Amino acid dipepetide frequency for Nitrosospira briensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.364AlaAla: 11.364 ± 0.144	1.088AlaCys: 1.088 ± 0.036	5.311AlaAsp: 5.311 ± 0.076	6.35AlaGlu: 6.35 ± 0.098	3.599AlaPhe: 3.599 ± 0.072	8.553AlaGly: 8.553 ± 0.112	2.116AlaHis: 2.116 ± 0.047	5.683AlaIle: 5.683 ± 0.088	3.927AlaLys: 3.927 ± 0.08	10.773AlaLeu: 10.773 ± 0.119	2.729AlaMet: 2.729 ± 0.059	3.0AlaAsn: 3.0 ± 0.06	4.032AlaPro: 4.032 ± 0.077	3.846AlaGln: 3.846 ± 0.08	6.543AlaArg: 6.543 ± 0.092	5.849AlaSer: 5.849 ± 0.083	4.738AlaThr: 4.738 ± 0.083	7.025AlaVal: 7.025 ± 0.078	1.332AlaTrp: 1.332 ± 0.043	2.54AlaTyr: 2.54 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.953CysAla: 0.953 ± 0.032	0.177CysCys: 0.177 ± 0.019	0.551CysAsp: 0.551 ± 0.027	0.599CysGlu: 0.599 ± 0.027	0.365CysPhe: 0.365 ± 0.017	0.979CysGly: 0.979 ± 0.035	0.348CysHis: 0.348 ± 0.026	0.525CysIle: 0.525 ± 0.024	0.322CysLys: 0.322 ± 0.02	0.884CysLeu: 0.884 ± 0.033	0.224CysMet: 0.224 ± 0.016	0.33CysAsn: 0.33 ± 0.018	0.527CysPro: 0.527 ± 0.026	0.271CysGln: 0.271 ± 0.015	0.688CysArg: 0.688 ± 0.033	0.564CysSer: 0.564 ± 0.024	0.452CysThr: 0.452 ± 0.023	0.629CysVal: 0.629 ± 0.024	0.121CysTrp: 0.121 ± 0.011	0.297CysTyr: 0.297 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	5.087AspAla: 5.087 ± 0.084	0.499AspCys: 0.499 ± 0.023	2.588AspAsp: 2.588 ± 0.069	3.621AspGlu: 3.621 ± 0.064	2.326AspPhe: 2.326 ± 0.058	4.028AspGly: 4.028 ± 0.087	1.177AspHis: 1.177 ± 0.036	3.265AspIle: 3.265 ± 0.063	2.25AspLys: 2.25 ± 0.055	5.309AspLeu: 5.309 ± 0.083	1.27AspMet: 1.27 ± 0.036	1.753AspAsn: 1.753 ± 0.043	2.837AspPro: 2.837 ± 0.065	1.718AspGln: 1.718 ± 0.04	3.075AspArg: 3.075 ± 0.057	2.994AspSer: 2.994 ± 0.052	2.559AspThr: 2.559 ± 0.053	3.604AspVal: 3.604 ± 0.051	0.831AspTrp: 0.831 ± 0.03	1.719AspTyr: 1.719 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.289GluAla: 6.289 ± 0.095	0.494GluCys: 0.494 ± 0.024	2.742GluAsp: 2.742 ± 0.056	3.728GluGlu: 3.728 ± 0.071	2.245GluPhe: 2.245 ± 0.054	3.917GluGly: 3.917 ± 0.066	1.458GluHis: 1.458 ± 0.041	4.05GluIle: 4.05 ± 0.073	3.329GluLys: 3.329 ± 0.075	6.251GluLeu: 6.251 ± 0.09	1.646GluMet: 1.646 ± 0.041	2.385GluAsn: 2.385 ± 0.059	2.663GluPro: 2.663 ± 0.057	2.797GluGln: 2.797 ± 0.054	4.408GluArg: 4.408 ± 0.077	3.33GluSer: 3.33 ± 0.062	3.322GluThr: 3.322 ± 0.058	4.119GluVal: 4.119 ± 0.07	0.847GluTrp: 0.847 ± 0.034	1.616GluTyr: 1.616 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.679PheAla: 3.679 ± 0.066	0.461PheCys: 0.461 ± 0.021	2.507PheAsp: 2.507 ± 0.047	2.279PheGlu: 2.279 ± 0.049	1.766PhePhe: 1.766 ± 0.054	3.191PheGly: 3.191 ± 0.058	0.881PheHis: 0.881 ± 0.032	2.257PheIle: 2.257 ± 0.047	1.312PheLys: 1.312 ± 0.037	3.589PheLeu: 3.589 ± 0.079	0.914PheMet: 0.914 ± 0.027	1.493PheAsn: 1.493 ± 0.044	1.836PhePro: 1.836 ± 0.041	1.233PheGln: 1.233 ± 0.04	2.317PheArg: 2.317 ± 0.052	2.838PheSer: 2.838 ± 0.062	2.11PheThr: 2.11 ± 0.051	2.626PheVal: 2.626 ± 0.06	0.577PheTrp: 0.577 ± 0.027	1.207PheTyr: 1.207 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.86GlyAla: 6.86 ± 0.102	0.879GlyCys: 0.879 ± 0.033	3.819GlyAsp: 3.819 ± 0.077	4.776GlyGlu: 4.776 ± 0.096	3.309GlyPhe: 3.309 ± 0.064	6.226GlyGly: 6.226 ± 0.114	1.883GlyHis: 1.883 ± 0.054	5.016GlyIle: 5.016 ± 0.08	4.103GlyLys: 4.103 ± 0.073	7.622GlyLeu: 7.622 ± 0.098	2.307GlyMet: 2.307 ± 0.056	2.801GlyAsn: 2.801 ± 0.071	2.612GlyPro: 2.612 ± 0.063	2.753GlyGln: 2.753 ± 0.052	4.8GlyArg: 4.8 ± 0.07	4.762GlySer: 4.762 ± 0.078	4.094GlyThr: 4.094 ± 0.072	5.534GlyVal: 5.534 ± 0.075	1.195GlyTrp: 1.195 ± 0.037	2.452GlyTyr: 2.452 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.329HisAla: 2.329 ± 0.05	0.303HisCys: 0.303 ± 0.016	1.181HisAsp: 1.181 ± 0.031	1.493HisGlu: 1.493 ± 0.04	0.991HisPhe: 0.991 ± 0.029	2.042HisGly: 2.042 ± 0.05	0.76HisHis: 0.76 ± 0.03	1.328HisIle: 1.328 ± 0.032	0.759HisLys: 0.759 ± 0.031	2.355HisLeu: 2.355 ± 0.05	0.519HisMet: 0.519 ± 0.024	0.73HisAsn: 0.73 ± 0.026	1.501HisPro: 1.501 ± 0.043	0.855HisGln: 0.855 ± 0.031	1.457HisArg: 1.457 ± 0.042	1.27HisSer: 1.27 ± 0.04	1.103HisThr: 1.103 ± 0.035	1.532HisVal: 1.532 ± 0.051	0.335HisTrp: 0.335 ± 0.016	0.787HisTyr: 0.787 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.284IleAla: 6.284 ± 0.09	0.559IleCys: 0.559 ± 0.023	3.238IleAsp: 3.238 ± 0.063	3.86IleGlu: 3.86 ± 0.078	2.162IlePhe: 2.162 ± 0.05	4.566IleGly: 4.566 ± 0.071	1.26IleHis: 1.26 ± 0.035	3.005IleIle: 3.005 ± 0.057	2.425IleLys: 2.425 ± 0.059	5.109IleLeu: 5.109 ± 0.088	1.173IleMet: 1.173 ± 0.038	2.138IleAsn: 2.138 ± 0.051	2.966IlePro: 2.966 ± 0.055	1.827IleGln: 1.827 ± 0.041	3.484IleArg: 3.484 ± 0.065	3.893IleSer: 3.893 ± 0.061	3.344IleThr: 3.344 ± 0.056	3.824IleVal: 3.824 ± 0.069	0.602IleTrp: 0.602 ± 0.028	1.502IleTyr: 1.502 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.029LysAla: 4.029 ± 0.076	0.293LysCys: 0.293 ± 0.018	2.043LysAsp: 2.043 ± 0.047	2.549LysGlu: 2.549 ± 0.061	1.311LysPhe: 1.311 ± 0.042	2.735LysGly: 2.735 ± 0.06	0.977LysHis: 0.977 ± 0.033	2.54LysIle: 2.54 ± 0.057	2.175LysLys: 2.175 ± 0.058	4.49LysLeu: 4.49 ± 0.089	1.14LysMet: 1.14 ± 0.036	1.665LysAsn: 1.665 ± 0.049	2.397LysPro: 2.397 ± 0.051	1.748LysGln: 1.748 ± 0.049	2.845LysArg: 2.845 ± 0.056	2.48LysSer: 2.48 ± 0.053	2.501LysThr: 2.501 ± 0.064	2.694LysVal: 2.694 ± 0.052	0.49LysTrp: 0.49 ± 0.023	0.989LysTyr: 0.989 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.471LeuAla: 11.471 ± 0.137	1.013LeuCys: 1.013 ± 0.035	5.689LeuAsp: 5.689 ± 0.084	6.12LeuGlu: 6.12 ± 0.106	3.881LeuPhe: 3.881 ± 0.08	7.588LeuGly: 7.588 ± 0.11	2.38LeuHis: 2.38 ± 0.054	5.553LeuIle: 5.553 ± 0.084	4.529LeuLys: 4.529 ± 0.086	11.142LeuLeu: 11.142 ± 0.157	2.488LeuMet: 2.488 ± 0.058	3.401LeuAsn: 3.401 ± 0.065	5.782LeuPro: 5.782 ± 0.089	3.702LeuGln: 3.702 ± 0.071	6.658LeuArg: 6.658 ± 0.082	6.773LeuSer: 6.773 ± 0.099	5.541LeuThr: 5.541 ± 0.077	6.794LeuVal: 6.794 ± 0.085	1.24LeuTrp: 1.24 ± 0.045	2.371LeuTyr: 2.371 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.524MetAla: 2.524 ± 0.049	0.167MetCys: 0.167 ± 0.011	1.201MetAsp: 1.201 ± 0.035	1.492MetGlu: 1.492 ± 0.04	0.762MetPhe: 0.762 ± 0.031	1.791MetGly: 1.791 ± 0.044	0.629MetHis: 0.629 ± 0.025	1.29MetIle: 1.29 ± 0.039	1.328MetLys: 1.328 ± 0.036	2.764MetLeu: 2.764 ± 0.06	0.624MetMet: 0.624 ± 0.029	1.017MetAsn: 1.017 ± 0.035	1.435MetPro: 1.435 ± 0.039	1.026MetGln: 1.026 ± 0.034	1.68MetArg: 1.68 ± 0.047	1.583MetSer: 1.583 ± 0.038	1.38MetThr: 1.38 ± 0.034	1.651MetVal: 1.651 ± 0.05	0.199MetTrp: 0.199 ± 0.014	0.387MetTyr: 0.387 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.335AsnAla: 3.335 ± 0.061	0.37AsnCys: 0.37 ± 0.022	1.678AsnAsp: 1.678 ± 0.047	1.81AsnGlu: 1.81 ± 0.041	1.447AsnPhe: 1.447 ± 0.043	2.663AsnGly: 2.663 ± 0.056	0.781AsnHis: 0.781 ± 0.026	2.028AsnIle: 2.028 ± 0.046	1.225AsnLys: 1.225 ± 0.031	3.717AsnLeu: 3.717 ± 0.065	0.766AsnMet: 0.766 ± 0.027	1.292AsnAsn: 1.292 ± 0.046	2.218AsnPro: 2.218 ± 0.051	1.204AsnGln: 1.204 ± 0.039	2.337AsnArg: 2.337 ± 0.055	1.93AsnSer: 1.93 ± 0.047	1.713AsnThr: 1.713 ± 0.045	2.312AsnVal: 2.312 ± 0.053	0.534AsnTrp: 0.534 ± 0.024	1.014AsnTyr: 1.014 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.103ProAla: 5.103 ± 0.092	0.408ProCys: 0.408 ± 0.022	3.334ProAsp: 3.334 ± 0.063	3.762ProGlu: 3.762 ± 0.067	1.841ProPhe: 1.841 ± 0.048	4.388ProGly: 4.388 ± 0.073	1.154ProHis: 1.154 ± 0.035	2.304ProIle: 2.304 ± 0.056	1.714ProLys: 1.714 ± 0.049	4.917ProLeu: 4.917 ± 0.086	1.096ProMet: 1.096 ± 0.036	1.468ProAsn: 1.468 ± 0.042	2.608ProPro: 2.608 ± 0.074	1.856ProGln: 1.856 ± 0.044	2.503ProArg: 2.503 ± 0.058	2.828ProSer: 2.828 ± 0.061	2.02ProThr: 2.02 ± 0.051	4.081ProVal: 4.081 ± 0.075	0.648ProTrp: 0.648 ± 0.023	1.297ProTyr: 1.297 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.012GlnAla: 4.012 ± 0.085	0.293GlnCys: 0.293 ± 0.019	1.617GlnAsp: 1.617 ± 0.045	2.131GlnGlu: 2.131 ± 0.051	1.363GlnPhe: 1.363 ± 0.04	2.642GlnGly: 2.642 ± 0.051	0.951GlnHis: 0.951 ± 0.027	2.116GlnIle: 2.116 ± 0.048	1.607GlnLys: 1.607 ± 0.048	4.006GlnLeu: 4.006 ± 0.076	0.945GlnMet: 0.945 ± 0.035	1.231GlnAsn: 1.231 ± 0.035	1.898GlnPro: 1.898 ± 0.047	1.763GlnGln: 1.763 ± 0.057	2.621GlnArg: 2.621 ± 0.059	2.045GlnSer: 2.045 ± 0.052	1.818GlnThr: 1.818 ± 0.045	2.639GlnVal: 2.639 ± 0.054	0.49GlnTrp: 0.49 ± 0.022	1.003GlnTyr: 1.003 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	5.628ArgAla: 5.628 ± 0.09	0.599ArgCys: 0.599 ± 0.024	3.432ArgAsp: 3.432 ± 0.062	4.407ArgGlu: 4.407 ± 0.085	2.857ArgPhe: 2.857 ± 0.049	4.176ArgGly: 4.176 ± 0.073	1.773ArgHis: 1.773 ± 0.043	4.006ArgIle: 4.006 ± 0.063	2.818ArgLys: 2.818 ± 0.061	7.069ArgLeu: 7.069 ± 0.101	1.721ArgMet: 1.721 ± 0.044	2.468ArgAsn: 2.468 ± 0.05	2.764ArgPro: 2.764 ± 0.059	2.704ArgGln: 2.704 ± 0.06	4.348ArgArg: 4.348 ± 0.084	3.526ArgSer: 3.526 ± 0.063	2.994ArgThr: 2.994 ± 0.063	4.191ArgVal: 4.191 ± 0.081	0.921ArgTrp: 0.921 ± 0.033	2.191ArgTyr: 2.191 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.79SerAla: 5.79 ± 0.088	0.601SerCys: 0.601 ± 0.025	2.969SerAsp: 2.969 ± 0.05	3.204SerGlu: 3.204 ± 0.064	2.455SerPhe: 2.455 ± 0.051	5.787SerGly: 5.787 ± 0.095	1.403SerHis: 1.403 ± 0.039	3.335SerIle: 3.335 ± 0.057	2.146SerLys: 2.146 ± 0.052	6.261SerLeu: 6.261 ± 0.104	1.552SerMet: 1.552 ± 0.037	1.976SerAsn: 1.976 ± 0.044	3.075SerPro: 3.075 ± 0.059	2.091SerGln: 2.091 ± 0.049	4.173SerArg: 4.173 ± 0.071	3.968SerSer: 3.968 ± 0.08	3.046SerThr: 3.046 ± 0.076	4.101SerVal: 4.101 ± 0.08	0.809SerTrp: 0.809 ± 0.03	1.659SerTyr: 1.659 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.196ThrAla: 5.196 ± 0.078	0.451ThrCys: 0.451 ± 0.025	2.637ThrAsp: 2.637 ± 0.052	2.851ThrGlu: 2.851 ± 0.059	1.958ThrPhe: 1.958 ± 0.052	4.967ThrGly: 4.967 ± 0.086	1.175ThrHis: 1.175 ± 0.038	2.737ThrIle: 2.737 ± 0.057	1.615ThrLys: 1.615 ± 0.042	5.912ThrLeu: 5.912 ± 0.087	1.084ThrMet: 1.084 ± 0.038	1.445ThrAsn: 1.445 ± 0.038	2.887ThrPro: 2.887 ± 0.059	1.775ThrGln: 1.775 ± 0.041	3.158ThrArg: 3.158 ± 0.066	3.076ThrSer: 3.076 ± 0.07	2.464ThrThr: 2.464 ± 0.047	3.92ThrVal: 3.92 ± 0.071	0.614ThrTrp: 0.614 ± 0.027	1.268ThrTyr: 1.268 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.92ValAla: 6.92 ± 0.088	0.685ValCys: 0.685 ± 0.025	3.729ValAsp: 3.729 ± 0.065	4.415ValGlu: 4.415 ± 0.086	2.63ValPhe: 2.63 ± 0.054	4.574ValGly: 4.574 ± 0.082	1.465ValHis: 1.465 ± 0.041	4.199ValIle: 4.199 ± 0.055	3.001ValLys: 3.001 ± 0.063	7.272ValLeu: 7.272 ± 0.095	1.881ValMet: 1.881 ± 0.044	2.45ValAsn: 2.45 ± 0.053	3.36ValPro: 3.36 ± 0.061	2.246ValGln: 2.246 ± 0.057	4.351ValArg: 4.351 ± 0.079	4.296ValSer: 4.296 ± 0.066	3.932ValThr: 3.932 ± 0.07	5.29ValVal: 5.29 ± 0.088	0.827ValTrp: 0.827 ± 0.032	1.693ValTyr: 1.693 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.992TrpAla: 0.992 ± 0.035	0.129TrpCys: 0.129 ± 0.012	0.729TrpAsp: 0.729 ± 0.032	0.7TrpGlu: 0.7 ± 0.028	0.546TrpPhe: 0.546 ± 0.026	0.837TrpGly: 0.837 ± 0.03	0.382TrpHis: 0.382 ± 0.021	0.728TrpIle: 0.728 ± 0.026	0.567TrpLys: 0.567 ± 0.026	1.698TrpLeu: 1.698 ± 0.054	0.361TrpMet: 0.361 ± 0.019	0.507TrpAsn: 0.507 ± 0.023	0.534TrpPro: 0.534 ± 0.027	0.656TrpGln: 0.656 ± 0.025	1.047TrpArg: 1.047 ± 0.036	0.712TrpSer: 0.712 ± 0.025	0.635TrpThr: 0.635 ± 0.028	0.901TrpVal: 0.901 ± 0.032	0.227TrpTrp: 0.227 ± 0.016	0.383TrpTyr: 0.383 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.552TyrAla: 2.552 ± 0.056	0.338TyrCys: 0.338 ± 0.018	1.514TyrAsp: 1.514 ± 0.051	1.492TyrGlu: 1.492 ± 0.044	1.257TyrPhe: 1.257 ± 0.036	2.151TyrGly: 2.151 ± 0.054	0.675TyrHis: 0.675 ± 0.028	1.256TyrIle: 1.256 ± 0.039	0.939TyrLys: 0.939 ± 0.037	2.977TyrLeu: 2.977 ± 0.062	0.49TyrMet: 0.49 ± 0.022	0.823TyrAsn: 0.823 ± 0.027	1.402TyrPro: 1.402 ± 0.039	1.118TyrGln: 1.118 ± 0.036	2.102TyrArg: 2.102 ± 0.043	1.685TyrSer: 1.685 ± 0.042	1.422TyrThr: 1.422 ± 0.039	1.752TyrVal: 1.752 ± 0.039	0.429TyrTrp: 0.429 ± 0.023	0.842TyrTyr: 0.842 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2913 proteins (933013 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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