Amino acid dipepetide frequency for Jannaschia pohangensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.044AlaAla: 18.044 ± 0.201
1.231AlaCys: 1.231 ± 0.035
7.82AlaAsp: 7.82 ± 0.087
7.901AlaGlu: 7.901 ± 0.091
4.574AlaPhe: 4.574 ± 0.069
11.156AlaGly: 11.156 ± 0.115
2.206AlaHis: 2.206 ± 0.049
6.052AlaIle: 6.052 ± 0.078
3.166AlaLys: 3.166 ± 0.061
14.066AlaLeu: 14.066 ± 0.141
4.044AlaMet: 4.044 ± 0.062
2.739AlaAsn: 2.739 ± 0.053
6.407AlaPro: 6.407 ± 0.086
4.3AlaGln: 4.3 ± 0.068
9.991AlaArg: 9.991 ± 0.13
5.557AlaSer: 5.557 ± 0.076
7.052AlaThr: 7.052 ± 0.075
8.736AlaVal: 8.736 ± 0.103
1.613AlaTrp: 1.613 ± 0.041
2.37AlaTyr: 2.37 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.131CysAla: 1.131 ± 0.036
0.095CysCys: 0.095 ± 0.009
0.63CysAsp: 0.63 ± 0.023
0.427CysGlu: 0.427 ± 0.021
0.308CysPhe: 0.308 ± 0.018
0.947CysGly: 0.947 ± 0.027
0.274CysHis: 0.274 ± 0.017
0.391CysIle: 0.391 ± 0.018
0.18CysLys: 0.18 ± 0.012
0.888CysLeu: 0.888 ± 0.031
0.154CysMet: 0.154 ± 0.012
0.212CysAsn: 0.212 ± 0.014
0.513CysPro: 0.513 ± 0.022
0.208CysGln: 0.208 ± 0.011
0.594CysArg: 0.594 ± 0.023
0.404CysSer: 0.404 ± 0.02
0.445CysThr: 0.445 ± 0.021
0.669CysVal: 0.669 ± 0.028
0.105CysTrp: 0.105 ± 0.009
0.183CysTyr: 0.183 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
8.423AspAla: 8.423 ± 0.098
0.547AspCys: 0.547 ± 0.022
4.133AspAsp: 4.133 ± 0.096
3.168AspGlu: 3.168 ± 0.057
2.387AspPhe: 2.387 ± 0.051
6.453AspGly: 6.453 ± 0.113
1.496AspHis: 1.496 ± 0.043
3.212AspIle: 3.212 ± 0.054
1.426AspLys: 1.426 ± 0.036
7.134AspLeu: 7.134 ± 0.098
1.755AspMet: 1.755 ± 0.045
1.161AspAsn: 1.161 ± 0.034
4.087AspPro: 4.087 ± 0.059
1.76AspGln: 1.76 ± 0.041
5.185AspArg: 5.185 ± 0.074
2.203AspSer: 2.203 ± 0.047
3.229AspThr: 3.229 ± 0.067
4.717AspVal: 4.717 ± 0.064
1.357AspTrp: 1.357 ± 0.034
1.412AspTyr: 1.412 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.125GluAla: 8.125 ± 0.099
0.316GluCys: 0.316 ± 0.016
3.102GluAsp: 3.102 ± 0.062
2.949GluGlu: 2.949 ± 0.069
1.546GluPhe: 1.546 ± 0.035
5.001GluGly: 5.001 ± 0.077
0.915GluHis: 0.915 ± 0.029
3.102GluIle: 3.102 ± 0.053
1.472GluLys: 1.472 ± 0.04
4.416GluLeu: 4.416 ± 0.072
1.806GluMet: 1.806 ± 0.039
1.328GluAsn: 1.328 ± 0.037
2.329GluPro: 2.329 ± 0.05
1.637GluGln: 1.637 ± 0.037
3.913GluArg: 3.913 ± 0.071
1.975GluSer: 1.975 ± 0.041
3.738GluThr: 3.738 ± 0.061
4.412GluVal: 4.412 ± 0.065
0.709GluTrp: 0.709 ± 0.028
0.893GluTyr: 0.893 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.719PheAla: 4.719 ± 0.072
0.413PheCys: 0.413 ± 0.02
3.019PheAsp: 3.019 ± 0.065
2.035PheGlu: 2.035 ± 0.045
1.344PhePhe: 1.344 ± 0.041
3.717PheGly: 3.717 ± 0.063
0.753PheHis: 0.753 ± 0.024
1.502PheIle: 1.502 ± 0.039
0.745PheLys: 0.745 ± 0.028
3.599PheLeu: 3.599 ± 0.064
0.757PheMet: 0.757 ± 0.03
0.9PheAsn: 0.9 ± 0.03
1.565PhePro: 1.565 ± 0.035
0.956PheGln: 0.956 ± 0.03
2.322PheArg: 2.322 ± 0.052
1.848PheSer: 1.848 ± 0.04
2.015PheThr: 2.015 ± 0.043
2.723PheVal: 2.723 ± 0.058
0.585PheTrp: 0.585 ± 0.025
0.828PheTyr: 0.828 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.226GlyAla: 10.226 ± 0.098
0.838GlyCys: 0.838 ± 0.028
5.525GlyAsp: 5.525 ± 0.109
4.405GlyGlu: 4.405 ± 0.063
3.739GlyPhe: 3.739 ± 0.062
8.063GlyGly: 8.063 ± 0.118
2.027GlyHis: 2.027 ± 0.048
4.342GlyIle: 4.342 ± 0.063
2.75GlyLys: 2.75 ± 0.057
9.794GlyLeu: 9.794 ± 0.099
2.544GlyMet: 2.544 ± 0.048
2.135GlyAsn: 2.135 ± 0.067
4.284GlyPro: 4.284 ± 0.063
3.251GlyGln: 3.251 ± 0.054
6.207GlyArg: 6.207 ± 0.083
4.206GlySer: 4.206 ± 0.078
5.391GlyThr: 5.391 ± 0.093
6.648GlyVal: 6.648 ± 0.078
1.589GlyTrp: 1.589 ± 0.039
2.131GlyTyr: 2.131 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.321HisAla: 2.321 ± 0.049
0.207HisCys: 0.207 ± 0.015
1.382HisAsp: 1.382 ± 0.042
0.95HisGlu: 0.95 ± 0.032
0.749HisPhe: 0.749 ± 0.026
1.905HisGly: 1.905 ± 0.043
0.577HisHis: 0.577 ± 0.026
0.924HisIle: 0.924 ± 0.03
0.393HisLys: 0.393 ± 0.017
2.137HisLeu: 2.137 ± 0.053
0.544HisMet: 0.544 ± 0.02
0.381HisAsn: 0.381 ± 0.021
1.385HisPro: 1.385 ± 0.037
0.532HisGln: 0.532 ± 0.022
1.398HisArg: 1.398 ± 0.039
0.812HisSer: 0.812 ± 0.029
0.753HisThr: 0.753 ± 0.026
1.598HisVal: 1.598 ± 0.04
0.372HisTrp: 0.372 ± 0.018
0.496HisTyr: 0.496 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.826IleAla: 6.826 ± 0.088
0.569IleCys: 0.569 ± 0.022
3.75IleAsp: 3.75 ± 0.063
3.141IleGlu: 3.141 ± 0.052
1.669IlePhe: 1.669 ± 0.043
4.734IleGly: 4.734 ± 0.068
0.921IleHis: 0.921 ± 0.032
1.979IleIle: 1.979 ± 0.053
1.115IleLys: 1.115 ± 0.033
4.972IleLeu: 4.972 ± 0.066
0.998IleMet: 0.998 ± 0.029
1.113IleAsn: 1.113 ± 0.033
2.346IlePro: 2.346 ± 0.044
1.042IleGln: 1.042 ± 0.032
3.142IleArg: 3.142 ± 0.048
2.53IleSer: 2.53 ± 0.05
2.814IleThr: 2.814 ± 0.056
3.888IleVal: 3.888 ± 0.068
0.783IleTrp: 0.783 ± 0.029
0.965IleTyr: 0.965 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.325LysAla: 3.325 ± 0.059
0.147LysCys: 0.147 ± 0.01
1.444LysAsp: 1.444 ± 0.033
1.062LysGlu: 1.062 ± 0.037
0.762LysPhe: 0.762 ± 0.03
2.23LysGly: 2.23 ± 0.049
0.481LysHis: 0.481 ± 0.02
1.254LysIle: 1.254 ± 0.038
0.883LysLys: 0.883 ± 0.039
2.447LysLeu: 2.447 ± 0.049
0.724LysMet: 0.724 ± 0.025
0.562LysAsn: 0.562 ± 0.026
1.542LysPro: 1.542 ± 0.041
0.625LysGln: 0.625 ± 0.023
1.863LysArg: 1.863 ± 0.045
1.492LysSer: 1.492 ± 0.043
1.65LysThr: 1.65 ± 0.041
1.971LysVal: 1.971 ± 0.049
0.35LysTrp: 0.35 ± 0.018
0.482LysTyr: 0.482 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.0LeuAla: 14.0 ± 0.137
0.954LeuCys: 0.954 ± 0.028
6.385LeuAsp: 6.385 ± 0.089
4.863LeuGlu: 4.863 ± 0.069
3.441LeuPhe: 3.441 ± 0.068
8.443LeuGly: 8.443 ± 0.095
1.939LeuHis: 1.939 ± 0.045
5.062LeuIle: 5.062 ± 0.076
2.443LeuLys: 2.443 ± 0.047
9.206LeuLeu: 9.206 ± 0.111
2.699LeuMet: 2.699 ± 0.054
2.451LeuAsn: 2.451 ± 0.043
5.94LeuPro: 5.94 ± 0.078
2.492LeuGln: 2.492 ± 0.047
7.959LeuArg: 7.959 ± 0.091
6.568LeuSer: 6.568 ± 0.081
6.842LeuThr: 6.842 ± 0.091
6.874LeuVal: 6.874 ± 0.083
1.471LeuTrp: 1.471 ± 0.043
1.751LeuTyr: 1.751 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
3.657MetAla: 3.657 ± 0.06
0.187MetCys: 0.187 ± 0.014
1.486MetAsp: 1.486 ± 0.037
1.307MetGlu: 1.307 ± 0.037
0.801MetPhe: 0.801 ± 0.027
2.355MetGly: 2.355 ± 0.057
0.443MetHis: 0.443 ± 0.02
1.492MetIle: 1.492 ± 0.036
0.926MetLys: 0.926 ± 0.031
2.499MetLeu: 2.499 ± 0.047
0.745MetMet: 0.745 ± 0.023
0.805MetAsn: 0.805 ± 0.026
1.553MetPro: 1.553 ± 0.039
0.88MetGln: 0.88 ± 0.028
1.853MetArg: 1.853 ± 0.039
1.594MetSer: 1.594 ± 0.037
2.244MetThr: 2.244 ± 0.045
1.923MetVal: 1.923 ± 0.041
0.225MetTrp: 0.225 ± 0.016
0.302MetTyr: 0.302 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.956AsnAla: 2.956 ± 0.052
0.237AsnCys: 0.237 ± 0.016
1.474AsnAsp: 1.474 ± 0.062
0.958AsnGlu: 0.958 ± 0.033
0.853AsnPhe: 0.853 ± 0.029
2.209AsnGly: 2.209 ± 0.053
0.467AsnHis: 0.467 ± 0.021
1.16AsnIle: 1.16 ± 0.035
0.518AsnLys: 0.518 ± 0.023
2.405AsnLeu: 2.405 ± 0.047
0.606AsnMet: 0.606 ± 0.02
0.556AsnAsn: 0.556 ± 0.031
1.738AsnPro: 1.738 ± 0.039
0.585AsnGln: 0.585 ± 0.024
1.724AsnArg: 1.724 ± 0.04
1.025AsnSer: 1.025 ± 0.033
1.182AsnThr: 1.182 ± 0.031
1.735AsnVal: 1.735 ± 0.043
0.406AsnTrp: 0.406 ± 0.021
0.524AsnTyr: 0.524 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.084ProAla: 6.084 ± 0.084
0.392ProCys: 0.392 ± 0.02
4.655ProAsp: 4.655 ± 0.069
4.078ProGlu: 4.078 ± 0.072
2.03ProPhe: 2.03 ± 0.045
4.996ProGly: 4.996 ± 0.072
1.084ProHis: 1.084 ± 0.032
2.299ProIle: 2.299 ± 0.045
1.453ProLys: 1.453 ± 0.038
4.915ProLeu: 4.915 ± 0.073
1.37ProMet: 1.37 ± 0.038
1.26ProAsn: 1.26 ± 0.034
2.526ProPro: 2.526 ± 0.068
1.512ProGln: 1.512 ± 0.038
3.255ProArg: 3.255 ± 0.058
2.43ProSer: 2.43 ± 0.051
2.872ProThr: 2.872 ± 0.057
4.567ProVal: 4.567 ± 0.058
0.748ProTrp: 0.748 ± 0.024
0.98ProTyr: 0.98 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.033GlnAla: 4.033 ± 0.065
0.193GlnCys: 0.193 ± 0.013
1.677GlnAsp: 1.677 ± 0.034
1.308GlnGlu: 1.308 ± 0.036
0.99GlnPhe: 0.99 ± 0.03
2.567GlnGly: 2.567 ± 0.052
0.462GlnHis: 0.462 ± 0.02
1.806GlnIle: 1.806 ± 0.039
0.806GlnLys: 0.806 ± 0.026
2.501GlnLeu: 2.501 ± 0.047
0.969GlnMet: 0.969 ± 0.03
0.767GlnAsn: 0.767 ± 0.029
1.46GlnPro: 1.46 ± 0.039
0.952GlnGln: 0.952 ± 0.038
1.981GlnArg: 1.981 ± 0.047
1.657GlnSer: 1.657 ± 0.038
1.912GlnThr: 1.912 ± 0.043
2.433GlnVal: 2.433 ± 0.049
0.382GlnTrp: 0.382 ± 0.021
0.458GlnTyr: 0.458 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
9.151ArgAla: 9.151 ± 0.1
0.474ArgCys: 0.474 ± 0.021
5.165ArgAsp: 5.165 ± 0.073
3.414ArgGlu: 3.414 ± 0.063
2.738ArgPhe: 2.738 ± 0.053
5.187ArgGly: 5.187 ± 0.071
1.632ArgHis: 1.632 ± 0.039
3.998ArgIle: 3.998 ± 0.064
1.97ArgLys: 1.97 ± 0.047
7.8ArgLeu: 7.8 ± 0.096
2.151ArgMet: 2.151 ± 0.039
1.683ArgAsn: 1.683 ± 0.041
3.743ArgPro: 3.743 ± 0.066
2.345ArgGln: 2.345 ± 0.048
5.45ArgArg: 5.45 ± 0.085
3.326ArgSer: 3.326 ± 0.058
3.49ArgThr: 3.49 ± 0.058
5.123ArgVal: 5.123 ± 0.074
0.927ArgTrp: 0.927 ± 0.027
1.479ArgTyr: 1.479 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.584SerAla: 5.584 ± 0.076
0.411SerCys: 0.411 ± 0.016
3.316SerAsp: 3.316 ± 0.052
2.589SerGlu: 2.589 ± 0.051
1.97SerPhe: 1.97 ± 0.042
5.374SerGly: 5.374 ± 0.073
0.934SerHis: 0.934 ± 0.032
2.289SerIle: 2.289 ± 0.054
1.208SerLys: 1.208 ± 0.037
4.864SerLeu: 4.864 ± 0.068
1.236SerMet: 1.236 ± 0.028
1.209SerAsn: 1.209 ± 0.036
2.559SerPro: 2.559 ± 0.055
1.433SerGln: 1.433 ± 0.034
3.275SerArg: 3.275 ± 0.054
2.303SerSer: 2.303 ± 0.048
2.361SerThr: 2.361 ± 0.047
3.839SerVal: 3.839 ± 0.066
0.694SerTrp: 0.694 ± 0.025
1.124SerTyr: 1.124 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
6.742ThrAla: 6.742 ± 0.076
0.557ThrCys: 0.557 ± 0.024
3.584ThrAsp: 3.584 ± 0.063
3.089ThrGlu: 3.089 ± 0.051
2.192ThrPhe: 2.192 ± 0.05
5.985ThrGly: 5.985 ± 0.097
1.118ThrHis: 1.118 ± 0.032
2.825ThrIle: 2.825 ± 0.06
1.277ThrLys: 1.277 ± 0.036
6.671ThrLeu: 6.671 ± 0.076
1.29ThrMet: 1.29 ± 0.038
1.269ThrAsn: 1.269 ± 0.034
3.862ThrPro: 3.862 ± 0.06
1.557ThrGln: 1.557 ± 0.033
4.056ThrArg: 4.056 ± 0.066
2.728ThrSer: 2.728 ± 0.051
3.095ThrThr: 3.095 ± 0.062
4.561ThrVal: 4.561 ± 0.088
0.749ThrTrp: 0.749 ± 0.026
1.21ThrTyr: 1.21 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
9.746ValAla: 9.746 ± 0.091
0.663ValCys: 0.663 ± 0.028
4.268ValAsp: 4.268 ± 0.064
4.394ValGlu: 4.394 ± 0.063
2.837ValPhe: 2.837 ± 0.058
5.729ValGly: 5.729 ± 0.072
1.314ValHis: 1.314 ± 0.036
4.082ValIle: 4.082 ± 0.067
1.77ValLys: 1.77 ± 0.052
7.652ValLeu: 7.652 ± 0.079
2.071ValMet: 2.071 ± 0.042
1.916ValAsn: 1.916 ± 0.047
3.908ValPro: 3.908 ± 0.055
2.066ValGln: 2.066 ± 0.044
4.439ValArg: 4.439 ± 0.06
4.15ValSer: 4.15 ± 0.057
5.438ValThr: 5.438 ± 0.093
5.769ValVal: 5.769 ± 0.08
1.091ValTrp: 1.091 ± 0.033
1.305ValTyr: 1.305 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.484TrpAla: 1.484 ± 0.038
0.137TrpCys: 0.137 ± 0.01
0.921TrpAsp: 0.921 ± 0.03
0.657TrpGlu: 0.657 ± 0.023
0.624TrpPhe: 0.624 ± 0.026
1.059TrpGly: 1.059 ± 0.033
0.341TrpHis: 0.341 ± 0.017
0.727TrpIle: 0.727 ± 0.028
0.393TrpLys: 0.393 ± 0.023
1.724TrpLeu: 1.724 ± 0.045
0.421TrpMet: 0.421 ± 0.018
0.413TrpAsn: 0.413 ± 0.017
0.793TrpPro: 0.793 ± 0.027
0.625TrpGln: 0.625 ± 0.024
1.178TrpArg: 1.178 ± 0.036
0.826TrpSer: 0.826 ± 0.026
0.95TrpThr: 0.95 ± 0.029
0.964TrpVal: 0.964 ± 0.026
0.279TrpTrp: 0.279 ± 0.016
0.262TrpTyr: 0.262 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.449TyrAla: 2.449 ± 0.049
0.192TyrCys: 0.192 ± 0.014
1.507TyrAsp: 1.507 ± 0.044
0.987TyrGlu: 0.987 ± 0.032
0.791TyrPhe: 0.791 ± 0.026
1.988TyrGly: 1.988 ± 0.047
0.434TyrHis: 0.434 ± 0.02
0.799TyrIle: 0.799 ± 0.028
0.404TyrLys: 0.404 ± 0.02
2.095TyrLeu: 2.095 ± 0.045
0.391TyrMet: 0.391 ± 0.017
0.459TyrAsn: 0.459 ± 0.02
0.968TyrPro: 0.968 ± 0.03
0.56TyrGln: 0.56 ± 0.022
1.459TyrArg: 1.459 ± 0.037
0.935TyrSer: 0.935 ± 0.031
0.942TyrThr: 0.942 ± 0.029
1.456TyrVal: 1.456 ± 0.03
0.343TyrTrp: 0.343 ± 0.017
0.458TyrTyr: 0.458 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3732 proteins (1134252 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski