.027	0.195CysHis: 0.195 ± 0.01	0.175CysIle: 0.175 ± 0.01	0.11CysLys: 0.11 ± 0.008	0.747CysLeu: 0.747 ± 0.023	0.141CysMet: 0.141 ± 0.009	0.131CysAsn: 0.131 ± 0.009	0.478CysPro: 0.478 ± 0.016	0.144CysGln: 0.144 ± 0.008	0.653CysArg: 0.653 ± 0.022	0.421CysSer: 0.421 ± 0.017	0.468CysThr: 0.468 ± 0.018	0.659CysVal: 0.659 ± 0.02	0.104CysTrp: 0.104 ± 0.008	0.198CysTyr: 0.198 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.125AspAla: 7.125 ± 0.073	0.344AspCys: 0.344 ± 0.016	3.563AspAsp: 3.563 ± 0.05	3.744AspGlu: 3.744 ± 0.054	1.524AspPhe: 1.524 ± 0.034	6.148AspGly: 6.148 ± 0.07	1.338AspHis: 1.338 ± 0.028	1.921AspIle: 1.921 ± 0.039	0.998AspLys: 0.998 ± 0.028	6.143AspLeu: 6.143 ± 0.069	0.892AspMet: 0.892 ± 0.023	0.813AspAsn: 0.813 ± 0.022	4.694AspPro: 4.694 ± 0.055	1.261AspGln: 1.261 ± 0.029	5.284AspArg: 5.284 ± 0.061	2.027AspSer: 2.027 ± 0.034	2.723AspThr: 2.723 ± 0.045	4.894AspVal: 4.894 ± 0.055	0.86AspTrp: 0.86 ± 0.027	1.259AspTyr: 1.259 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.516GluAla: 7.516 ± 0.079	0.419GluCys: 0.419 ± 0.016	2.82GluAsp: 2.82 ± 0.044	4.465GluGlu: 4.465 ± 0.057	1.492GluPhe: 1.492 ± 0.035	4.369GluGly: 4.369 ± 0.059	1.601GluHis: 1.601 ± 0.036	2.736GluIle: 2.736 ± 0.044	1.466GluLys: 1.466 ± 0.033	6.973GluLeu: 6.973 ± 0.077	1.06GluMet: 1.06 ± 0.025	1.133GluAsn: 1.133 ± 0.031	3.73GluPro: 3.73 ± 0.052	2.126GluGln: 2.126 ± 0.041	6.527GluArg: 6.527 ± 0.082	2.493GluSer: 2.493 ± 0.046	2.981GluThr: 2.981 ± 0.048	5.017GluVal: 5.017 ± 0.065	0.898GluTrp: 0.898 ± 0.023	1.191GluTyr: 1.191 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.749PheAla: 3.749 ± 0.049	0.272PheCys: 0.272 ± 0.014	1.892PheAsp: 1.892 ± 0.035	1.401PheGlu: 1.401 ± 0.028	0.894PhePhe: 0.894 ± 0.025	2.946PheGly: 2.946 ± 0.048	0.607PheHis: 0.607 ± 0.018	0.964PheIle: 0.964 ± 0.028	0.478PheLys: 0.478 ± 0.016	2.554PheLeu: 2.554 ± 0.042	0.463PheMet: 0.463 ± 0.017	0.576PheAsn: 0.576 ± 0.021	1.416PhePro: 1.416 ± 0.031	0.663PheGln: 0.663 ± 0.02	1.933PheArg: 1.933 ± 0.038	1.515PheSer: 1.515 ± 0.03	1.937PheThr: 1.937 ± 0.032	2.244PheVal: 2.244 ± 0.033	0.411PheTrp: 0.411 ± 0.016	0.629PheTyr: 0.629 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	9.938GlyAla: 9.938 ± 0.089	0.847GlyCys: 0.847 ± 0.021	5.132GlyAsp: 5.132 ± 0.057	5.701GlyGlu: 5.701 ± 0.063	2.837GlyPhe: 2.837 ± 0.041	8.67GlyGly: 8.67 ± 0.1	2.064GlyHis: 2.064 ± 0.038	3.367GlyIle: 3.367 ± 0.044	2.275GlyLys: 2.275 ± 0.052	9.11GlyLeu: 9.11 ± 0.087	2.259GlyMet: 2.259 ± 0.035	1.526GlyAsn: 1.526 ± 0.034	5.118GlyPro: 5.118 ± 0.063	2.217GlyGln: 2.217 ± 0.044	8.446GlyArg: 8.446 ± 0.072	4.567GlySer: 4.567 ± 0.065	5.363GlyThr: 5.363 ± 0.063	8.383GlyVal: 8.383 ± 0.088	1.606GlyTrp: 1.606 ± 0.033	2.372GlyTyr: 2.372 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.641HisAla: 2.641 ± 0.04	0.175HisCys: 0.175 ± 0.011	1.294HisAsp: 1.294 ± 0.031	1.143HisGlu: 1.143 ± 0.024	0.508HisPhe: 0.508 ± 0.019	2.208HisGly: 2.208 ± 0.039	0.609HisHis: 0.609 ± 0.02	0.743HisIle: 0.743 ± 0.023	0.287HisLys: 0.287 ± 0.013	2.299HisLeu: 2.299 ± 0.046	0.324HisMet: 0.324 ± 0.015	0.364HisAsn: 0.364 ± 0.016	1.754HisPro: 1.754 ± 0.039	0.485HisGln: 0.485 ± 0.016	2.035HisArg: 2.035 ± 0.037	0.842HisSer: 0.842 ± 0.021	1.045HisThr: 1.045 ± 0.023	1.736HisVal: 1.736 ± 0.033	0.29HisTrp: 0.29 ± 0.014	0.475HisTyr: 0.475 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.532IleAla: 5.532 ± 0.069	0.329IleCys: 0.329 ± 0.016	2.566IleAsp: 2.566 ± 0.039	2.405IleGlu: 2.405 ± 0.045	0.917IlePhe: 0.917 ± 0.023	4.005IleGly: 4.005 ± 0.049	0.673IleHis: 0.673 ± 0.021	1.257IleIle: 1.257 ± 0.03	0.877IleLys: 0.877 ± 0.025	3.023IleLeu: 3.023 ± 0.046	0.678IleMet: 0.678 ± 0.022	0.81IleAsn: 0.81 ± 0.027	2.159IlePro: 2.159 ± 0.042	0.762IleGln: 0.762 ± 0.024	2.845IleArg: 2.845 ± 0.039	1.961IleSer: 1.961 ± 0.035	2.527IleThr: 2.527 ± 0.047	3.424IleVal: 3.424 ± 0.048	0.444IleTrp: 0.444 ± 0.018	0.678IleTyr: 0.678 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.588LysAla: 2.588 ± 0.047	0.12LysCys: 0.12 ± 0.009	1.029LysAsp: 1.029 ± 0.028	1.248LysGlu: 1.248 ± 0.033	0.385LysPhe: 0.385 ± 0.017	1.623LysGly: 1.623 ± 0.042	0.388LysHis: 0.388 ± 0.016	1.035LysIle: 1.035 ± 0.031	0.678LysLys: 0.678 ± 0.033	1.847LysLeu: 1.847 ± 0.038	0.393LysMet: 0.393 ± 0.016	0.474LysAsn: 0.474 ± 0.018	1.305LysPro: 1.305 ± 0.033	0.549LysGln: 0.549 ± 0.02	1.643LysArg: 1.643 ± 0.034	0.969LysSer: 0.969 ± 0.027	1.183LysThr: 1.183 ± 0.032	1.866LysVal: 1.866 ± 0.042	0.239LysTrp: 0.239 ± 0.012	0.412LysTyr: 0.412 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.726LeuAla: 15.726 ± 0.142	0.794LeuCys: 0.794 ± 0.022	6.247LeuAsp: 6.247 ± 0.063	4.913LeuGlu: 4.913 ± 0.069	2.65LeuPhe: 2.65 ± 0.046	8.771LeuGly: 8.771 ± 0.083	2.073LeuHis: 2.073 ± 0.04	4.111LeuIle: 4.111 ± 0.057	1.797LeuLys: 1.797 ± 0.036	11.072LeuLeu: 11.072 ± 0.119	1.676LeuMet: 1.676 ± 0.031	1.764LeuAsn: 1.764 ± 0.036	6.427LeuPro: 6.427 ± 0.077	1.939LeuGln: 1.939 ± 0.036	9.243LeuArg: 9.243 ± 0.092	5.398LeuSer: 5.398 ± 0.058	6.357LeuThr: 6.357 ± 0.059	8.793LeuVal: 8.793 ± 0.078	1.324LeuTrp: 1.324 ± 0.031	1.845LeuTyr: 1.845 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.473MetAla: 2.473 ± 0.043	0.132MetCys: 0.132 ± 0.01	0.905MetAsp: 0.905 ± 0.022	0.846MetGlu: 0.846 ± 0.021	0.505MetPhe: 0.505 ± 0.02	1.391MetGly: 1.391 ± 0.029	0.334MetHis: 0.334 ± 0.015	0.91MetIle: 0.91 ± 0.024	0.423MetLys: 0.423 ± 0.016	2.005MetLeu: 2.005 ± 0.037	0.352MetMet: 0.352 ± 0.015	0.446MetAsn: 0.446 ± 0.018	1.221MetPro: 1.221 ± 0.025	0.407MetGln: 0.407 ± 0.017	1.813MetArg: 1.813 ± 0.033	1.345MetSer: 1.345 ± 0.031	1.515MetThr: 1.515 ± 0.035	1.454MetVal: 1.454 ± 0.029	0.237MetTrp: 0.237 ± 0.013	0.299MetTyr: 0.299 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.118AsnAla: 2.118 ± 0.039	0.146AsnCys: 0.146 ± 0.009	0.874AsnAsp: 0.874 ± 0.025	0.86AsnGlu: 0.86 ± 0.028	0.462AsnPhe: 0.462 ± 0.015	1.827AsnGly: 1.827 ± 0.043	0.384AsnHis: 0.384 ± 0.016	0.673AsnIle: 0.673 ± 0.022	0.357AsnLys: 0.357 ± 0.023	1.716AsnLeu: 1.716 ± 0.032	0.311AsnMet: 0.311 ± 0.014	0.379AsnAsn: 0.379 ± 0.018	1.379AsnPro: 1.379 ± 0.031	0.48AsnGln: 0.48 ± 0.017	1.398AsnArg: 1.398 ± 0.03	0.751AsnSer: 0.751 ± 0.021	0.981AsnThr: 0.981 ± 0.025	1.485AsnVal: 1.485 ± 0.03	0.273AsnTrp: 0.273 ± 0.015	0.39AsnTyr: 0.39 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	8.241ProAla: 8.241 ± 0.09	0.378ProCys: 0.378 ± 0.016	4.55ProAsp: 4.55 ± 0.049	4.636ProGlu: 4.636 ± 0.064	1.62ProPhe: 1.62 ± 0.03	6.712ProGly: 6.712 ± 0.079	1.306ProHis: 1.306 ± 0.027	1.936ProIle: 1.936 ± 0.029	1.182ProLys: 1.182 ± 0.026	5.347ProLeu: 5.347 ± 0.068	1.055ProMet: 1.055 ± 0.025	0.92ProAsn: 0.92 ± 0.025	4.495ProPro: 4.495 ± 0.071	1.538ProGln: 1.538 ± 0.034	4.481ProArg: 4.481 ± 0.066	3.474ProSer: 3.474 ± 0.052	3.06ProThr: 3.06 ± 0.054	5.425ProVal: 5.425 ± 0.057	0.952ProTrp: 0.952 ± 0.023	1.509ProTyr: 1.509 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.498GlnAla: 3.498 ± 0.055	0.123GlnCys: 0.123 ± 0.009	1.08GlnAsp: 1.08 ± 0.025	1.44GlnGlu: 1.44 ± 0.031	0.54GlnPhe: 0.54 ± 0.02	1.906GlnGly: 1.906 ± 0.032	0.491GlnHis: 0.491 ± 0.016	1.212GlnIle: 1.212 ± 0.026	0.49GlnLys: 0.49 ± 0.019	2.242GlnLeu: 2.242 ± 0.044	0.423GlnMet: 0.423 ± 0.016	0.47GlnAsn: 0.47 ± 0.016	1.48GlnPro: 1.48 ± 0.035	0.93GlnGln: 0.93 ± 0.043	2.275GlnArg: 2.275 ± 0.041	0.959GlnSer: 0.959 ± 0.03	1.227GlnThr: 1.227 ± 0.032	2.216GlnVal: 2.216 ± 0.036	0.377GlnTrp: 0.377 ± 0.018	0.46GlnTyr: 0.46 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.493ArgAla: 10.493 ± 0.097	0.636ArgCys: 0.636 ± 0.021	4.684ArgAsp: 4.684 ± 0.059	5.653ArgGlu: 5.653 ± 0.063	2.607ArgPhe: 2.607 ± 0.041	6.282ArgGly: 6.282 ± 0.059	2.091ArgHis: 2.091 ± 0.039	3.662ArgIle: 3.662 ± 0.047	1.782ArgLys: 1.782 ± 0.034	10.056ArgLeu: 10.056 ± 0.083	2.102ArgMet: 2.102 ± 0.032	1.501ArgAsn: 1.501 ± 0.032	5.641ArgPro: 5.641 ± 0.073	2.223ArgGln: 2.223 ± 0.039	9.506ArgArg: 9.506 ± 0.101	4.158ArgSer: 4.158 ± 0.057	4.788ArgThr: 4.788 ± 0.05	6.898ArgVal: 6.898 ± 0.075	1.518ArgTrp: 1.518 ± 0.033	2.018ArgTyr: 2.018 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.285SerAla: 6.285 ± 0.071	0.38SerCys: 0.38 ± 0.016	2.427SerAsp: 2.427 ± 0.037	2.395SerGlu: 2.395 ± 0.039	1.488SerPhe: 1.488 ± 0.031	5.67SerGly: 5.67 ± 0.075	0.911SerHis: 0.911 ± 0.023	1.714SerIle: 1.714 ± 0.028	0.895SerLys: 0.895 ± 0.024	4.582SerLeu: 4.582 ± 0.058	1.09SerMet: 1.09 ± 0.027	0.729SerAsn: 0.729 ± 0.022	3.355SerPro: 3.355 ± 0.054	1.071SerGln: 1.071 ± 0.029	3.942SerArg: 3.942 ± 0.055	2.591SerSer: 2.591 ± 0.047	2.699SerThr: 2.699 ± 0.04	3.874SerVal: 3.874 ± 0.047	0.885SerTrp: 0.885 ± 0.022	1.09SerTyr: 1.09 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	7.796ThrAla: 7.796 ± 0.081	0.444ThrCys: 0.444 ± 0.018	2.914ThrAsp: 2.914 ± 0.041	2.785ThrGlu: 2.785 ± 0.046	1.551ThrPhe: 1.551 ± 0.037	6.181ThrGly: 6.181 ± 0.059	0.976ThrHis: 0.976 ± 0.024	2.121ThrIle: 2.121 ± 0.038	0.933ThrLys: 0.933 ± 0.026	5.768ThrLeu: 5.768 ± 0.063	1.02ThrMet: 1.02 ± 0.025	0.845ThrAsn: 0.845 ± 0.023	4.202ThrPro: 4.202 ± 0.064	1.028ThrGln: 1.028 ± 0.026	4.083ThrArg: 4.083 ± 0.058	2.729ThrSer: 2.729 ± 0.043	3.29ThrThr: 3.29 ± 0.049	5.718ThrVal: 5.718 ± 0.067	0.816ThrTrp: 0.816 ± 0.021	1.099ThrTyr: 1.099 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.164ValAla: 11.164 ± 0.096	0.764ValCys: 0.764 ± 0.026	4.952ValAsp: 4.952 ± 0.054	5.327ValGlu: 5.327 ± 0.061	2.644ValPhe: 2.644 ± 0.043	6.428ValGly: 6.428 ± 0.072	1.859ValHis: 1.859 ± 0.035	3.662ValIle: 3.662 ± 0.049	1.731ValLys: 1.731 ± 0.04	9.555ValLeu: 9.555 ± 0.097	1.516ValMet: 1.516 ± 0.028	1.723ValAsn: 1.723 ± 0.035	5.47ValPro: 5.47 ± 0.066	1.858ValGln: 1.858 ± 0.037	7.544ValArg: 7.544 ± 0.069	4.467ValSer: 4.467 ± 0.059	5.663ValThr: 5.663 ± 0.053	8.4ValVal: 8.4 ± 0.097	1.158ValTrp: 1.158 ± 0.031	1.732ValTyr: 1.732 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.523TrpAla: 1.523 ± 0.031	0.136TrpCys: 0.136 ± 0.009	0.747TrpAsp: 0.747 ± 0.023	0.815TrpGlu: 0.815 ± 0.023	0.494TrpPhe: 0.494 ± 0.018	0.98TrpGly: 0.98 ± 0.026	0.359TrpHis: 0.359 ± 0.017	0.635TrpIle: 0.635 ± 0.02	0.32TrpLys: 0.32 ± 0.014	1.79TrpLeu: 1.79 ± 0.041	0.293TrpMet: 0.293 ± 0.013	0.403TrpAsn: 0.403 ± 0.017	0.841TrpPro: 0.841 ± 0.023	0.471TrpGln: 0.471 ± 0.017	1.574TrpArg: 1.574 ± 0.031	0.878TrpSer: 0.878 ± 0.024	0.947TrpThr: 0.947 ± 0.027	1.012TrpVal: 1.012 ± 0.026	0.363TrpTrp: 0.363 ± 0.016	0.362TrpTyr: 0.362 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.657TyrAla: 2.657 ± 0.041	0.179TyrCys: 0.179 ± 0.01	1.355TyrAsp: 1.355 ± 0.027	1.213TyrGlu: 1.213 ± 0.029	0.623TyrPhe: 0.623 ± 0.019	2.34TyrGly: 2.34 ± 0.042	0.456TyrHis: 0.456 ± 0.017	0.636TyrIle: 0.636 ± 0.022	0.354TyrLys: 0.354 ± 0.017	2.239TyrLeu: 2.239 ± 0.038	0.278TyrMet: 0.278 ± 0.012	0.443TyrAsn: 0.443 ± 0.016	1.155TyrPro: 1.155 ± 0.03	0.56TyrGln: 0.56 ± 0.023	1.991TyrArg: 1.991 ± 0.036	0.91TyrSer: 0.91 ± 0.024	1.176TyrThr: 1.176 ± 0.024	1.714TyrVal: 1.714 ± 0.031	0.338TyrTrp: 0.338 ± 0.014	0.458TyrTyr: 0.458 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5075 proteins (1694156 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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