Amino acid dipepetide frequency for Tepidiphilus thermophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.545AlaAla: 17.545 ± 0.231	1.188AlaCys: 1.188 ± 0.05	5.308AlaAsp: 5.308 ± 0.092	8.771AlaGlu: 8.771 ± 0.134	4.223AlaPhe: 4.223 ± 0.099	9.58AlaGly: 9.58 ± 0.13	2.799AlaHis: 2.799 ± 0.078	5.676AlaIle: 5.676 ± 0.094	3.747AlaLys: 3.747 ± 0.075	16.373AlaLeu: 16.373 ± 0.218	3.027AlaMet: 3.027 ± 0.069	2.295AlaAsn: 2.295 ± 0.065	6.217AlaPro: 6.217 ± 0.121	5.307AlaGln: 5.307 ± 0.102	10.719AlaArg: 10.719 ± 0.132	5.176AlaSer: 5.176 ± 0.092	5.009AlaThr: 5.009 ± 0.088	9.046AlaVal: 9.046 ± 0.124	2.046AlaTrp: 2.046 ± 0.066	2.534AlaTyr: 2.534 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.143CysAla: 1.143 ± 0.042	0.138CysCys: 0.138 ± 0.017	0.514CysAsp: 0.514 ± 0.031	0.556CysGlu: 0.556 ± 0.024	0.298CysPhe: 0.298 ± 0.023	1.026CysGly: 1.026 ± 0.042	0.285CysHis: 0.285 ± 0.021	0.346CysIle: 0.346 ± 0.024	0.202CysLys: 0.202 ± 0.018	0.849CysLeu: 0.849 ± 0.036	0.152CysMet: 0.152 ± 0.018	0.201CysAsn: 0.201 ± 0.019	0.564CysPro: 0.564 ± 0.031	0.212CysGln: 0.212 ± 0.019	0.776CysArg: 0.776 ± 0.034	0.429CysSer: 0.429 ± 0.024	0.44CysThr: 0.44 ± 0.025	0.621CysVal: 0.621 ± 0.027	0.132CysTrp: 0.132 ± 0.013	0.232CysTyr: 0.232 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	6.129AspAla: 6.129 ± 0.113	0.372AspCys: 0.372 ± 0.024	2.439AspAsp: 2.439 ± 0.066	4.28AspGlu: 4.28 ± 0.084	1.871AspPhe: 1.871 ± 0.05	3.966AspGly: 3.966 ± 0.089	0.917AspHis: 0.917 ± 0.036	1.832AspIle: 1.832 ± 0.057	1.341AspLys: 1.341 ± 0.044	5.411AspLeu: 5.411 ± 0.097	0.815AspMet: 0.815 ± 0.028	0.85AspAsn: 0.85 ± 0.033	3.58AspPro: 3.58 ± 0.07	1.209AspGln: 1.209 ± 0.045	3.64AspArg: 3.64 ± 0.081	1.6AspSer: 1.6 ± 0.048	2.197AspThr: 2.197 ± 0.059	3.778AspVal: 3.778 ± 0.072	1.068AspTrp: 1.068 ± 0.039	1.376AspTyr: 1.376 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	10.18GluAla: 10.18 ± 0.141	0.48GluCys: 0.48 ± 0.027	3.039GluAsp: 3.039 ± 0.064	5.247GluGlu: 5.247 ± 0.099	2.081GluPhe: 2.081 ± 0.055	5.181GluGly: 5.181 ± 0.101	1.718GluHis: 1.718 ± 0.054	3.473GluIle: 3.473 ± 0.067	2.326GluLys: 2.326 ± 0.056	6.983GluLeu: 6.983 ± 0.112	1.42GluMet: 1.42 ± 0.046	1.435GluAsn: 1.435 ± 0.048	3.458GluPro: 3.458 ± 0.08	2.306GluGln: 2.306 ± 0.062	7.958GluArg: 7.958 ± 0.15	2.633GluSer: 2.633 ± 0.061	3.584GluThr: 3.584 ± 0.085	5.308GluVal: 5.308 ± 0.097	0.841GluTrp: 0.841 ± 0.04	1.342GluTyr: 1.342 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.738PheAla: 4.738 ± 0.079	0.395PheCys: 0.395 ± 0.023	2.269PheAsp: 2.269 ± 0.057	2.274PheGlu: 2.274 ± 0.052	1.494PhePhe: 1.494 ± 0.05	3.185PheGly: 3.185 ± 0.067	0.768PheHis: 0.768 ± 0.029	1.439PheIle: 1.439 ± 0.049	0.855PheLys: 0.855 ± 0.038	3.723PheLeu: 3.723 ± 0.098	0.586PheMet: 0.586 ± 0.033	0.739PheAsn: 0.739 ± 0.03	1.638PhePro: 1.638 ± 0.051	0.848PheGln: 0.848 ± 0.039	2.173PheArg: 2.173 ± 0.051	1.893PheSer: 1.893 ± 0.056	1.697PheThr: 1.697 ± 0.058	3.002PheVal: 3.002 ± 0.08	0.567PheTrp: 0.567 ± 0.034	0.96PheTyr: 0.96 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	8.367GlyAla: 8.367 ± 0.131	0.862GlyCys: 0.862 ± 0.038	3.356GlyAsp: 3.356 ± 0.071	6.035GlyGlu: 6.035 ± 0.106	3.21GlyPhe: 3.21 ± 0.073	6.173GlyGly: 6.173 ± 0.109	1.899GlyHis: 1.899 ± 0.052	4.052GlyIle: 4.052 ± 0.086	3.231GlyLys: 3.231 ± 0.067	8.486GlyLeu: 8.486 ± 0.117	2.151GlyMet: 2.151 ± 0.067	1.747GlyAsn: 1.747 ± 0.052	3.1GlyPro: 3.1 ± 0.065	2.539GlyGln: 2.539 ± 0.058	6.59GlyArg: 6.59 ± 0.108	3.621GlySer: 3.621 ± 0.07	3.926GlyThr: 3.926 ± 0.078	6.288GlyVal: 6.288 ± 0.112	1.581GlyTrp: 1.581 ± 0.049	2.16GlyTyr: 2.16 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.641HisAla: 2.641 ± 0.064	0.271HisCys: 0.271 ± 0.018	1.117HisAsp: 1.117 ± 0.041	1.426HisGlu: 1.426 ± 0.043	0.88HisPhe: 0.88 ± 0.03	2.101HisGly: 2.101 ± 0.055	0.668HisHis: 0.668 ± 0.031	0.756HisIle: 0.756 ± 0.031	0.531HisLys: 0.531 ± 0.026	2.423HisLeu: 2.423 ± 0.072	0.382HisMet: 0.382 ± 0.024	0.387HisAsn: 0.387 ± 0.024	1.831HisPro: 1.831 ± 0.066	0.665HisGln: 0.665 ± 0.03	1.858HisArg: 1.858 ± 0.052	0.808HisSer: 0.808 ± 0.032	0.996HisThr: 0.996 ± 0.038	1.529HisVal: 1.529 ± 0.048	0.457HisTrp: 0.457 ± 0.03	0.645HisTyr: 0.645 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.11IleAla: 6.11 ± 0.098	0.333IleCys: 0.333 ± 0.023	3.277IleAsp: 3.277 ± 0.069	4.025IleGlu: 4.025 ± 0.095	1.326IlePhe: 1.326 ± 0.049	3.855IleGly: 3.855 ± 0.088	0.943IleHis: 0.943 ± 0.034	1.409IleIle: 1.409 ± 0.051	1.269IleLys: 1.269 ± 0.052	4.127IleLeu: 4.127 ± 0.076	0.594IleMet: 0.594 ± 0.036	1.08IleAsn: 1.08 ± 0.042	2.41IlePro: 2.41 ± 0.059	1.214IleGln: 1.214 ± 0.044	3.033IleArg: 3.033 ± 0.066	1.681IleSer: 1.681 ± 0.049	2.103IleThr: 2.103 ± 0.061	3.713IleVal: 3.713 ± 0.069	0.403IleTrp: 0.403 ± 0.025	0.902IleTyr: 0.902 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.477LysAla: 3.477 ± 0.078	0.162LysCys: 0.162 ± 0.016	1.363LysAsp: 1.363 ± 0.043	1.96LysGlu: 1.96 ± 0.056	0.781LysPhe: 0.781 ± 0.03	2.269LysGly: 2.269 ± 0.064	0.55LysHis: 0.55 ± 0.027	1.657LysIle: 1.657 ± 0.052	1.319LysLys: 1.319 ± 0.052	2.99LysLeu: 2.99 ± 0.065	0.718LysMet: 0.718 ± 0.034	0.888LysAsn: 0.888 ± 0.038	1.782LysPro: 1.782 ± 0.06	0.883LysGln: 0.883 ± 0.039	2.5LysArg: 2.5 ± 0.06	1.366LysSer: 1.366 ± 0.047	1.71LysThr: 1.71 ± 0.047	2.191LysVal: 2.191 ± 0.059	0.281LysTrp: 0.281 ± 0.02	0.667LysTyr: 0.667 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	16.974LeuAla: 16.974 ± 0.207	0.979LeuCys: 0.979 ± 0.041	6.19LeuAsp: 6.19 ± 0.094	8.432LeuGlu: 8.432 ± 0.143	3.707LeuPhe: 3.707 ± 0.097	9.085LeuGly: 9.085 ± 0.127	2.258LeuHis: 2.258 ± 0.058	4.438LeuIle: 4.438 ± 0.087	3.081LeuLys: 3.081 ± 0.078	11.891LeuLeu: 11.891 ± 0.186	2.133LeuMet: 2.133 ± 0.057	1.878LeuAsn: 1.878 ± 0.057	7.112LeuPro: 7.112 ± 0.104	3.493LeuGln: 3.493 ± 0.075	9.14LeuArg: 9.14 ± 0.126	5.372LeuSer: 5.372 ± 0.086	5.792LeuThr: 5.792 ± 0.094	8.56LeuVal: 8.56 ± 0.136	1.647LeuTrp: 1.647 ± 0.062	2.221LeuTyr: 2.221 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.604MetAla: 2.604 ± 0.068	0.142MetCys: 0.142 ± 0.015	0.947MetAsp: 0.947 ± 0.04	1.125MetGlu: 1.125 ± 0.036	0.527MetPhe: 0.527 ± 0.03	1.672MetGly: 1.672 ± 0.052	0.406MetHis: 0.406 ± 0.023	1.019MetIle: 1.019 ± 0.039	0.89MetLys: 0.89 ± 0.036	2.252MetLeu: 2.252 ± 0.059	0.546MetMet: 0.546 ± 0.034	0.794MetAsn: 0.794 ± 0.035	1.201MetPro: 1.201 ± 0.041	0.825MetGln: 0.825 ± 0.032	1.672MetArg: 1.672 ± 0.056	1.239MetSer: 1.239 ± 0.039	1.238MetThr: 1.238 ± 0.048	1.4MetVal: 1.4 ± 0.047	0.148MetTrp: 0.148 ± 0.014	0.292MetTyr: 0.292 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.489AsnAla: 2.489 ± 0.063	0.244AsnCys: 0.244 ± 0.022	1.02AsnAsp: 1.02 ± 0.04	1.181AsnGlu: 1.181 ± 0.04	0.788AsnPhe: 0.788 ± 0.032	1.728AsnGly: 1.728 ± 0.048	0.396AsnHis: 0.396 ± 0.024	0.808AsnIle: 0.808 ± 0.04	0.537AsnLys: 0.537 ± 0.028	2.413AsnLeu: 2.413 ± 0.058	0.366AsnMet: 0.366 ± 0.024	0.425AsnAsn: 0.425 ± 0.027	1.63AsnPro: 1.63 ± 0.048	0.631AsnGln: 0.631 ± 0.029	1.663AsnArg: 1.663 ± 0.054	0.652AsnSer: 0.652 ± 0.037	0.937AsnThr: 0.937 ± 0.041	1.757AsnVal: 1.757 ± 0.052	0.312AsnTrp: 0.312 ± 0.022	0.5AsnTyr: 0.5 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.602ProAla: 6.602 ± 0.122	0.46ProCys: 0.46 ± 0.029	3.203ProAsp: 3.203 ± 0.066	5.017ProGlu: 5.017 ± 0.084	2.023ProPhe: 2.023 ± 0.058	4.576ProGly: 4.576 ± 0.084	1.131ProHis: 1.131 ± 0.044	2.151ProIle: 2.151 ± 0.056	1.635ProLys: 1.635 ± 0.056	6.106ProLeu: 6.106 ± 0.103	1.137ProMet: 1.137 ± 0.044	1.19ProAsn: 1.19 ± 0.041	3.63ProPro: 3.63 ± 0.093	2.192ProGln: 2.192 ± 0.07	3.715ProArg: 3.715 ± 0.089	2.687ProSer: 2.687 ± 0.068	2.416ProThr: 2.416 ± 0.057	4.366ProVal: 4.366 ± 0.087	1.037ProTrp: 1.037 ± 0.04	1.306ProTyr: 1.306 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	4.774GlnAla: 4.774 ± 0.101	0.249GlnCys: 0.249 ± 0.021	1.289GlnAsp: 1.289 ± 0.044	2.281GlnGlu: 2.281 ± 0.068	0.888GlnPhe: 0.888 ± 0.041	2.825GlnGly: 2.825 ± 0.056	0.772GlnHis: 0.772 ± 0.033	1.566GlnIle: 1.566 ± 0.05	1.144GlnLys: 1.144 ± 0.05	3.118GlnLeu: 3.118 ± 0.071	0.815GlnMet: 0.815 ± 0.031	0.682GlnAsn: 0.682 ± 0.032	1.843GlnPro: 1.843 ± 0.05	1.449GlnGln: 1.449 ± 0.055	3.274GlnArg: 3.274 ± 0.072	1.378GlnSer: 1.378 ± 0.057	1.791GlnThr: 1.791 ± 0.055	2.262GlnVal: 2.262 ± 0.052	0.654GlnTrp: 0.654 ± 0.03	0.614GlnTyr: 0.614 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	9.093ArgAla: 9.093 ± 0.121	0.764ArgCys: 0.764 ± 0.035	3.677ArgAsp: 3.677 ± 0.082	6.124ArgGlu: 6.124 ± 0.106	3.522ArgPhe: 3.522 ± 0.065	5.124ArgGly: 5.124 ± 0.082	2.299ArgHis: 2.299 ± 0.06	4.164ArgIle: 4.164 ± 0.084	2.164ArgLys: 2.164 ± 0.061	11.544ArgLeu: 11.544 ± 0.165	1.805ArgMet: 1.805 ± 0.05	1.56ArgAsn: 1.56 ± 0.049	4.123ArgPro: 4.123 ± 0.08	3.157ArgGln: 3.157 ± 0.072	7.958ArgArg: 7.958 ± 0.13	3.245ArgSer: 3.245 ± 0.076	3.664ArgThr: 3.664 ± 0.067	5.701ArgVal: 5.701 ± 0.114	1.665ArgTrp: 1.665 ± 0.055	2.336ArgTyr: 2.336 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.0SerAla: 5.0 ± 0.08	0.463SerCys: 0.463 ± 0.026	1.983SerAsp: 1.983 ± 0.056	2.556SerGlu: 2.556 ± 0.064	1.67SerPhe: 1.67 ± 0.053	4.374SerGly: 4.374 ± 0.078	0.853SerHis: 0.853 ± 0.038	1.848SerIle: 1.848 ± 0.057	1.044SerLys: 1.044 ± 0.039	5.143SerLeu: 5.143 ± 0.084	0.984SerMet: 0.984 ± 0.041	0.895SerAsn: 0.895 ± 0.038	2.785SerPro: 2.785 ± 0.061	1.278SerGln: 1.278 ± 0.047	3.378SerArg: 3.378 ± 0.068	2.235SerSer: 2.235 ± 0.064	1.856SerThr: 1.856 ± 0.052	3.034SerVal: 3.034 ± 0.063	0.798SerTrp: 0.798 ± 0.038	0.99SerTyr: 0.99 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.421ThrAla: 5.421 ± 0.101	0.373ThrCys: 0.373 ± 0.025	2.097ThrAsp: 2.097 ± 0.06	2.603ThrGlu: 2.603 ± 0.058	1.633ThrPhe: 1.633 ± 0.05	4.025ThrGly: 4.025 ± 0.083	1.143ThrHis: 1.143 ± 0.041	2.153ThrIle: 2.153 ± 0.053	1.123ThrLys: 1.123 ± 0.041	6.465ThrLeu: 6.465 ± 0.122	0.969ThrMet: 0.969 ± 0.036	1.014ThrAsn: 1.014 ± 0.045	3.338ThrPro: 3.338 ± 0.077	1.57ThrGln: 1.57 ± 0.052	3.285ThrArg: 3.285 ± 0.073	1.963ThrSer: 1.963 ± 0.059	2.237ThrThr: 2.237 ± 0.062	4.022ThrVal: 4.022 ± 0.083	0.58ThrTrp: 0.58 ± 0.029	0.969ThrTyr: 0.969 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.243ValAla: 9.243 ± 0.116	0.782ValCys: 0.782 ± 0.037	3.66ValAsp: 3.66 ± 0.073	5.012ValGlu: 5.012 ± 0.084	2.802ValPhe: 2.802 ± 0.065	5.573ValGly: 5.573 ± 0.109	1.614ValHis: 1.614 ± 0.047	3.623ValIle: 3.623 ± 0.078	2.121ValLys: 2.121 ± 0.064	9.098ValLeu: 9.098 ± 0.131	1.608ValMet: 1.608 ± 0.058	1.497ValAsn: 1.497 ± 0.052	4.278ValPro: 4.278 ± 0.077	2.315ValGln: 2.315 ± 0.059	6.456ValArg: 6.456 ± 0.092	3.601ValSer: 3.601 ± 0.08	3.707ValThr: 3.707 ± 0.078	6.278ValVal: 6.278 ± 0.103	1.036ValTrp: 1.036 ± 0.039	1.574ValTyr: 1.574 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.425TrpAla: 1.425 ± 0.047	0.187TrpCys: 0.187 ± 0.016	0.63TrpAsp: 0.63 ± 0.031	0.876TrpGlu: 0.876 ± 0.035	0.615TrpPhe: 0.615 ± 0.032	0.966TrpGly: 0.966 ± 0.037	0.432TrpHis: 0.432 ± 0.029	0.776TrpIle: 0.776 ± 0.033	0.413TrpLys: 0.413 ± 0.024	2.319TrpLeu: 2.319 ± 0.069	0.38TrpMet: 0.38 ± 0.021	0.373TrpAsn: 0.373 ± 0.024	0.866TrpPro: 0.866 ± 0.04	0.839TrpGln: 0.839 ± 0.033	1.739TrpArg: 1.739 ± 0.058	0.69TrpSer: 0.69 ± 0.034	0.548TrpThr: 0.548 ± 0.029	1.202TrpVal: 1.202 ± 0.041	0.335TrpTrp: 0.335 ± 0.024	0.338TrpTyr: 0.338 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.631TyrAla: 2.631 ± 0.064	0.274TyrCys: 0.274 ± 0.021	1.292TyrAsp: 1.292 ± 0.046	1.214TyrGlu: 1.214 ± 0.041	0.905TyrPhe: 0.905 ± 0.035	2.09TyrGly: 2.09 ± 0.048	0.521TyrHis: 0.521 ± 0.024	0.623TyrIle: 0.623 ± 0.033	0.54TyrLys: 0.54 ± 0.028	2.668TyrLeu: 2.668 ± 0.068	0.352TyrMet: 0.352 ± 0.022	0.547TyrAsn: 0.547 ± 0.029	1.195TyrPro: 1.195 ± 0.041	0.735TyrGln: 0.735 ± 0.032	2.163TyrArg: 2.163 ± 0.056	0.898TyrSer: 0.898 ± 0.04	1.131TyrThr: 1.131 ± 0.041	1.819TyrVal: 1.819 ± 0.056	0.362TyrTrp: 0.362 ± 0.024	0.647TyrTyr: 0.647 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2181 proteins (701948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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